Quantification of epicardial adipose tissue in coronary calcium score and CT coronary angiography image data sets: Comparison of attenuation values, thickness and volumes
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OBJECTIVE: The aim of the study was to compare epicardial adipose tissue (EAT) characteristics assessed with coronary calcium score (CS) and CT coronary angiography (CTCA) image data sets. METHODS: In 76 patients (mean age 59 ± 13 years) who underwent CS and CTCA owing to suspected coronary artery disease (CAD), EAT was quantified in terms of density (Hounsfield units), thickness and volume. The EAT volume was extracted with a semi-automatic software. RESULTS: A moderate correlation was found between EAT density in CS and CTCA image data sets (-100 ± 19 HU vs -70 ± 24 HU; p < 0.05, r = 0.55). The distribution of EAT was not symmetrical with a maximal thickness at the right atrioventricular groove (14.2 ± 5.3 mm in CS, 15.7 ± 5 mm in CTCA; p > 0.05, r = 0.76). The EAT volume resulted as 122 ± 50 cm(3) in CS and 86 ± 40 cm(3) in CTCA (Δ = 30%, p < 0.05, r = 0.92). After adjustment for post-contrast EAT attenuation difference (Δ = 30 HU), the volume was 101 ± 47 cm(3) (Δ = 17%, p < 0.05, r = 0.92). Based on EAT volume median values, no differences were found between groups with smaller and larger volumes in terms of Agatston score and CAD severity. CONCLUSION: CS and CTCA image data sets may be equally employed for EAT assessment; however, an underestimation of volume is found with the latter acquisition even after post-contrast attenuation adjustment. ADVANCES IN KNOWLEDGE: EAT may be measured by processing either the CS or CTCA image data sets.
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CCT enables an accurate and reproducible quantification of EAT, even in particular sites such as around the coronary arteries and from either unenhanced scan for calcium scoring or angiographic imaging.
“The CCT technique enables an accurate and reproducible quantification of EAT, even in particular sites such as around the coronary arteries and from either unenhanced scan for calcium scoring or angiographic imaging [110].”
From Dysregulated epicardial adipose tissue as a risk factor and potential therapeutic target of heart failure with preserved ejection fraction in diabetes (2022) · cites this paper as [110]
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Sorin, V., Fatade, K., Morris, M. F., Gupta, A. B., & Rajiah, P. S. (2026) · Radiographics · doi:10.1148/rg.260068
- Authors
- La Grutta, L., Toia, P., Farruggia, A., Albano, D., Grassedonio, E., Palmeri, A., Maffei, E., Galia, M., Vitabile, S., Cademartiri, F., & Midiri, M.
- Affiliations
- University of Palermo (IT)
- Montreal Heart Institute (CA)
- ORCID
- Venue
- The British Journal of Radiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-06
- Volume
- 89
- Issue
- 1062
- Pages
- 20150773
- ISSN
- 0007-1285 (ISSN-L)
- 1748-880X
- PMC
- PMC5258148
- OpenAlex
- W2297066054
- Cited by
- 46
- References
- 37
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 8 · 2022: 7 · 2021: 4 · 2020: 6 · 2019: 6 · 2018: 2 · 2017: 1 · 2016: 2
- FWCI
- 3.02
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- British Journal of Radiology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Coronary Artery Anomalies
- Keywords
- epicardial adipose tissue, coronary artery calcium score, coronary CT angiography, Hounsfield units, EAT volume, EAT thickness, coronary artery disease, Agatston score
- MeSH terms
- Computed Tomography Angiography, Adipose Tissue, Algorithms, Coronary Artery Disease, Female, Humans, Male, Middle Aged, Pericardium, Radiographic Image Interpretation, Computer-Assisted, Sensitivity and Specificity, Reproducibility of Results, Coronary Angiography, Imaging, Three-Dimensional, Adiposity, Vascular Calcification
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