MyD88: a central player in innate immune signaling

Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway

Yamamoto, M., Sato, S., Hemmi, H., Hoshino, K., Kaisho, T., Sanjo, H., Takeuchi, O., Sugiyama, M., Okabe, M., Takeda, K., et al. (2003) · Science · doi:10.1126/science.1087262 · Cited by 3,286

CpG Motifs in Bacterial DNA and Their Immune Effects

Krieg, A. Μ. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100301.064842 · Cited by 2,598

Unresponsiveness of MyD88-deficient mice to endotoxin.

Kawai, T., Adachi, O., Ogawa, T., Takeda, K., & Akira, S. (1999) · Immunity · doi:10.1016/s1074-7613(00)80086-2 · Cited by 2,367

Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function.

Adachi, O., Kawai, T., Takeda, K., Matsumoto, M., Tsutsui, H., Sakagami, M., Nakanishi, K., & Akira, S. (1998) · Immunity · doi:10.1016/s1074-7613(00)80596-8 · Cited by 2,358

MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways.

Medzhitov, R., Preston-Hurlburt, P., Kopp, E., Stadlen, A., Chen, C.-Q., Ghosh, S., & Janeway, C. (1998) · Molecules and Cells · doi:10.1016/s1097-2765(00)80136-7 · Cited by 1,783

Oncogenically active MYD88 mutations in human lymphoma

Ngo, V. N., Young, R. M., Schmitz, R., Jhavar, S. G., Xiao, W., Lim, K., Kohlhammer, H., Xu, W., Yang, Y., Zhao, H., et al. (2010) · Nature · doi:10.1038/nature09671 · Cited by 1,560

Toll-like Receptor Signaling

Akira, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.r300028200 · Cited by 1,499

Crystal Structure of the TLR1-TLR2 Heterodimer Induced by Binding of a Tri-Acylated Lipopeptide

Jin, M. S., Kim, S. E., Heo, J. Y., Lee, M. E., Kim, H. M., Paik, S., Lee, H., & Lee, J. (2007) · Cell · doi:10.1016/j.cell.2007.09.008 · Cited by 1,391

Toll-like receptors control activation of adaptive immune responses

Schnare, M., Barton, G. M., Czopik, A. K., Takeda, K., Akira, S., & Medzhitov, R. M. (2001) · Nature Immunology · doi:10.1038/ni712 · Cited by 1,364

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β

Kagan, J. C., Su, T., Horng, T., Chow, A. Y., Akira, S., & Medzhitov, R. M. (2008) · Nature Immunology · doi:10.1038/ni1569 · Cited by 1,310

CCN1 is an opsonin for bacterial clearance and a direct activator of Toll-like receptor signaling

Jun, J.-I., & Lau, L. F. (2020) · Nature Communications · doi:10.1038/s41467-020-15075-5 · Cited by 55

Comparative Proteomic Analysis Reveals Varying Impact on Immune Responses in Phorbol 12-Myristate-13-Acetate-Mediated THP-1 Monocyte-to-Macrophage Differentiation

Pinto, S. M., Kim, H., Subbannayya, Y., Giambelluca, M. S., Bösl, K., Ryan, L., Sharma, A., & Kandasamy, R. K. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.679458 · Cited by 59

Inflammation-driven NF-κB signaling represses ferroportin transcription in macrophages via HDAC1 and HDAC3

Marques, O., Horvat, N. K., Zechner, L., Colucci, S., Sparla, R., Zimmermann, S., Neufeldt, C. J., Altamura, S., Qiu, R., Müdder, K., et al. (2024) · Blood · doi:10.1182/blood.2023023417 · Cited by 55

Immune dysfunction during S. aureus biofilm-associated implant infections: opportunities for novel therapeutic strategies

Brandquist, N. D., & Kielian, T. (2025) · npj Biofilms and Microbiomes · doi:10.1038/s41522-025-00782-y · Cited by 57

Innate Immune Recognition: An Issue More Complex Than Expected

Kubelková, K., & Macela, A. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00241 · Cited by 55

Acetylation of TIR domains in the TLR4-Mal-MyD88 complex regulates immune responses in sepsis

Li, X., Li, X., Huang, P., Zhang, F., Du, J. K., Kong, Y., Shao, Z., Wu, X., Fan, W., Tao, H., et al. (2024) · The EMBO Journal · doi:10.1038/s44318-024-00237-8 · Cited by 52

