Cited by 692Immune Response and InflammationNF-κB Signaling PathwaysInflammasome and immune disorders

The DOI matches its Crossref record; 65 of the 66 references it cites were found in a registry or an index.

MyD88: a central player in innate immune signaling

Open access

Deguine, Jacques, Barton, Gregory M.·2014·F1000Prime Reports

Open this paper in CoChat — free account Open PDF

Abstract

MyD88 is the canonical adaptor for inflammatory signaling pathways downstream of members of the Toll-like receptor (TLR) and interleukin-1 (IL-1) receptor families. MyD88 links IL-1 receptor (IL-1R) or TLR family members to IL-1R-associated kinase (IRAK) family kinases via homotypic protein-protein interaction. Activation of IRAK family kinases leads to a variety of functional outputs, including the activation of nuclear factor-kappa B (NFκB), mitogen-activated protein kinases, and activator protein 1, making MyD88 a central node of inflammatory pathways. As more details of MyD88-dependent signaling have been elucidated, it has become clear that the functions of this critical signaling component can be influenced by multiple interaction partners in distinct subcellular compartments. In this review, we will focus on recent developments in the understanding of the assembly of MyD88 signaling complexes and the mechanisms leading to the diversification of MyD88-based signaling.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.12703/p6-97

Cites

65 of 66 references verified1 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway
Yamamoto, M., Sato, S., Hemmi, H., Hoshino, K., Kaisho, T., Sanjo, H., Takeuchi, O., Sugiyama, M., Okabe, M., Takeda, K., et al. (2003) · Science · doi:10.1126/science.1087262 · Cited by 3,286
CpG Motifs in Bacterial DNA and Their Immune Effects
Krieg, A. Μ. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100301.064842 · Cited by 2,598
Unresponsiveness of MyD88-deficient mice to endotoxin.
Kawai, T., Adachi, O., Ogawa, T., Takeda, K., & Akira, S. (1999) · Immunity · doi:10.1016/s1074-7613(00)80086-2 · Cited by 2,367
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function.
Adachi, O., Kawai, T., Takeda, K., Matsumoto, M., Tsutsui, H., Sakagami, M., Nakanishi, K., & Akira, S. (1998) · Immunity · doi:10.1016/s1074-7613(00)80596-8 · Cited by 2,358
MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways.
Medzhitov, R., Preston-Hurlburt, P., Kopp, E., Stadlen, A., Chen, C.-Q., Ghosh, S., & Janeway, C. (1998) · Molecules and Cells · doi:10.1016/s1097-2765(00)80136-7 · Cited by 1,783
Oncogenically active MYD88 mutations in human lymphoma
Ngo, V. N., Young, R. M., Schmitz, R., Jhavar, S. G., Xiao, W., Lim, K., Kohlhammer, H., Xu, W., Yang, Y., Zhao, H., et al. (2010) · Nature · doi:10.1038/nature09671 · Cited by 1,560
Toll-like Receptor Signaling
Akira, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.r300028200 · Cited by 1,499
Crystal Structure of the TLR1-TLR2 Heterodimer Induced by Binding of a Tri-Acylated Lipopeptide
Jin, M. S., Kim, S. E., Heo, J. Y., Lee, M. E., Kim, H. M., Paik, S., Lee, H., & Lee, J. (2007) · Cell · doi:10.1016/j.cell.2007.09.008 · Cited by 1,388
Toll-like receptors control activation of adaptive immune responses
Schnare, M., Barton, G. M., Czopik, A. K., Takeda, K., Akira, S., & Medzhitov, R. M. (2001) · Nature Immunology · doi:10.1038/ni712 · Cited by 1,364
Self-citation
TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β
Kagan, J. C., Su, T., Horng, T., Chow, A. Y., Akira, S., & Medzhitov, R. M. (2008) · Nature Immunology · doi:10.1038/ni1569 · Cited by 1,310

