Cited by 147Effects and risks of endocrine disrupting chemicalsSexual Differentiation and DisordersEstrogen and related hormone effects

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Effects of Perinatal Exposure to Bisphenol A on Play Behavior of Female and Male Juvenile Rats

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Dessì-Fulgheri, Francesco, Porrini, Stefania, Farabollini, Francesca·2002·Environmental Health Perspectives

DOI 10.1289/ehp.02110s3403PMC PMC1241190

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Abstract

In higher vertebrates, estrogen can exert an organizational effect on sexually dimorphic areas of the central nervous system (CNS) during the perinatal phase of development. The possibility that estrogenic pollutants may mimic estrogen action on the CNS during development and produce long-lasting or irreversible effects is an issue of great concern. Bisphenol A (BPA), a compound widely used in the food industry and in dentistry, has proven estrogenic actions. To study its potential developmental effects on behavior, we gave female Sprague-Dawley rats 40 microg/kg/day BPA from conception to weaning postnatal day 21 and 400 microg/kg/day BPA from gestation day 14 to postnatal day 6. After exposure, we studied social behavior in a play situation in juvenile male and female offspring. The attempt to use play behavior to study the effects of BPA yielded some interesting results. We observed an early action of BPA on several behavioral categories in both males and females. In particular we observed a masculinization of female behavior in two behavioral categories (play with females and sociosexual exploration), an effect probably mediated by the estrogenic activity of BPA in the CNS. These long-lasting effects of BPA could have important consequences at individual and population levels.

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Authors: Dessì-Fulgheri, F., Porrini, S., & Farabollini, F.
Affiliations: University of Florence (IT)
Venue: Environmental Health Perspectives
Publisher: American Chemical Society (ACS)
Published: 2002-03-27
Volume: 110
Issue: s3
Pages: 403-407
ISSN: 0091-6765 (ISSN-L)
DOI: 10.1289/ehp.02110s3403
PMC: PMC1241190
OpenAlex: W1983073558
Cited by: 146
References: 18
Citations by year: 2025: 1 · 2023: 5 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 6 · 2018: 5 · 2017: 4 · 2016: 6 · 2015: 9 · 2014: 8 · 2013: 11 · 2012: 7
FWCI: 5.63
Type: journal article
Language: en
Open access: gold
doi.org
Locations: Environmental Health Perspectives (publishedVersion)
Environmental Health Perspectives (publishedVersion, public-domain)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Florence Research (University of Florence) (submittedVersion)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Keywords: bisphenol A, perinatal exposure, xenoestrogens, social play, sex differences in behavior, endocrine disruptors, young rats
MeSH terms: Bisphenol A Compounds, Administration, Oral, Animals, Animals, Newborn, Behavior, Animal, Benzhydryl Compounds, Central Nervous System, Endocrine System, Environmental Exposure, Estrogens, Non-Steroidal, Female, Male, Phenols, Play and Playthings, Pregnancy, Prenatal Exposure Delayed Effects, Sex Characteristics, Social Behavior, Rats, Sprague-Dawley, Rats

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Effects of Perinatal Exposure to Bisphenol A on Play Behavior of Female and Male Juvenile Rats

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