Effects of astaxanthin in obese mice fed a high-fat diet
Abstract
Astaxanthin is a natural antioxidant carotenoid that occurs in a wide variety of living organisms. We investigated the effects of astaxanthin supplementation in obese mice fed a high-fat diet. Astaxanthin inhibited the increases in body weight and weight of adipose tissue that result from feeding a high-fat diet. In addition, astaxanthin reduced liver weight, liver triglyceride, plasma triglyceride, and total cholesterol. These results suggest that astaxanthin might be of value in reducing the likelihood of obesity and metabolic syndrome in affluent societies.
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Astaxanthin prevents obesity.
“The intake of astaxanthin has been shown to have a protective effect against ethanol-induced gastric ulcers caused by Helicobacter pylori (Kamath et al., 2008) and affects cholesterol levels in blood, which could be helpful for curing heart disease (Olaizola, 2005), preventing obesity (Ikeuchi et al., 2007) and preventing age-related cognitive function in humans (Satoh et al., 2009).”
From Microalgae Metabolites: A Rich Source for Food and Medicine (2019) · cites this paper as Ikeuchi et al., 2007
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Cites
A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES
Folch, J., Lees, M., & Stanley, G. H. S. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64849-5 · Cited by 65,189 · see citing works
Haematococcus astaxanthin: applications for human health and nutrition
Guerin, M., Huntley, M. E., & Olaizola, M. (2003) · Trends in Biotechnology · doi:10.1016/s0167-7799(03)00078-7 · Cited by 1,495 · see citing works
Antioxidant Activities of Astaxanthin and Related Carotenoids
Naguib, Y. M. A. (2000) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf991106k · Cited by 975 · see citing works
Effects of Capsaicin on Lipid Metabolism in Rats Fed a High Fat Diet
Kawada, T., Hagihara, K.-I., & Iwai, K. (1986) · Journal of Nutrition · doi:10.1093/jn/116.7.1272 · Cited by 307 · see citing works
Chew, B. P., Park, J. S., Wong, M. W., & Wong, T. S. (1999) · PubMed · Cited by 269 · see citing works
Bennedsen, M., Wang, X., Wïllén, R., Wadström, T., & Andersen, L. P. (2000) · Immunology Letters · doi:10.1016/s0165-2478(99)00145-5 · Cited by 216 · see citing works
The Influence of Different Fats and Fatty Acids on Obesity, Insulin Resistance and Inflammation
Bray, G. A., Lovejoy, J. C., Smith, S. R., DeLany, J. P., Lefevre, M., Hwang, D. H., Ryan, D. H., & York, D. A. (2002) · Journal of Nutrition · doi:10.1093/jn/132.9.2488 · Cited by 200 · see citing works
Prevention of diabetic nephropathy by treatment with astaxanthin in diabetic db/db mice
Naito, Y., Uchiyama, K., Aoi, W., Hasegawa, G., Nakamura, N., Yoshida, N., Maoka, T., Takahashi, J., & Yoshikawa, T. (2004) · BioFactors · doi:10.1002/biof.5520200105 · Cited by 200 · see citing works
Self-citationEffects of Astaxanthin Supplementation on Exercise-Induced Fatigue in Mice
Ikeuchi, M., Koyama, T., Takahashi, J., & Yazawa, K. (2006) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.29.2106 · Cited by 145 · see citing works
Self-citationProspects for beta 3-adrenoceptor agonists in the treatment of obesity and diabetes.
Arch, J. R. S., & Wilson, S. (1996) · PubMed · Cited by 134 · see citing works
Kobayashi, M. (2000) · Applied Microbiology and Biotechnology · doi:10.1007/s002530000416 · Cited by 120 · see citing works
Fukuzawa, K., Inokami, Y., Tokumura, A., Terao, J., & Suzuki, A. (1998) · Lipids · doi:10.1007/s11745-998-0266-y · Cited by 113 · see citing works
Reaven, G. M. (2000) · Current Atherosclerosis Reports · doi:10.1007/s11883-000-0050-z · Cited by 83 · see citing works
Capsaicin activates heat loss and heat production simultaneously and independently in rats
Kobayashi, A., Osaka, T., Namba, Y., Inoue, S., Lee, T. H., & Kimura, S. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.275.1.r92 · Cited by 80 · see citing works
Schiff, E. R., & Tagle, F. M. (1997) · Clinics in Liver Disease · doi:10.1016/s1089-3261(05)70327-5 · Cited by 75 · see citing works
Dietary composition, substrate balances and body fat in subjects with a predisposition to obesity.
