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Cited by 666

The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.

Spinal Cord Injury Reveals Multilineage Differentiation of Ependymal Cells

Open access
Meletis, Konstantinos, Barnabé-Heider, Fanie, Carlén, Marie, Evergren, Emma, Tomilin, Nikolay, Shupliakov, Oleg, Frisén, Jonas·2008·PLoS Biology

Abstract

Spinal cord injury often results in permanent functional impairment. Neural stem cells present in the adult spinal cord can be expanded in vitro and improve recovery when transplanted to the injured spinal cord, demonstrating the presence of cells that can promote regeneration but that normally fail to do so efficiently. Using genetic fate mapping, we show that close to all in vitro neural stem cell potential in the adult spinal cord resides within the population of ependymal cells lining the central canal. These cells are recruited by spinal cord injury and produce not only scar-forming glial cells, but also, to a lesser degree, oligodendrocytes. Modulating the fate of ependymal progeny after spinal cord injury may offer an alternative to cell transplantation for cell replacement therapies in spinal cord injury.

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Registry

Crossref · 10.1371/journal.pbio.0060182

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Metadata

Authors
Meletis, K., Barnabé-Heider, F., Carlén, M., Evergren, E., Tomilin, N., Shupliakov, O., & Frisén, J.
Venue
PLoS Biology
Published
2008-07-22
Volume
6
Issue
7
Pages
e182
ISSN
  • 1544-9173 (ISSN-L)
  • 1545-7885
OpenAlex
W2052604373
Cited by
666
References
68
FWCI
8.35
Type
journal article
Language
en
Open access
gold

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.