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Joint Estimation of Contamination, Error and Demography for Nuclear DNA from Ancient Humans
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Genome editing technologies such as CRISPR-Cas9, pluripotent iPS stem cells and miniaturized organoid systems mimicking simplified organs now offer possibility to investigate functional consequences of virtually any change in sequence of a given genome.
“Genome editing technologies such as CRISPR-Cas9 344 , pluripotent iPS stem cells 345 and miniaturized organoid systems mimicking simplified organs 346 now offer the possibility to investigate the functional consequences of virtually any change in the sequence of a given genome.”
From Ancient DNA analysis (2021) · cites this paper as [346]
The Discussion (page not provided) describes DICE, a method for estimating contamination, sequencing error and demographic parameters in ancient DNA. Searches for CRISPR-Cas9, iPS cells, organoids and functional consequences of genome edits found no passage addressing the attributed claim. (LLM, conf=0.75)
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Metadata
- Authors
- Racimo, F., Renaud, G., & Slatkin, M.
- Venue
- PLOS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2016-04-06
- Volume
- 12
- Issue
- 4
- Pages
- e1005972
- ISSN
- 1553-7404
- PMC
- PMC4822957
- Cited by
- 56
- References
- 17
- Language
- en
- Update notices
- correction (2016-11-08)
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