Stimulus-specific responses in innate immunity: Multilayered regulatory circuits

Luecke, S., Sheu, K. M., & Hoffmann, A. (2021) · Immunity · doi:10.1016/j.immuni.2021.08.018 · Cited by 52

Modulation of Toll-like receptor signaling in innate immunity by natural products

Chen, L., & Yu, J. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.02.005 · Cited by 51

TLR-Mediated Signal Transduction and Neurodegenerative Disorders

Adhikarla, S. V., Jha, N. K., Goswami, V. K., Sharma, A., Bhardwaj, A., Dey, A., Villa, C., Kumar, Y., & Jha, S. K. (2021) · Brain Sciences · doi:10.3390/brainsci11111373 · Cited by 50

Long non‐coding RNA MALAT1 sponges miR‐149 to promote inflammatory responses of LPS‐induced acute lung injury by targeting MyD88

Liang, W., Zeng, X., Jiang, S., Tan, H., Yan, M.-Y., & Yang, H. (2019) · Cell Biology International · doi:10.1002/cbin.11235 · Cited by 50

The STING1-MYD88 complex drives ACOD1/IRG1 expression and function in lethal innate immunity

Chen, F., Wu, R., Liu, J., Kang, R., Li, J., & Tang, D. (2022) · iScience · doi:10.1016/j.isci.2022.104561 · Cited by 50

TLR4 signaling induces TLR3 up-regulation in alveolar macrophages during acute lung injury

Ding, X., Jin, S., Tong, Y., Jiang, X., Chen, Z., Mei, S., Zhang, L., Billiar, T. R., & Li, Q. (2017) · Scientific Reports · doi:10.1038/srep34278 · Cited by 51

Limonin Inhibits IL‐1β‐Induced Inflammation and Catabolism in Chondrocytes and Ameliorates Osteoarthritis by Activating Nrf2

Jin, J., Lv, X., Wang, B., Ren, C., Jiang, J., Chen, H., Chen, X., Gu, M., Pan, Z., Tian, N., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/7292512 · Cited by 50

LEF1 mediates osteoarthritis progression through circRNF121/miR-665/MYD88 axis via NF-кB signaling pathway

Wang, T., Hao, Z., Liu, C., Yuan, L., Li, L., Yin, M., Li, Q., Qi, Z., & Wang, Z. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-02769-3 · Cited by 49

Syk-MyD88 Axis Is a Critical Determinant of Inflammatory-Response in Activated Macrophages

Yi, Y., Kim, H. G., Kim, J. H., Yang, W. S., Kim, E., Jeong, D., Park, J. G., Aziz, N., Kim, S., Parameswaran, N., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.767366 · Cited by 50

Innate immune regulations and various siRNA modalities

Kaushal, A. (2023) · Drug Delivery and Translational Research · doi:10.1007/s13346-023-01361-4 · Cited by 52

E3 ubiquitin ligases, the powerful modulator of innate antiviral immunity

Zheng, Y., & Gao, C. (2019) · Cellular Immunology · doi:10.1016/j.cellimm.2019.04.003 · Cited by 50

Dysregulated gene expression associated with inflammatory and translation pathways in activated monocytes from children with autism spectrum disorder

Hughes, H. K., Rowland, M. E., Onore, C. E., Rogers, S. J., Ciernia, A. V., & Ashwood, P. (2022) · Translational Psychiatry · doi:10.1038/s41398-021-01766-0 · Cited by 51

Periodontitis promotes bacterial extracellular vesicle-induced neuroinflammation in the brain and trigeminal ganglion

Ha, J. Y., Seok, J., Kim, S., Jung, H.-J., Ryu, K., Nakamura, M., Jang, I., Hong, S., Lee, Y., & Lee, H. (2023) · PLoS Pathogens · doi:10.1371/journal.ppat.1011743 · Cited by 49

IL-1R/TLR2 through MyD88 Divergently Modulates Osteoclastogenesis through Regulation of Nuclear Factor of Activated T Cells c1 (NFATc1) and B Lymphocyte-induced Maturation Protein-1 (Blimp1)

Chen, Z., Su, L., Xu, Q., Katz, J., Michalek, S. M., Fan, M., Feng, X., & Zhang, P. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.663518 · Cited by 48

The ameliorative effect of melatonin on LPS-induced Sertoli cells inflammatory and tight junctions damage via suppression of the TLR4/MyD88/NF-κB signaling pathway in newborn calf

