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Cited by 1,834

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Guidelines for performing Mendelian randomization investigations

Open access
Burgess, Stephen, Davey Smith, George, Davies, Neil M., Dudbridge, Frank, Gill, Dipender, Glymour, M. Maria, Hartwig, Fernando P., Holmes, Michael V., Minelli, Cosetta, Relton, Caroline L., Theodoratou, Evropi·2019·Wellcome Open Research
DOI 10.12688/wellcomeopenres.15555.1
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Abstract

This paper provides guidelines for performing Mendelian randomization investigations. It is aimed at practitioners seeking to undertake analyses and write up their findings, and at journal editors and reviewers seeking to assess Mendelian randomization manuscripts. The guidelines are divided into nine sections: motivation and scope, data sources, choice of genetic variants, variant harmonization, primary analysis, supplementary and sensitivity analyses (one section on robust methods and one on other approaches), data presentation, and interpretation. These guidelines will be updated based on feedback from the community and advances in the field. Updates will be made periodically as needed, and at least every 18 months.

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Cited by

Metadata

Authors
Burgess, S., Davey Smith, G., Davies, N. M., Dudbridge, F., Gill, D., Glymour, M. M., Hartwig, F. P., Holmes, M. V., Minelli, C., Relton, C. L., & Theodoratou, E.
Venue
Wellcome Open Research
Publisher
F1000 Research Ltd
Published
2019-11-26
Volume
4
Pages
186
ISSN
2398-502X (ISSN-L)
DOI
10.12688/wellcomeopenres.15555.1
OpenAlex
W4253754191
Cited by
1,834
References
41
FWCI
41.99
Type
journal article
Language
en
Update notices
Open access
gold
Licence
creativecommons.org/licenses/by/4.0/ (tdm)
Funders
  • Economic and Social Research Council (ES/N000757/1)
  • Cancer Research UK (C31250/A22804)
  • Wellcome Trust (204623)
  • Medical Research Council (MC_UU_00011/5, MC_UU_12013/9, MC_UU_00011/1, MC_UU_12013/1)
  • British Heart Foundation (FS/18/23/33512)

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