A systematic review of leukocyte telomere length and age in adults

Müezzinler, Aysel; Zaineddin, Aida Karina; Brenner, Hermann

doi:10.1016/j.arr.2013.01.003

Cited by 475Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsEpigenetics and DNA Methylation

A systematic review of leukocyte telomere length and age in adults

Müezzinler, Aysel, Zaineddin, Aida Karina, Brenner, Hermann·2013·Ageing Research Reviews

DOI 10.1016/j.arr.2013.01.003

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Abstract

Objective To provide a systematic review of the relationship between age and leukocyte telomere length (LTL) in adults.Methods Relevant studies were identified by a systematic search of Medline, EMBASE and ISI Web of Knowledge databases. Key data, such as age and LTL, were extracted from the studies along with correlation coefficients and yearly attrition rates where available. Obtained data were used to calculate weighted means and correlation coefficients.Results Overall, 124 cross-sectional studies and 5 longitudinal studies were identified. A statistically significant inverse correlation between mean age and mean LTL across cross-sectional studies was observed for both absolute (r=-0.338, p<0.0001) and relative LTL (r=-0.295, p=0.0088). From mean LTL and ages, a yearly telomere loss of 24.7 base pairs (BP)/year was estimated by weighted linear regression. Weighted means of within study correlation of age and TL and yearly telomere loss rate estimates from cross-sectional studies were also in a similar order of magnitude (-0.380 and 21.91 BP/year). The few longitudinal studies reported somewhat higher mean telomere loss rates (between 32.2 and 45.5 BP/year).Conclusion While a decrease of LTL with age is out of question, data on variation of the decrease according to sex, age and other potential determinants especially from longitudinal data are still sparse.

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Leukocyte telomere length generally decreases progressively over the lifespan, with average attrition rates of 14-103 bp/year in cross-sectional studies (weighted mean 21.9 bp/year) and 32.2-45.5 bp/year in longitudinal studies (weighted mean 40.7 bp/year).
“Leukocyte telomere length generally decreases progressively over the lifespan, with estimates of average attrition rate ranging between 14 to 103 base pairs (bp) per year (weighted mean of 21.9 bp per year) in cross-sectional studies, and between 32.2 to 45.5 bp per year (weighted mean of 40.7 bp per year) in longitudinal studies (Muezzinler et al., 2013).”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Muezzinler et al., 2013
Some individuals maintain and may even lengthen average LTL for some periods.
“Some individuals maintain and may even lengthen average LTL for some periods (Epel, 2012; Muezzinler et al., 2013).”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Muezzinler et al., 2013

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Mean leukocyte telomere length shortening and type 2 diabetes mellitus: a case-control study
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Telomere length in leukocytes correlates with bone mineral density and is shorter in women with osteoporosis
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Short Telomere Length and Breast Cancer Risk: A Study in Sister Sets
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Telomere length of patients with major depression is shortened but independent from therapy and severity of the disease
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Sex-specific telomere length profiles and age-dependent erosion dynamics of individual chromosome arms in humans
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Annual Ambient Black Carbon Associated with Shorter Telomeres in Elderly Men: Veterans Affairs Normative Aging Study
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Telomeres, sex, reactive oxygen species, and human cardiovascular aging
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Telomere length is age-dependent and reduced in monocytes of Alzheimer patients
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Telomere length in small‐for‐gestational‐age babies
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Effects of estrogens and androgens on erythrocyte antioxidant superoxide dismutase, catalase and glutathione peroxidase activities during the menstrual cycle
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A Prospective Study of Relative Telomere Length and Postmenopausal Breast Cancer Risk
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Telomere length and reproductive aging
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Association of Leukocyte Telomere Length With Circulating Biomarkers of the Renin-Angiotensin-Aldosterone System
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Large-scale parent–child comparison confirms a strong paternal influence on telomere length
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Oxidative stress, chronic inflammation, and telomere length in patients with periodontitis
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Leukocyte telomere length is associated with cognitive performance in healthy women
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Effect of Long-Term Hormone Therapy on Telomere Length in Postmenopausal Women
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Telomere length and progression of diabetic nephropathy in patients with type 1 diabetes
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Shorter telomeres are associated with obesity and weight gain in the elderly
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Genome-Wide Association Study of Relative Telomere Length
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Association of Telomere Length in Older Men With Mortality and Midlife Body Mass Index and Smoking
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Leukocyte telomere length is associated with complications of Type 2 diabetes mellitus
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Shorter Telomeres May Mark Early Risk of Dementia: Preliminary Analysis of 62 Participants from the Nurses' Health Study
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Longer Relative Telomere Length in Blood from Women with Sporadic and Familial Breast Cancer Compared with Healthy Controls
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Shorter Leukocyte Telomere Length in Midlife Women with Poor Sleep Quality