Flagged first, then by citations

Show all 66 references

Sorted by citations

Items 601–687 of 687

Investigating age- and virulence factor- dependent innate immune activation during neonatal meningitis associated E. coli infection
Chambers, C. A. (2021) · doi:10.32469/10355/90985
Bleeding in the Setting of Lymphoma, with a Focus on Waldenström Macroglobulinaemia
Brysland, S. A., Maqbool, M. G., Talaulikar, D., & Gardiner, E. E. (2022) · Interdisciplinary cancer research · doi:10.1007/16833_2022_98
The gut microbiota
Scheithauer, T. P. M. (2023) · doi:10.5463/thesis.82
Tissue tropism of Tilapia Lake Virus infection by experimental route in Tilapines (Oreochromis niloticus)Preprint
ArunKumar, S. R. S., & Sudhakaran, R. (2023) · Research Square · doi:10.21203/rs.3.rs-2585352/v1
Neuron-Glia Crosstalk: Investigating Immune-Cell Modulation in the CNP1 Null Mutant Mouse
Aicher, M. L. (2023) · doi:10.53846/goediss-9749
Study on the correlation of the TLR4/MyD88 axis with the degree of inflammatory response in patients with synovitis of the knee joint
Yang, Y., Lu, X., Sun, X., Li, M., Mierzhati, A., & Li, H. (2023) · Cellular and Molecular Biology · doi:10.14715/cmb/2023.69.7.31
Exploring the Common Gene Signatures Between Myocardial Infarction-Reperfusion Injury and the Gut Microbiome Using Bioinformatics
Jiang, X. L., Li, C., Xia, X., Tong, J., Cheng, J., & Li, X. (2023) · The Heart Surgery Forum · doi:10.59958/hsf.5775
PlentiPlex ™ MYD88 Waldenström lymphoma qPCR assay: A highly sensitive method for detection of MYD88 L265P mutation
Viscovo, M., Clemmensen, M. D. L., Fosso, F., Maiolo, E., Autore, F., Laurenti, L., Hohaus, S., & Chiusolo, P. (2024) · International Journal of Laboratory Hematology · doi:10.1111/ijlh.14255
MISSENSE MUTATIONS IN THE IRAK1 GENE ARE ASSOCIATED WITH AN INCREASED RISK OF SYSTEMIC LUPUS ERYTHEMATOSUS
Adnan, A., Perwitasari, D. A., Maliza, R., & Sulistyani, N. (2024) · Medical Sains Jurnal Ilmiah Kefarmasian · doi:10.37874/ms.v9i1.1073
Schnitzler-Syndrom
Aichner, M., Frischhut, N., Zelger, B. W. H., & Böckle, B. (2024) · Aktuelle Dermatologie · doi:10.1055/a-2217-7016
Myeloid Cells and Sphingosine-1-Phosphate Are Required for TCRαβ Intraepithelial Lymphocyte Recruitment to the Colon Epithelium
Danielson, S. M., Lefferts, A. R., Norman, E., Regner, E. H., Schulz, H. M., Sansone-Poe, D., Orlicky, D. J., & Kuhn, K. A. (2024) · The Journal of Immunology · doi:10.4049/jimmunol.2200556
In vitro study of momordin Ic in improving atopic dermatitis by regulating claudin-1/MyD88 and targeting NLRP3
Guo, Y., Wang, L., Zhang, J., Jing, T., Fu, L., & Miao, G. (2024) · Acta Poloniae Pharmaceutica - Drug Research · doi:10.32383/appdr/187814
Skin Microbial Diversity and Immune Mechanism of Rotten Skin Disease in Quasipaa SpinosaPreprint
Zhu, L., Chen, M., Lin, K., Han, L., Ma, Y., Dong, R., Shi, N., & Zheng, R. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4870597
The Role of Alternative Splicing of Immune Response Genes in Cancer Aggression
Al-Rahim, A. M., Mohammed, M. M., Oohayyed, N. A., Suleiman, A. A., & Shaban, S. A. (2024) · Ain Shams Medical Journal · doi:10.21608/asmj.2024.281773.1261
A Mystery in a Case: Unraveling the Complexity of Bing-Neel Syndrome
Kotlarz, P. N., García, G., Rosario, M. A., Vargas, I., & Zhen, K. C. (2024) · Cureus · doi:10.7759/cureus.65042
Innate Immunity and Angiogenesis
Sharma, J., Sahakyan, S., Yan, B., Arora, K., Albalakhi, A., Singh, N., Thanos, A., Maidana, D. E., & Paschalis, E. I. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13820-1.00146-8
Tempol mitigates inflammation, oxidative stress, and histopathological alterations of cadmium-induced parotid gland injury in rats
El-Fatah, S. S. A., Nafea, O. E., Yousef, D. M., Samy, W. M., Hussien, M. H. S., & Arakeep, H. M. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.123233
African trypanosomiasis: Comprehending the parasite pathogenesis in the brain
Masocha, W., Ssempijja, F., Kasozi, K. I., Tesoriero, C., Gallo, F. D., Abah, S., Etet, P. F. S., Welburn, S. C., & Kennedy, P. G. E. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-19130-5.00016-2
Additional benefits of combined ceftriaxone and adipose-derived mesenchymal stem cells on revamping the outcomes in rodent after acute spinal infection
