ROS production in neutrophils from alloxan-induced diabetic rats treated in vivo with astaxanthin
Abstract
Background Astaxanthin (ASTA) is a carotenoid which has powerful antioxidant, anti-tumor, anti-diabetic, anti-inflammatory and cardioprotective properties. The present study investigated the effect of daily ASTA intake on oxidative stress and the functional properties of neutrophils from alloxan-induced diabetic rats.Methods Neutrophils isolated from ASTA-fed rats (30days, 20mg ASTA/kg of body weight - BW) induced to diabetes by alloxan treatment (i.p. 75mg/BW) were assessed by: production of superoxide and hydrogen peroxide, nitric oxide, basal calcium release, oxidative damage (TBARS and carbonyls content), and activities of major antioxidant enzymes.Results Our results show that diabetes promotes a significant oxidative stress in neutrophils. The production of superoxide was significantly increased in neutrophils from diabetic rats and treatment with ASTA was not effective in reducing superoxide levels. At the same time, a reduction in the activity of total superoxide dismutase enzyme was observed, which was not restored after treatment with ASTA. At resting conditions, neutrophils have a higher basal production of hydrogen peroxide, which is enhanced following PMA-stimulation. Treatment with ASTA does not restore values to the basal levels. The indicators of oxidative damage to biomolecules showed that diabetic rats significantly increased the lipid and protein damage, but this change was reversed after treatment with ASTA.Conclusion Our results show that diabetes condition promotes a marked oxidative stress in neutrophils and treatment with ASTA for 30days at a dose of 20mg/kg of BW partially reverses those deleterious effects.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Administration of astaxanthin in alloxan-induced diabetic rats can partially reverse oxidative stress in neutrophils.
“For instance, it has been shown that administration of astaxanthin in alloxan-induced diabetic rats can partially reverse oxidative stress in neutrophils (Marin et al., 2011).”
From Microalgae Metabolites: A Rich Source for Food and Medicine (2019) · cites this paper as Marin et al., 2011
Cites
1 retracted
Otton, R., da Silva, D. O., Campoio, T. R., Silveira, L. R., de Souza, M. O., Hatanaka, E., & Curi, R. (2007) · Journal of Endocrinology · doi:10.1677/joe-07-0195 · Cited by 18 · see citing works
Self-citationRetractedBradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302 · see citing works
Aebi, H. (1984) · Methods in Enzymology · doi:10.1016/s0076-6879(84)05016-3 · Cited by 25,696 · see citing works
A new generation of Ca2+ indicators with greatly improved fluorescence properties.
Grynkiewicz, G., Poenie, M., & Tsien, R. Y. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)83641-4 · Cited by 21,722 · see citing works
Free radicals and antioxidants in normal physiological functions and human disease
Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T. D., Mazur, M., & Telser, J. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.07.001 · Cited by 14,269 · see citing works
Role of Oxidative Stress in Development of Complications in Diabetes
Baynes, J. (1991) · Diabetes · doi:10.2337/diab.40.4.405 · Cited by 3,791 · see citing works
Diabetes, oxidative stress, and antioxidants: A review
Maritim, A. C., Sanders, R. A., & Watkins, J. B. (2003) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.10058 · Cited by 3,128 · see citing works
Wendel, A. (1981) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(81)77046-0 · Cited by 3,011 · see citing works
Ding, A. H., Nathan, C., & Stuehr, D. J. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.141.7.2407 · Cited by 2,840 · see citing works
Role of oxidative stress in diabetic complications: a new perspective on an old paradigm.
Baynes, J. W., & Thorpe, S. R. (1999) · Diabetes · doi:10.2337/diabetes.48.1.1 · Cited by 2,441 · see citing works
Cellular response to oxidative stress: Signaling for suicide and survival *
Martindale, J., & Holbrook, N. (2002) · Journal of Cellular Physiology · doi:10.1002/jcp.10119 · Cited by 2,392 · see citing works
Antioxidants in health and disease
Young, I. S., & Woodside, J. V. (2001) · Journal of Clinical Pathology · doi:10.1136/jcp.54.3.176 · Cited by 1,949 · see citing works
Carotenoid actions and their relation to health and disease
Krinsky, N. I., & Johnson, E. J. (2005) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2005.10.001 · Cited by 1,426 · see citing works
Pick, E., & Mizel, D. E. (1981) · Journal of Immunological Methods · doi:10.1016/0022-1759(81)90138-1 · Cited by 1,143 · see citing works
Antioxidant Activities of Astaxanthin and Related Carotenoids
Naguib, Y. M. A. (2000) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf991106k · Cited by 975 · see citing works
Role of oxidative stress in development of complications in diabetes
Baynes, J. W. (1991) · Diabetes · doi:10.2337/diabetes.40.4.405 · Cited by 810 · see citing works
Fraga, C. G., Leibovitz, B. E., & Tappel, A. L. (1988) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(88)90023-8 · Cited by 679 · see citing works
Vascular complications in diabetes mellitus: the role of endothelial dysfunction
Schalkwijk, C. G., & Stehouwer, C. D. A. (2005) · Clinical Science · doi:10.1042/cs20050025 · Cited by 657 · see citing works
Astaxanthin, a Carotenoid with Potential in Human Health and Nutrition
Hussein, G. M. E., Sankawa, U., Goto, H., Matsumoto, K., & Watanabe, H. (2005) · Journal of Natural Products · doi:10.1021/np050354+ · Cited by 653 · see citing works
Microplate Superoxide Dismutase Assay Employing a Nonenzymatic Superoxide Generator
Ewing, J. F., & Janero, D. R. (1995) · Analytical Biochemistry · doi:10.1006/abio.1995.0014 · Cited by 439 · see citing works
Nishikawa, T., & Araki, E. (2007) · Antioxidants & Redox Signaling · doi:10.1089/ars.2006.1458 · Cited by 391 · see citing works
Lipid Peroxidation in Diabetes Mellitus
Davı̀, G., Falco, A., & Patrono, C. (2004) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.256 · Cited by 377 · see citing works
Woodall, A., Britton, G., & Jackson, M. J. (1997) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(97)00007-x · Cited by 349 · see citing works
Mannervik, B. (1985) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(85)13063-6 · Cited by 332 · see citing works
Diabetes and Advanced Glycoxidation End Products
Huebschmann, A. G., Regensteiner, J. G., Vlassara, H., & Reusch, J. E. B. (2006) · Diabetes Care · doi:10.2337/dc05-2096 · Cited by 331 · see citing works
Effects of Astaxanthin on Lipopolysaccharide-Induced Inflammation In Vitro and In Vivo
Ohgami, K., Shiratori, K., Kotake, S., Nishida, T., Mizuki, N., Yazawa, K., & Ohno, S. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.02-0822 · Cited by 307 · see citing works
Inhibition of Low-Density Lipoprotein Oxidation by Astaxanthin
Iwamoto, T., Hosoda, K., Hirano, R., Kurata, H., Matsumoto, A., Miki, W., Kamiyama, M., Itakura, H., Yamamoto, S., & Kondo, K. N. (2000) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat1994.7.216 · Cited by 305 · see citing works
Arai, K. I., Maguchi, S., Fujii, S., Ishibashi, H., Oikawa, K., & Taniguchi, N. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45479-8 · Cited by 265 · see citing works
Odeberg, J. M., Lignell, Å., Pettersson, A. F., & Höglund, P. (2003) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(03)00135-0 · Cited by 261 · see citing works
Effects of astaxanthin in obese mice fed a high-fat diet
IKEUCHI, M., KOYAMA, T., TAKAHASHI, J., & YAZAWA, K. (2007) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.60521 · Cited by 222 · see citing works
The Role of Oxidative Stress in Diabetic Vascular and Neural Disease
Yorek, M. A. (2003) · Free Radical Research · doi:10.1080/1071576031000083161 · Cited by 219 · cited 1× · see citing works
“Accumulated evidence points out that hyperglycemia can lead to an elevated reactive oxygen (ROS) and nitrogen species (RNS) production by the mitochondrial respiratory system [6], glucose autoxidation [7], activation of the polyol pathway [8], formation of advanced glycation end-products (AGEs) [9], antioxidant enzyme…”
BackgroundPrevention of diabetic nephropathy by treatment with astaxanthin in diabetic db/db mice
Naito, Y., Uchiyama, K., Aoi, W., Hasegawa, G., Nakamura, N., Yoshida, N., Maoka, T., Takahashi, J., & Yoshikawa, T. (2004) · BioFactors · doi:10.1002/biof.5520200105 · Cited by 200 · see citing works
Gallacher, S., Thomson, G., Fraser, W. D., Fisher, B. M., Gemmell, C. G., & MacCuish, A. C. (1995) · Diabetic Medicine · doi:10.1111/j.1464-5491.1995.tb00396.x · Cited by 199 · see citing works
Intervention against the Maillard reaction in vivo
Monnier, V. M. (2003) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2003.08.014 · Cited by 196 · see citing works
Diabetes causes marked changes in function and metabolism of rat neutrophils
Alba‐Loureiro, T. C., Hirabara, S. M., Mendonça, J. R., Curi, R., & Pithon‐Curi, T. C. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06438 · Cited by 181 · see citing works
Regulation of superoxide production in neutrophils: role of calcium influx
Bréchard, S., & Tschirhart, E. J. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0807553 · Cited by 172 · see citing works
Rimele, T. J., Sturm, R. J., Adams, L. M., Henry, D., Heaslip, R. J., Weichman, B. M., & Grimes, D. (1988) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22304-7 · Cited by 163 · see citing works
Priming of neutrophil oxidative burst in diabetes requires preassembly of the NADPH oxidase
Omori, K., Ohira, T., Uchida, Y., Ayilavarapu, S., Júnior, E. L. B., Yagi, M., Iwata, T., Liu, H., Hastürk, H., Kantarcı, A., et al. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.1207832 · Cited by 139 · see citing works
Murphy, M. E., & Kehrer, J. P. (1989) · Biochemical Journal · doi:10.1042/bj2600359 · Cited by 129 · see citing works
Cameron, N. E., Cotter, M. A., & Hohman, T. C. (1996) · Diabetologia · doi:10.1007/bf00403960 · Cited by 97 · see citing works
Astaxanthin addition improves human neutrophils function: in vitro study
Macedo, R. C., Bolin, A. P., Marin, D. P., & Otton, R. (2010) · European Journal of Nutrition · doi:10.1007/s00394-010-0103-1 · Cited by 93 · see citing works
Self-citationAstaxanthin ameliorates the redox imbalance in lymphocytes of experimental diabetic rats
Otton, R., Marin, D. P., Bolin, A. P., dos Santos, R. D. C. M., Polotow, T. G., Sampaio, S. C., & Barros, M. P. (2010) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2010.05.011 · Cited by 88 · see citing works
Self-citationAntioxidant synergism between carotenoids in membranes. Astaxanthin as a radical transfer bridge
Liang, J., Tian, Y., Yang, F., Zhang, J., & Skibsted, L. H. (2009) · Food Chemistry · doi:10.1016/j.foodchem.2009.01.074 · Cited by 85 · see citing works
Uchimura, K., Nagasaka, A., Hayashi, R., Makino, M., Nagata, M., Kakizawa, H., Kobayashi, T., Fujiwara, K., Kato, T., Iwase, K., et al. (1999) · Journal of Diabetes and its Complications · doi:10.1016/s1056-8727(99)00053-7 · Cited by 78 · see citing works
Condell, R. A., & Tappel, A. L. (1983) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(83)90604-5 · Cited by 76 · see citing works
DNA cleavage induced by glycation of Cu, Zn-superoxide dismutase
Kaneto, H., Fujii, J., Suzuki, K., Kasai, H., Kawamori, R., Kamada, T., & Taniguchi, N. (1994) · Biochemical Journal · doi:10.1042/bj3040219 · Cited by 76 · see citing works
Nakano, M. H., ONODERA, A., Saito, E., Tanabe, M., YAJIMA, K., Takahashi, J., & Chuyên, N. V. (2008) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.54.329 · Cited by 64 · see citing works
Mekinová, D., Chorváthová, V., Volkovová, K., Staruchová, M., Graňičová, E., Klvanová, J., & Ondreič, R. (1995) · Food / Nahrung · doi:10.1002/food.19950390402 · Cited by 63 · see citing works
Astaxanthin prevents in vitro auto-oxidative injury in human lymphocytes
Bolin, A. P., Macedo, R. C., Marin, D. P., Barros, M. P., & Otton, R. (2010) · Cell Biology and Toxicology · doi:10.1007/s10565-010-9156-4 · Cited by 62 · see citing works
Self-citationAstaxanthin uptake in domestic dogs and cats
Park, J. S., Kim, H. W., Mathison, B. D., Hayek, M. G., Massimino, S., Reinhart, G. A., & Chew, B. P. (2010) · Nutrition & Metabolism · doi:10.1186/1743-7075-7-52 · Cited by 44 · see citing works
Tuttle, K. R., Anderberg, R. J., Cooney, S. K., & Meek, R. L. (2008) · American Journal of Nephrology · doi:10.1159/000154470 · Cited by 39 · see citing works
Zozulińska‐Ziółkiewicz, D., Wierusz‐Wysocka, B., Wysocki, H., Majchrzak, A., & Wykrętowicz, A. (1996) · Diabetes Research and Clinical Practice · doi:10.1016/0168-8227(96)01289-2 · Cited by 30 · see citing works
Effects of α-tocopherol and astaxanthin on LDL oxidation and atherosclerosis in WHHL rabbits
Jacobsson, L., Yuan, X., Ziedén, B., & OLSSON, A. G. (2004) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2004.01.003 · Cited by 28 · see citing works
Low proliferation capacity of lymphocytes from alloxan-diabetic rats
Otton, R., Carvalho, C. R. D. O., Mendonça, J. R., & Curi, R. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)02141-0 · Cited by 27 · see citing works
Self-citationOtton, R., Graziola, F., Hirata, M. H., Curi, R., & Williams, J. F. (1998) · IUBMB Life · doi:10.1080/15216549800204052 · Cited by 12 · see citing works
Self-citationEffects of $alpha;-tocopherol and astaxanthin on LDL oxidation and atherosclerosis in WHHL rabbits
Jacobsson, L. (2004) · Atherosclerosis · doi:10.1016/s0021-9150(04)00034-6 · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Microalgae Metabolites: A Rich Source for Food and Medicine
Sathasivam, R., Radhakrishnan, R., Hashem, A., & Abd_Allah, E. F. (2019) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2017.11.003 · Cited by 872 · see citing works
Kaulmann, A., & Bohn, T. (2014) · Nutrition Research · doi:10.1016/j.nutres.2014.07.010 · Cited by 675 · see citing works
Astaxanthin: A mechanistic review on its biological activities and health benefits
Fakhri, S., Abbaszadeh, F., Dargahi, L., & Jorjani, M. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.08.012 · Cited by 465 · see citing works
Algae as an emerging source of bioactive pigments
Patel, A. K., Albarico, F. P. J. B., Perumal, P. K., Vadrale, A. P., Nian, C. T., Chau, H. T. B., Anwar, C., Wani, H. M. U. D., Pal, A., Saini, R., et al. (2022) · Bioresource Technology · doi:10.1016/j.biortech.2022.126910 · Cited by 260 · see citing works
M. U., N., Mehar, J. G., Mudliar, S. N., & Shekh, A. Y. (2019) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12500 · Cited by 236 · see citing works
Microalgal carotenoids: beneficial effects and potential in human health
Zhang, J., Sun, Z., Sun, P., Chen, T., & Chen, F. (2013) · Food & Function · doi:10.1039/c3fo60607d · Cited by 205 · see citing works
Biotechnological Applications of Microalgae
Chu, W.-L. (2012) · International e-Journal of Science, Medicine & Education · doi:10.56026/imu.6.suppl1.s24 · Cited by 174 · see citing works
Li, J., Wang, F., Xia, Y., Dai, W., Chen, K., Li, S., Liu, T., Zheng, Y., Wang, J., Lu, W., et al. (2015) · Marine Drugs · doi:10.3390/md13063368 · Cited by 160 · see citing works
Dowey, R., Iqbal, A., Heller, S. R., Sabroe, I., & Prince, L. R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.678771 · Cited by 144 · see citing works
Barros, M. P., Poppe, S. C., & Bondan, E. F. (2014) · Nutrients · doi:10.3390/nu6031293 · Cited by 134 · see citing works
Jannel, S., Caro, Y., Bermudes, M., & Petit, T. (2020) · Journal of Marine Science and Engineering · doi:10.3390/jmse8100789 · Cited by 132 · see citing works
Hamidi, M., Kozani, P. S., Kozani, P. S., Pierre, G., Michaud, P., & Delattre, C. (2019) · Marine Drugs · doi:10.3390/md18010028 · Cited by 107 · see citing works
Carotenoids of Microalgae Used in Food Industry and Medicine
Gâteau, H., Solymosi, K., Marchand, J., & Schoefs, B. (2016) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557516666160808123841 · Cited by 101 · see citing works
Inhibition of inflammation by astaxanthin alleviates cognition deficits in diabetic mice
Zhou, X., Zhang, F., Hu, X., Chen, J., Wen, X., Sun, Y., Liu, Y., Tang, R., Zheng, K., & Song, Y. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.08.015 · Cited by 94 · see citing works
Natural antioxidants in diabetes treatment and management: prospects of astaxanthin
Kanwugu, O. N., Glukhareva, T. V., Danilova, I. G., & Kovaleva, E. G. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1881434 · Cited by 90 · see citing works
Yano, H., Kinoshita, M., Fujino, K., Nakashima, M., Yamamoto, Y., Miyazaki, H., Hamada, K., Ono, S., Iwaya, K., Saitoh, D., et al. (2012) · Infection and Immunity · doi:10.1128/iai.00787-12 · Cited by 83 · see citing works
Fu, X., Liu, H., Huang, G., & Dai, S. (2021) · MedComm · doi:10.1002/mco2.69 · Cited by 77 · see citing works
Ko, J., Chen, J., Wang, T., Zheng, H., Chen, W.-C., Chang, P.-Y., & Lin, Y. (2016) · Biochemical Pharmacology · doi:10.1016/j.bcp.2016.02.016 · Cited by 73 · see citing works
Antidiabetic effect of secoisolariciresinol diglucoside in streptozotocin-induced diabetic rats
Moree, S. S., Gawli, K., & Rajesha, J. (2012) · Phytomedicine · doi:10.1016/j.phymed.2012.11.011 · Cited by 67 · see citing works
Lin, X., Zhao, Y., & Li, S. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.04.008 · Cited by 63 · see citing works
Wang, M., Zhang, J., Song, X., Liu, W., Zhang, L., Wang, X., & Lv, C. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.03.004 · Cited by 58 · see citing works
Anticoagulatory and Antiinflammatory Effects of Astaxanthin in Diabetic Rats
Chan, K., Pen, P.-J., & Yin, M. (2012) · Journal of Food Science · doi:10.1111/j.1750-3841.2011.02558.x · Cited by 56 · see citing works
Barros, M. P., Marin, D. P., Bolin, A. P., Macedo, R. D. C. S., Campoio, T. R., Fineto, C., Guerra, B. A., Polotow, T. G., Vardaris, C. V., Mattei, R., et al. (2012) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2012.03.005 · Cited by 55 · see citing works
Self-citationYan, T., Zhao, Y., Zhang, X., & Lin, X. (2016) · Marine Drugs · doi:10.3390/md14030056 · Cited by 55 · see citing works
Astaxanthin attenuated thrombotic risk factors in type 2 diabetic patients
Chan, K., Chen, S.-C., & Chen, P.-C. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.12.012 · Cited by 52 · see citing works
Anti-inflammatory Effect of Astaxanthin on the Sickness Behavior Induced by Diabetes Mellitus
Ying, C., Zhang, F., Zhou, X., Hu, X., Chen, J., Wen, X., Sun, Y., Zheng, K., Tang, R., & Song, Y. (2015) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-015-0197-3 · Cited by 52 · see citing works
Song, X., Wang, M., Zhang, L., Zhang, J., Wang, X., Liu, W., Gu, X., & Lv, C. (2012) · Toxicology Mechanisms and Methods · doi:10.3109/15376516.2012.717119 · Cited by 49 · see citing works
Rtibi, K., Jabri, M., Selmi, S., Souli, A., Sebaï, H., Benna, J. E., Amri, M., & Marzouki, L. (2015) · RSC Advances · doi:10.1039/c5ra14719k · Cited by 46 · see citing works
Iron toxicity mediated by oxidative stress enhances tissue damage in an animal model of diabetes
Sampaio, A. F. S., Silva, M., Dornas, W. C., Costa, D. C., Silva, M. E., dos Santos, R. C., de Lima, W. G., & Pedrosa, M. L. (2014) · BioMetals · doi:10.1007/s10534-014-9717-8 · Cited by 45 · see citing works
Intact polyaniline coating as a conductive guidance is beneficial to repairing sciatic nerve injury
Wang, G., Wu, W., Yang, H., Zhang, P., & Wang, J. (2019) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.34372 · Cited by 41 · see citing works
Benlarbi, M., Hajri, K., Dellaa, A., Baccouche, B., Hammoum, I., Boudhrioua, N. M., Dhifi, W., & Chaouacha‐Chekir, R. B. (2019) · Food Science & Nutrition · doi:10.1002/fsn3.1259 · Cited by 41 · see citing works
Ourique, F., Tramonte, V. L. C. G., Parisenti, J., Lima-Garcia, J. F., Maraschin, M., & da Silva, E. L. (2014) · Food Bioscience · doi:10.1016/j.fbio.2014.11.001 · Cited by 35 · see citing works
Astaxanthin; a Promising Protector Against Gentamicin-Induced Nephrotoxicity in Rats
Mosaad, Y. O., Gobba, N. A., & Hussein, M. A. (2016) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201017666160922110740 · Cited by 35 · see citing works
Gowd, V., Xiao, J., Wang, M., Chen, F., & Cheng, K. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202100252 · Cited by 35 · see citing works
Bryan, N., Ashwin, H. M., Smart, N. J., Bayon, Y., Scarborough, N. L., & Hunt, J. A. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.05.058 · Cited by 32 · see citing works
Liao, K., Wei, C.-L., Chen, J., Zheng, H., Chen, W.-C., Wu, C.-H., Wang, T., Peng, Y.-S., Chang, P.-Y., & Lin, Y. (2016) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2016.09.031 · Cited by 30 · see citing works
Green tea polyphenol extract in vivo attenuates inflammatory features of neutrophils from obese rats
Albuquerque, K. F. F. S., Marinovic, M. P., Morandi, A. C., Bolin, A. P., & Otton, R. (2015) · European Journal of Nutrition · doi:10.1007/s00394-015-0940-z · Cited by 29 · see citing works
Self-citationRichardson, I. M., Calo, C. J., & Hind, L. E. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.661537 · Cited by 27 · see citing works
Guerra, B. A., Bolin, A. P., & Otton, R. (2012) · Toxicology in Vitro · doi:10.1016/j.tiv.2012.06.010 · Cited by 26 · see citing works
Self-citationCarotenoid intake does not affect immune-stimulated oxidative burst in greenfinches
Sild, E., Sepp, T., Männiste, M., & Hõrak, P. (2011) · Journal of Experimental Biology · doi:10.1242/jeb.062182 · Cited by 26 · see citing works
Rossoni, J. V., de Araújo, G. R., Pádua, B. D. C., Chaves, M. M., Pedrosa, M. L., Silva, M. E., & Costa, D. C. (2011) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.11-49 · Cited by 24 · see citing works
Ghule, A. E., Jadhav, S. S., & Bodhankar, S. L. (2012) · Asian Pacific Journal of Tropical Disease · doi:10.1016/s2222-1808(12)60088-7 · Cited by 25 · see citing works
Chen, J.-C., Wu, C.-H., Peng, Y.-S., Zheng, H., Lin, Y.-C., Ma, P.-F., Chen, T., Chen, T.-Y., & Lin, Y. (2018) · Toxicology Research · doi:10.1039/c7tx00292k · Cited by 23 · see citing works
Diao, L., Ding, M., Sun, H., Xu, Y., Yin, R., & Chen, H. (2023) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2023.109205 · Cited by 22 · see citing works
Diao, L., Liu, W., Xu, Y., Zhang, B., Meng, L., Yin, R., & Chen, H. (2023) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2023.109259 · Cited by 21 · see citing works
Neutrophil-Associated Inflammatory Changes in the Pre-Diabetic Pancreas of Early-Age NOD Mice
Garciafigueroa, Y., Phillips, B. E., Engman, C., Trucco, M., & Giannoukakis, N. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.565981 · Cited by 20 · see citing works
Rossoni, J. V., de Araújo, G. R., Pádua, B. D. C., Magalhães, C. L. D. B., Chaves, M. M., Pedrosa, M. L., Silva, M. E., & Costa, D. C. (2012) · Free Radical Research · doi:10.3109/10715762.2012.656100 · Cited by 19 · see citing works
Favorable Effects of Astaxanthin on Brain Damage due to Ischemia- Reperfusion Injury
Çakır, E. Y., Çakır, U., Tayman, C., Türkmenoğlu, T. T., Gönel, A., & Turan, İ. Ö. (2020) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/1386207323666200219121600 · Cited by 18 · see citing works
Lai, H., Liu, N., Zeng, L., Zhang, Y., & Pan, W. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.300460 · Cited by 17 · see citing works
Solanum nigrum Leaf: Natural Food Against Diabetes and its Bioactive Compounds
Murthy, P. S., Dasgupta, N., & Peddha, M. S. (2016) · Research Journal of Medicinal Plant · doi:10.3923/rjmp.2016.181.193 · Cited by 16 · see citing works
Jain, A., & Vavilala, S. L. (2020) · Wiley eBooks · doi:10.1002/9781119143802.ch2 · Cited by 16 · see citing works
Guerra, B. A., Bolin, A. P., Morandi, A. C., & Otton, R. (2012) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2012.07.004 · Cited by 14 · see citing works
Self-citationHałatek, T., Stanisławska, M., Kamińska, I., Cieślak, M., Świercz, R., & Wąsowicz, W. (2016) · Journal of Environmental Science and Health Part A · doi:10.1080/10934529.2016.1253397 · Cited by 11 · see citing works
Protective effect of astaxanthin on indomethacin-induced gastric ulcerations in mice
Aly, M. H., Said, A. K., Farghaly, A. M., Eldaly, D. A., Ahmed, D. S., Gomaa, M. H., Elgebaly, N. H., Sameh, O., Elahwany, S. K., Ebrahem, T. T., et al. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03206-4 · Cited by 9 · see citing works
Leite, M. F., de Lima, A. M., & Otton, R. (2012) · International Endodontic Journal · doi:10.1111/j.1365-2591.2012.02080.x · Cited by 9 · see citing works
Self-citationde Lima, F. R., Marin, D. P., Ferreira, L. T., Filho, C. P. B. S., Astorino, T. A., Prestes, J., Marquezi, M. L., & Otton, R. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.720773 · Cited by 8 · see citing works
Self-citationAstaxanthin prevents nephrotoxicity through Nrf2/HO-1 pathway
Lorestani, F., Movahedian, A., Mohammadalipour, A., Hashemnia, M., & Aarabi, M. H. (2023) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2023-0015 · Cited by 5 · see citing works
Tikhonova, I. V., Dyukina, A. R., Grinevich, A. A., Shaykhutdinova, E. R., & Safronova, V. G. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.03.006 · Cited by 4 · see citing works
Effect of Lamium Album on Mitochondrial Oxidative Stress in Diabetic Rats
Khanaki, K., Abedinzade, M., Gazor, R., Norasfard, M., & Jafari-Shakib, R. (2017) · Research in Molecular Medicine · doi:10.29252/rmm.5.2.9 · Cited by 3 · see citing works
Immune system and diabetes mellitus
Dhar, A. K., Anitha, K., & Bhatt, S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13195-0.00002-8 · Cited by 3 · see citing works
Bioactive Carotenoids from Microalgae
Guedes, A. C., Amaro, H. M., Sousa‐Pinto, I., & Malcata, F. X. (2013) · doi:10.1002/9781118412893.ch7 · Cited by 3 · see citing works
Pasternak, T. P. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.22.263079 · Cited by 3 · see citing works
Habibi, E., Baâti, T., Selmi, S., M’Rabet, Y., Njim, L., Ashraf, S. A., Humaidi, J. R., Hamadou, W. S., Snoussi, M., Noumi, E., et al. (2024) · Cellular and Molecular Biology · doi:10.14715/cmb/2024.70.5.9 · Cited by 2 · see citing works
Bernhardt, V., & D’Souza, J. (2012) · Cited by 2 · see citing works
Safety assessment and pharmaceutical effects of astaxanthin: An overview
Perumal, M. K., Naveen, J., Janani, R., & Baskaran, V. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823304-7.00023-4 · Cited by 2 · see citing works
Astaxanthin–ascorbyl palmitate co-loaded transfersomes: Targeting oxidative stress and inflammation
Srnec, A., Kašpárková, V., Vašíček, O., Urbánková, L., Kadlečková, M., Martínková, M., & Humpolíček, P. (2026) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2026.115739 · Cited by 2 · see citing works
Vijay, K., Sowmya, P. R., Arathi, B. P., & Lakshminarayana, R. (2016) · Journal of Food Chemistry and Nanotechnology · doi:10.17756/jfcn.2016-024 · Cited by 1 · see citing works
Recovery of high value carotenoids from microalgae: Health beneficial metabolites
Nayak, M., Padhi, D., Das, N., & Kashyap, S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-23967-0.00009-7
- Authors
- Marin, D. P., Bolin, A. P., Macedo, R. D. C. S., Sampaio, S. C., & Otton, R.
- Affiliations
- Universidade Cruzeiro do Sul (BR)
- Instituto Butantan (BR)
- Corresponding author
- Otton, Rosemari
- Venue
- International Immunopharmacology
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 11
- Issue
- 1
- Pages
- 103-109
- ISSN
- 1567-5769 (ISSN-L)
- OpenAlex
- W2089790886
- Cited by
- 75
- References
- 56
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 5 · 2023: 3 · 2022: 1 · 2021: 8 · 2020: 6 · 2019: 4 · 2018: 3 · 2017: 4 · 2016: 8 · 2015: 5 · 2014: 6 · 2013: 3 · 2012: 15
- FWCI
- 4.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Immunopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- astaxanthin, neutrophils, reactive oxygen species, oxidative stress, diabetes mellitus, alloxan-induced diabetes, superoxide, hydrogen peroxide, nitric oxide, superoxide dismutase, lipid peroxidation, protein carbonylation, antioxidant enzymes, carotenoids
- MeSH terms
- Alloxan, Animals, Antioxidants, Diabetes Mellitus, Experimental, Male, Neutrophils, Nitric Oxide, Rats, Wistar, Reactive Oxygen Species, Oxidative Stress, Xanthophylls, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review