General Principals of miRNA Biogenesis and Regulation in the Brain
Open accessAbstract
MicroRNAs (miRNAs) are small, noncoding RNAs that mediate posttranscriptional gene suppression in a sequence-specific manner. The ability of a single miRNA species to target multiple messenger RNAs (mRNAs) makes miRNAs exceptionally important regulators of various cellular functions. The regulatory capacity of miRNAs is increased further by the miRNA ability to suppress gene expression using multiple mechanisms that range from translational inhibition to mRNA degradation. The high miRNA diversity multiplied by the large number of individual miRNA targets generates a vast regulatory RNA network than enables flexible control of mRNA expression. The gene-regulatory capacity and diversity of miRNAs is particularly valuable in the brain, where functional specialization of neurons and persistent flow of information requires constant neuronal adaptation to environmental cues. In this review we will summarize the current knowledge about miRNA biogenesis and miRNA expression regulation with a focus on the role of miRNAs in the mammalian nervous system.
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A common post-transcriptional process mediated at least in part by miRNA alters the structure of dendrites and neurogenesis.
“A common post-transcriptional process mediated at least in part by miRNA alters the structure of dendrites and neurogenesis.”
From Epigenetic mechanisms of major depression: Targeting neuronal plasticity (2018) · cites this paper as [147]
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Tumor suppression by RNA from the 3′ untranslated region of α-tropomyosin
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- REVIEW .............................................................................................................................................. Neuropsychopharmacology REVIEWS
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The Cellular and Molecular Landscapes of the Developing Human Central Nervous System
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Merienne, N., Douce, J. L., Faivre, E., Déglon, N., & Bonvento, G. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00106 · Cited by 58 · see citing works
- Authors
- O'Carroll, D., & Schaefer, A.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Schaefer, Anne
- ORCID
- Schaefer, Anne
- Venue
- Neuropsychopharmacology
- Published
- 2012-06-06
- Volume
- 38
- Issue
- 1
- Pages
- 39-54
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC3521995
- OpenAlex
- W1992687523
- Cited by
- 205
- References
- 222
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 15 · 2023: 14 · 2022: 15 · 2021: 19 · 2020: 17 · 2019: 9 · 2018: 13 · 2017: 16 · 2016: 25 · 2015: 15 · 2014: 17 · 2013: 15 · 2012: 5
- FWCI
- 1.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- National Institutes of Health (W81XWH)
- National Institute on Drug Abuse (R03DA025962, DA025962)
- Medical Research and Materiel Command
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- microRNA biogenesis, miRNA expression regulation, post-transcriptional regulation, brain, neural adaptation, protein synthesis inhibition, mRNA degradation, miRNA target networks, nervous system
- MeSH terms
- Animals, Mental Disorders, Brain Chemistry, Biological Evolution, Humans, Nervous System Diseases, MicroRNAs
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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