Cited by 46Cardiovascular Disease and AdiposityCardiac Imaging and DiagnosticsCoronary Artery Anomalies

Quantification of epicardial adipose tissue in coronary calcium score and CT coronary angiography image data sets: Comparison of attenuation values, thickness and volumes

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La Grutta, Ludovico, Toia, Patrizia, Farruggia, Alfonso, Albano, Domenico, Grassedonio, Emanuele, Palmeri, Antonella, Maffei, Erica, Galia, Massimo +3 more·2016·The British Journal of Radiology

Abstract

OBJECTIVE: The aim of the study was to compare epicardial adipose tissue (EAT) characteristics assessed with coronary calcium score (CS) and CT coronary angiography (CTCA) image data sets. METHODS: In 76 patients (mean age 59 ± 13 years) who underwent CS and CTCA owing to suspected coronary artery disease (CAD), EAT was quantified in terms of density (Hounsfield units), thickness and volume. The EAT volume was extracted with a semi-automatic software. RESULTS: A moderate correlation was found between EAT density in CS and CTCA image data sets (-100 ± 19 HU vs -70 ± 24 HU; p < 0.05, r = 0.55). The distribution of EAT was not symmetrical with a maximal thickness at the right atrioventricular groove (14.2 ± 5.3 mm in CS, 15.7 ± 5 mm in CTCA; p > 0.05, r = 0.76). The EAT volume resulted as 122 ± 50 cm(3) in CS and 86 ± 40 cm(3) in CTCA (Δ = 30%, p < 0.05, r = 0.92). After adjustment for post-contrast EAT attenuation difference (Δ = 30 HU), the volume was 101 ± 47 cm(3) (Δ = 17%, p < 0.05, r = 0.92). Based on EAT volume median values, no differences were found between groups with smaller and larger volumes in terms of Agatston score and CAD severity. CONCLUSION: CS and CTCA image data sets may be equally employed for EAT assessment; however, an underestimation of volume is found with the latter acquisition even after post-contrast attenuation adjustment. ADVANCES IN KNOWLEDGE: EAT may be measured by processing either the CS or CTCA image data sets.

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Crossref · 10.1259/bjr.20150773

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Authors
La Grutta, L., Toia, P., Farruggia, A., Albano, D., Grassedonio, E., Palmeri, A., Maffei, E., Galia, M., Vitabile, S., Cademartiri, F., & Midiri, M.
Affiliations
  • University of Palermo (IT)
  • Montreal Heart Institute (CA)
Venue
The British Journal of Radiology
Published
2016-06
Volume
89
Issue
1062
Pages
20150773
ISSN
  • 0007-1285 (ISSN-L)
  • 1748-880X
OpenAlex
W2297066054
Cited by
46
References
37
Citations by year
2026: 3 · 2025: 3 · 2024: 4 · 2023: 8 · 2022: 7 · 2021: 4 · 2020: 6 · 2019: 6 · 2018: 2 · 2017: 1 · 2016: 2
FWCI
3.02
Type
journal article
Language
en
Open access
Locations
  • British Journal of Radiology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
  • RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
  • Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Coronary Artery Anomalies
Keywords
epicardial adipose tissue, coronary artery calcium score, coronary CT angiography, Hounsfield units, EAT volume, EAT thickness, coronary artery disease, Agatston score
MeSH terms
Computed Tomography Angiography, Adipose Tissue, Algorithms, Coronary Artery Disease, Female, Humans, Male, Middle Aged, Pericardium, Radiographic Image Interpretation, Computer-Assisted, Sensitivity and Specificity, Reproducibility of Results, Coronary Angiography, Imaging, Three-Dimensional, Adiposity, Vascular Calcification

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