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Mettl3 regulates the pathogenesis of Alzheimer’s disease via fine-tuning Lingo2

Zhao, X., Ma, C., Sun, Q., Huang, X., Qu, W., Chen, Y., Liu, Z., Bao, A., Sun, B., Yang, Y., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-02984-4 · Cited by 10 · see citing works

IGF2BP2-Shox2 axis regulates hippocampal-neuronal senescence to alleviate microgravity-induced recognition disturbance

Zhao, Y., Ji, G., Zhou, S., Cai, S., Li, K., Zhang, W., Zhang, C., Yan, N., Zhang, S., Li, X., et al. (2024) · iScience · doi:10.1016/j.isci.2024.109917 · Cited by 9 · see citing works

m5C RNA methylation: a potential mechanism for infectious Alzheimer’s disease

Teng, S., Han, C., Zhou, J., He, Z., & Qian, W. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1440143 · Cited by 9 · see citing works

The indispensability of methyltransferase-like 3 in the immune system: from maintaining homeostasis to driving function

Zhang, M., Gou, Z., Qu, Y., & Su, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1456891 · Cited by 9 · see citing works

Targeting RNA adenosine editing and modification enzymes for RNA therapeutics

Vlachogiannis, N. I., Polycarpou‐Schwarz, M., Avdi, A.-P., Tual‐Chalot, S., & Stellos, K. (2025) · Molecular Therapy · doi:10.1016/j.ymthe.2025.05.021 · Cited by 9 · see citing works

Neuromodulatory role and therapeutic potential of N6-methyladenosine RNA methylation in neurodegenerative diseases

Zhang, J., Ma, W., Liu, R., Li, X., Yuan, Z., & Cheng, J. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-01648 · Cited by 10 · see citing works

Unraveling IGFBP3-mediated m6A modification in fracture healing

Lai, A., Sun, J., Dai, Z., Guo, L. Y., Tao, D., Li, H., Chen, B., & Zhou, R. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155220 · Cited by 9 · see citing works

Effects of m6A methylation of MAT2A mRNA regulated by METTL16 on learning and memory, hippocampal synaptic plasticity and Aβ1–42 in 5 × FAD mice

Chen, H., Guo, F., Zhao, Y., Liu, W., Chen, B., Wang, C., Huang, L., Jiang, S., Ma, X., Ren, H., et al. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1572976 · Cited by 8 · see citing works

Identification and validation of pyroptosis-related genes in Alzheimer’s disease based on multi-transcriptome and machine learning

Wang, Y., Li, Y., Zhou, L., Yuan, Y., Liu, C., Zeng, Z., Chen, Y., He, Q., & Wu, Z. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1568337 · Cited by 5 · see citing works

N6-methyladenosine RNA modification regulates microglial phagocytosis in the APP/PS1 mouse model of Alzheimer’s disease

Qu, X., Li, L., Li, Y., Chen, Y., & Chen, Y. (2025) · Genes and Immunity · doi:10.1038/s41435-025-00347-1 · Cited by 5 · see citing works

Astrocytic Mettl14 depletion enhances cognitive function by attenuating astrogliosis via the DUSP1/MAPK pathway in APP/PS1 mice: targeting neuroinflammation in Alzheimer’s disease

Teng, Y., Xu, J., He, S., Yi, J., Li, M., Tang, Q., Chen, X., Wei, F., Liu, Y., Jiang, H., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03211-w · Cited by 5 · see citing works

Accumulation of m 6 A exhibits stronger correlation with MAPT than β-amyloid pathology in an APP NL-G-F /MAPT P301S mouse model of Alzheimer’s diseasePreprint

Jiang, L., Roberts, R., Wong, M., Zhang, L., Webber, C. J., Kilci, A., Jenkins, M., Sun, G., Rashad, S., Sun, J., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.28.534515 · Cited by 6 · see citing works

Identifying Alzheimer's disease-associated genes related to N6-methyladenosine modification as potential biomarkers through correlation analysis: A retrospective observational study

Yang, L., Zheng, P., Huang, C. X., Gao, C., Pang, X., Liu, H., Wei, Y., & Pang, C.-Y. (2025) · NeuroMarkers. · doi:10.1016/j.neumar.2025.100036 · Cited by 4 · see citing works

RNA modification-mediated aberrant alternative splicing: An underlying driver of disease pathogenesis

Zeng, J., Diao, L., Xie, S., & Xiao, Z. (2025) · Cell investigation. · doi:10.1016/j.clnves.2025.100047 · Cited by 4 · see citing works

Tubulin Acetylation: A Critical Regulator of Microtubule Function

Delgado, I. L. S., Carmona, B., Nolasco, S., Marques, R., Gonçalves, J., & Soares, H. (2025) · Results and problems in cell differentiation · doi:10.1007/978-3-031-91459-1_4 · Cited by 5 · see citing works

