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Distinctive Patterns of MicroRNA Expression Associated with Karyotype in Acute Myeloid Leukaemia

Dixon-McIver, Amanda, East, Phil, Mein, Charles A., Cazier, Jean-Baptiste, Molloy, Gael, Chaplin, Tracy, Andrew Lister, T., Young, Bryan D., Debernardi, Silvana·2008·PLoS ONE
DOI 10.1371/journal.pone.0002141PMC PMC2373886
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Figure 1 Unsupervised hierarchical cluster analysis of 123 miRNA expression profiles for 102 leukaemia samples. Each column represents a sample, and each row represents a single miRNA. The colour display encodes the logarithm of the expression changes, where varying shades of red and green indicate up and down regulation, respectively. Values ranged from log2 (−10) to log2(+10). MiRNAs passing a 5% FDR threshold from the leukaemia versus normal bone marrow comparison are highlighted in red or green on the left of the heatmap. Karyotype labels are also indicated on the top of the heatmap. The colour-key for the labelling is on the top left.
Figure 1 Unsupervised hierarchical cluster analysis of 123 miRNA expression profiles for 102 leukaemia samples. Each column represents a sample, and each row represents a single miRNA. The colour display encodes the logarithm of the expression changes, where varying shades of red and green indicate up and down regulation, respectively. Values ranged from log2 (−10) to log2(+10). MiRNAs passing a 5% FDR threshold from the leukaemia versus normal bone marrow comparison are highlighted in red or green on the left of the heatmap. Karyotype labels are also indicated on the top of the heatmap. The colour-key for the labelling is on the top left.CC BY · PubMed Central
Figure 2 MiRNA detection in cryopreserved bone marrow cells by LNA-FISH. Patients n. 109 (lanes 1–3) and n. 111 (lanes 4–6) carrying the t(15;17) and t(9;22) translocations, respectively, are shown. All images were obtained with the confocal microscope as described in the method. The DAPI nuclear staining (blue), the fluorescent in situ hybridisation signals obtained with FITC-conjugated antibody (green), and the combined images are indicated. The A and B panels show the detection of miR-127 and miR-154, respectively. Both miRNAs are detected in the cytoplasm of cells (lanes 2 and 3) of patient n. 109 but not in patient n. 111 (lanes 5 and 6). The C panel shows the nuclear expression of U6, the small RNA used as positive control, in both samples (lanes 2 and 5). No signal was detected when cells were hybridised with a scrambled oligonucleotide (negative control), as shows in lanes 2 and 5 of the D panel.
Figure 2 MiRNA detection in cryopreserved bone marrow cells by LNA-FISH. Patients n. 109 (lanes 1–3) and n. 111 (lanes 4–6) carrying the t(15;17) and t(9;22) translocations, respectively, are shown. All images were obtained with the confocal microscope as described in the method. The DAPI nuclear staining (blue), the fluorescent in situ hybridisation signals obtained with FITC-conjugated antibody (green), and the combined images are indicated. The A and B panels show the detection of miR-127 and miR-154, respectively. Both miRNAs are detected in the cytoplasm of cells (lanes 2 and 3) of patient n. 109 but not in patient n. 111 (lanes 5 and 6). The C panel shows the nuclear expression of U6, the small RNA used as positive control, in both samples (lanes 2 and 5). No signal was detected when cells were hybridised with a scrambled oligonucleotide (negative control), as shows in lanes 2 and 5 of the D panel.CC BY · PubMed Central

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Metadata

Authors
Dixon-McIver, A., East, P., Mein, C. A., Cazier, J.-B., Molloy, G., Chaplin, T., Andrew Lister, T., Young, B. D., & Debernardi, S.
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2008-05-14
Volume
3
Issue
5
Pages
e2141
ISSN
1932-6203
DOI
10.1371/journal.pone.0002141
PMC
PMC2373886
Cited by
225
References
2
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (unspecified)

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CoChat. (2026). Citation check: Distinctive Patterns of MicroRNA Expression Associated with Karyotype in Acute Myeloid Leukaemia. https://app.cochat.ai/papers/10.1371/journal.pone.0002141
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Dixon-McIver, A., East, P., Mein, C. A., Cazier, J.-B., Molloy, G., Chaplin, T., Andrew Lister, T., Young, B. D., & Debernardi, S. (2008). Distinctive Patterns of MicroRNA Expression Associated with Karyotype in Acute Myeloid Leukaemia. PLoS ONE. https://doi.org/10.1371/journal.pone.0002141