The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Long Noncoding RNA MALAT1 Controls Cell Cycle Progression by Regulating the Expression of Oncogenic Transcription Factor B-MYB
Open accessAbstract
The long noncoding MALAT1 RNA is upregulated in cancer tissues and its elevated expression is associated with hyper-proliferation, but the underlying mechanism is poorly understood. We demonstrate that MALAT1 levels are regulated during normal cell cycle progression. Genome-wide transcriptome analyses in normal human diploid fibroblasts reveal that MALAT1 modulates the expression of cell cycle genes and is required for G1/S and mitotic progression. Depletion of MALAT1 leads to activation of p53 and its target genes. The cell cycle defects observed in MALAT1-depleted cells are sensitive to p53 levels, indicating that p53 is a major downstream mediator of MALAT1 activity. Furthermore, MALAT1-depleted cells display reduced expression of B-MYB (Mybl2), an oncogenic transcription factor involved in G2/M progression, due to altered binding of splicing factors on B-MYB pre-mRNA and aberrant alternative splicing. In human cells, MALAT1 promotes cellular proliferation by modulating the expression and/or pre-mRNA processing of cell cycle-regulated transcription factors. These findings provide mechanistic insights on the role of MALAT1 in regulating cellular proliferation.
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Cites
Alternative isoform regulation in human tissue transcriptomes
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Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43
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Common markers of proliferation
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Cited by
ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age‐Related Diseases
Davalli, P., Mitic, T., Caporali, A., Lauriola, A., & D’Arca, D. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3565127 · Cited by 1,059
Long Noncoding RNA MALAT1 Regulates Endothelial Cell Function and Vessel Growth
Michalik, K. M., You, X., Manavski, Y., Doddaballapur, A., Zörnig, M., Braun, T., John, D., Ponomareva, Y., Chen, W., Uchida, S., et al. (2014) · Circulation Research · doi:10.1161/circresaha.114.303265 · Cited by 940
The long noncoding RNA Malat1: Its physiological and pathophysiological functions
Zhang, X., Hamblin, M. H., & Yin, K.-J. (2017) · RNA Biology · doi:10.1080/15476286.2017.1358347 · Cited by 482
Endothelial cell senescence in aging-related vascular dysfunction
Jia, G., Aroor, A. R., Jia, C., & Sowers, J. R. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.08.008 · Cited by 454
Horiuchi, K., Kawamura, T., Iwanari, H., Ohashi, R., Naito, M., Kodama, T., & Hamakubo, T. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.500397 · Cited by 353
Metadata
- Authors
- Tripathi, V., Shen, Z., Chakraborty, A., Giri, S., Freier, S. M., Wu, X., Zhang, Y., Gorospe, M., Prasanth, S. G., Lal, A., & Prasanth, K. V.
- Venue
- PLoS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-03-21
- Volume
- 9
- Issue
- 3
- Pages
- e1003368
- ISSN
- 1553-7390 (ISSN-L)
- 1553-7404
- OpenAlex
- W2087528029
- Cited by
- 754
- References
- 11
- FWCI
- 23.80
- Type
- journal article
- Language
- en
- Open access
- gold
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- Tripathi, V., Shen, Z., Chakraborty, A., Giri, S., Freier, S. M., Wu, X., Zhang, Y., Gorospe, M., Prasanth, S. G., Lal, A., & Prasanth, K. V. (2013). Long Noncoding RNA MALAT1 Controls Cell Cycle Progression by Regulating the Expression of Oncogenic Transcription Factor B-MYB. PLoS Genetics. https://doi.org/10.1371/journal.pgen.1003368
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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