N6-Methyladenosine in Vascular Aging and Related Diseases: Clinical Perspectives

Li, C., Liu, L., Li, S., & Liu, Y. (2023) · Aging and Disease · doi:10.14336/ad.2023.0924-1 · Cited by 4 · see citing works

Customizable NAND Logic-Gate Biosensing System Enabled by an Engineered Methylation-CRISPR/Cas12a Consensus Sequence for Ultrasensitive DNA Methyltransferase Detection

Zhao, J., Sui, Z., Chen, B., Wu, R., Xu, J., & Dong, H. (2026) · Analytical Chemistry · doi:10.1021/acs.analchem.5c06772 · Cited by 3 · see citing works

Targeting epigenetic remodeling of the blood-brain barrier: current knowledge for drug therapy

Akhoury, M., Vegara, N., Stamatovic, S. M., Keep, R. F., & Andjelkovic, A. V. (2026) · Epigenomics · doi:10.1080/17501911.2026.2637419 · Cited by 3 · see citing works

The role of RNA modifications in disease-associated macrophages

Huart, C., Gupta, M. S., & Ginderachter, J. A. V. (2024) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2024.102315 · Cited by 3 · see citing works

Molecular mechanism of METTL3 regulating hippocampal neuronal injury induced by sepsis-associated encephalopathy

Zhang, Q., Huo, Y., Zhu, R., Zhang, X., Zeng, L., & Hu, Z. (2025) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2025.2465337 · Cited by 3 · see citing works

Identification of the m6A/m5C/m1A methylation modification genes in Alzheimer’s disease based on bioinformatic analysis

Tan, Q., Zhou, D., Guo, Y., Chen, H., & Xie, P. (2024) · Aging · doi:10.18632/aging.206146 · Cited by 3 · see citing works

Unlocking NAC’s potential ATF4 and m6A dynamics in rescuing cognitive impairments in PTSD

Zhou, Y., Yuan, X., & Guo, M. (2025) · Metabolic Brain Disease · doi:10.1007/s11011-024-01485-7 · Cited by 3 · see citing works

Epitranscriptomic dysregulation in neurodegenerative diseases and its implications for disease pathology and mechanisms

Shafik, A. M., & Jin, P. (2025) · Neurochemistry International · doi:10.1016/j.neuint.2025.106037 · Cited by 2 · see citing works

ZNF831-YTHDF1-DNMT1/3a feedback loop regulates lung carcinogenesis and progression through WNT7B-FZD5-β-catenin signalling axis

Chen, D.-J., Chen, H., Zeng, Y., Shi, Y., Guo, F., Fan, J., Zhang, Z., Zhou, S., Wang, N., Deng, S., et al. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.09.030 · Cited by 2 · see citing works

Associations of air pollution and genetic risk and their interaction with risk of Alzheimer’s disease: identification of risk loci and potential biological pathways

Ran, S., Zhang, J., Cai, M., Chen, L., Qian, Z. M., Tian, F., Wu, G., Boyd, R., McMillin, S. E., Zeng, H.-C., et al. (2026) · GeroScience · doi:10.1007/s11357-026-02102-4 · Cited by 1 · see citing works

Combined lead exposure and high-copper intake exacerbates synaptic loss via METTL3-mediated m6A methylation in mice

Li, R., Tan, S., Wu, D., Wang, H., Li, Y., Xiong, J., Tian, H., Wang, T., & Zheng, G. (2026) · Toxicology Letters · doi:10.1016/j.toxlet.2026.113177 · Cited by 1 · see citing works

The role of N6-methyladenosine modification in neurodegenerative diseases

Song, J., & Yan, S. (2024) · Ageing and Neurodegenerative Diseases · doi:10.20517/and.2024.14 · Cited by 1 · see citing works

Identification of key regulatory factors for m6A in myasthenia gravis and characteristics of the immune characteristicsPreprint

Wu, Y., Cai, X., Jiao, Y., Zhao, L., Jiang, Q., Chen, T., Yang, P., Huang, T., Yang, J., & Song, Y. (2024) · Research Square · doi:10.21203/rs.3.rs-5264805/v1

Unscheduled m6A Deposition in RNA via m6ATP Incorporation by DNA Polymerases

Qu, F., Fuente, J., Chapagain, P. P., & Liu, Y. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199263

RNA modifications in intestinal macrophages: Implications for gut immunity and inflammation

Su, M., Fan, J., & Li, H. (2025) · Genes & Diseases · doi:10.1016/j.gendis.2025.101881

Additional file 1 of N6-methyladenosine-modified circRIMS2 mediates synaptic and memory impairments by activating GluN2B ubiquitination in Alzheimer's disease

Wang, X., Xie, J., Tan, L., Lu, Y., Shen, N., Li, J., Hu, H., Li, H., Li, X., & Cheng, L. (2023) · Figshare · doi:10.6084/m9.figshare.24647128

Electroacupuncture reduces amyloid beta accumulation and improves cerebral ischemia-induced cognitive impairment in a N6-methyladenosine-dependent manner

