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Shorter Telomeres May Mark Early Risk of Dementia: Preliminary Analysis of 62 Participants from the Nurses' Health Study
Open accessAbstract
BACKGROUND: Dementia takes decades to develop, and effective prevention will likely require early intervention. Thus, it is critical to identify biomarkers of preclinical disease, allowing targeting of high-risk subjects for preventive efforts. Since telomeres shorten with age and oxidative stress, both of which are important contributors to the onset of dementia, telomere length might be a valuable biomarker. METHODOLOGY/PRINCIPAL FINDINGS: Among 62 participants of the Nurses' Health Study, we conducted neurologic evaluations, including patient and caregiver interviews, physical exam, neurologic exam, and neuropsychologic testing. We also conducted magnetic resonance imaging (MRI) in a sample of 29 of these women. In these preliminary data, after adjustment for numerous health and lifestyle factors, we found that truncated telomeres in peripheral blood leukocytes segregate with preclinical dementia states, including mild cognitive impairment (MCI); the odds of MCI were 12-fold higher (odds ratio = 12.00, 95% confidence interval 1.24-116.5) for those with shorter telomere length compared to longer telomere length. In addition, decreasing telomere length was strongly related to decreasing hippocampal volume (p = 0.038). CONCLUSIONS: These preliminary data suggest that telomere length may be a possible early marker of dementia risk, and merits further study in large, prospective investigations.
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“Characteristic telomere shortening is observed during cellular aging, and has been linked to increased risk of dementia in AD [503].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [503]
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Metadata
- Authors
- Grodstein, F., van Oijen, M., Irizarry, M. C., Rosas, H. D., Hyman, B. T., Growdon, J. H., & De Vivo, I.
- Affiliations
- Brigham and Women's Hospital (US)
- GlaxoSmithKline (United States) (US)
- Harvard University (US)
- Corresponding author
- Grodstein, Francine
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2008-02-13
- Volume
- 3
- Issue
- 2
- Pages
- e1590
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC2536511
- OpenAlex
- W2031002692
- Cited by
- 104
- References
- 13
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 6 · 2020: 12 · 2019: 5 · 2018: 7 · 2017: 7 · 2016: 4 · 2015: 9 · 2014: 8 · 2013: 6 · 2012: 10
- FWCI
- 3.51
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, other-oa)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- RePub (Erasmus University Rotterdam) (submittedVersion)
- Funders
- National Institutes of Health (CA 87969, AG05134)
- National Institute on Aging (AG15424, R01AG015424, P50AG005134, AG 05134)
- National Cancer Institute (CA-87969, P01CA087969)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Keywords
- telomere length, dementia risk, preclinical dementia, mild cognitive impairment, biomarkers, hippocampal volume, leukocytes, oxidative stress, aging, dementia prevention, Nurses' Health Study
- MeSH terms
- Aged, Cognition Disorders, Dementia, Female, Hippocampus, Humans, Leukocytes, Organ Size, Pilot Projects, Predictive Value of Tests, Logistic Models, Telomere
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