Yin, T., Lin, H.-S., Sung, P., Chiang, J. Y., Yang, C., Yip, H.-K., & Chen, K. (2025) · Journal of Molecular Histology · doi:10.1007/s10735-024-10344-9
Toll-Like Receptors as a New Era in Cancer Therapy
Almorish, M., & Alyahawi, A. A. (2025) · IntechOpen eBooks · doi:10.5772/intechopen.1007600
A systems biology investigation to identify potential biomarkers in leprosy-affected host cellsPreprint
Chowdhury, S., Ansari, A., Verma, P., Mavlankar, A., Tripathi, A., Peña, M. T., Sharma, R., Caskey, J., Truman, R. W., & Singh, P. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.28.646010
Aspectos genéticos y genómicos de la susceptibilidad y resistencia a las infecciones
Paz‐y‐Miño, C. (2024) · Bionatura · doi:10.70373/rb/2024.09.03.14
Antiinflammatory, modulatory and analgesic activities of African medicinal plants and their derivatives
Osafo, N., Boakye, Y. D., Yeboah, K. O., & Agyare, C. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-30170-4.00018-8
Signaling Pathways Downstream of TLRs and IL-1 Family Receptors
DeFranco, A. L. (2025) · Elsevier eBooks · doi:10.1016/b978-0-12-824465-4.00186-1
Effects of Stems and Leaves of Panax notoginseng on mRNA Expression of TLR Signaling Pathway in Hepatic Tissue of Duzang Pigs
Zhang, N., Yi, L., Xie, Y., Jia, H., Song, G., Cheng, W. T. K., Shi, W., Zhu, J., & Zhao, S. (2025) · Genes · doi:10.3390/genes16070781
0614 MyD88 restricts dysbiosis-mediated inflammation in filaggrin deficient skin
Wu, M.-C., Ravipati, A., Wang, Y., Feller, L., Chu, A., Damarla, R., Li, Z., Tsoi, L. C., Griffin, R., Hou, P., et al. (2025) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2025.06.622
Bladder Cancer: Role of Circular RNAs in Oncogenesis, Tumor Suppression, and Therapeutic Target Identification
Nahkuri, S., & Weidle, U. H. (2025) · Cancer Genomics & Proteomics · doi:10.21873/cgp.20528 · Cited by 1
Avaliação do papel supressor tumoral de miR-665 em linhagens de câncer de tiroide
da Silva, I. N. (2025) · doi:10.47749/t/unicamp.2025.1498988
Imiquimod (R837), a TLR7-Specific Agonist, Regulates Boar Sperm Motility via PI3K/GSK3α/β/Hexokinase Pathway
Zhang, W., Adetunji, A. O., Zeng, W., Bastawy, E. M., Min, L., Ding, N., & Zhu, Z. (2025) · Biology · doi:10.3390/biology14091182
Targeting FOXO3a, TLR2/MyD88/NF-κB cascade, and ferroptosis by theaflavin ameliorates iron-elicited liver toxicity
Bakhsh, A., Salama, S. A., Althobaiti, M. M., Alsufyani, S. E., Almalki, A. M., & Alanazi, S. (2025) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2025.127758
Long Noncoding RNA Lnc-MTPAP-1 Overexpressed by Particulate Matter Suppresses Apoptosis in Non-Small Cell Lung Cancer (NSCLC) Cells
Park, J. W., Kang, D., Lee, M., Lee, Y., Lee, S. Y., Woo, S. Y., Yang, K. J., Jeong, I. B., Park, H. S., Son, J. W., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110486
Additional file 5 of Blockage of CacyBP inhibits macrophage recruitment and improves anti-PD-1 therapy in hepatocellular carcinoma
Wang, J., Zhang, X., Ma, X., Chen, D., Cai, M., Xiao, L., Li, J., Huang, Z., Huang, Y., & Lian, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26640901
Additional file 4 of Blockage of CacyBP inhibits macrophage recruitment and improves anti-PD-1 therapy in hepatocellular carcinoma
Wang, J., Zhang, X., Ma, X., Chen, D., Cai, M., Xiao, L., Li, J., Huang, Z., Huang, Y., & Lian, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26640898
Additional file 3 of Blockage of CacyBP inhibits macrophage recruitment and improves anti-PD-1 therapy in hepatocellular carcinoma
Wang, J., Zhang, X., Ma, X., Chen, D., Cai, M., Xiao, L., Li, J., Huang, Z., Huang, Y., & Lian, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26640895
Additional file 6 of Blockage of CacyBP inhibits macrophage recruitment and improves anti-PD-1 therapy in hepatocellular carcinoma
Wang, J., Zhang, X., Ma, X., Chen, D., Cai, M., Xiao, L., Li, J., Huang, Z., Huang, Y., & Lian, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26640904
Additional file 1 of Blockage of CacyBP inhibits macrophage recruitment and improves anti-PD-1 therapy in hepatocellular carcinoma
Wang, J., Zhang, X., Ma, X., Chen, D., Cai, M., Xiao, L., Li, J., Huang, Z., Huang, Y., & Lian, Y. (2023) · Figshare · doi:10.6084/m9.figshare.24571827
