Cited by 205MicroRNA in disease regulationPlant Molecular Biology ResearchRNA Research and Splicing

General Principals of miRNA Biogenesis and Regulation in the Brain

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O'Carroll, Dónal, Schaefer, Anne·2013·Neuropsychopharmacology

Abstract

MicroRNAs (miRNAs) are small, noncoding RNAs that mediate posttranscriptional gene suppression in a sequence-specific manner. The ability of a single miRNA species to target multiple messenger RNAs (mRNAs) makes miRNAs exceptionally important regulators of various cellular functions. The regulatory capacity of miRNAs is increased further by the miRNA ability to suppress gene expression using multiple mechanisms that range from translational inhibition to mRNA degradation. The high miRNA diversity multiplied by the large number of individual miRNA targets generates a vast regulatory RNA network than enables flexible control of mRNA expression. The gene-regulatory capacity and diversity of miRNAs is particularly valuable in the brain, where functional specialization of neurons and persistent flow of information requires constant neuronal adaptation to environmental cues. In this review we will summarize the current knowledge about miRNA biogenesis and miRNA expression regulation with a focus on the role of miRNAs in the mammalian nervous system.

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  • A common post-transcriptional process mediated at least in part by miRNA alters the structure of dendrites and neurogenesis.

    “A common post-transcriptional process mediated at least in part by miRNA alters the structure of dendrites and neurogenesis.”

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Authors
O'Carroll, D., & Schaefer, A.
Affiliations
Icahn School of Medicine at Mount Sinai (US)
Corresponding author
Schaefer, Anne
Venue
Neuropsychopharmacology
Published
2012-06-06
Volume
38
Issue
1
Pages
39-54
ISSN
  • 0893-133X (ISSN-L)
  • 1740-634X
OpenAlex
W1992687523
Cited by
205
References
222
Citations by year
2026: 3 · 2025: 7 · 2024: 15 · 2023: 14 · 2022: 15 · 2021: 19 · 2020: 17 · 2019: 9 · 2018: 13 · 2017: 16 · 2016: 25 · 2015: 15 · 2014: 17 · 2013: 15 · 2012: 5
FWCI
1.24
Type
journal article
Language
en
Open access
Locations
  • Neuropsychopharmacology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Alliance for Research on Schizophrenia and Depression
  • National Institutes of Health (W81XWH)
  • National Institute on Drug Abuse (R03DA025962, DA025962)
  • Medical Research and Materiel Command
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Keywords
microRNA biogenesis, miRNA expression regulation, post-transcriptional regulation, brain, neural adaptation, protein synthesis inhibition, mRNA degradation, miRNA target networks, nervous system
MeSH terms
Animals, Mental Disorders, Brain Chemistry, Biological Evolution, Humans, Nervous System Diseases, MicroRNAs

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