The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Perfluorooctanesulfonate and other fluorochemicals in the serum of American Red Cross adult blood donors.
Open accessAbstract
Perfluorooctanesulfonyl fluoride-based products have included surfactants, paper and packaging treatments, and surface protectants (e.g., for carpet, upholstery, textile). Depending on the specific functional derivatization or degree of polymerization, such products may degrade or metabolize, to an undetermined degree, to perfluorooctanesulfonate (PFOS), a stable and persistent end product that has the potential to bioaccumulate. In this investigation, a total of 645 adult donor serum samples from six American Red Cross blood collection centers were analyzed for PFOS and six other fluorochemicals using HPLC-electrospray tandem mass spectrometry. PFOS concentrations ranged from the lower limit of quantitation of 4.1 ppb to 1656.0 ppb with a geometric mean of 34.9 ppb [95% confidence interval (CI), 33.3-36.5]. The geometric mean was higher among males (37.8 ppb; 95% CI, 35.5-40.3) than among females (31.3 ppb; 95% CI, 30.0-34.3). No substantial difference was observed with age. The estimate of the 95% tolerance limit of PFOS was 88.5 ppb (upper limit of 95% CI, 100.0 ppb). The measures of central tendency for the other fluorochemicals (N-ethyl perfluorooctanesulfonamidoacetate, N-methyl perfluorooctanesulfonamidoacetate, perfluorooctanesulfonamidoacetate, perfluorooctanesulfonamide, perfluorooctanoate, and perfluorohexanesulfonate) were approximately an order of magnitude lower than PFOS. Because serum PFOS concentrations correlate with cumulative human exposure, this information can be useful for risk characterization.
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Cites
Global Distribution of Perfluorooctane Sulfonate in Wildlife
Giesy, J. P., & Kannan, K. (2001) · Environmental Science & Technology · doi:10.1021/es001834k · Cited by 2,750
Compound-specific, quantitative characterization of organic fluorochemicals in biological matrices
Hansen, K. J., Clemen, L. A., Ellefson, M. E., & Johnson, H. O. (2001) · Environmental Science & Technology · doi:10.1021/es001489z · Cited by 923
Self-citationSubchronic Toxicity Studies on Perfluorooctanesulfonate Potassium Salt in Cynomolgus Monkeys
Seacat, A. M. (2002) · Toxicological Sciences · doi:10.1093/toxsci/68.1.249 · Cited by 564 · cited 1×
“The mean calculated TOF of 31.7 ppb in the present study is also consistent with the low–parts-per-billion TOF measurements of general population samples that have been reported since the 1960s (Belisle 1981; Singer and Ophaug 1979; Taves 1968; Taves et al. 1976).”
ResultInfluentialThibodeaux, J. R., Hanson, R. G., Rogers, J. M., Grey, B. E., Barbee, B. D., Richards, J. H., Butenhoff, J. L., Stevenson, L. A., & Lau, C. (2003) · Toxicological Sciences · doi:10.1093/toxsci/kfg121 · Cited by 445
Martin, J. W., Muir, D. C. G., Moody, C. A., Ellis, D. A., Kwan, W. C., Solomon, K. R., & Mabury, S. A. (2002) · Analytical Chemistry · doi:10.1021/ac015630d · Cited by 299
Berthiaume, J., & Wallace, K. B. (2002) · Toxicology Letters · doi:10.1016/s0378-4274(01)00466-0 · Cited by 246
Cited by
Perfluoroalkyl Acids: A Review of Monitoring and Toxicological Findings
Lau, C., Anitole, K., Hodes, C., Lai, D., Pfahles-Hutchens, A., & Seed, J. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfm128 · Cited by 2,620
Sources, fate and transport of perfluorocarboxylates
Prevedouros, K., Cousins, I. T., Buck, R. C., & Korzeniowski, S. H. (2006) · Environmental Science & Technology · doi:10.1021/es0512475 · Cited by 2,594
Calafat, A. M., Wong, L.-Y., Kuklenyik, Z., Reidy, J. A., & Needham, L. L. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.10598 · Cited by 1,247
A first global production, emission, and environmental inventory for perfluorooctane sulfonate
Paul, A. G., Jones, K. C., & Sweetman, A. J. (2009) · Environmental Science & Technology · doi:10.1021/es802216n · Cited by 1,096
Perfluorooctanesulfonate and related fluorochemicals in human blood from several countries
Kannan, K., Corsolini, S., Falandysz, J., Fillmann, G., Kumar, K. S., Loganathan, B. G., Mohd, M. A., Olivero, J., Wouwe, N. V., Yang, J. H., et al. (2004) · Environmental Science & Technology · doi:10.1021/es0493446 · Cited by 1,056
Metadata
- Authors
- Olsen, G. W., Church, T. R., Miller, J. P., Burris, J. M., Hansen, K. J., Lundberg, J. K., Armitage, J. B., Herron, R. M., Medhdizadehkashi, Z., Nobiletti, J. B., O'Neill, E. M., Mandel, J. H., & Zobel, L. R.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2003-12
- Volume
- 111
- Issue
- 16
- Pages
- 1892-1901
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W2042880426
- Cited by
- 404
- References
- 6
- FWCI
- 21.72
- Type
- journal article
- Language
- en
- Open access
- gold
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- Olsen, G. W., Church, T. R., Miller, J. P., Burris, J. M., Hansen, K. J., Lundberg, J. K., Armitage, J. B., Herron, R. M., Medhdizadehkashi, Z., Nobiletti, J. B., O'Neill, E. M., Mandel, J. H., & Zobel, L. R. (2003). Perfluorooctanesulfonate and other fluorochemicals in the serum of American Red Cross adult blood donors. Environmental Health Perspectives. https://doi.org/10.1289/ehp.6316
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