Additional file 2 of Mechanism of MyD88S mediated signal termination
Pustelny, K., Kuśka, K., Górecki, A., Musielak, B., Dobosz, E., Władyka, B., Kozieł, J., Czarna, A., Holak, T. A., & Dubin, G. (2022) · Figshare · doi:10.6084/m9.figshare.18849165
Additional file 2 of Blockage of CacyBP inhibits macrophage recruitment and improves anti-PD-1 therapy in hepatocellular carcinoma
Wang, J., Zhang, X., Ma, X., Chen, D., Cai, M., Xiao, L., Li, J., Huang, Z., Huang, Y., & Lian, Y. (2024) · Figshare · doi:10.6084/m9.figshare.24572272
Chlamydia psittaci inclusion membrane protein CPSIT_0844 elicits inflammatory IL-6 and IL-8 production in human monocytes via TLR2/TLR4 signaling pathways
Yan, X., Wang, B., Zheng, K., Luo, D., Li, Y., Xiao, J., Chen, Y., He, Z., Wen, Y., Wang, C., et al. (2026) · Immunobiology · doi:10.1016/j.imbio.2026.153160
Persistent foot-and-mouth disease virus infection of the bovine nasopharynx is associated with suppression of innate and cellular immunity
Litz, B., Pfaff, F., Forth, L. F., Hägglund, S., Valarcher, J., Beer, M., & Eschbaumer, M. (2026) · PLoS ONE · doi:10.1371/journal.pone.0340425
Pregnancy loss due to early developmental defects in lupus mice expressing human TLR8Preprint
Maria, N. I., Xia, Y., Raparia, C., Lin, K., Martinez, S., Yi, Z., Zhang, W., Aziz, M., Wang, P., Guerra, M. M., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.07.701591
Modulation of macrophage survival during Klebsiella pneumoniae infections
Nithya, N., Ali, A. M., P., S. K., Mehto, S., & Antony, C. (2026) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2026.1757662
Modulation des fonctions des cellules dendritiques humaines par des fragments d'anticorps
Lamendour, L. (2018) · theses.fr (ABES) · doi:10.70675/ae57c9a5z51a3z4911za39fzbaeebf37f339
Identification et analyse des facteurs bactériens impliqués dans les stades intra-macrophagiques de Burkholderia cenocepacia chez le poisson zèbre
Tasrini, Y. (2019) · theses.fr (ABES) · doi:10.70675/b0628fe3zafefz4a72z8359zce51e0b3f706
Rôle des cellules dendritiques CD11b+ dans l'athérosclérose
Ouhachi, M. (2018) · theses.fr (ABES) · doi:10.70675/466b938ez5204z4f08za2fbze1543fdab864
Dynamique transcriptionnelle de la différenciation normale et pathologique des lymphocytes B naïfs en cellules effectrices
Hipp, N. (2019) · theses.fr (ABES) · doi:10.70675/6f1560d0zfdfez461dzbdd3z60ef0a90366d
Implication du gène Dicer1 dans le vieillissement et ses pathologies chez la souris
de Cauwer, A. (2020) · theses.fr (ABES) · doi:10.70675/22c08094z1342z429fza3fez5ff6b78d1481
Etude du rôle de MYD88 et des voies NF-kB dans l'émergence des lymphomes B
Roland, L. (2021) · theses.fr (ABES) · doi:10.70675/6739e9f3z2bd7z4be9za9a7z91fc78f6c596
Two examples of exploiting bacteriophages to defeat Pseudomonas aeruginosa : study of the viral protein Gp92 and in vivo evaluation of the efficacy of a bacteriophage cocktail to treat pneumonia in immunocompromised animals
de Jode, M. (2021) · doi:10.70675/d176148dz0521z4576zb81ez5848b2c0dbbf
Caractérisation de la réponse lymphocytaire B mémoire contre le SARS-CoV-2 après infection ou vaccination
Sokal, A. (2022) · theses.fr (ABES) · doi:10.70675/00bd0a63z263fz470az876czb50b49ba4313
Infection-driven bladder carcinogenesis: Molecular mechanisms of pathogen-urothelial cell interactions
Feifan, T., Songbai, L., & Xianliang, H. (2026) · Pathology - Research and Practice · doi:10.1016/j.prp.2026.156488
Epidermal PPARγ Signaling as a Suppressor of Toll-like Receptor-Mediated Inflammation and Fibrosis: Relevance to Cutaneous Squamous Cell Carcinoma
Konger, R. L., & Derr-Yellin, E. C. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27094136
Streptococcus anginosus activates the NLRP3 inflammasome to promote inflammatory responses from macrophages
Arias, A. M., Reinartz, D. M., Sairs, C., Kumar, S. S., Byrnes, H. C., & Wilson, J. E. (2026) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiag061
Importance of the inflammasome in gut-brain axis: from pathological driver to therapeutic target
Sarkar, S., Roy, S., & Choudhury, L. (2026) · Inflammopharmacology · doi:10.1007/s10787-026-02230-5
Respuesta de las interacciones redox sensibles de la nucleorredoxina ante el estrés oxidante producido por la enfermedad hepática alcohólica durante el envejecimiento en el hígado del ratón