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Estimating age of humans based on telomere shortening
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Association of Longer Telomeres With Better Health in Centenarians
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Telomere length is shorter in healthy offspring of subjects with coronary artery disease: support for the telomere hypothesis
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Telomere length and obesity
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Homocysteine levels and leukocyte telomere length
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Telomere length is associated with left ventricular function in the oldest old: the Newcastle 85+ study
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Association of shorter mean telomere length with risk of incident myocardial infarction: A prospective, nested case–control approach
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Leukocyte telomere shortening in elderly Type2DM patients with previous myocardial infarction
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Telomere length and risk of Parkinson's disease
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No association between socio‐economic status and white blood cell telomere length
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Low-dose persistent organic pollutants increased telomere length in peripheral leukocytes of healthy Koreans
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A Percentage Analysis of the Telomere Length in Parkinson's Disease Patients
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Shortening of telomeres in recipients of both autologous and allogeneic hematopoietic stem cell transplantation
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The use of telomere length in ecology and evolutionary biology
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A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere length
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Leukocyte telomere length is associated with HDL cholesterol levels: The Bogalusa heart study
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Telomere length changes in patients undergoing hematopoietic stem cell transplantation
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Telomere shortening in sleep apnea syndrome
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Reduction of leucocyte telomere length in radiographic hand osteoarthritis: a population-based study
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Study of telomere length and different markers of oxidative stress in patients with Parkinson's disease
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Telomere length and its associations with oxidized-LDL carotid artery distensibility and smoking
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Association of Leukocyte Telomere Length With Echocardiographic Left Ventricular Mass
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Higher circulating levels of IGF-1 are associated with longer leukocyte telomere length in healthy subjects
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Shared environmental factors associated with telomere length maintenance in elderly male twins
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Common variants near TERC are associated with leukocyte telomere length in the Chinese Han population
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Telomere Shortening of Peripheral Blood Mononuclear Cells in Coronary Disease Patients with Metabolic Disorders.
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Mean Telomere Length and Risk of Incident Colorectal Carcinoma: A Prospective, Nested Case-Control Approach
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Telomere length in vascular tissues from patients with atherosclerotic disease
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Novel estrogens and their radical scavenging effects, iron-chelating, and total antioxidative activities: 17α-substituted analogs of Δ9(11)-dehydro-17β-estradiol
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Leukocytes of exceptionally old persons display ultra-short telomeres
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Telomere Length in Human Adults and High Level Natural Background Radiation
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Telomere length and type 2 diabetes in males, a premature aging syndrome
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Leukocyte telomere length is associated with measures of subclinical atherosclerosis
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Association Between Left Ventricular Mass and Telomere Length in a Population Study
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Change in the telomere length distribution with age in the Japanese population
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Telomere Length and Mental Well-Being in Elderly Men from the Netherlands and Greece
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Leukocyte Telomere Length Is Associated with Disability in Older U.S. Population
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No Evidence for Shorter Leukocyte Telomere Length in Parkinson's Disease Patients
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Leukocyte telomere length and marital status among middle-aged adults
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No Association Between Physical Activity and Telomere Length in an Elderly Chinese Population 65 Years and Older
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Association of shorter mean telomere length with large artery stiffness in patients with coronary heart disease
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Telomerase activity and telomere length of peripheral blood mononuclear cells in SLE patients
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Cognitive performance and leukocyte telomere length in two narrow age-range cohorts: a population study
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Telomere shortening and haemodialysis
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Older men with higher self-rated socioeconomic status have shorter telomeres
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Is telomere length in peripheral blood lymphocytes correlated with cancer susceptibility or radiosensitivity?