Feng, R., Adeniran, S. O., Huang, F., Li, Y., Ma, M., Zheng, P., & Zhang, G. (2021) · Theriogenology · doi:10.1016/j.theriogenology.2021.11.020 · Cited by 46

Pharmacological mechanisms of sinomenine in anti-inflammatory immunity and osteoprotection in rheumatoid arthritis: A systematic review

Li, J.-M., Yao, Y.-D., Luo, J.-F., Liu, J.-X., Lu, L., Liu, Z., Dong, Y., Xie, Y., & Zhou, H. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.155114 · Cited by 46

Neuroinflammaging: A Tight Line Between Normal Aging and Age-Related Neurodegenerative Disorders

Soraci, L., Corsonello, A., Paparazzo, E., Montesanto, A., Piacenza, F., Olivieri, F., Gambuzza, M. E., Savedra, E. V., Marino, S., Lattanzio, F., et al. (2024) · Aging and Disease · doi:10.14336/ad.2023.1001 · Cited by 49

Co-encapsulation of synthetic lipidated TLR4 and TLR7/8 agonists in the liposomal bilayer results in a rapid, synergistic enhancement of vaccine-mediated humoral immunity

Short, K. K., Miller, S. M., Walsh, L. M., Cybulski, V., Bazin, H. G., Evans, J. T., & Burkhart, D. J. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.10.025 · Cited by 46

Enhanced Adipose Expression of Interferon Regulatory Factor (IRF)-5 Associates with the Signatures of Metabolic Inflammation in Diabetic Obese Patients

Sindhu, S. T. A. K., Kochumon, S., Thomas, R., Bennakhi, A., Al‐Mulla, F., & Ahmad, R. (2020) · Cells · doi:10.3390/cells9030730 · Cited by 46

SPOP promotes ubiquitination and degradation of MyD88 to suppress the innate immune response

Li, Q., Wang, F., Wang, Q., Zhang, N., Zheng, J., Zheng, M., Liu, R., Cui, H., Wen, J., & Zhao, G. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008188 · Cited by 47

Irisin Protects Brain against Ischemia/Reperfusion Injury through Suppressing TLR4/MyD88 Pathway

Yu, Q., Li, G., Ding, Q., Lei, T., Li, J., Sun, L., Sun, X., & Yang, Y. (2020) · Cerebrovascular Diseases · doi:10.1159/000505961 · Cited by 47

IL-38 in modulating hyperlipidemia and its related cardiovascular diseases

Lai, M., Peng, H., Wu, X., Chen, X., Wang, B., & Su, X. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108876 · Cited by 47

Insight into the role of macrophages in periodontitis restoration and development

Mo, K., Wang, Y., Lu, C., & Li, Z. (2024) · Virulence · doi:10.1080/21505594.2024.2427234 · Cited by 45

Intrinsic MyD88-Akt1-mTOR Signaling Coordinates Disparate Tc17 and Tc1 Responses during Vaccine Immunity against Fungal Pneumonia

Nanjappa, S. G., Hernández‐Santos, N., Galles, K., Wüthrich, M., Suresh, M., & Klein, B. S. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005161 · Cited by 44

Untitled work

Raju (2005) · doi:10.3389/fvets.2021.640968 · Cited by 42

Network pharmacology based research into the effect and potential mechanism of Portulaca oleracea L. polysaccharide against ulcerative colitis

Yang, Y., Zhou, X., Jia, G., Li, T., Li, Y., Zhao, R., & Wang, Y. (2023) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2023.106999 · Cited by 42

Epigenetic regulation of nitric oxide synthase 2, inducible (Nos2) by NLRC4 inflammasomes involves PARP1 cleavage

Buzzo, C. D. L., Medina, T. D. S., Branco, L. M., Lage, S. L., Ferreira, L. C. D. S., Amarante-Mendes, G. P., Hottiger, M. O., Carvalho, D. D. D., & Bortoluci, K. R. (2017) · Scientific Reports · doi:10.1038/srep41686 · Cited by 44

Modeling DNA damage-induced pneumopathy in mice: insight from danger signaling cascades

Wirsdörfer, F., & Jendrossek, V. (2017) · Radiation Oncology · doi:10.1186/s13014-017-0865-1 · Cited by 43

Microbiome modulates intestinal homeostasis against inflammatory diseases

Sun, X., & Jia, Z. (2018) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2018.10.014 · Cited by 44

