The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Prenatal Phthalate Exposures and Anogenital Distance in Swedish Boys
Open accessAbstract
BACKGROUND: Phthalates are used as plasticizers in soft polyvinyl chloride (PVC) and in a large number of consumer products. Because of reported health risks, diisononyl phthalate (DiNP) has been introduced as a replacement for di(2-ethylhexyl) phthalate (DEHP) in soft PVC. This raises concerns because animal data suggest that DiNP may have antiandrogenic properties similar to those of DEHP. The anogenital distance (AGD)--the distance from the anus to the genitals--has been used to assess reproductive toxicity. OBJECTIVE: The objective of this study was to examine the associations between prenatal phthalate exposure and AGD in Swedish infants. METHODS: AGD was measured in 196 boys at 21 months of age, and first-trimester urine was analyzed for 10 phthalate metabolites of DEP (diethyl phthalate), DBP (dibutyl phthalate), DEHP, BBzP (benzylbutyl phthalate), as well as DiNP and creatinine. Data on covariates were collected by questionnaires. RESULTS: The most significant associations were found between the shorter of two AGD measures (anoscrotal distance; AGDas) and DiNP metabolites and strongest for oh-MMeOP [mono-(4-methyl-7-hydroxyloctyl) phthalate] and oxo-MMeOP [mono-(2-ethyl-5-oxohexyl) phthalate]. However, the AGDas reduction was small (4%) in relation to more than an interquartile range increase in DiNP exposure. CONCLUSIONS: These findings call into question the safety of substituting DiNP for DEHP in soft PVC, particularly because a shorter male AGD has been shown to relate to male genital birth defects in children and impaired reproductive function in adult males and the fact that human levels of DiNP are increasing globally.
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Decrease in anogenital distance among male infants with prenatal phthalate exposure
Swan, S. H., Main, K. M., Liu, F., Stewart, S. L., Kruse, R. L., Calafat, A. M., Mao, C. S., Redmon, J. B., Ternand, C. L., Sullivan, S., et al. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.8100 · Cited by 1,586
Self-citationState-of-the-science of endocrine disrupting chemicals, 2012
Bergman, Å., Heindel, J., Jobling, S., Kidd, K., & Zoeller, R. T. (2012) · Toxicology Letters · doi:10.1016/j.toxlet.2012.03.020 · Cited by 1,388
Gray, L. E. (2000) · Toxicological Sciences · doi:10.1093/toxsci/58.2.350 · Cited by 1,084
Swan, S. H. (2008) · Environmental Research · doi:10.1016/j.envres.2008.08.007 · Cited by 856
Self-citationBornehag, C.-G., Sundell, J., Weschler, C. J., Sigsgaard, T., Lundgren, B., Hasselgren, M., & Hägerhed-Engman, L. (2004) · Environmental Health Perspectives · doi:10.1289/ehp.7187 · Cited by 851
Self-citationAssessing exposure to phthalates – The human biomonitoring approach
Wittassek, M., Koch, H. M., Angerer, J., & Brüning, T. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000121 · Cited by 742
Rudel, R. A., Gray, J. M., Engel, C. L., Rawsthorne, T. W., Dodson, R. E., Ackerman, J. M., Rizzo, J., Nudelman, J. L., & Brody, J. G. (2011) · Environmental Health Perspectives · doi:10.1289/ehp.1003170 · Cited by 594
FOSTER, P. M. D. (2006) · International Journal of Andrology · doi:10.1111/j.1365-2605.2005.00563.x · Cited by 578
Endocrine disrupting chemicals in indoor and outdoor air
Rudel, R. A., & Perovich, L. J. (2009) · Atmospheric Environment · doi:10.1016/j.atmosenv.2008.09.025 · Cited by 546
Sharpe, R. M., Fisher, J. S., Millar, M. M., Jobling, S., & Sumpter, J. P. (1995) · Environmental Health Perspectives · doi:10.1289/ehp.951031136 · Cited by 492
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Endocrine-disrupting chemicals: Implications for human health
Kahn, L. G., Philippat, C., Nakayama, S. F., Slama, R., & Trasande, L. (2020) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(20)30129-7 · Cited by 797
Radke, E. G., Braun, J. M., Meeker, J. D., & Cooper, G. S. (2018) · Environment International · doi:10.1016/j.envint.2018.07.029 · Cited by 439
From cohorts to molecules: adverse impacts of endocrine disrupting mixtures
Caporale, N., Leemans, M., Birgersson, L., Germain, P.-L., Cheroni, C., Borbély, G., Engdahl, E., Lindh, C., Bressan, R. B., Cavallo, F., et al. (2022) · Science · doi:10.1126/science.abe8244 · Cited by 368
Self-citationAnogenital distance as a marker of androgen exposure in humans
Thankamony, A., Pasterski, V., Ong, K. K., Acerini, C. L., & Hughes, I. A. (2016) · Andrology · doi:10.1111/andr.12156 · Cited by 238
Barrett, E. S., Hoeger, K. M., Sathyanarayana, S., Abbott, D. H., Redmon, J. B., Nguyen, R. H. N., & Swan, S. H. (2018) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174417001118 · Cited by 145
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Metadata
- Authors
- Bornehag, C.-G., Carlstedt, F., Jönsson, B. A., Lindh, C. H., Jensen, T. K., Bodin, A., Jonsson, C., Janson, S., & Swan, S. H.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-01
- Volume
- 123
- Issue
- 1
- Pages
- 101-107
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W1983290283
- Cited by
- 276
- References
- 48
- FWCI
- 14.12
- Type
- journal article
- Language
- en
- Open access
- gold
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