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Aging-Related Alterations of Subtelomeric Methylation in Sarcoidosis Patients
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Telomere Length Among the Elderly and Oldest-Old
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Relative Leukocyte Telomere Length and Risk of Incident Ischemic Stroke in Men: A Prospective, Nested Case-Control Approach
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Telomere shortening in peripheral blood cells was related with aging but not with white blood cell count
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An Analysis of Telomere Length in Sarcoidosis
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The effect of telomere length, a marker of biological aging, on bone mineral density in elderly population
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Telomere Dysfunction–Related Serological Markers Are Associated With Type 2 Diabetes
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Serum Insulin-Like Growth Factor-I Concentration Is Associated with Leukocyte Telomere Length in a Population-Based Cohort of Elderly Men
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Insulin-Like Growth Factors and Leukocyte Telomere Length: The Cardiovascular Health Study
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Age-Related Changes in Subtelomeric Methylation in the Normal Japanese Population
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Aldosterone and Telomere Length in White Blood Cells
Benetos, A., Gardner, J. P., Kimura, M., Labat, C., Nzietchueng, R., Dousset, B., Zannad, F. M., Lacolley, P. J., & Aviv, A. (2005) · The Journals of Gerontology Series A · doi:10.1093/gerona/60.12.1593 · Cited by 28 · see citing works
Lower red blood cell counts in middle‐aged subjects with shorter peripheral blood leukocyte telomere length
Meyer, T. D., Buyzere, M. D., Langlois, M. R., Rietzschel, E. R., Cassiman, P., Bacquer, D. D., Oostveldt, P. V., Backer, G. D., Gillebert, T. C., Criekinge, W. V., et al. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00419.x · Cited by 27 · see citing works
Telomere Length in Leukocytes and Cultured Gingival Fibroblasts from Patients with Aggressive Periodontitis
Takahashi, K., Nishida, H., Takeda, H., & Shin, K. (2004) · Journal of Periodontology · doi:10.1902/jop.2004.75.1.84 · Cited by 26 · see citing works
Telomere length and anaemia in old age: results from the Newcastle 85-plus Study* and the Leiden 85-plus Study
den Elzen, W. P. J., Martin-Ruiz, C. M., von Zglinicki, T., Westendorp, R. G. J., Kirkwood, T. B. L., & Gussekloo, J. (2011) · Age and Ageing · doi:10.1093/ageing/afr048 · Cited by 17 · see citing works
In vitro and in vivo reconstitution and stability of vertebrate chromosome ends
Li, L., Lejnine, S., Макаров, В. Л., & Langmore, J. P. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.12.2908 · Cited by 16 · see citing works
Analysis of telomere dynamics in peripheral blood cells from patients with Lynch syndrome
Bozzao, C., Lastella, P., de Leòn, M. P., Pedroni, M., Gregorio, C. D., D'Ovidio, F. D., Resta, N., Prete, F., Guanti, G., & Stella, A. (2011) · Cancer · doi:10.1002/cncr.26022 · Cited by 14 · see citing works
Shorter Telomere Length in Peripheral Blood Cells Associated With Migraine in Women
Ren, H., Collins, V., Fernandez, F., Quinlan, S., Griffiths, L. R., & Choo, K. H. A. (2010) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2010.01693.x · Cited by 10 · see citing works
Leukocyte telomere length is inversely correlated with plasma Von Willebrand factor
Hjelmborg, J., Nzietchueng, R., Kimura, M., Gardner, J. P., Bladbjerg, E., Christensen, K., Aviv, A., & Bénétos, A. (2010) · Thrombosis Research · doi:10.1016/j.thromres.2010.03.006 · Cited by 9 · see citing works
Lack of association between leukocyte telomere length and genetic variants in two ageing-related candidate genes
Zhang, F., Kato, B. S., Gardner, J. P., Kimura, M., Spector, T. D., & Ahmadi, K. R. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.05.007 · Cited by 8 · see citing works
Shorter Telomere Length is Associated With Greater Decrease in Ankle-Brachial Index in Elderly Chinese Women but not Men
Woo, J., Tang, N. L. S., Suen, E., & Leung, J. C. S. (2010) · Angiology · doi:10.1177/0003319710371618 · Cited by 3 · see citing works

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Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis
Haycock, P. C., Heydon, E. E., Kaptoge, S., Butterworth, A. S., Thompson, A., & Willeit, P. (2014) · BMJ · doi:10.1136/bmj.g4227 · Cited by 856 · see citing works
Measuring biological aging in humans: a quest
Ferrucci, L., Gonzalez‐Freire, M., Fabbri, E., Simonsick, E., Tanaka, T., Moore, Z., Salimi, S., Sierra, F., & de Cabo, R. (2020) · Aging Cell · doi:10.1111/acel.13080 · Cited by 781 · see citing works
Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Perspectives.