Neutralization of pro‐inflammatory monocytes by targeting TLR2 dimerization ameliorates colitis

Shmuel-Galia, L., Aychek, T., Fink, A., Porat, Z., Zarmi, B., Bernshtein, B., Brenner, O. J., Jung, S., & Shai, Y. (2016) · The EMBO Journal · doi:10.15252/embj.201592649 · Cited by 41

MyD88-dependent pro-interleukin-1β induction in dendritic cells exposed to food-grade synthetic amorphous silica

Winkler, H. C., Kornprobst, J., Wick, P., von Moos, L. M. E., Trantakis, I. A., Schraner, E. M., Bathke, B., Hochrein, H., Suter, M., & Naegeli, H. (2017) · Particle and Fibre Toxicology · doi:10.1186/s12989-017-0202-8 · Cited by 41

Hypofractionated EGFR tyrosine kinase inhibitor limits tumor relapse through triggering innate and adaptive immunity

Liu, Z., Han, C., Dong, C., Shen, A., Hsu, E. J., Ren, Z., Lu, C., Liu, L., Zhang, A., Timmerman, C., et al. (2019) · Science Immunology · doi:10.1126/sciimmunol.aav6473 · Cited by 41

Phenol-soluble modulins α are major virulence factors of Staphylococcus aureus secretome promoting inflammatory response in human epidermis

Damour, A., Robin, B., Deroche, L., Broutin, L., Bellin, N., Verdon, J., Lina, G., Leclère, F. M., Garcia, M., Cremniter, J., et al. (2021) · Virulence · doi:10.1080/21505594.2021.1975909 · Cited by 44

Pharmacological inhibition of HDAC6 suppresses NLRP3 inflammasome-mediated IL-1β release

Bockstiegel, J., Wurnig, S. L., Engelhardt, J., Enns, J., Hansen, F. K., & Weindl, G. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115693 · Cited by 40

Inflammation via myeloid differentiation primary response gene 88 signaling mediates the fibrotic response to implantable synthetic poly(ethylene glycol) hydrogels

Amer, L. D., Saleh, L. S., Walker, C. J., Thomas, S. M., Janssen, W. J., Alper, S., & Bryant, S. J. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.09.043 · Cited by 42

The Implementation of TNFRSF Co-Stimulatory Domains in CAR-T Cells for Optimal Functional Activity

He, Y., Vlaming, M., van Meerten, T., & Bremer, E. (2022) · Cancers · doi:10.3390/cancers14020299 · Cited by 40

Irisin, Exercise, and COVID-19

Alves, H. R., Lomba, G. S. B., Gonçalves-de-Albuquerque, C. F., & Burth, P. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.879066 · Cited by 41

MyD88-dependent influx of monocytes and neutrophils impairs lymph node B cell responses to chikungunya virus infection via Irf5, Nos2 and Nox2

McCarthy, M. K., Reynoso, G. V., Winkler, E. S., Mack, M., Diamond, M., Hickman, H. D., & Morrison, T. E. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008292 · Cited by 39

TLR-2 and MyD88-Dependent Activation of MAPK and STAT Proteins Regulates Proinflammatory Cytokine Response and Immunity to Experimental Trypanosoma congolense Infection

Kuriakose, S. M., Onyilagha, C., Singh, R. V., Olayinka‐Adefemi, F., Jia, P., & Uzonna, J. E. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02673 · Cited by 38

Allergic Reactions and Immunity in Response to Tick Salivary Biogenic Substances and Red Meat Consumption in the Zebrafish Model

Contreras, M., Pacheco, I., Alberdi, P., Sanchez, S. D., Artigas-Jerónimo, S., Mateos‐Hernández, L., Villar, M., Cabezas‐Cruz, A., & de la Fuente, J. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00078 · Cited by 38

Distinct non‐coding RNA cargo of extracellular vesicles from M1 and M2 human primary macrophages

Pantazi, P., Clements, T., Venø, M. T., Abrahams, V. M., & Holder, B. S. (2022) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12293 · Cited by 38

Ultrasound‐Activated Piezoelectric Nanoparticles Trigger Microglia Activity Against Glioblastoma Cells

Montorsi, M., Pucci, C., Pasquale, D. D., Marino, A., Ceccarelli, M. C., Mazzuferi, M., Bartolucci, M., Petretto, A., Prato, M., Debellis, D., et al. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202304331 · Cited by 38