García, O. G. I. (2024) · doi:10.24275/uami.3j333315p
Gastroprotective potential of canagliflozin in indomethacin-induced peptic ulcer: impact on inflammation, pyroptosis, autophagy, and gut integrity
Mohamed, S. K., & Raafat, E. M. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.118121
MicroRNA-21 restrains myD88-dependent protective inflammation worsening Staphylococcus aureus skin infectionPreprint
Salina, A. C. G., Blackman, A., de Medeiros, A. I., & Serezani, C. H. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.01.729375
Characterizing the impact of intracutaneous dissemination on host responses during Borrelia burgdorferi infection
Crane, S., McKinney, A.-N., Jarrett, C. O., Clancy, C. S., Nilsson, O., Hawley, K. L., & Groshong, A. M. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1850665
Microcystin-LR induces dopaminergic neurodegeneration by MyD88-dependent neuroinflammation in zebrafish (Danio rerio)
He, Y., Ou-Yang, K., Yang, H., Wang, L., Li, M., Li, D., & Li, L. (2026) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2026.142640
A South African perspective on MYD88 and CXCR4 variants in lymphoplasmacytic lymphoma or Waldenström macroglobulinaemia
Hodkinson, K. E., Ketseoglou, I., van Zijl, H., Vaughan, J., & Walton, A. H. (2026) · South African Journal of Oncology · doi:10.4102/sajo.v10i0.342
Design, Synthesis, and Biological Evaluation of a MyD88-Targeted Molecular Glue d21 for the Treatment of Acute Lung Injury
Zhu, L., Tang, D., Chen, T., Sun, C., Dong, K., Chen, Q. W., 戴勤学, 莫云长, Chen, P., Sun, J., et al. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6c00755
Human XIRP1 is a new podosome protein targeting cytosolic bacteria as part of the IFN-γ defense program
Urbano, R., Low, A. S., Ntokou, A., Park, E., Tretina, K., Tunaru, A., Gaudet, R. G., & MacMicking, J. D. (2026) · The Journal of Immunology · doi:10.1093/jimmun/vkag116
Inhibition of Toxoplasma gondii proliferation by dimethyl itaconate: Evidence from in vitro and in vivo studies
Zhao, J., Bao, L., Chen, H., Zhao, T., Tang, D., Sun, Y., Zuo, Y., Shang, J., Liu, Y., Zhou, X., et al. (2026) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0014454
NF-κB-Dependent Transcriptional Regulation of Piezo1 Mediates Bacterial Clearance on Infected Lung Stiffness
Orsini, E. M., Boulton, A. M., Abraham, S., Brown, A., Ricci, H., Ahuja, A., Pant, B., Snyder, C. M., Reinhardt, A., Attaway, A. H., et al. (2026) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1093/ajrcmb/aanag112
Resident myeloid-derived immune cells contribute to early lipopolysaccharide-induced cytokine secretion in mouse soleus musclePreprint
Fitton, F. P., Morse, D. A., Cusack, K. J., Gambino, B. J., & Clanton, T. L. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.23.734036
PPARγ mediates selenomethionine-induced suppression of NF-κB signaling in bovine endometrial epithelial cells
Cui, L., He, S., Song, W., Jiang, B., Yuan, C., Guo, L., Liu, K., Dong, J., Li, J., & Wang, H. (2026) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2026.105666
Emerging features of macrophages and their intricate roles in chronic allograft rejection
Kloc, M., Ghobrial, R. M., & Li, X. C. (2026) · Immunity & Inflammation · doi:10.1007/s44466-026-00046-0
The transcriptome of dendritic cells redraws the boundaries between pathogenicity and commensalism in yeast
Rizzetto, L., Stefanini, I., Nenciarini, S., Paola, M. D., Riccadonna, S., Gut, I. G., Gut, M., Heath, S. C., & Cavalieri, D. (2026) · Microbial Cell · doi:10.15698/mic2026.07.882
Interactions between ESKAPE pathogens and the host immune system
Umadevi, K., Sundeep, D., & Kumari, S. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-26726-0.00011-6
FAP-derived CCL2 is required for adequate monocyte/macrophage infiltration to support acute skeletal muscle injury repair
Wang, X., Wang, Y., Yuan, R., Smith, G. R., Ruf-Zamojski, F. M., Homma, S. T., Sealfon, S. C., & Zhou, L. (2026) · iScience · doi:10.1016/j.isci.2026.116933
Prevalence of bovine endometritis, virulence mechanisms of Escherichia coli , and current therapeutic strategies: A review
Wang, M., Wen, X., Li, X., Li, H., Cheng, J., & liu, M. (2026) · Virulence · doi:10.1080/21505594.2026.2707822
