The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Exposure to Polyfluoroalkyl Chemicals and Attention Deficit/Hyperactivity Disorder in U.S. Children 12–15 Years of Age
Open accessAbstract
BACKGROUND: Polyfluoroalkyl chemicals (PFCs) have been widely used in consumer products. Exposures in the United States and in world populations are widespread. PFC exposures have been linked to various health impacts, and data in animals suggest that PFCs may be potential developmental neurotoxicants. OBJECTIVES: We evaluated the associations between exposures to four PFCs and parental report of diagnosis of attention deficit/hyperactivity disorder (ADHD). METHODS: Data were obtained from the National Health and Nutrition Examination Survey (NHANES) 1999-2000 and 2003-2004 for children 12-15 years of age. Parental report of a previous diagnosis by a doctor or health care professional of ADHD in the child was the primary outcome measure. Perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), and perfluorohexane sulfonic acid (PFHxS) levels were measured in serum samples from each child. RESULTS: Parents reported that 48 of 571 children included in the analysis had been diagnosed with ADHD. The adjusted odds ratio (OR) for parentally reported ADHD in association with a 1-μg/L increase in serum PFOS (modeled as a continuous predictor) was 1.03 [95% confidence interval (CI), 1.01-1.05]. Adjusted ORs for 1-μg/L increases in PFOA and PFHxS were also statistically significant (PFOA: OR = 1.12; 95% CI, 1.01-1.23; PFHxS: OR = 1.06; 95% CI, 1.02-1.11), and we observed a nonsignificant positive association with PFNA (OR = 1.32; 95% CI, 0.86-2.02). CONCLUSIONS: Our results, using cross-sectional data, are consistent with increased odds of ADHD in children with higher serum PFC levels. Given the extremely prevalent exposure to PFCs, follow-up of these data with cohort studies is needed.
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Cites
Prevalence and development of psychiatric disorders in childhood and adolescence
Costello, E. J., Mustillo, S., Erkanli, A., Keeler, G., & Angold, A. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.8.837 · Cited by 4,035
Perfluoroalkyl Acids: A Review of Monitoring and Toxicological Findings
Lau, C., Anitole, K., Hodes, C., Lai, D., Pfahles-Hutchens, A., & Seed, J. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfm128 · Cited by 2,620
Olsen, G. W., Burris, J. M., Ehresman, D. J., Froehlich, J. W., Seacat, A. M., Butenhoff, J. L., & Zobel, L. R. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.10009 · Cited by 2,049
Calafat, A. M., Wong, L.-Y., Kuklenyik, Z., Reidy, J. A., & Needham, L. L. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.10598 · Cited by 1,247
Johansson, N., Fredriksson, A., & Eriksson, P. (2008) · NeuroToxicology · doi:10.1016/j.neuro.2007.10.008 · Cited by 463
Shoeib, M., Harner, T., Wilford, B. H., Jones, K. C., & Zhu, J. (2005) · Environmental Science & Technology · doi:10.1021/es048340y · Cited by 328
Martin, J. W., Muir, D. C. G., Moody, C. A., Ellis, D. A., Kwan, W. C., Solomon, K. R., & Mabury, S. A. (2002) · Analytical Chemistry · doi:10.1021/ac015630d · Cited by 299
Detection of perfluorooctane surfactants in Great Lakes water
Boulanger, B., Vargo, J., Schnoor, J. L., & Hornbuckle, K. C. (2004) · Environmental Science & Technology · doi:10.1021/es0496975 · Cited by 299
Developmental Neurotoxicity of Perfluorinated Chemicals Modeled in Vitro
Slotkin, T. A., MacKillop, E. A., Melnick, R. L., Thayer, K. A., & Seidler, F. J. (2008) · Environmental Health Perspectives · doi:10.1289/ehp.11253 · Cited by 225
Maternal cigarette smoking and child psychiatric morbidity: a longitudinal study
Williams, G. M., O'Callaghan, M., Najman, J. M., Bor, W., Andersen, F. M. J., Richards, A. D., & BSc, C. U. (1998) · PEDIATRICS · doi:10.1542/peds.102.1.e11 · Cited by 203
Cited by
Epidemiologic Evidence on the Health Effects of Perfluorooctanoic Acid (PFOA)
Steenland, K., Fletcher, T., & Savitz, D. A. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.0901827 · Cited by 660
Post, G. B., Cohn, P. D., & Cooper, K. R. (2012) · Environmental Research · doi:10.1016/j.envres.2012.03.007 · Cited by 639
Biomonitoring of Perfluoroalkyl Acids in Human Urine and Estimates of Biological Half-Life
Zhang, Y., Beesoon, S., Zhu, L., & Martin, J. W. (2013) · Environmental Science & Technology · doi:10.1021/es401905e · Cited by 530
Brunn, H., Arnold, G., Körner, W., Rippen, G., Steinhäuser, K. G., & Valentin, I. (2023) · Environmental Sciences Europe · doi:10.1186/s12302-023-00721-8 · Cited by 504
Gaballah, S., Swank, A., Sobus, J. R., Howey, X. M., Schmid, J., Catron, T., McCord, J., Hines, E., Strynar, M., & Tal, T. (2020) · Environmental Health Perspectives · doi:10.1289/ehp5843 · Cited by 437
Metadata
- Authors
- Hoffman, K., Webster, T. F., Weisskopf, M. G., Weinberg, J., & Vieira, V. M.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-12
- Volume
- 118
- Issue
- 12
- Pages
- 1762-1767
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W2009748009
- Cited by
- 262
- References
- 10
- FWCI
- 12.68
- Type
- journal article
- Language
- en
- Open access
- gold
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