Role of Signaling Molecules in Mitochondrial Stress Response

Hill, S., Sataranatarajan, K., & Remmen, H. V. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00225 · Cited by 39

Anti-inflammatory action of cysteine derivative S-1-propenylcysteine by inducing MyD88 degradation

Suzuki, J., Kodera, Y., Miki, S., Ushijima, M., Takashima, M., Matsutomo, T., & Morihara, N. (2018) · Scientific Reports · doi:10.1038/s41598-018-32431-0 · Cited by 37

Therapeutic aspects of cell signaling and communication in Duchenne muscular dystrophy

Starosta, A., & Konieczny, P. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03821-x · Cited by 41

MYD88 Mutations: Transforming the Landscape of IgM Monoclonal Gammopathies

Alcoceba, M., García‐Álvarez, M., Medina, A., Maldonado, R., González‐Calle, V., Chillón, C., Sarasquete, M. E., González, M., García‐Sánz, R., & Jiménez, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105570 · Cited by 37

The Effect of Enteric-Derived Lipopolysaccharides on Obesity

Wang, K., Lai, W., Min, T., Wei, J., Bai, Y., Cao, H., Guo, J., & Su, Z. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084305 · Cited by 38

Inflammation accelerating intestinal fibrosis: from mechanism to clinic

Xin, S., Liu, X., He, C., Gao, H., Wang, B., Hua, R., Gao, L., Shang, H., Sun, F., & Xu, J. (2024) · European journal of medical research · doi:10.1186/s40001-024-01932-2 · Cited by 36

Toll-like receptor 3 modulates the behavioral effects of cocaine in mice

Zhu, R., Bu, Q., Fu, D., Shao, X., Jiang, L., Guo, W., Chen, B., Liu, B., Hu, Z., Tian, J., et al. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1130-8 · Cited by 36

Hypothesized mechanisms explaining poor prognosis in type 2 diabetes patients with COVID-19: a review

Lisco, G., Tullio, A. D., Giagulli, V. A., Guastamacchia, E., Pergola, G. D., & Triggiani, V. (2020) · Endocrine · doi:10.1007/s12020-020-02444-9 · Cited by 37

Chasing Virus Replication and Infection: PAMP-PRR Interaction Drives Type I Interferon Production, Which in Turn Activates ISG Expression and ISGylation

Muhammad, I., Contes, K. M., Bility, M. T., & Tang, Q. (2025) · Viruses · doi:10.3390/v17040528 · Cited by 38

The Role of Toll-like Receptors (TLRs) Mediated Inflammation in Pancreatic Cancer Pathophysiology

Orlacchio, A., & Mazzone, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312743 · Cited by 34

T-Cell MyD88 Is a Novel Regulator of Cardiac Fibrosis Through Modulation of T-Cell Activation

Bayer, A. L., Smolgovsky, S. A., Ngwenyama, N., Hernández-Martínez, A., Kaur, K., Sulka, K. B., Amrute, J., Aronovitz, M. J., Lavine, K. J., Sharma, S., et al. (2023) · Circulation Research · doi:10.1161/circresaha.123.323030 · Cited by 33

Innate immune adaptor MyD88 deficiency prevents skin inflammation in SHARPIN-deficient mice

Sharma, B. R., Karki, R., Lee, E., Zhu, Q., Gurung, P., & Kanneganti, T. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0159-7 · Cited by 33

Immunomodulatory role of the extracellular matrix protein tenascin-C in neuroinflammation

Wiemann, S., Reinhard, J., & Faissner, A. (2019) · Biochemical Society Transactions · doi:10.1042/bst20190081 · Cited by 34

Antibiotics, Inflammation, and Preterm Labor: A Missed Conclusion

Hantoushzadeh, S., Aliabad, R. A., & Norooznezhad, A. H. (2020) · Journal of Inflammation Research · doi:10.2147/jir.s248382 · Cited by 33

Beyond Macrophages and T Cells: B Cells and Immunoglobulins Determine the Fate of the Atherosclerotic Plaque

Mangge, H., Prüller, F., Schnedl, W. J., Renner, W., & Almer, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21114082 · Cited by 33

Alzheimer’s Disease (AD) Therapeutics—2: Beyond Amyloid—Re-Defining AD and Its Causality to Discover Effective Therapeutics

Mullane, K., & Williams, M. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.09.027 · Cited by 32

Influence of gut and lung dysbiosis on lung cancer progression and their modulation as promising therapeutic targets: a comprehensive review

