The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
New Genes Tied to Endocrine, Metabolic, and Dietary Regulation of Lifespan from a Caenorhabditis elegans Genomic RNAi Screen
Open accessAbstract
Most of our knowledge about the regulation of aging comes from mutants originally isolated for other phenotypes. To ask whether our current view of aging has been affected by selection bias, and to deepen our understanding of known longevity pathways, we screened a genomic Caenorhabditis elegans RNAi library for clones that extend lifespan. We identified 23 new longevity genes affecting signal transduction, the stress response, gene expression, and metabolism and assigned these genes to specific longevity pathways. Our most important findings are (i) that dietary restriction extends C. elegans' lifespan by down-regulating expression of key genes, including a gene required for methylation of many macromolecules, (ii) that integrin signaling is likely to play a general, evolutionarily conserved role in lifespan regulation, and (iii) that specific lipophilic hormones may influence lifespan in a DAF-16/FOXO-dependent fashion. Surprisingly, of the new genes that have conserved sequence domains, only one could not be associated with a known longevity pathway. Thus, our current view of the genetics of aging has probably not been distorted substantially by selection bias.
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Self-citationThe plasticity of aging: insights from long-lived mutants
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Self-citationA systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity
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Self-citationApfeld, J., O'Connor, G., McDonagh, T., DiStefano, P. S., & Curtis, R. (2004) · Genes & Development · doi:10.1101/gad.1255404 · Cited by 643
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Self-citationRegulation of C. elegans Longevity by Specific Gustatory and Olfactory Neurons
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Cited by
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Biological and Chemical Approaches to Diseases of Proteostasis Deficiency
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Self-citationMitonuclear protein imbalance as a conserved longevity mechanism
Houtkooper, R. H., Mouchiroud, L., Ryu, D., Moullan, N., Katsyuba, E., Knott, G., Williams, R. W., & Auwerx, J. (2013) · Nature · doi:10.1038/nature12188 · Cited by 1,035
Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism
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Extension of Chronological Life Span in Yeast by Decreased TOR Pathway Signaling
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Metadata
- Authors
- Hansen, M., Hsu, A.-L., Dillin, A., & Kenyon, C.
- Venue
- PLoS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2005-07-25
- Volume
- 1
- Issue
- 1
- Pages
- e17
- ISSN
- 1553-7390 (ISSN-L)
- 1553-7404
- OpenAlex
- W2032462953
- Cited by
- 541
- References
- 8
- FWCI
- 8.93
- Type
- journal article
- Language
- en
- Open access
- gold
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- Hansen, M., Hsu, A.-L., Dillin, A., & Kenyon, C. (2005). New Genes Tied to Endocrine, Metabolic, and Dietary Regulation of Lifespan from a Caenorhabditis elegans Genomic RNAi Screen. PLoS Genetics. https://doi.org/10.1371/journal.pgen.0010017
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