Gaze-informed, task-situated representation of space in primate hippocampus during virtual navigation
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To elucidate how gaze informs the construction of mental space during wayfinding in visual species like primates, we jointly examined navigation behavior, visual exploration, and hippocampal activity as macaque monkeys searched a virtual reality maze for a reward. Cells sensitive to place also responded to one or more variables like head direction, point of gaze, or task context. Many cells fired at the sight (and in anticipation) of a single landmark in a viewpoint- or task-dependent manner, simultaneously encoding the animal's logical situation within a set of actions leading to the goal. Overall, hippocampal activity was best fit by a fine-grained state space comprising current position, view, and action contexts. Our findings indicate that counterparts of rodent place cells in primates embody multidimensional, task-situated knowledge pertaining to the target of gaze, therein supporting self-awareness in the construction of space.
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The increasing similarity between firing patterns of schema cells was not driven by visual similarity between environments, but by their common spatial geometry, and by past and future actions within the task structure.
“The increasing similarity between firing patterns of schema cells was not driven by visual similarity between environments, as indicated by point-ofgaze maps 14,118 , but by their common spatial geometry 14 , and by past and future actions within the task structure 14,105 .”
From From cognitive maps to spatial schemas (2023) · cites this paper as [118]
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A place with a view: A first‐person perspective in the hippocampal memory space
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Territorial blueprint in the hippocampal system
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Consistent Hierarchies of Single-Neuron Timescales in Mice, Macaques, and Humans
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L’orientation spatiale chez le primate
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Self-citationProtean Kinematics: A Blended Model of VR Physics
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- Authors
- Wirth, S., Baraduc, P., Planté, A., Pinède, S., & Duhamel, J.-R.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Wirth, Sylvia
- Venue
- PLOS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2017-02-27
- Volume
- 15
- Issue
- 2
- Pages
- e2001045
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- PMC
- PMC5328243
- OpenAlex
- W2593882037
- Cited by
- 129
- References
- 65
- Citations by year
- 2026: 6 · 2025: 28 · 2024: 21 · 2023: 12 · 2022: 13 · 2021: 12 · 2020: 8 · 2019: 12 · 2018: 8 · 2017: 9
- FWCI
- 5.80
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS Biology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- Agence Nationale de la Recherche (ANR-11-LABX-0042)
- Centre National de la Recherche Scientifique
- Université de Lyon
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- hippocampus, place cells, point of gaze, wayfinding, virtual reality navigation, macaque, head direction, landmark-based navigation, state-space model, task context, self-awareness, spatial cognition, visual exploration
- MeSH terms
- Animals, Behavior, Animal, Fixation, Ocular, Hippocampus, Macaca mulatta, Space Perception, Task Performance and Analysis, Visual Pathways, Spatial Navigation
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