Heme Oxygenase-1 Accelerates Cutaneous Wound Healing in Mice
Open accessAbstract
Heme oxygenase-1 (HO-1), a cytoprotective, pro-angiogenic and anti-inflammatory enzyme, is strongly induced in injured tissues. Our aim was to clarify its role in cutaneous wound healing. In wild type mice, maximal expression of HO-1 in the skin was observed on the 2(nd) and 3(rd) days after wounding. Inhibition of HO-1 by tin protoporphyrin-IX resulted in retardation of wound closure. Healing was also delayed in HO-1 deficient mice, where lack of HO-1 could lead to complete suppression of reepithelialization and to formation of extensive skin lesions, accompanied by impaired neovascularization. Experiments performed in transgenic mice bearing HO-1 under control of keratin 14 promoter showed that increased level of HO-1 in keratinocytes is enough to improve the neovascularization and hasten the closure of wounds. Importantly, induction of HO-1 in wounded skin was relatively weak and delayed in diabetic (db/db) mice, in which also angiogenesis and wound closure were impaired. In such animals local delivery of HO-1 transgene using adenoviral vectors accelerated the wound healing and increased the vascularization. In summary, induction of HO-1 is necessary for efficient wound closure and neovascularization. Impaired wound healing in diabetic mice may be associated with delayed HO-1 upregulation and can be improved by HO-1 gene transfer.
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S. epidermidis association promotes expression of angiogenesis genes Ang and Hgf and tissue repair genes Ceacam1, Grn, Hmox1, Igf1, and Pdgfa.
“S. epidermidis association promoted the expression of genes associated specifically with angiogenesis, including angiogenin (Ang) and Hgf (47, 48), as well as genes that more broadly promote tissue repair, like Ceacam1, Grn, Hmox1, Igf1, and Pdgfa (49–53) (Fig. 3R).”
From MAIT cells are imprinted by the microbiota in early life and promote tissue repair (2019) · cites this paper as [53]
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Gurtner, G. C., Werner, S., Barrandon, Y., & Longaker, M. T. (2008) · Nature · doi:10.1038/nature07039 · Cited by 6,542 · see citing works
Wound healing and its impairment in the diabetic foot
Falanga, V. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67700-8 · Cited by 2,645 · see citing works
THE HEME OXYGENASE SYSTEM:A Regulator of Second Messenger Gases
Maines, M. D. (1997) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.37.1.517 · Cited by 2,489 · see citing works
Heme oxygenase: Function, multiplicity, regulatory mechanisms, and clinical applications
Maines, M. D. (1988) · The FASEB Journal · doi:10.1096/fasebj.2.10.3290025 · Cited by 1,707 · see citing works
Reduced stress defense in heme oxygenase 1-deficient cells
Poss, K. D., & Tonegawa, S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.10925 · Cited by 1,293 · see citing works
Heme oxygenase 1 is required for mammalian iron reutilization
Poss, K. D., & Tonegawa, S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.10919 · Cited by 1,016 · see citing works
Physiology and healing dynamics of chronic cutaneous wounds
Stadelmann, W. K., Digenis, A. G., & Tobin, G. R. (1998) · The American Journal of Surgery · doi:10.1016/s0002-9610(98)00183-4 · Cited by 910 · see citing works
Galiano, R. D., Tepper, O. M., Pelo, C. R., Bhatt, K. A., Callaghan, M. J., Bastidas, N., Bunting, S., Steinmetz, H., & Gurtner, G. C. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63754-6 · Cited by 801 · see citing works
Heme Oxygenase-1 in Tumors: Is It a False Friend?
Józkowicz, A., Waś, H., & Dulak, J. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1659 · Cited by 381 · see citing works
Self-citationBruce, C. R., Carey, A. L., Hawley, J. A., & Febbraio, M. A. (2003) · Diabetes · doi:10.2337/diabetes.52.9.2338 · Cited by 318 · see citing works
Heme Oxygenase-1 and Carbon Monoxide in Vascular Pathobiology
Dulak, J., Deshane, J. S., Józkowicz, A., & Agarwal, A. (2008) · Circulation · doi:10.1161/circulationaha.107.698316 · Cited by 303 · see citing works
Self-citationStromal cell–derived factor 1 promotes angiogenesis via a heme oxygenase 1–dependent mechanism
Deshane, J. S., Chen, S., Caballero, S., Grochot‐Przeczek, A., Waś, H., Calzi, S. L., Lach, R., Hock, T., Chen, B., Hill‐Kapturczak, N., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061609 · Cited by 283 · see citing works
Self-citationEffects of Antioxidants in Diabetes-Induced Oxidative Stress in the Glomeruli of Diabetic Rats