Vaiserman, A., & Krasnienkov, D. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2020.630186 · Cited by 454 · see citing works
Brain age and other bodily ‘ages’: implications for neuropsychiatry
Cole, J. H., Marioni, R. E., Harris, S. E., & Deary, I. J. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0098-1 · Cited by 435 · see citing works
Immunoglobulin G glycosylation in aging and diseases
Gudelj, I., Lauc, G., & Pezer, M. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.07.009 · Cited by 405 · see citing works
Glycans Are a Novel Biomarker of Chronological and Biological Ages
Krištić, J., Vučković, F., Menni, C., Klarić, L., Keser, T., Beceheli, I., Pučić-Baković, M., Novokmet, M., Mangino, M., Thaqi, K., et al. (2014) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glt190 · Cited by 400 · see citing works
Physical activity and telomere length: Impact of aging and potential mechanisms of action
Arsenis, N. C., You, T., Ogawa, E. F., Tinsley, G. M., & Zuo, L. (2017) · Oncotarget · doi:10.18632/oncotarget.16726 · Cited by 288 · see citing works
Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging
Lindqvist, D., Epel, E. S., Mellon, S. H., Penninx, B. W., Révész, D., Verhoeven, J. E., Reus, V. I., Lin, J., Mahan, L., Hough, C. M., et al. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.05.007 · Cited by 285 · see citing works
The epigenetic clock and telomere length are independently associated with chronological age and mortality
Marioni, R. E., Harris, S. E., Shah, S. H., McRae, A. F., von Zglinicki, T., Martin-Ruiz, C. M., Wray, N. R., Visscher, P. M., & Deary, I. J. (2016) · International Journal of Epidemiology · doi:10.1093/ije/dyw041 · Cited by 285 · see citing works
Effect of Cytotoxic Chemotherapy on Markers of Molecular Age in Patients With Breast Cancer
Sanoff, H. K., Deal, A. M., Krishnamurthy, J., Torrice, C., Dillon, P., Sorrentino, J., Ibrahim, J. G., Jolly, T. A., Williams, G., Carey, L. A., et al. (2014) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/dju057 · Cited by 283 · see citing works
Oxidative Stress in Pulmonary Fibrosis
Otoupalova, E., Smith, S., Cheng, G., & Thannickal, V. J. (2020) · Comprehensive physiology · doi:10.1002/cphy.c190017 · Cited by 309 · see citing works
Depression and telomere length: a meta-analysis
Ridout, K. K., Ridout, S. J., Price, L. H., Sen, S., & Tyrka, A. R. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.11.052 · Cited by 258 · see citing works
Telomere and its role in the aging pathways: telomere shortening, cell senescence and mitochondria dysfunction
Zhu, Y., Liu, X., Ding, X., Wang, F., & Geng, X. (2019) · Biogerontology · doi:10.1007/s10522-018-9769-1 · Cited by 255 · see citing works
Aging Hallmarks: The Benefits of Physical Exercise
Rebelo-Marques, A., De Sousa Lages, A., Andrade, R., Ribeiro, C. F., Mota-Pinto, A., Carrilho, F., & Espregueira-Mendes, J. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00258 · Cited by 246 · see citing works
Dihydrotestosterone: Biochemistry, Physiology, and Clinical Implications of Elevated Blood Levels
Swerdloff, R. S., Dudley, R. E., Page, S. T., Wang, C., & Salameh, W. A. (2017) · Endocrine Reviews · doi:10.1210/er.2016-1067 · Cited by 247 · see citing works
The association between psychiatric disorders and telomere length: a meta-analysis involving 14,827 persons
Darrow, S. M., Verhoeven, J. E., Révész, D., Lindqvist, D., Penninx, B. W. J. H., Delucchi, K. L., Wolkowitz, O. M., & Mathews, C. A. (2016) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000356 · Cited by 229 · see citing works
Effect of obesity on telomere length: Systematic review and meta-analysis
Mundstock, E., Sarria, E. E., Zatti, H., Louzada, F. M., Grün, L. K., Jones, M. H., Guma, F. T. C. R., Memoriam, J. M. I., Epifânio, M., Stein, R. T., et al. (2015) · Obesity · doi:10.1002/oby.21183 · Cited by 210 · see citing works
