Hippocampal Neurons Encode Information about Different Types of Memory Episodes Occurring in the Same Location
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Firing patterns of hippocampal complex-spike neurons were examined for the capacity to encode information important to the memory demands of a task even when the overt behavior and location of the animal are held constant. Neuronal activity was recorded as rats continuously alternated left and right turns from the central stem of a modified T maze. Two-thirds of the cells fired differentially as the rat traversed the common stem on left-turn and right-turn trials, even when potentially confounding variations in running speed, heading, and position on the stem were taken into account. Other cells fired differentially on the two trial types in combination with behavioral and spatial factors or appeared to fire similarly on both trial types. This pattern of results suggests that hippocampal representations encode some of the information necessary for representing specific memory episodes.
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Place cells encode the animal's position in an environment and, more generally, events of episodic experience, and have been causally linked to memory functions.
“These neurons encode the animal’s position in an environment1 and, more generally, events of episodic experience2–4 and have been causally linked to memory functions5–7.”
From Place and behavioral modulation of hippocampal neurons during immobility (2026) · cites this paper as [2]
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Ross, R. S., LoPresti, M. L., Schon, K., & Stern, C. E. (2013) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/s13415-013-0170-x · Cited by 28 · see citing works
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- Authors
- Wood, E. R., Dudchenko, P. A., Robitsek, R. J., & Eichenbaum, H.
- Affiliations
- Boston University (US)
- Corresponding author
- Wood, Emma R.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2000-09
- Volume
- 27
- Issue
- 3
- Pages
- 623-633
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2099630522
- Cited by
- 992
- References
- 39
- Citations by year
- 2026: 36 · 2025: 54 · 2024: 53 · 2023: 50 · 2022: 47 · 2021: 58 · 2020: 49 · 2019: 53 · 2018: 43 · 2017: 47 · 2016: 30 · 2015: 42 · 2014: 45 · 2013: 38 · 2012: 33
- FWCI
- 13.62
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neuron (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- memory encoding, spatial memory, T-maze
- MeSH terms
- Action Potentials, Animals, Hippocampus, Locomotion, Male, Memory, Neurons, Reaction Time, Space Perception, Maze Learning, Rats, Long-Evans, Rats
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