Cited by 88Blood Pressure and Hypertension StudiesCardiovascular Health and Disease PreventionSodium Intake and Health

Risk Stratification by Self-Measured Home Blood Pressure across Categories of Conventional Blood Pressure: A Participant-Level Meta-Analysis

Open access
Asayama, Kei, Thijs, Lutgarde, Brguljan-Hitij, Jana, Niiranen, Teemu J., Hozawa, Atsushi, Boggia, José, Aparicio, Lucas S., Hara, Azusa +10 more·2014·PLoS Medicine

Abstract

BACKGROUND: The Global Burden of Diseases Study 2010 reported that hypertension is worldwide the leading risk factor for cardiovascular disease, causing 9.4 million deaths annually. We examined to what extent self-measurement of home blood pressure (HBP) refines risk stratification across increasing categories of conventional blood pressure (CBP). METHODS AND FINDINGS: This meta-analysis included 5,008 individuals randomly recruited from five populations (56.6% women; mean age, 57.1 y). All were not treated with antihypertensive drugs. In multivariable analyses, hazard ratios (HRs) associated with 10-mm Hg increases in systolic HBP were computed across CBP categories, using the following systolic/diastolic CBP thresholds (in mm Hg): optimal, <120/<80; normal, 120-129/80-84; high-normal, 130-139/85-89; mild hypertension, 140-159/90-99; and severe hypertension, ≥160/≥100. Over 8.3 y, 522 participants died, and 414, 225, and 194 had cardiovascular, cardiac, and cerebrovascular events, respectively. In participants with optimal or normal CBP, HRs for a composite cardiovascular end point associated with a 10-mm Hg higher systolic HBP were 1.28 (1.01-1.62) and 1.22 (1.00-1.49), respectively. At high-normal CBP and in mild hypertension, the HRs were 1.24 (1.03-1.49) and 1.20 (1.06-1.37), respectively, for all cardiovascular events and 1.33 (1.07-1.65) and 1.30 (1.09-1.56), respectively, for stroke. In severe hypertension, the HRs were not significant (p≥0.20). Among people with optimal, normal, and high-normal CBP, 67 (5.0%), 187 (18.4%), and 315 (30.3%), respectively, had masked hypertension (HBP≥130 mm Hg systolic or ≥85 mm Hg diastolic). Compared to true optimal CBP, masked hypertension was associated with a 2.3-fold (1.5-3.5) higher cardiovascular risk. A limitation was few data from low- and middle-income countries. CONCLUSIONS: HBP substantially refines risk stratification at CBP levels assumed to carry no or only mildly increased risk, in particular in the presence of masked hypertension. Randomized trials could help determine the best use of CBP vs. HBP in guiding BP management. Our study identified a novel indication for HBP, which, in view of its low cost and the increased availability of electronic communication, might be globally applicable, even in remote areas or in low-resource settings.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1371/journal.pmed.1001591

Cites

49 of 49 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Out-of-clinic blood pressure measurements (home and ambulatory) are more predictive of target organ damage and mortality than clinic measurements in population cohort studies.

    “Out-of-clinic BP measurements (i.e. home and ABP) are recognized to be more predictive of target organ damage and mortality in population cohort studies33, 34”
  • Diagnosis and monitoring of hypertension and treatment efficacy is difficult because a single blood pressure measurement in the clinic often does not capture true average BP, BP fluctuates throughout the day based on circadian rhythms and daily activity, and white coat syndrome can lead to higher BP measurements in the clinic.

    “Diagnosis and monitoring of hypertension and treatment efficacy is difficult for a few reasons: a single blood pressure (BP) measurement in the clinic often does not capture true average BP, BP fluctuates throughout the day based on circadian rhythms and daily activity, and the ‘white coat syndrome’ can lead to higher BP measurements in the clinic [68-73].”

    From Wearables and the Medical Revolution (2018) · cites this paper as [71]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Asayama, K., Thijs, L., Brguljan-Hitij, J., Niiranen, T. J., Hozawa, A., Boggia, J., Aparicio, L. S., Hara, A., Johansson, J. K., Ohkubo, T., Tzourio, C., Stergiou, G. S., Sandoya, E., Tsuji, I., Jula, A. M., Imai, Y., Staessen, J. A., & for the International Database of Home Blood Pressure in Relation to Cardiovascular Outcome (IDHOCO) investigators
Affiliations
  • Tohoku University (JP)
  • KU Leuven (BE)
  • Ljubljana University Medical Centre (SI)
  • Turku University Hospital (FI)
  • Hospital Italiano de Buenos Aires (AR)
  • Finnish Institute for Health and Welfare (FI)
  • Teikyo University (JP)
  • Inserm (FR)
  • National and Kapodistrian University of Athens (GR)
  • Maastricht University (NL)
Corresponding author
Staessen, Jan A.
Venue
PLoS Medicine
Published
2014-01-21
Volume
11
Issue
1
Pages
e1001591
ISSN
  • 1549-1277 (ISSN-L)
  • 1549-1676
OpenAlex
W2008818755
Cited by
87
References
48
Citations by year
2026: 3 · 2025: 5 · 2024: 3 · 2023: 5 · 2022: 6 · 2021: 4 · 2020: 4 · 2019: 7 · 2018: 9 · 2017: 12 · 2016: 6 · 2015: 12 · 2014: 11
FWCI
9.39
Type
journal article
Language
en
Open access
Locations
  • PLoS Medicine (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Research Publications (Maastricht University) (publishedVersion, cc-by)
  • Lirias (submittedVersion, cc-by)
  • RePEc: Research Papers in Economics (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
  • STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
  • Research Publications (Maastricht University) (submittedVersion, other-oa)
  • Greater South Information System
Funders
  • National Institute for Health and Care Research
  • European Commission (LSHM-CT-2006-037093, G.0881.13, 201550, IC15-CT98-0329-EPOGH, 278249, G.0880.13, 305507)
  • Työsuojelurahasto
  • Ministry of Health, Labour and Welfare (H23–Junkankitou [Seishuu]–Ippan–005)
  • Daiwa Securities Health Foundation
  • Suomen Hammaslääkäriliitto
  • Vlaamse regering
  • Japan Society for the Promotion of Science (25253059)
  • Barts and The London School of Medicine and Dentistry
  • FP7 Ideas: European Research Council (294713)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
Keywords
home blood pressure, self-measured blood pressure, hypertension risk stratification, masked hypertension, white coat effect, cardiovascular events, stroke, cardiovascular mortality, systolic blood pressure, high-normal blood pressure, mild hypertension, severe hypertension, cardiovascular risk prediction, cardiovascular risk communication
MeSH terms
Adult, Aged, Blood Pressure, Cardiovascular Diseases, Europe, Female, Humans, Japan, Male, Middle Aged, Prospective Studies, Uruguay, Multivariate Analysis, Risk Assessment, Blood Pressure Monitoring, Ambulatory, Young Adult, Self Report

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review