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The Effects of Twelve Weeks of Bed Rest on Bone Histology, Biochemical Markers of Bone Turnover, and Calcium Homeostasis in Eleven Normal Subjects
Abstract
This study was undertaken to examine the effects of 12 weeks of skeletal unloading on parameters of calcium homeostasis, calcitropic hormones, bone histology, and biochemical markers of bone turnover in 11 normal subjects (9 men, 2 women; 34 ± 11 years of age). Following an ambulatory control evaluation, all subjects underwent 12 weeks of bed rest. An additional metabolic evaluation was performed after 12 days of reambulation. Bone mineral density declined at the spine (−2.9%, p = 0.092) and at the hip (−3.8%, p = 0.002 for the trochanter). Bed rest prompted a rapid, sustained, significant increase in urinary calcium and phosphorus as well as a significant increase in serum calcium. Urinary calcium increased from a pre-bed rest value of 5.3 mmol/day to values as high as 7.3 mmol/day during bed rest. Immunoreactive parathyroid hormone and serum 1,25-dihydroxyvitamin D declined significantly during bed rest, although the mean values remained within normal limits. Significant changes in bone histology included a suppression of osteoblastic surface for cancellous bone (3.1 ± 1.3% to 1.9 ± 1.5%, p = 0.0142) and increased bone resorption for both cancellous and cortical bone. Cortical eroded surface increased from 3.5 ± 1.1% to 7.3 ± 4.0% (p = 0.018) as did active osteoclastic surface (0.2 ± 0.3% to 0.7 ± 0.7%, p = 0.021). Cancellous eroded surface increased from 2.1 ± 1.1% to 4.7 ± 2.2% (p = 0.002), while mean active osteoclastic surface doubled (0.2 ± 0.2% to 0.4 ± 0.3%, p = 0.020). Serum biochemical markers of bone formation (osteocalcin, bone-specific alkaline phosphatase, and type I procollagen extension peptide) did not change significantly during bed rest. Urinary biochemical markers of bone resorption (hydroxyproline, deoxypyridinoline, and N-telopeptide of type I collagen) as well as a serum marker of bone resorption (type I collagen carboxytelopeptide) all demonstrated significant increases during bed rest which declined toward normal during reambulation. Thus, under the conditions of this study, the human skeleton appears to respond to unloading by a rapid and sustained increase in bone resorption and a more subtle decrease in bone formation.
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Cites
Quantitative histological data on disuse osteoporosis: Comparison with biological data
Minaire, P., Meunier, P., Edouard, C., Bernard, J., Courpron, P., & Bourret, J. (1974) · Calcified Tissue Research · doi:10.1007/bf02547214 · Cited by 435
Cited by
Vico, L., Collet, P., Guignandon, A., Lafage-Proust, M.-H., Thomas, T., Rehailia, M., & Alexandre, C. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02217-0 · Cited by 821
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Pearson, O. M., & Lieberman, D. E. (2004) · American Journal of Physical Anthropology · doi:10.1002/ajpa.20155 · Cited by 745
From space to Earth: Advances in human physiology from 20 years of bed rest studies (1986–2006)
Pavy-Le Traon, A., Heer, M., Narici, M. V., Rittweger, J., & Vernikos, J. (2007) · European Journal of Applied Physiology · doi:10.1007/s00421-007-0474-z · Cited by 658
Cardiac atrophy after bed rest and spaceflight
Perhonen, M. A., Franco, F., Lane, L. D., Buckey, J. C., Blomqvist, C. G., Zerwekh, J. E., Peshock, R. M., Weatherall, P. T., & Levine, B. D. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.2.645 · Cited by 494
Self-citationResistance exercise as a countermeasure to disuse-induced bone loss
Shackelford, L. C., LeBlanc, A. D., Driscoll, T. B., Evans, H. J., Rianon, N. J., Smith, S. M., Spector, E., Feeback, D. L., & Lai, D. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00741.2003 · Cited by 392
(2007) · PubMed · Cited by 337
Smith, S. M., Zwart, S. R., Block, G., Rice, B. L., & Davis-Street, J. E. (2005) · The Journal of Nutrition · doi:10.1093/jn/135.3.437 · Cited by 316
Secondary Causes of Osteoporosis
FITZPATRICK, L. A. (2002) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(11)62214-3 · Cited by 311
Bone turnover markers in the management of postmenopausal osteoporosis
