Place Field Repetition and Purely Local Remapping in a Multicompartment Environment
Open accessAbstract
Hippocampal place cells support spatial memory using sensory information from the environment and self-motion information to localize their firing fields. Currently, there is disagreement about whether CA1 place cells can use pure self-motion information to disambiguate different compartments in environments containing multiple visually identical compartments. Some studies report that place cells can disambiguate different compartments, while others report that they do not. Furthermore, while numerous studies have examined remapping, there has been little examination of remapping in different subregions of a single environment. Is remapping purely local or do place fields in neighboring, unaffected, regions detect the change? We recorded place cells as rats foraged across a 4-compartment environment and report 3 new findings. First, we find that, unlike studies in which rats foraged in 2 compartments, place fields showed a high degree of spatial repetition with a slight degree of rate-based discrimination. Second, this repetition does not diminish with extended experience. Third, remapping was found to be purely local for both geometric change and contextual change. Our results reveal the limited capacity of the path integrator to drive pattern separation in hippocampal representations, and suggest that doorways may play a privileged role in segmenting the neural representation of space.
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It is not yet entirely conclusive that all goldfish neurons with border activity are functionally closer to BVCs than PCs, because some PCs can also exhibit PF duplications in parallel compartments.
“Second, it is not yet entirely conclusive that all goldfish neurons with border activity are functionally closer to BVCs than PCs, because some PCs can also exhibit PF duplications in parallel compartments48–50.”
From A population code for spatial representation in the zebrafish telencephalon (2024) · cites this paper as [50]
Geometric modifications are accompanied by more substantial changes in the firing patterns of place cells than are surface modifications, suggesting that HPC remapping actively supports the role of geometry in the stability of spatial representations.
“Geometric modifications are accompanied by more substantial changes in the firing patterns of place cells than are surface modifications 15,113,114 , suggesting that HPC remapping actively supports the role of geometry in the stability of spatial representations 115 .”
From From cognitive maps to spatial schemas (2023) · cites this paper as [15]
Rodent HPC cells show repeated firing in multicompartment environments, with increased clustering of activity when the animal is near open doorways.
“Rodent HPC cells show repeated firing in multicompartment environments, with increased clustering of activity when the animal is near open doorways 15,16 .”
From From cognitive maps to spatial schemas (2023) · cites this paper as [15]
Hippocampal place cells fired in analogous positions in geometrically identical environments learned in a single training session, even with proprioceptive and vestibular cues present.
“similar results were observed in a recent rodent neurophysiology study which found that hippocampal place cells fired in analogous positions in geometrically identical environments that were learned in a single training session, even though these proprioceptive and vestibular cues were present45.”
From Anchoring the neural compass: coding of local spatial reference frames in human medial parietal lobe (2014) · cites this paper as [45]
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“Second, it is not yet entirely conclusive that all goldfish neurons with border activity are functionally closer to BVCs than PCs, because some PCs can also exhibit PF duplications in parallel compartments 48–50 .”
- Authors
- Spiers, H. J., Hayman, R. M. A., Jovalekic, A., Marozzi, E., & Jeffery, K. J.
- Affiliations
- University College London (GB)
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-08-13
- Volume
- 25
- Issue
- 1
- Pages
- 10-25
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- PMC
- PMC4400414
- OpenAlex
- W2153695024
- Cited by
- 138
- References
- 39
- Citations by year
- 2026: 9 · 2025: 8 · 2024: 10 · 2023: 6 · 2022: 17 · 2021: 10 · 2020: 11 · 2019: 15 · 2018: 11 · 2017: 18 · 2016: 8 · 2015: 8 · 2014: 7
- FWCI
- 4.21
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by
- Locations
- Cerebral Cortex (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust (103896/Z/14/Z)
- Biotechnology and Biological Sciences Research Council (BB/J009792/1)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- place cells, hippocampal CA1, spatial memory, pattern separation, geometric changes, context change, spatial representation
- MeSH terms
- Animals, Male, Neurons, Space Perception, Rats, CA1 Region, Hippocampal, Spatial Navigation
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