A stimuli-responsive hydrogel that targets myeloid differentiation primary response 88 signaling in the foreign body response
Grey, E. L., Thompson, B. J., Chang, C., Estrin, D., & Bryant, S. J. (2026) · Journal of Controlled Release · doi:10.1016/j.jconrel.2026.115225
Extracellular Vesicles from Candida albicans and Aspergillus fumigatus Differentially Integrate PRR and cGAS-STING Signaling to Shape Macrophage Responses
Froldi, J. L., Piraine, R. E. A., Tavares, L., Nogueira, L. F. B., dos Santos, P. W. D. S., & Almeida, F. B. D. R. (2026) · Journal of Fungi · doi:10.3390/jof12080575
MyD88 ‐Family Adaptors: Compartmentalised Signalling and Non‐Immune Functions
Pothabathula, S. V., Mishra, S., Kannan, P., Bellar, A., Attaway, A. H., Welch, N., & Dasarathy, S. (2026) · Immunology · doi:10.1111/imm.70184
Roles of Toll-like receptor 4 in the normal testis and during testicular ischemia-reperfusion injury: a sanitiser or a killer?
Ajike, R. A., Olayiwola, P. A., Afolabi, O. A., Lawal, O. A., Hezekiah, O. S., Olapade, O. S., Akano, S. A., Ikotun, A. E., Adekunleoke, P. P., Oyekunle, O. S., et al. (2026) · Comparative Clinical Pathology · doi:10.1007/s00580-026-03834-7
Dual-site CRISPR/Cas9-mediated mutations in Toll-like receptor 4 (TLR4): complete characterization reveals divergent autophagic reprogramming of LPS-related downstream activities
Fagbohun, O. F., Olawoye, B. T., Oriyomi, O. V., McDougle, X., Iragena, O., Kellenbarger, R., Joseph, J. S., Fadare, O., & Kincaid, R. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.153947
A dual-function interleukin-1 receptor couples bacterial recognition to MyD88-dependent NF-κB activation during antibacterial immunity in shrimp
Huang, S., Lu, W., 石玉新, Lin, T., Xueer, T. A. N. G., Guo, S., Chen, X., & Yang, L. (2026) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2026.111650
Molybdenum and cadmium co-activation of TLR4/MyD88/NF-κB: the hidden driver of lymphocyte inflammation in sheep spleen
Gao, F., Lu, Z., Jiang, M., Xiong, Z., Chen, H., Li, J., Liu, M., Dai, X., Yang, F., & Cao, H. (2026) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2026.110663
I am me and my circumstance – Context dictates the outcome of IL-1 signaling in and around T cells
Domenjo‐Vila, E., Gavin, M. A., & Prlic, M. (2026) · Seminars in Immunology · doi:10.1016/j.smim.2026.102065
Advances in Understanding Large Yellow Croaker Iridovirus and Host Immune Responses
Zhou, Z., Xing, C., Huang, Y., Wang, Z., & Han, F. (2026) · Reviews in Aquaculture · doi:10.1111/raq.70216
Development of Paquinimod‐Loaded Implants to Modulate the Foreign Body Response
Weber, C., Vanderzee, I., Danon, S., Lin, M., Kodikalla, S., & Morris, A. H. (2026) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.70168
Multi-Scale Integrative Transcriptomic Analysis of Alzheimer’s Disease and Atopic Dermatitis Reveals Shared Immune and Cellular Networks
Liu, H., Yin, Z., Ye, Z., & Chen, Y. (2026) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/15333175261495656
TLR9–MyD88–TRAF6 signaling mediates mitochondrial DNA–induced systemic inflammatory response after radiofrequency ablation of hepatic hemangioma, with Merlin as a downstream participant
Gao, R., Wu, S., Zeng, B., Li, N., Gao, J., & Wang, S. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.117546
BindingDB Entry 50022779: Discovery of Novel MyD88 Inhibitor A5S to Alleviate Acute Lung Injury with Favorable Drug-like Properties.
BindingDB (2026) · UC San Diego · doi:10.7270/q23201q2
BindingDB Entry 50007130: Development of 2-amino-4-phenylthiazole analogues to disrupt myeloid differentiation factor 88 and prevent inflammatory responses in acute lung injury.
BindingDB (2021) · UC San Diego · doi:10.7270/q2028vvw
Functional characterization of PfTLR4-like during bacterial challenge and xenogeneic graft-associated immune responses in Pinctada fucata
Sang, X., Peng, C., Wang, P., Fan, D., Guo, Y., Qi, M., 韦, 柳., Yu, D., & Bai, L. (2026) · Aquaculture · doi:10.1016/j.aquaculture.2026.744662
Agonist-Specific Modulation of MyD88 Interactions Governs the Temporal Dynamics of Immune Responses
Saha, S., Gillen, J., Issara-Amphorn, J., Verma, R., Bhushan, V., Bridgwater, C., Jones, S., & Nita‐Lazar, A. (2026) · Journal of Proteome Research · doi:10.1021/acs.jproteome.6c00480

