Cited by 992Memory and Neural MechanismsMemory Processes and InfluencesNeuroscience and Neuropharmacology Research

Hippocampal Neurons Encode Information about Different Types of Memory Episodes Occurring in the Same Location

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Wood, Emma R., Dudchenko, Paul A., Robitsek, R.Jonathan, Eichenbaum, Howard·2000·Neuron

Abstract

Firing patterns of hippocampal complex-spike neurons were examined for the capacity to encode information important to the memory demands of a task even when the overt behavior and location of the animal are held constant. Neuronal activity was recorded as rats continuously alternated left and right turns from the central stem of a modified T maze. Two-thirds of the cells fired differentially as the rat traversed the common stem on left-turn and right-turn trials, even when potentially confounding variations in running speed, heading, and position on the stem were taken into account. Other cells fired differentially on the two trial types in combination with behavioral and spatial factors or appeared to fire similarly on both trial types. This pattern of results suggests that hippocampal representations encode some of the information necessary for representing specific memory episodes.

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Crossref · 10.1016/s0896-6273(00)00071-4

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  • Place cells encode the animal's position in an environment and, more generally, events of episodic experience, and have been causally linked to memory functions.

    “These neurons encode the animal’s position in an environment1 and, more generally, events of episodic experience2–4 and have been causally linked to memory functions5–7.”

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Authors
Wood, E. R., Dudchenko, P. A., Robitsek, R. J., & Eichenbaum, H.
Affiliations
Boston University (US)
Corresponding author
Wood, Emma R.
Venue
Neuron
Publisher
Elsevier BV
Published
2000-09
Volume
27
Issue
3
Pages
623-633
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2099630522
Cited by
992
References
39
Citations by year
2026: 36 · 2025: 54 · 2024: 53 · 2023: 50 · 2022: 47 · 2021: 58 · 2020: 49 · 2019: 53 · 2018: 43 · 2017: 47 · 2016: 30 · 2015: 42 · 2014: 45 · 2013: 38 · 2012: 33
FWCI
13.62
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
memory encoding, spatial memory, T-maze
MeSH terms
Action Potentials, Animals, Hippocampus, Locomotion, Male, Memory, Neurons, Reaction Time, Space Perception, Maze Learning, Rats, Long-Evans, Rats

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