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Cited by 65Bone health and osteoporosis researchAdrenal Hormones and DisordersHormonal Regulation and Hypertension

Bone metabolism and mass in women with Cushing’s syndrome and adrenal incidentaloma

Francucci, Cristiano Maria, Pantanetti, Paola, Garrapa, Gabriella Giuseppina, Massi, Fernando, Arnaldi, Giorgio, Mantero, Franco·2002·Clinical Endocrinology
DOI 10.1046/j.1365-2265.2002.01602.x
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Abstract

OBJECTIVE: The aim of this study was to compare bone turnover and mass in women with either Cushing's syndrome (CS) or adrenal incidentaloma (AI), which is a possible model for minimal hypersecretion of cortisol. DESIGN AND PATIENTS: We studied 15 patients with CS (seven premenopausal and eight postmenopausal women); 23 patients with AI (five premenopausal and 18 postmenopausal women) and 20 matched controls (seven premenopausal and 13 postmenopausal women). Alkaline phosphatase (ALP), bone alkaline phosphatase (bALP), osteocalcin (BGP), 24-h urinary pyridinoline (Pyr) and deoxypyridinoline (D-Pyr) and serum and 24-h urinary calcium and phosphorus were determined in all subjects. Bone mineral density (BMD) at lumbar spine and proximal femur was measured by dual energy X-ray absorptiometry (DEXA). RESULTS: We found a significant reduction of BGP and serum phosphorus in CS and AI (P < 0.05) vs. controls and significantly lower levels of Pyr only in CS (P < 0.05) vs. AI and controls. Spinal and femoral BMD z-values were significantly lower (P < 0.05) in patients with CS (z-score: lumbar spine -1.44 +/- 1.5 and femoral neck -1.07 +/- 1; mean +/- SD) compared to AI and controls. CONCLUSIONS: Our data show that hypercortisolism reduces osteoblastic function and bone resorption and that osteocalcin can contribute to the precocious diagnosis of silent glucocorticoid excess. Patients with active CS were found to have lower BMD, particularly at vertebral level.

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Crossref · 10.1046/j.1365-2265.2002.01602.x

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  • In patients with ACS, bone formation is reported as decreased, normal, or increased alongside normal bone resorption.

    “However, in patients with ACS, a mixed picture is reported with either decreased, normal, or even increased bone formation reported alongside normal bone resorption (229,242,259-262).”

    From Adrenal incidentaloma (2020) · cites this paper as [261]

  • Both trabecular and cortical bone loss have been described in patients with ACS.

    “Both trabecular (65,261-263) and cortical (259,262,264-266) bone loss have been described in patients with ACS.”

    From Adrenal incidentaloma (2020) · cites this paper as [261]

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Authors
Francucci, C. M., Pantanetti, P., Garrapa, G. G., Massi, F., Arnaldi, G., & Mantero, F.
Affiliations
Azienda Ospedaliero-Universitaria delle Marche (IT)
Corresponding author
Francucci, Cristiano Maria
ORCID
Venue
Clinical Endocrinology
Publisher
Wiley
Published
2002-10-22
Volume
57
Issue
5
Pages
587-593
ISSN
  • 0300-0664 (ISSN-L)
  • 1365-2265
DOI
10.1046/j.1365-2265.2002.01602.x
OpenAlex
W1804473122
Cited by
65
References
58
Citations by year
2026: 2 · 2025: 1 · 2024: 4 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 5 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 1 · 2014: 2 · 2013: 1 · 2012: 1
FWCI
4.07
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Clinical Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion)
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
Keywords
Cushing's syndrome, adrenal incidentaloma, bone metabolism, bone mineral density, bone turnover markers, osteocalcin, bone-specific alkaline phosphatase, urinary pyridinoline, deoxypyridinoline, hypercortisolism, glucocorticoid excess, bone resorption, postmenopausal women, lumbar spine, femoral neck
MeSH terms
Adrenal Cortex Neoplasms, Aged, Amino Acids, Bone and Bones, Calcium, Cushing Syndrome, Female, Femur Neck, Humans, Hydrocortisone, Lumbar Vertebrae, Middle Aged, Phosphorus, Bone Density, Osteocalcin, Chi-Square Distribution, Case-Control Studies, Incidental Findings

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