Authors: Deguine, J., & Barton, G. M.
Affiliations: University of California, Berkeley (US)
Corresponding author: Deguine, Jacques
Barton, Gregory M.
ORCID: Deguine, Jacques
Barton, Gregory M.
Venue: F1000Prime Reports
Publisher: H1 Connect
Published: 2014-11-04
Volume: 6
Pages: 97-97
ISSN: 2051-7599 (ISSN-L)
DOI: 10.12703/p6-97
PMC: PMC4229726
OpenAlex: W2158738222
Cited by: 692
References: 66
Citations by year: 2026: 50 · 2025: 86 · 2024: 104 · 2023: 91 · 2022: 80 · 2021: 85 · 2020: 60 · 2019: 56 · 2018: 30 · 2017: 18 · 2016: 18 · 2015: 14
FWCI: 1.63
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: F1000Prime Reports (publishedVersion)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Funders: Burroughs Wellcome Fund
Lupus Research Institute
Lupus Research Alliance
National Institutes of Health
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Keywords: MyD88, Toll-like receptors, interleukin-1 receptor, innate immune signaling, NF-κB activation, MAPK signaling, activator protein-1, signaling complex assembly, protein-protein interaction, subcellular compartmentalization

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

MyD88: a central player in innate immune signaling

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks