The DOI matches its Crossref record; 17 of the 18 references it cites were found in a registry or an index.
Effects of Perinatal Exposure to Bisphenol A on Play Behavior of Female and Male Juvenile Rats
Open accessAbstract
In higher vertebrates, estrogen can exert an organizational effect on sexually dimorphic areas of the central nervous system (CNS) during the perinatal phase of development. The possibility that estrogenic pollutants may mimic estrogen action on the CNS during development and produce long-lasting or irreversible effects is an issue of great concern. Bisphenol A (BPA), a compound widely used in the food industry and in dentistry, has proven estrogenic actions. To study its potential developmental effects on behavior, we gave female Sprague-Dawley rats 40 microg/kg/day BPA from conception to weaning postnatal day 21 and 400 microg/kg/day BPA from gestation day 14 to postnatal day 6. After exposure, we studied social behavior in a play situation in juvenile male and female offspring. The attempt to use play behavior to study the effects of BPA yielded some interesting results. We observed an early action of BPA on several behavioral categories in both males and females. In particular we observed a masculinization of female behavior in two behavioral categories (play with females and sociosexual exploration), an effect probably mediated by the estrogenic activity of BPA in the CNS. These long-lasting effects of BPA could have important consequences at individual and population levels.
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In the citing paper
“Perinatal exposure to bisphenol A, an environmental estrogen, or diethylstilbestrol dipropionate, a synthetic estrogen, also increases play in female rats and rhesus macaques, respectively (Dessi-Fulgheri et al., 2002; Goy & Deputte, 1996).”
From Developmental origins of sex differences in the neural circuitry of play (2020) · cites this paper as Dessi-Fulgheri et al., 2002
In the citing paper
“BPA can also influence social interactions and anxiety in rodents [7], [15], [16], [17].”
From Gestational Exposure to Low Dose Bisphenol A Alters Social Behavior in Juvenile Mice (2011) · cites this paper as [15]
In the citing paper
“In juvenile females, BPA increased both non-social and social investigation [15].”
From Gestational Exposure to Low Dose Bisphenol A Alters Social Behavior in Juvenile Mice (2011) · cites this paper as [15]
In the citing paper
“When tested with males, juvenile females exposed to BPA exhibited reduced play and social grooming.”
From Gestational Exposure to Low Dose Bisphenol A Alters Social Behavior in Juvenile Mice (2011) · cites this paper as [15]
In the citing paper
“However, in none of those three studies was the litter statistically controlled.”
From Developmental Treatment with Ethinyl Estradiol, but Not Bisphenol A, Causes Alterations in Sexually Dimorphic Behaviors in Male and Female Sprague Dawley Rats (2014) · cites this paper as Dessi-Fulgheri et al., 2002
In the citing paper
“However, recent research showed that estrogens or estrogenic EDCs are also involved in the development of play behavior in rats [15–19].”
From Developmental exposure to low levels of ethinylestradiol affects social play in juvenile male rats (2020) · cites this paper as [15]
In the citing paper
“and it is associated with cognitive and social impairments in rodents [ 48 , 133–135 ].”
From DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? (2016) · cites this paper as [133]
Citations
Cites
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Estrogenicity of Resin-Based Composites and Sealants Used in Dentistry
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Xenoestrogens Released from Lacquer Coatings in Food Cans
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Exposure to bisphenol A advances puberty
Howdeshell, K. L., Hotchkiss, A. K., Thayer, K. A., Vandenbergh, J. G., & vom Saal, F. S. (1999) · Nature · doi:10.1038/44517 · Cited by 820 · cited 3×
“Low doses of BPA administered perinatally can modify explorative behavior and anxiety in rats (9) and can advance puberty in female mice (10), although some effects are controversial (11).”
BackgroundOrganizational and activational effects of sex steroids on brain and behavior: A reanalysis
Arnold, A. P. (1985) · Hormones and Behavior · doi:10.1016/0018-506x(85)90042-x · Cited by 807
The neurobiology of social play behavior in rats
Vanderschuren, L. J. M. J., Niesink, R. J. M., & Van Pee, J. M. (1997) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(96)00020-6 · Cited by 559
The Environmental Estrogen Bisphenol A Stimulates Prolactin Release in Vitro and in Vivo
Steinmetz, R. W., Brown, N. G., Allen, D. L., Bigsby, R. M., & Ben‐Jonathan, N. (1997) · Endocrinology · doi:10.1210/endo.138.5.5132 · Cited by 520
Bisphenol A interacts with the estrogen receptor α in a distinct manner from estradiol
Gould, J. C., Leonard, L. S., Maness, S. C., Wagner, B. L., Conner, K., Zacharewski, T., Safe, S., McDonnell, D. P., & Gaido, K. W. (1998) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(98)00084-7 · Cited by 510
PELLIS, S. M., FIELD, E. F., SMITH, L. K., & PELLIS, V. C. (1997) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(95)00060-7 · Cited by 234
Environmental estrogens: health implications for humans and wildlife.
Colborn, T. L. (1995) · Environmental Health Perspectives · doi:10.1289/ehp.95103s7135 · Cited by 204
Perinatal Exposure to the Estrogenic Pollutant Bisphenol A Affects Behavior in Male and Female Rats
Farabollini, F. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(99)00136-7 · Cited by 186
Self-citationMeaney, M. J., Stewart, J., Poulin, P., & McEwen, B. S. (2008) · Neuroendocrinology · doi:10.1159/000123524 · Cited by 144
Reproductive function in rats exposed neonatally to bisphenol A and estradiol benzoate
Nagao, T., Saito, Y., Usumi, K., Kuwagata, M., & Imai, K. (1999) · Reproductive Toxicology · doi:10.1016/s0890-6238(99)00017-9 · Cited by 126
Editorial: Estrogens from Plastic—Are We Being Exposed?
Feldman, D. I. (1997) · Endocrinology · doi:10.1210/endo.138.5.5213 · Cited by 78
Influenza di xenoestrogeni (bisfenolo A) sul sistema a SRIF in alcune aree limbiche di ratto femmina
Facciolo, R. M., Alò, R., Pappaianni, F., M., M., Carelli, A., Canonaco, M., & Dessì‐Fulgheri, F. (2001) · Cited by 1
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Bisphenol-A and the Great Divide: A Review of Controversies in the Field of Endocrine Disruption
Vandenberg, L. N., Maffini, M. V., Sonnenschein, C., Rubin, B. S., & Soto, A. M. (2009) · Endocrine Reviews · doi:10.1210/er.2008-0021 · Cited by 1,407
Saal, F. S. V., & Hughes, C. L. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.7713 · Cited by 1,174
In vivo effects of bisphenol A in laboratory rodent studies
Richter, C. A., Birnbaum, L. S., Farabollini, F., Newbold, R. R., Rubin, B. S., Talsness, C. E., Vandenbergh, J. G., Walser-Kuntz, D. R., & vom Saal, F. S. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.06.004 · Cited by 1,147
Self-citationComponents of plastic: experimental studies in animals and relevance for human health
Talsness, C. E., Martino‐Andrade, A. J., Kuriyama, S. N., Taylor, J. A., & Saal, F. S. V. (2009) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2008.0281 · Cited by 663
NTP‐CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A
Chapin, R. E., Adams, J., Boekelheide, K., Gray, L. E., Hayward, S. W., Lees, P. S. J., Mcintyre, B., Portier, K. M., Schnorr, T. M., Selevan, S. G., et al. (2008) · Birth Defects Research Part B Developmental and Reproductive Toxicology · doi:10.1002/bdrb.20147 · Cited by 514
Metadata
- Authors
- Dessì-Fulgheri, F., Porrini, S., & Farabollini, F.
- Affiliations
- University of Florence (IT)
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2002-03-27
- Volume
- 110
- Issue
- s3
- Pages
- 403-407
- ISSN
- 0091-6765 (ISSN-L)
- PMC
- PMC1241190
- OpenAlex
- W1983073558
- Cited by
- 146
- References
- 18
- Citations by year
- 2025: 1 · 2023: 5 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 6 · 2018: 5 · 2017: 4 · 2016: 6 · 2015: 9 · 2014: 8 · 2013: 11 · 2012: 7
- FWCI
- 5.63
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Environmental Health Perspectives (publishedVersion)
- Environmental Health Perspectives (publishedVersion, public-domain)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- bisphenol A, perinatal exposure, xenoestrogens, social play, sex differences in behavior, endocrine disruptors, young rats
- MeSH terms
- Bisphenol A Compounds, Administration, Oral, Animals, Animals, Newborn, Behavior, Animal, Benzhydryl Compounds, Central Nervous System, Endocrine System, Environmental Exposure, Estrogens, Non-Steroidal, Female, Male, Phenols, Play and Playthings, Pregnancy, Prenatal Exposure Delayed Effects, Sex Characteristics, Social Behavior, Rats, Sprague-Dawley, Rats
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