The DOI matches its Crossref record; 84 of the 84 references it cites were found in a registry or an index.
Spatial Relational Memory Requires Hippocampal Adult Neurogenesis
Open accessAbstract
The dentate gyrus of the hippocampus is one of the few regions of the mammalian brain where new neurons are generated throughout adulthood. This adult neurogenesis has been proposed as a novel mechanism that mediates spatial memory. However, data showing a causal relationship between neurogenesis and spatial memory are controversial. Here, we developed an inducible transgenic strategy allowing specific ablation of adult-born hippocampal neurons. This resulted in an impairment of spatial relational memory, which supports a capacity for flexible, inferential memory expression. In contrast, less complex forms of spatial knowledge were unaltered. These findings demonstrate that adult-born neurons are necessary for complex forms of hippocampus-mediated learning.
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Cites
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Learning enhances adult neurogenesis in the hippocampal formation
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Cited by
New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?
Deng, W., Aimone, J. B., & Gage, F. H. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2822 · Cited by 2,120
Adult hippocampal neurogenesis and cognitive flexibility — linking memory and mood
Anacker, C., & Hen, R. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.45 · Cited by 1,014
The role of adult hippocampal neurogenesis in brain health and disease
Toda, T., Parylak, S. L., Linker, S. B., & Gage, F. H. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0036-2 · Cited by 719
Aimone, J. B., Deng, W., & Gage, F. H. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.010 · Cited by 663
Jessberger, S., Clark, R. E., Broadbent, N. J., Clemenson, G. D., Consiglio, A., Lie, D. C., Squire, L. R., & Gage, F. H. (2009) · Learning & Memory · doi:10.1101/lm.1172609 · Cited by 654
Metadata
- Authors
- Dupret, D., Revest, J.-M., Koehl, M., Ichas, F., De Giorgi, F., Costet, P., Abrous, D. N., & Piazza, P. V.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2008-04-09
- Volume
- 3
- Issue
- 4
- Pages
- e1959
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2010053974
- Cited by
- 593
- References
- 84
- FWCI
- 15.80
- Type
- journal article
- Language
- en
- Open access
- gold
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- Dupret, D., Revest, J.-M., Koehl, M., Ichas, F., De Giorgi, F., Costet, P., Abrous, D. N., & Piazza, P. V. (2008). Spatial Relational Memory Requires Hippocampal Adult Neurogenesis. PLoS ONE. https://doi.org/10.1371/journal.pone.0001959
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
