The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
The role of oxygen free radicals in occupational and environmental lung diseases.
Open accessAbstract
Oxygen free radicals and their metabolites, collectively described as reactive oxygen species (ROS), have been implicated in the pathogenesis of many diseases. The pulmonary system is particularly vulnerable to ROS-induced injury because of its continuous exposure to toxic pollutants from a wide variety of sources in the ambient air. Additionally, lungs are exposed systemically to ROS generated from xenobiotic compounds and endogenous sources. This review describes the sources of endogenous and exogenous ROS generation in the lung. Special emphasis is given to major sources of ROS in occupational and environmental exposures to asbestos, crystalline silica, coal, chromium, herbicides, bleomycin, and cigarette smoke. ROS-induced lung injury at different target levels may contribute to similar patterns of cell injury and alterations at the molecular level by initiation, propagation, and autocatalytic chain reactions. Intracellular signalling, activation and inactivation of enzymes, stimulation, secretion, and release of proinflammatory cytokines, chemokines, and nuclear factor activation and alterations are also common events. Understanding the interactions of these intricate mechanistic events is important in the prevention and amelioration of lung injury that results from acute and chronic exposures to toxins in ambient air.
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Cites
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LXXIII.—Oxidation of tartaric acid in presence of iron
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The role of free radicals in asbestos-induced diseases
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Hydroxyl Radicals are Formed in the Rat Lung After Asbestos Instillation In Vivo
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Generation of Reactive Oxygen Species by Quartz Particles and Its Implication for Cellular Damage
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Self-citation
Cited by
Nitric oxide in health and disease of the respiratory system
Ricciardolo, F. L. M., Sterk, P. J., Gaston, B., & Folkerts, G. (2004) · Physiological Reviews · doi:10.1152/physrev.00034.2003 · Cited by 903
Silica binding and toxicity in alveolar macrophages
Hamilton, R. F., Thakur, S. A., & Holian, A. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.12.027 · Cited by 415
Diseases caused by asbestos: mechanisms of injury and disease development
Manning, C. B., Vallyathan, V., & Mossman, B. T. (2002) · International Immunopharmacology · doi:10.1016/s1567-5769(01)00172-2 · Cited by 228
Self-citationSanchez, V. C., Pietruska, J. R., Miselis, N. R., Hurt, R. H., & Kane, A. B. (2009) · WIREs Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.41 · Cited by 186
Zhou, H., & Kobzik, L. (2007) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2006-0293oc · Cited by 129
Metadata
- Authors
- Vallyathan, V, & Shi, X.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 1997-02
- Volume
- 105
- Issue
- suppl 1
- Pages
- 165-177
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W1985501344
- Cited by
- 239
- References
- 9
- FWCI
- 5.38
- Type
- journal article
- Language
- en
- Open access
- gold
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
