Metabolic Syndrome and Cardiac Disease in Japanese Men: Applicability of the Concept of Metabolic Syndrome Defined by the National Cholesterol Education Program-Adult Treatment Panel III to Japanese Men-The Tanno and Sobetsu Study
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Results of a 6-year follow-up study were used to determine whether the concept of and the criteria for metabolic syndrome as defined by the National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III) can be applied to Japanese men for prediction of the occurrence of cardiac disease. The subjects were 808 men who underwent mass health check-ups in 1993 and who were not on medication for hypertension, diabetes or hyperlipidemia. Individuals who had hypertriglyceridemia, hypo-high density lipoprotein (HDL) cholesterolemia, high blood pressure, and/or high fasting plasma glucose levels were identified on the basis of the NCEP-ATP III criteria. Not in conformity with the NCEP-ATP Ill, however, a cut-off value of 85 cm was used for waist girth as an indicator of abdominal obesity. The subjects who had 3 or more risk factors were judged as having metabolic syndrome. The proportion of subjects having metabolic syndrome was 25.3%. In the 6-year follow-up study, cardiac disease occurred in 11.7% of the subjects in the metabolic syndrome group and in 6.7% of the subjects in the non-metabolic syndrome group. Results of regression analysis using Cox's proportional hazards model showed that subjects in the metabolic syndrome group had a 2.2-times greater risk of developing cardiac disease than did subjects in the non-metabolic syndrome group. The concept of metabolic syndrome as defined in the NCEP-ATP III was therefore considered to be useful for predicting the occurrence of cardiac disease in Japanese men.
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Metabolic syndrome is a condition that poses a high risk for the development of cardiovascular disease.
“[Statement]Metabolic syndrome is a condition that poses a high risk for the development of cardiovascular disease (Evidence level: E-1b).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [327]
Conditions such as metabolic syndrome that involve the clustering of multiple risk factors have been shown to increase the risk of cardiovascular diseases in epidemiological studies and meta-analyses, as well as in CIRCS study, Tanno and Sobetsu study, and Hisayama study.
“Conditions, such as metabolic syndrome, that involve the clustering of multiple risk factors have been shown to increase the risk of cardiovascular diseases in epidemiological studies323–326) and meta-analyses327), as well as in CIRCS study78), the Tanno and Sobetsu study328) and the Hisayama study317).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [327]
Metabolic syndrome is significant because it is a high risk of ASCVD even if the levels of hyperglycemia, dyslipidemia and elevated blood pressure are relatively mild.
“Metabolic syndrome is significant because it is a high risk of ASCVD even if the levels of hyperglycemia, dyslipidemia and elevated blood pressure are relatively mild323–327).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [327]
A meta-analysis of 87 clinical studies showed that the presence of metabolic syndrome results in an added risk for total mortality, coronary events, and cerebrovascular events for patients with CAD.
“The results of a meta-analysis of 87 clinical studies have shown that the presence of metabolic syndrome results in an added risk for total mortality, coronary events, and cerebrovascular events for patients with CAD327).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [327]
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- Authors
- TAKEUCHI, H., SAITOH, S., TAKAGI, S., OHNISHI, H., OHHATA, J., ISOBE, T., & SHIMAMOTO, K.
- Affiliations
- Sapporo Medical University (JP)
- Corresponding author
- TAKEUCHI, Hiroshi
- Venue
- Hypertension Research
- Publisher
- Japanese Society of Hypertension
- Published
- 2005
- Volume
- 28
- Issue
- 3
- Pages
- 203-208
- ISSN
- 0916-9636 (ISSN-L)
- 1348-4214
- OpenAlex
- W2074939007
- Cited by
- 164
- References
- 27
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 4 · 2016: 2 · 2015: 4 · 2014: 5 · 2013: 3 · 2012: 12
- FWCI
- 14.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hypertension Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Keywords
- metabolic syndrome, NCEP ATP III criteria, Japanese men, cardiovascular risk, abdominal obesity, waist circumference, hypertriglyceridemia, low HDL cholesterol, hypertension, fasting blood glucose, risk prediction
- MeSH terms
- Aged, Follow-Up Studies, Heart Diseases, Humans, Insulin Resistance, Japan, Male, Middle Aged, Predictive Value of Tests, Prognosis, Risk Factors, Proportional Hazards Models, Metabolic Syndrome
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