Determinants of accelerated metabolomic and epigenetic aging in a UK cohort
Robinson, O., Chadeau Hyam, M., Karaman, I., Climaco Pinto, R., Ala-Korpela, M., Handakas, E., Fiorito, G., Gao, H., Heard, A., Jarvelin, M., et al. (2020) · Aging Cell · doi:10.1111/acel.13149 · Cited by 205 · see citing works
Maternal pre-pregnancy body mass index and newborn telomere length
Martens, D. S., Plusquin, M., Gyselaers, W., Vivo, I. D., & Nawrot, T. S. (2016) · BMC Medicine · doi:10.1186/s12916-016-0689-0 · Cited by 189 · see citing works
Body mass index and leukocyte telomere length in adults: a systematic review and meta‐analysis
Müezzinler, A., Zaineddin, A. K., & Brenner, H. (2013) · Obesity Reviews · doi:10.1111/obr.12126 · Cited by 179 · see citing works
Self-citation
Lifelong leukocyte telomere dynamics and survival in a free-living mammal
Fairlie, J., Holland, R., Pilkington, J. G., Pemberton, J. M., Harrington, L. A., & Nussey, D. H. (2015) · Aging Cell · doi:10.1111/acel.12417 · Cited by 174 · see citing works
Body mass index is negatively associated with telomere length: a collaborative cross-sectional meta-analysis of 87 observational studies
Gielen, M., Hageman, G. J., Antoniou, E. E., Nordfjäll, K., Mangino, M., Balasubramanyam, M., Meyer, T. D., Hendricks, A. E., Giltay, E. J., Hunt, S. C., et al. (2018) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqy107 · Cited by 168 · see citing works
Telomere shortening in neurological disorders: an abundance of unanswered questions
Eitan, E., Hutchison, E. R., & Mattson, M. P. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.02.010 · Cited by 158 · see citing works
Premature Physiologic Aging as a Paradigm for Understanding Increased Risk of Adverse Health Across the Lifespan of Survivors of Childhood Cancer
Ness, K. K., Kirkland, J. L., Gramatges, M. M., Wang, Z., Kundu, M., McCastlain, K., Li-Harms, X., Zhang, J., Tchkonia, T., Pluijm, S. M. F., et al. (2018) · Journal of Clinical Oncology · doi:10.1200/jco.2017.76.7467 · Cited by 140 · see citing works
Dynamic DNA methylation during aging: A "prophet" of age-related outcomes
Xiao, F.-H., Wang, H.-T., & Kong, Q.-P. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00107 · Cited by 140 · see citing works
Automated Assay of Telomere Length Measurement and Informatics for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort
Lapham, K., Kvale, M. N., Lin, J., Connell, S., Croen, L., Dispensa, B. P., Fang, L., Hesselson, S., Hoffmann, T. J., Iribarren, C., et al. (2015) · Genetics · doi:10.1534/genetics.115.178624 · Cited by 139 · see citing works
Dietary inflammatory index and telomere length in subjects with a high cardiovascular disease risk from the PREDIMED-NAVARRA study: cross-sectional and longitudinal analyses over 5 y
García-Calzón, S., Zalba, G., Ruiz‐Canela, M., Shivappa, N., Hébert, J. R., Martínez, J. A., Fitó, M., Gómez‐Gracia, E., Martínez‐González, M. Á., & Martí, A. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.116863 · Cited by 135 · see citing works
Telomere Length as a Marker of Cellular Aging Is Associated With Prevalence and Progression of Metabolic Syndrome
Révész, D., Milaneschi, Y., Verhoeven, J. E., & Penninx, B. W. J. H. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1851 · Cited by 134 · see citing works
Systematic and Cell Type-Specific Telomere Length Changes in Subsets of Lymphocytes
Lin, J., Cheon, J., Brown, R. R., Coccia, M., Puterman, E. M., Aschbacher, K., Sinclair, E., Epel, E. S., & Blackburn, E. H. (2016) · Journal of Immunology Research · doi:10.1155/2016/5371050 · Cited by 118 · see citing works
Adverse Childhood Experiences Run Deep: Toxic Early Life Stress, Telomeres, and Mitochondrial DNA Copy Number, the Biological Markers of Cumulative Stress
Ridout, K. K., Khan, M. B., & Ridout, S. J. (2018) · BioEssays · doi:10.1002/bies.201800077 · Cited by 118 · see citing works
Is biological aging accelerated in drug addiction?