Yang, J., Xu, J., Wang, X., Ma, Z., Dai, Y., & Lin, X. (2026) · Journal of Molecular Histology · doi:10.1007/s10735-025-10700-3

Sevoflurane postconditioning mitigates cognitive impairment induced by hemorrhagic shock resuscitation through inhibition of METTL3-mediated m6A modification of Sirt1 mRNA

Wu, Y., Niu, Z., Zhu, S., Huang, W., Wang, J., Tao, W., Fan, B., Zhang, L., & Hu, X. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.178578

Maladaptive aging trajectory in late-onset Alzheimer's disease

Lv, T., Sun, H., Xia, T., Zhu, M. L., & Li, Y. (2026) · The Innovation Life · doi:10.59717/j.xinn-life.2026.100206

Integrative Multi-Analysis Identifies METTL3-Regulated FGF19 and H6PD as Candidate Targets in Diabetic Cognitive Impairment

Fu, J. Q., Wang, H., Yan, J., Chen, W., Wang, R., Gao, H., & Li, C. (2026) · Biomolecules · doi:10.3390/biom16030468

METTL3–m6A–LOXL2 Axis Post-Transcriptionally Fine-Tunes Macrophage Migration and Invasion

Li, Z., Sa, X., Han, Y., Wang, P., Song, X., & Sun, M. (2026) · Current Medical Science · doi:10.1007/s11596-026-00204-w

Riboregulation: a non-canonical tau function

LeBlanc, K. R., Eck, R. J., Benbow, S. J., & Kraemer, B. C. (2026) · Molecular Neurodegeneration · doi:10.1186/s13024-026-00949-x

Neuronal YTHDF2 suppresses innate immune activation in Aβ pathology by promoting m 6 A-dependent decay of cytosolic mitochondrial mRNAs

Pan, W., Yang, L., Zhang, Y., Chen, Y., Xu, Y., Li, Y., Fu, Y., Ma, C., Liu, C., Li, Q., et al. (2026) · Science Advances · doi:10.1126/sciadv.adz0887

Interplay between RNA m6A modification and transglutaminase 2 inhibitor effects on mitophagy dysfunction in Alzheimer’s disease

Chatterjee, A., Singh, T., Singh, S., Kaur, A., & Vishwas, S. (2026) · Drug Discovery Today · doi:10.1016/j.drudis.2026.104748

Epitranscriptomic imprints on glial cell polarization: METTL3/IGF2BP2 axis as a driver of neurodegeneration in Alzheimer’s disease

Neha, & Aran, K. R. (2026) · Psychopharmacology · doi:10.1007/s00213-026-07137-1

Epigenetic Mechanisms in Neurodegenerative Diseases: From Genetic Regulation to Therapeutic Potential

Lv, X., 黄敏聪, 龙文娟, Li, X., 胡中扬, Feng, Y., Du, J., Long, Q., Chen, Y., Shi, M., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27209322

РОЛЬ МАКРОФАГІВ І МІКРОГЛІЇ В ПАТОГЕНЕЗІ НЕЙРОДЕГЕНЕРАТИВНИХ ЗАХВОРЮВАНЬ

Andriushchenko, A. (2026) · Immunology and Allergy Science and Practice · doi:10.37321/immunology.2026.3-04

Inhibition of N6-Methyladenosine Accumulation by Targeting METTL3 Mitigates Tau Pathology and Cognitive Decline in Alzheimer’s DiseasePreprint

Jiang, L., Tucker, A., Sepehri, C., Patel, D., Wang, Q., Yuan, S., Sherman, E., Chen, Y., Beh, J., Downey, A., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-8379573/v1

Mettl3 regulates the pathogenesis of Alzheimer’s disease via fine-tuning Lingo2

Zhao, X., Ma, C., Sun, Q., Huang, X., Qu, W., Chen, Y., Liu, Z., Bao, A., Sun, B., Yang, Y., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-02984-4 · Cited by 10 · see citing works

METTL3-dependent RNA m6A dysregulation contributes to neurodegeneration in Alzheimer’s disease through aberrant cell cycle events

Zhao, F.-P., Xu, Y., Gao, S.-C., Qin, L., Austria, Q. M., Siedlak, S., Pajdzik, K., Dai, Q., He, C., Wang, W.-Z., et al. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00484-x · Cited by 182 · see citing works

Altered Expression of the m6A Methyltransferase METTL3 in Alzheimer’s Disease

Huang, H., Camats‐Perna, J., Medeiros, R., Anggono, V., & Widagdo, J. (2020) · eNeuro · doi:10.1523/eneuro.0125-20.2020 · Cited by 165 · see citing works

METTL3 confers protection against mitochondrial dysfunction and cognitive impairment in an Alzheimer disease mouse model by upregulating Mfn2 via N6-methyladenosine modification

Chen, H., Xing, H., Zhong, C., Lin, X., Chen, R., Luo, N., Chen, L., & Huang, Y. (2024) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlae010 · Cited by 24 · see citing works