Thapa, R., Magar, A. T., Shrestha, J., Panth, N., Idrees, S., Sadaf, T., Bashyal, S., Elwakil, B. H., Sugandhi, V. V., Rojekar, S. V., et al. (2024) · MedComm · doi:10.1002/mco2.70018 · Cited by 33

Immunopathogenesis of Craniotomy Infection and Niche-Specific Immune Responses to Biofilm

de Morais, S. D. B., Kak, G., Menousek, J. P., & Kielian, T. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.625467 · Cited by 34

Liquiritin reduces lipopolysaccharide-aroused HaCaT cell inflammation damage via regulation of microRNA-31/MyD88

Yang, X., Dang, X., Zhang, X., & Zhao, S. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.108283 · Cited by 32

miR-185-5p alleviates CCI-induced neuropathic pain by repressing NLRP3 inflammasome through dual targeting MyD88 and CXCR4

Huang, A., Ji, L., Huang, Y., Yu, Q., & Li, Y. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2021.108508 · Cited by 32

Necroptosis of nucleus pulposus cells involved in intervertebral disc degeneration through MyD88 signaling

Fan, H., Chen, Z., Tang, H., Shan, L., Chen, Z., Liu, S.-C., Zhang, Y., Guo, X., Yang, H., & Hao, D. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.994307 · Cited by 32

Modulating the systemic and local adaptive immune response after fracture improves bone regeneration during aging

Lopez, E. M., Leclerc, K., Ramsukh, M., Parente, P. E., Patel, K., Aranda, C. J., Josephson, A. M., Remark, L. H., Kirby, D. J., Buchalter, D. B., et al. (2022) · Bone · doi:10.1016/j.bone.2021.116324 · Cited by 31

Role of Vitamin D in Head and Neck Cancer—Immune Function, Anti-Tumour Effect, and Its Impact on Patient Prognosis

Starska, K. (2023) · Nutrients · doi:10.3390/nu15112592 · Cited by 31

MyD88 and Its Inhibitors in Cancer: Prospects and Challenges

Song, J., Li, Y., Wu, K., Hu, Y., & Fang, L. (2024) · Biomolecules · doi:10.3390/biom14050562 · Cited by 31

Geranylgeraniol Suppresses the Expression of IRAK1 and TRAF6 to Inhibit NFκB Activation in Lipopolysaccharide-Induced Inflammatory Responses in Human Macrophage-Like Cells

Giriwono, P. E., Shirakawa, H., Ohsaki, Y., Sato, A., Aoyama, Y., Ho, H., Gotō, T., & Komai, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092320 · Cited by 31

Toll-Like Receptors Recognize Intestinal Microbes in Liver Cirrhosis

Fan, Y., Li, Y., Chu, Y., Liu, J., Cui, L., & Zhang, D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.608498 · Cited by 31

Fine-tuning of antiviral innate immunity by ubiquitination

Zheng, Y., & Gao, C. (2019) · Advances in immunology · doi:10.1016/bs.ai.2019.11.004 · Cited by 31

Stearic Acid and TNF-α Co-Operatively Potentiate MIP-1α Production in Monocytic Cells via MyD88 Independent TLR4/TBK/IRF3 Signaling Pathway

Kochumon, S., Arefanian, H., Azim, R., Shenouda, S., JACOB, T. K., ABUKHALAF, N. A., Al‐Rashed, F., Hasan, A., Sindhu, S. T. A. K., Al‐Mulla, F., et al. (2020) · Biomedicines · doi:10.3390/biomedicines8100403 · Cited by 30

Emerging diagnostic tests for vitreoretinal lymphoma: a review

Dawson, A. C., Williams, K. A., Appukuttan, B., & Smith, J. R. (2018) · Clinical and Experimental Ophthalmology · doi:10.1111/ceo.13304 · Cited by 30

Inactivation of the tyrosine phosphatase SHP-2 drives vascular dysfunction in Sepsis

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Wesche, H., Henzel, W., Shillinglaw, W., Li, S., & Cao, Z.-D. (1997) · Immunity · doi:10.1016/s1074-7613(00)80402-1 · Cited by 1,247

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Barberá, M., & de, E. (2012) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)

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Burns, K., Martinon, F., Esslinger, C., Pahl, H. L., Schneider, P., Bodmer, J.-L., Marco, F. D., French, L. E., & Tschopp, J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.20.12203 · Cited by 631

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