Bachi, K., Sierra, S., Volkow, N. D., Goldstein, R. Z., & Nelly Alia-klein, A. (2016) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2016.09.007 · Cited by 115 · see citing works
Cardiomyocyte‐Specific Telomere Shortening is a Distinct Signature of Heart Failure in Humans
Sharifi‐Sanjani, M., Oyster, N. M., Tichy, E. D., Bedi, K. C., Harel, O., Margulies, K. B., & Mourkioti, F. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.116.005086 · Cited by 112 · see citing works
Effects of physical activity in telomere length: Systematic review and meta-analysis
Mundstock, E., Zatti, H., Louzada, F. M., Oliveira, S. G., Guma, F. T. C. R., Paris, M. M., Rueda, A. M. B., Machado, D. G., Stein, R. T., Jones, M. H., et al. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.02.004 · Cited by 115 · see citing works
Leukocyte Telomere Length and All-Cause, Cardiovascular Disease, and Cancer Mortality: Results From Individual-Participant-Data Meta-Analysis of 2 Large Prospective Cohort Studies
Mons, U., Müezzinler, A., Schöttker, B., Dieffenbach, A. K., Butterbach, K., Schick, M., Peasey, A., Vivo, I. D., Trichopoulou, A., Boffetta, P., et al. (2016) · American Journal of Epidemiology · doi:10.1093/aje/kww210 · Cited by 113 · see citing works
Self-citation
Air pollution and telomere length in adults: A systematic review and meta-analysis of observational studies
Miri, M., Nazarzadeh, M., Alahabadi, A., Ehrampoush, M. H., Rad, A., Lotfi, M. H., Sheikhha, M. H., Sakhvidi, M. J. Z., Nawrot, T. S., & Dadvand, P. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2018.09.130 · Cited by 111 · see citing works
Questioning causal involvement of telomeres in aging
Simons, M. J. P. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.08.002 · Cited by 108 · see citing works
Associations of Cadmium and Lead Exposure With Leukocyte Telomere Length: Findings From National Health and Nutrition Examination Survey, 1999–2002
Zota, A. R., Needham, B. L., Blackburn, E. H., Lin, J., Park, S. K., Rehkopf, D. H., & Epel, E. S. (2014) · American Journal of Epidemiology · doi:10.1093/aje/kwu293 · Cited by 108 · see citing works
Various Mechanistic Pathways Representing the Aging Process Are Altered in COPD
Rutten, E. P. A., Gopal, P., Wouters, E. F. �., Franssen, F. M. E., Hageman, G. J., Vanfleteren, L. E. G. W., Spruit, M. A., & Reynaert, N. L. (2015) · CHEST Journal · doi:10.1378/chest.15-0645 · Cited by 99 · see citing works
Leukocyte telomere length associates with prospective mortality independent of immune-related parameters and known genetic markers
Deelen, J., Beekman, M., Codd, V., Trompet, S., Broer, L., Hägg, S., Fischer, K., Thijssen, P. E., Suchiman, H. E. D., Postmus, I., et al. (2014) · International Journal of Epidemiology · doi:10.1093/ije/dyt267 · Cited by 97 · see citing works
Mediterranean diet and telomere length in high cardiovascular risk subjects from the PREDIMED-NAVARRA study
García-Calzón, S., Martínez‐González, M. Á., Razquín, C., Arós, F., Lapetra, J., Martínez, J. A., Zalba, G., & Martí, A. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.03.013 · Cited by 97 · see citing works
Spatio‐temporal variation in lifelong telomere dynamics in a long‐term ecological study
Spurgin, L. G., Bebbington, K., Fairfield, E. A., Hammers, M., Komdeur, J., Burke, T. A., Dugdale, H. L., & Richardson, D. S. (2017) · Journal of Animal Ecology · doi:10.1111/1365-2656.12741 · Cited by 92 · see citing works
Epigenetic Clock and Relative Telomere Length Represent Largely Different Aspects of Aging in the Berlin Aging Study II (BASE-II)
Vetter, V. M., Meyer, A., Karbasiyan, M., Steinhagen‐Thiessen, E., Hopfenmüller, W., & Demuth, I. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly184 · Cited by 93 · see citing works
Traumatic Stress and Accelerated Cellular Aging: From Epigenetics to Cardiometabolic Disease
Wolf, E. J., & Morrison, F. G. (2017) · Current Psychiatry Reports · doi:10.1007/s11920-017-0823-5 · Cited by 95 · see citing works
Epigenetic Mechanisms Impacting Aging: A Focus on Histone Levels and Telomeres
Song, S., & Johnson, F. B. (2018) · Genes · doi:10.3390/genes9040201 · Cited by 91 · see citing works
Loving-kindness meditation slows biological aging in novices: Evidence from a 12-week randomized controlled trial
Nguyen, K. D. L., Lin, J., Algoe, S. B., Brantley, M. M., Kim, S. L., Brantley, J. G., Salzberg, S., & Fredrickson, B. L. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.05.020 · Cited by 90 · see citing works
Racial discrimination and telomere shortening among African Americans: The Coronary Artery Risk Development in Young Adults (CARDIA) Study.
