Reciprocal regulation of microRNA and mRNA profiles in neuronal development and synapse formation
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Background: Synapse formation and the development of neural networks are known to be controlled by a coordinated program of mRNA synthesis. microRNAs are now recognized to be important regulators of mRNA translation and stability in a wide variety of organisms. While specific microRNAs are known to be involved in neural development, the extent to which global microRNA and mRNA profiles are coordinately regulated in neural development is unknown. Results: We examined mouse primary neuronal cultures, analyzing microRNA and mRNA expression. Three main developmental patterns of microRNA expression were observed: steady-state levels, up-regulated and down-regulated. Co-expressed microRNAs were found to have related target recognition sites and to be encoded in distinct genomic locations. A number of 43 differentially expressed miRNAs were located in five genomic clusters. Their predicted mRNA targets show reciprocal levels of expression. We identified a set of reciprocally expressed microRNAs that target mRNAs encoding postsynaptic density proteins and high-level steady-state microRNAs that target non-neuronal low-level expressed mRNAs. Conclusion: We characterized hundreds of miRNAs in neuronal culture development and identified three major modes of miRNA expression. We predict these miRNAs to regulate reciprocally expressed protein coding genes, including many genes involved in synaptogenesis. The identification of miRNAs that target mRNAs during synaptogenesis indicates a new level of regulation of the synapse.
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Many miRNAs display tissue-, cell type-, or condition-specific expression patterns and play key roles in the regulation of developmental programs.
“Many miRNAs also display tissue-, cell type-, or conditionspecific expression patterns and play key roles in the regulation of developmental programs (DeVeale et al., 2021;Manakov et al., 2009).”
From Scalable and deep profiling of mRNA targets for individual microRNAs with chimeric eCLIP (2022) · cites this paper as Manakov et al., 2009
The Results (miRNA Expression Analysis; page not provided) report many miRNAs changing expression during the development of mouse neuronal cultures. The Background and Discussion link miRNAs to brain development and suggest an important role in neuronal differentiation, but the study does not establish tissue- or cell-type-specific expression patterns or key roles across developmental programs generally. (LLM, conf=0.84)
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- Authors
- Manakov, S. A., Grant, S. G., & Enright, A. J.
- Affiliations
- European Bioinformatics Institute (GB)
- Wellcome Sanger Institute (GB)
- Corresponding author
- Enright, Anton J
- Venue
- BMC Genomics
- Published
- 2009-09-08
- Volume
- 10
- Issue
- 1
- Pages
- 419-419
- ISSN
- 1471-2164 (ISSN-L)
- PMC
- PMC2759968
- OpenAlex
- W2159635364
- Cited by
- 34
- References
- 69
- Citations by year
- 2025: 1 · 2022: 3 · 2021: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 4 · 2015: 3 · 2014: 4 · 2013: 2 · 2012: 7
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- BMC Genomics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Apollo (University of Cambridge) (submittedVersion, cc-by)
- Apollo (cc-by)
- Funders
- Wellcome Trust
- Darwin Trust of Edinburgh
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- microRNA, mRNA expression profiling, synaptogenesis, neuronal development, reciprocal gene regulation, microRNA binding sites, postsynaptic density proteins, mRNA stability, translational regulation, primary neuronal cultures, neural network development
- MeSH terms
- Animals, Embryo, Mammalian, Mice, Inbred C57BL, RNA, Messenger, Cluster Analysis, Genome, Sequence Analysis, RNA, Gene Expression Regulation, Developmental, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, MicroRNAs, Mice, Neurogenesis
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