Brown, J. P., Albert, C., Nassar, B. A., Adachi, J. D., Cole, D., Davison, K. S., Dooley, K. C., Don-Wauchope, A., Douville, P., Hanley, D. A., et al. (2009) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2009.04.001 · Cited by 204
Bone loss after bariatric surgery: causes, consequences, and management
Stein, E. M., & Silverberg, S. J. (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(13)70183-9 · Cited by 199
Orwoll, E. S., Adler, R. A., Amin, S., Binkley, N., Lewiecki, E. M., Petak, S. M., Shapses, S. A., Sinaki, M., Watts, N. B., & Sibonga, J. D. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1948 · Cited by 184
Bone loss in spinal cord-injured patients: from physiopathology to therapy
Maïmoun, L., Fattal, C., Micallef, J.-P., Peruchon, E., & Rabischong, P. (2006) · Spinal Cord · doi:10.1038/sj.sc.3101832 · Cited by 167
True fractional calcium absorption is decreased after Roux-en-Y gastric bypass surgery
Riedt, C. S., Brolin, R. E., Sherrell, R. M., Field, M. P., & Shapses, S. A. (2006) · Obesity · doi:10.1038/oby.2006.226 · Cited by 166
Participation in road cycling vs running is associated with lower bone mineral density in men
Rector, R. S., Rogers, R., Ruebel, M., & Hinton, P. S. (2008) · Metabolism · doi:10.1016/j.metabol.2007.09.005 · Cited by 143
Giangregorio, L., & Blimkie, C. J. (2002) · Sports Medicine · doi:10.2165/00007256-200232070-00005 · Cited by 135
Fifty Years of Human Space Travel: Implications for Bone and Calcium Research
Smith, S. M., Abrams, S. A., Davis-Street, J. E., Heer, M., O'Brien, K. O., Wastney, M. E., & Zwart, S. R. (2014) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071813-105440 · Cited by 111
Li, C. Y., Price, C., Delisser, K., Nasser, P., Laudier, D., Clement, M., Jepsen, K. J., & Schaffler, M. B. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.041010 · Cited by 96
Zwart, S. R., Hargens, A. R., Lee, S. M. C., Macias, B. R., Watenpaugh, D. E., Tse, K., & Smith, S. M. (2007) · Bone · doi:10.1016/j.bone.2006.09.014 · Cited by 86
Maternal activity restriction and the prevention of preterm birth
Sciscione, A. C. (2010) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2009.07.005 · Cited by 79
Adaptation of the Skeletal System During Long-Duration Spaceflight
Sibonga, J. D., Cavanagh, P. R., Lang, T. F., LeBlanc, A. D., Schneider, V. S., Shackelford, L. C., Smith, S. M., & Vico, L. (2007) · Clinical Reviews in Bone and Mineral Metabolism · doi:10.1007/s12018-008-9012-8 · Cited by 67
Beller, G., Belavý, D. L., Sun, L., Armbrecht, G., Alexandre, C., & Felsenberg, D. (2011) · Bone · doi:10.1016/j.bone.2011.06.021 · Cited by 60
Bed rest and other determinants of bone loss during pregnancy
Promislow, J. H. E., Hertz-Picciotto, I., Schramm, M., Watt-Morse, M., & Anderson, J. J. B. (2004) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2004.05.058 · Cited by 57
Yang Li, C., Majeska, R. J., Laudier, D. M., Mann, R., & Schaffler, M. B. (2005) · Bone · doi:10.1016/j.bone.2005.04.041 · Cited by 56
Effect of bed rest during pregnancy on bone turnover markers in pregnant and postpartum women
Kaji, T., Yasui, T., Suto, M., Mitani, R., Morine, M., Uemura, H., Maeda, K., & Irahara, M. (2007) · Bone · doi:10.1016/j.bone.2006.11.018 · Cited by 40
Effects of high-protein intake on bone turnover in long-term bed rest in women
Heer, M., Baecker, N., Frings-Meuthen, P., Graf, S., Zwart, S. R., Biolo, G., & Smith, S. M. (2017) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2016-0292 · Cited by 24
Baecker, N., Frings-Meuthen, P., Smith, S. M., & Heer, M. (2010) · Nutrition · doi:10.1016/j.nut.2009.06.006 · Cited by 22
Nutrition and Bone Health in Space
Smith, S. M., Heer, M., & Zwart, S. R. (2015) · Nutrition and Bone Health · doi:10.1007/978-1-4939-2001-3_41 · Cited by 14
Metadata
- Authors
- Zerwekh, J. E., Ruml, L. A., Gottschalk, F., & Pak, C. Y. C.
- Venue
- Journal of Bone and Mineral Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-10-01
- Volume
- 13
- Issue
- 10
- Pages
- 1594-1601
- ISSN
- 0884-0431 (ISSN-L)
- 1523-4681
- OpenAlex
- W2154148361
- Cited by
- 378
- References
- 1
- FWCI
- 4.42
- Type
- journal article
- Language
- en
- Open access
- closed
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