Astrup, A. V. (1993) · PubMed · Cited by 67 · see citing works
The Pharmacologic Approach to the Treatment of Obesity
Weiser, M. C., Frishman, W. H., Michaelson, M. D., & Abdeen, M. A. (1997) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1997.tb04323.x · Cited by 60 · see citing works
Effects of capsaicin analogs on adrenal catecholamine secretion in rats
Watanabe, T., Kawada, T., Katô, T., Harada, T., & Iwai, K. (1994) · Life Sciences · doi:10.1016/0024-3205(94)00793-4 · Cited by 55 · see citing works
Obesity and post-prandial lipid metabolism. Feast or famine?
Martins, I. J., & Redgrave, T. G. (2004) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2003.10.006 · Cited by 51 · see citing works
Landsberg, L., & Young, J. B. (1993) · PubMed · Cited by 40 · see citing works
High- versus low-fat diets in human diseases
Sanders, T. A. B. (2003) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200303000-00003 · Cited by 34 · see citing works
Bell, R. R., Spencer, M. J., & Sherriff, J. L. (1995) · Journal of Nutrition · doi:10.1093/jn/125.9.2356 · Cited by 28 · see citing works
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Sathasivam, R., Radhakrishnan, R., Hashem, A., & Abd_Allah, E. F. (2019) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2017.11.003 · Cited by 872 · see citing works
Potential health-promoting effects of astaxanthin: a high-value carotenoid mostly from microalgae
Yuan, J., Peng, J., Yin, K., & Wang, J. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000414 · Cited by 649 · see citing works
Possible anti-obesity therapeutics from nature--a review
Yun, J. W. (2010) · Phytochemistry · doi:10.1016/j.phytochem.2010.07.011 · Cited by 619 · see citing works
Skjånes, K., Rebours, C., & Lindblad, P. (2013) · Critical Reviews in Biotechnology · doi:10.3109/07388551.2012.681625 · Cited by 352 · see citing works
Functional properties of carotenoids originating from algae
Christaki, E., Bonos, E., Giannenas, I., & Florou‐Paneri, P. (2013) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.5902 · Cited by 346 · see citing works
Yoshida, H., Yanai, H., Ito, K., Tomono, Y., Koikeda, T., Tsukahara, H., & Tada, N. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.10.012 · Cited by 269 · see citing works
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Udayan, A., Arumugam, M., & Pandey, A. (2017) · Algal Green Chemistry · doi:10.1016/b978-0-444-63784-0.00004-7 · Cited by 143 · see citing works
Ursoniu, S., Sahebkar, A., Serban, M.-C., & Banach, M. (2015) · Archives of Medical Science · doi:10.5114/aoms.2015.50960 · Cited by 80 · see citing works
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Marin, D. P., Bolin, A. P., Macedo, R. D. C. S., Sampaio, S. C., & Otton, R. (2011) · International Immunopharmacology · doi:10.1016/j.intimp.2010.10.013 · Cited by 75 · see citing works
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- Authors
- IKEUCHI, M., KOYAMA, T., TAKAHASHI, J., & YAZAWA, K.
- Affiliations
- Tokyo University of Marine Science and Technology (JP)
- Venue
- Bioscience Biotechnology and Biochemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-04-23
- Volume
- 71
- Issue
- 4
- Pages
- 893-899
- ISSN
- 0916-8451 (ISSN-L)
- 1347-6947
- OpenAlex
- W2165803417
- Cited by
- 222
- References
- 22
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 12 · 2023: 14 · 2022: 13 · 2021: 12 · 2020: 24 · 2019: 14 · 2018: 10 · 2017: 20 · 2016: 16 · 2015: 12 · 2014: 7 · 2013: 7 · 2012: 12
- FWCI
- 6.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bioscience Biotechnology and Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- astaxanthin, obesity, high-fat diet, carotenoids, antioxidants, adipose tissue, hepatic triglycerides, plasma triglycerides, cholesterol, metabolic syndrome, body weight
- MeSH terms
- Adipose Tissue, Animals, Body Weight, Cholesterol, Dietary, Diet, Dietary Fats, Eating, Female, Lipids, Liver, Obesity, Organ Size, Oxygen Consumption, Triglycerides, Anti-Obesity Agents, Xanthophylls, Lipid Metabolism, Mice
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