Chae, D. H., Wang, Y., Martz, C. D., Slopen, N. B., Yip, T., Adler, N. E., Fuller‐Rowell, T. E., Lin, J., Matthews, K. A., Brody, G. H., et al. (2020) · Health Psychology · doi:10.1037/hea0000832 · Cited by 89 · see citing works
Telomere length and chronological age across the human lifespan: A systematic review and meta-analysis of 414 study samples including 743,019 individuals
Ye, Q., Apsley, A. T., Etzel, L. C., Hastings, W. J., Kozlosky, J. T., Walker, C., Wolf, S. E., & Shalev, I. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102031 · Cited by 89 · see citing works
Depression, telomeres and mitochondrial DNA: between- and within-person associations from a 10-year longitudinal study
Verhoeven, J. E., Révész, D., Picard, M. A., Epel, E. S., Wolkowitz, O. M., Matthews, K. A., Penninx, B. W. J. H., & Puterman, E. M. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.48 · Cited by 87 · see citing works
Shortened telomere length in patients with depression: A meta-analytic study.
Lin, P., Huang, Y.-C., & Hung, C.-F. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.01.015 · Cited by 82 · see citing works
The telomere world and aging: Analytical challenges and future perspectives
Mensa’, E., Latini, S., Ramini, D., Storci, G., Bonafè, M., & Olivieri, F. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.01.004 · Cited by 82 · see citing works
Longitudinal Associations Between Metabolic Syndrome Components and Telomere Shortening
Révész, D., Milaneschi, Y., Verhoeven, J. E., Lin, J., & Penninx, B. W. J. H. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-1995 · Cited by 84 · see citing works
Genetic, parental and lifestyle factors influence telomere length
Andreu‐Sánchez, S., Aubert, G., Ripoll-Cladellas, A., Henkelman, S., Zhernakova, D. V., Sinha, T., Kurilshikov, A., Cénit, M. C., Bonder, M. J., Study, L. C., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-03521-7 · Cited by 83 · see citing works
A new pleiotropic effect of statins in elderly: modulation of telomerase activity
Boccardi, V., Barbieri, M., Rizzo, M. R., Marfella, R., Esposito, A., Marano, L., & Paolisso, G. (2013) · The FASEB Journal · doi:10.1096/fj.13-232066 · Cited by 77 · see citing works
Accelerated DNA Methylation Age: Associations With Posttraumatic Stress Disorder and Mortality
Wolf, E. J., Logue, M. W., Stoop, T. B., Schichman, S. A., Stone, A., Sadeh, N., Hayes, J. P., & Miller, M. W. (2017) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000506 · Cited by 76 · see citing works
Leukocyte telomere length and late-life depression
Schaakxs, R., Verhoeven, J. E., Oude Voshaar, R. C., Comijs, H. C., & Penninx, B. W. J. H. (2015) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2014.06.003 · Cited by 75 · see citing works
Telomere Length Is Associated with Disability Progression in Multiple Sclerosis
Krysko, K. M., Henry, R. G., Cree, B., Lin, J., Caillier, S. J., Santaniello, A., Zhao, C., Gomez, R., Bevan, C. J., Smith, D. L., et al. (2019) · Annals of Neurology · doi:10.1002/ana.25592 · Cited by 75 · see citing works
Leukocyte Telomere Length and Age at Menopause
Gray, K. E., Schiff, M. A., Fitzpatrick, A. L., Kimura, M., Aviv, A., & Starr, J. R. (2013) · Epidemiology · doi:10.1097/ede.0000000000000017 · Cited by 72 · see citing works
Select aging biomarkers based on telomere length and chronological age to build a biological age equation
Zhang, W., Zhu, S., Bai, X., Zhao, D., Jiang, S.-M., Li, J., Li, Z.-X., Fu, B., Cai, G., Sun, X., et al. (2014) · AGE · doi:10.1007/s11357-014-9639-y · Cited by 74 · see citing works
