Gray matter differences correlate with spontaneous strategies in a human virtual navigation task
Open accessAbstract
Young healthy participants spontaneously use different strategies in a virtual radial maze, an adaptation of a task typically used with rodents. Functional magnetic resonance imaging confirmed previously that people who used spatial memory strategies showed increased activity in the hippocampus, whereas response strategies were associated with activity in the caudate nucleus. Here, voxel based morphometry was used to identify brain regions covarying with the navigational strategies used by individuals. Results showed that spatial learners had significantly more gray matter in the hippocampus and less gray matter in the caudate nucleus compared with response learners. Furthermore, the gray matter in the hippocampus was negatively correlated to the gray matter in the caudate nucleus, suggesting a competitive interaction between these two brain areas. In a second analysis, the gray matter of regions known to be anatomically connected to the hippocampus, such as the amygdala, parahippocampal, perirhinal, entorhinal and orbitofrontal cortices were shown to covary with gray matter in the hippocampus. Because low gray matter in the hippocampus is a risk factor for Alzheimer's disease, these results have important implications for intervention programs that aim at functional recovery in these brain areas. In addition, these data suggest that spatial strategies may provide protective effects against degeneration of the hippocampus that occurs with normal aging.
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The structural characteristics of hippocampus and amygdala are associated with cognitive and emotional processing in waking tasks.
“the structural characteristics of hippocampus and amygdala are associated with cognitive and emotional processing in waking tasks”
From The Functional Role of Dreaming in Emotional Processes (2019) · cites this paper as Bohbot et al., 2007
The paper reports that hippocampal gray matter differed between people using spatial and response strategies in a virtual navigation task, supporting an association with cognitive processing. The Results also report that amygdala gray matter covaried with hippocampal gray matter, but do not link amygdala structure to emotional processing; that part of the claim is unsupported. (LLM, conf=0.87)
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- Authors
- Bohbot, V. D., Lerch, J., Thorndycraft, B., Iaria, G., & Zijdenbos, A. P.
- Affiliations
- McGill University (CA)
- Montreal Neurological Institute and Hospital (CA)
- Fondazione Santa Lucia (IT)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-09-19
- Volume
- 27
- Issue
- 38
- Pages
- 10078-10083
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6672675
- OpenAlex
- W2003737825
- Cited by
- 347
- References
- 45
- Citations by year
- 2026: 9 · 2025: 17 · 2024: 7 · 2023: 15 · 2022: 14 · 2021: 32 · 2020: 49 · 2019: 15 · 2018: 19 · 2017: 27 · 2016: 20 · 2015: 21 · 2014: 17 · 2013: 28 · 2012: 25
- FWCI
- 3.00
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Keywords
- virtual navigation, response strategies, hippocampus, caudate nucleus, gray matter, hippocampal-amygdala interaction, Alzheimer's disease risk, normal aging, hippocampal neurodegeneration, radial maze
- MeSH terms
- Adult, Caudate Nucleus, Cerebral Cortex, Computer Simulation, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Photic Stimulation, Psychomotor Performance, Space Perception, User-Computer Interface, Maze Learning
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