The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Many Ribosomal Protein Genes Are Cancer Genes in Zebrafish
Open accessAbstract
We have generated several hundred lines of zebrafish (Danio rerio), each heterozygous for a recessive embryonic lethal mutation. Since many tumor suppressor genes are recessive lethals, we screened our colony for lines that display early mortality and/or gross evidence of tumors. We identified 12 lines with elevated cancer incidence. Fish from these lines develop malignant peripheral nerve sheath tumors, and in some cases also other tumor types, with moderate to very high frequencies. Surprisingly, 11 of the 12 lines were each heterozygous for a mutation in a different ribosomal protein (RP) gene, while one line was heterozygous for a mutation in a zebrafish paralog of the human and mouse tumor suppressor gene, neurofibromatosis type 2. Our findings suggest that many RP genes may act as haploinsufficient tumor suppressors in fish. Many RP genes might also be cancer genes in humans, where their role in tumorigenesis could easily have escaped detection up to now.
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Cites
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
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Signaling to p53: ribosomal proteins find their way
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Mechanisms of Haploinsufficiency Revealed by Genome-Wide Profiling in Yeast
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Coping with stress: multiple ways to activate p53
Horn, H. F., & Vousden, K. H. (2007) · Oncogene · doi:10.1038/sj.onc.1210263 · Cited by 522
The ribosomal protein genes and Minute loci of Drosophila melanogaster
Marygold, S. J., Roote, J., Reuter, G., Lambertsson, A., Ashburner, M., Millburn, G. H., Harrison, P. M., Yu, Z., Kenmochi, N., Kaufman, T. C., et al. (2007) · Genome Biology · doi:10.1186/gb-2007-8-10-r216 · Cited by 385
The Mdm2–p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor
Manfredi, J. J. (2010) · Genes & Development · doi:10.1101/gad.1941710 · Cited by 344
Ribosomal protein L24 defect in Belly spot and tail (Bst), a mouse Minute
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MDMX regulation of p53 response to ribosomal stress
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The other lives of ribosomal proteins
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Translate to divide: сontrol of the cell cycle by protein synthesis
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Self-citation
Metadata
- Authors
- Amsterdam, A., Sadler, K. C., Lai, K., Farrington, S., Bronson, R. T., Lees, J. A., & Hopkins, N.
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2004-05-11
- Volume
- 2
- Issue
- 5
- Pages
- e139
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- OpenAlex
- W2040524130
- Cited by
- 417
- References
- 1
- FWCI
- 8.90
- Type
- journal article
- Language
- en
- Open access
- gold
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