Telomeres are elongated in older individuals in a hibernating rodent, the edible dormouse (Glis glis)
Hoelzl, F., Smith, S., Cornils, J. S., Aydinonat, D., Bieber, C., & Ruf, T. (2016) · Scientific Reports · doi:10.1038/srep36856 · Cited by 74 · see citing works
Leukocyte telomere length in patients with bipolar disorder: An updated meta-analysis and subgroup analysis by mood status
Huang, Y., Wang, L., Tseng, P., Hung, C., & Lin, P. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.09.035 · Cited by 73 · see citing works
Multi-omics research strategies in ischemic stroke: A multidimensional perspective
Li, W., Shao, C., Zhou, H., Du, H., Chen, H., Wan, H., & He, Y. T. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101730 · Cited by 72 · see citing works
Prevalence of aging population in the Middle East and its implications on cancer incidence and care
Hajjar, R. R., Atlı, T., Al-Mandhari, Z., Oudrhiri, M. Y., Balducci, L., & Silbermann, M. (2013) · Annals of Oncology · doi:10.1093/annonc/mdt268 · Cited by 73 · see citing works
Biological and Functional Biomarkers of Aging: Definition, Characteristics, and How They Can Impact Everyday Cancer Treatment
Colloca, G. A., Capua, B. D., Bellieni, A., Fusco, D., Ciciarello, F., Tagliaferri, L., Valentini, V., & Balducci, L. (2020) · Current Oncology Reports · doi:10.1007/s11912-020-00977-w · Cited by 71 · see citing works
p16 a biomarker of aging and tolerance for cancer therapy
Muss, H. B., Smitherman, A. B., Wood, W. A., Nyrop, K. A., Tuchman, S. A., Randhawa, P. K., Entwistle, A., Mitin, N., & Shachar, S. S. (2020) · Translational Cancer Research · doi:10.21037/tcr.2020.03.39 · Cited by 68 · see citing works
Telomere shortening and immune activity in war veterans with posttraumatic stress disorder
Jergović, M., Tomičević, M., Vidović, A., Bendelja, K., Savić, A., Vojvoda, V., Rac, D., Lovrić-Čavar, D., Rabatić, S., Jovanovic, T., et al. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.06.010 · Cited by 67 · see citing works
Defining the toxicology of aging
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GERONTOLOGIC EPIDEMIOLOGY Leukocyte telomere dynamics in the elderly
Steenstrup, T., Hjelmborg, J. B., Christensen, K., & Aviv, A. (2016)

Authors: Müezzinler, A., Zaineddin, A. K., & Brenner, H.
Affiliations: German Cancer Research Center (DE)
Corresponding author: Müezzinler, Aysel
ORCID: Brenner, Hermann
Venue: Ageing Research Reviews
Publisher: Elsevier BV
Published: 2013-03
Volume: 12
Issue: 2
Pages: 509-519
ISSN: 1568-1637 (ISSN-L)
DOI: 10.1016/j.arr.2013.01.003
OpenAlex: W2000059391
Cited by: 474
References: 165
Citations by year: 2026: 14 · 2025: 19 · 2024: 34 · 2023: 31 · 2022: 49 · 2021: 41 · 2020: 46 · 2019: 60 · 2018: 36 · 2017: 49 · 2016: 38 · 2015: 28 · 2014: 23 · 2013: 5
FWCI: 3.45
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Ageing Research Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: European Commission
Klaus Tschira Stiftung
Hellenic Health Foundation
Topics: Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords: leukocyte telomere length, aging, telomere shortening, age-related telomere shortening, adults, sex differences
MeSH terms: Age Factors, Aged, Aged, 80 and over, Aging, Cross-Sectional Studies, Humans, Leukocytes, Longitudinal Studies, Middle Aged, Linear Models, Telomere Homeostasis, Telomere Shortening

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A systematic review of leukocyte telomere length and age in adults

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