Koya, D., Hayashi, K., Kitada, M., Kashiwagi, A., Kikkawa, R., & Haneda, M. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000077412.07578.44 · Cited by 277 · see citing works
Altavilla, D., Saitta, A., Cucinotta, D., Galeano, M., Deodato, B., Colonna, M. R., Torre, V., Russo, G. T., Sardella, A., Urna, G., et al. (2001) · Diabetes · doi:10.2337/diabetes.50.3.667 · Cited by 273 · see citing works
Androgen receptor–mediated inhibition of cutaneous wound healing
Ashcroft, G. S., & Mills, S. J. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15704 · Cited by 271 · see citing works
Heme Oxygenase-1 and the Vascular Bed: From Molecular Mechanisms to Therapeutic Opportunities
Łoboda, A., Jaźwa, A., Grochot‐Przeczek, A., Rutkowski, A. J., Cisowski, J., Agarwal, A., Józkowicz, A., & Dulak, J. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2043 · Cited by 263 · see citing works
Self-citationAndrogen receptor–mediated inhibition of cutaneous wound healing
Ashcroft, G. S., & Mills, S. J. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215704 · Cited by 255 · see citing works
Heme oxygenase: Protective gene or Trojan horse
Platt, J. L., & Nath, K. A. (1998) · Nature Medicine · doi:10.1038/3947 · Cited by 236 · see citing works
Heme oxygenase-1 accelerates tumor angiogenesis of human pancreatic cancer
Sunamura, M., Duda, D. G., Ghattas, M. H., Lozonschi, L., Motoi, F., Yamauchi, J.-I., Matsuno, S., Shibahara, S., & Abraham, N. G. (2003) · Angiogenesis · doi:10.1023/a:1025803600840 · Cited by 215 · see citing works
Józkowicz, A., Huk, I., Nigisch, A., Weigel, G., Dietrich, W., Motterlini, R., & Dulak, J. (2003) · Antioxidants and Redox Signaling · doi:10.1089/152308603764816514 · Cited by 196 · see citing works
Self-citationShukla, A., Rasik, A. M., & Patnaik, G. K. (1997) · Free Radical Research · doi:10.3109/10715769709097788 · Cited by 195 · see citing works
Howdieshell, T. R., Callaway, D., Webb, W. L., Gaines, M. D., Procter, C. D., Sathyanarayana, Pollock, J. S., Brock, T. L., & McNeil, P. L. (2001) · Journal of Surgical Research · doi:10.1006/jsre.2001.6089 · Cited by 188 · see citing works
Suh, W., Kim, K. L., Kim, J., Shin, I., Lee, Y., Lee, J., Jang, H., Lee, J., Byun, J., Choi, J., et al. (2005) · Stem Cells · doi:10.1634/stemcells.2004-0340 · Cited by 185 · see citing works
Dulak, J., Józkowicz, A., Foresti, R., Kasza, A., Frick, M., Huk, I., Green, C. J., Pachinger, O. M., Weidinger, F. F., & Motterlini, R. (2002) · Antioxidants and Redox Signaling · doi:10.1089/152308602753666280 · Cited by 182 · see citing works
Self-citationNolan, V. G., Adewoye, A. H., Baldwin, C. T., Wang, L., Ma, Q., Wyszynski, D. F., Farrell, J. J., Paola Sebastiani, B., Farrer, L. A., & Steinberg, M. H. (2006) · British Journal of Haematology · doi:10.1111/j.1365-2141.2006.06074.x · Cited by 171 · see citing works
The angiogenesis inhibitor endostatin impairs blood vessel maturation during wound healing
Bloch, W., Huggel, K., Sasaki, T., Grose, R. P., Bugnon, P., Addicks, K., Timpl, R., & Werner, S. (2000) · The FASEB Journal · doi:10.1096/fj.00-0490fje · Cited by 169 · see citing works
Ebrahimian, T. G., Heymes, C., Broquères-You, D., Blanc‐Brude, O., Mees, B., Waeckel, L., Duriez, M., Vilar, J., Brandes, R. P., Levy, B. I., et al. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.060042 · Cited by 163 · see citing works
Pitfalls using metalloporphyrins in carbon monoxide research
Grundemar, L., & Ny, L. (1997) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(97)01065-1 · Cited by 161 · see citing works
Galeano, M., Deodato, B., Altavilla, D., Cucinotta, D., Arsic, N., Marini, H. R., Torre, V., Giacca, M., & Squadrito, F. (2003) · Diabetologia · doi:10.1007/s00125-003-1064-1 · Cited by 157 · see citing works
Oxidative stress and cellular stress response in diabetic nephropathy
Calabrese, V., Mancuso, C., Sapienza, M. A., Puleo, E., Calafato, S., Cornelius, C., Finocchiaro, M., Mangiameli, A., Mauro, M. D., Stella, A. M. G., et al. (2007) · Cell Stress and Chaperones · doi:10.1379/csc-270.1 · Cited by 152 · see citing works
Goren, I., Müller, E., Schiefelbein, D., Christen, U., Pfeilschifter, J., Mühl, H., & Frank, S. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700842 · Cited by 151 · see citing works
Androgens modulate the inflammatory response during acute wound healing
Gilliver, S. C., Ashworth, J. J., Mills, S. J., Hardman, M. J., & Ashcroft, G. S. (2006) · Journal of Cell Science · doi:10.1242/jcs.02786 · Cited by 147 · see citing works
Interleukin-17, a regulator of angiogenic factor release by synovial fibroblasts
Honorati, M. C., Neri, S., Cattini, L., & Facchini, A. (2005) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2005.10.004 · Cited by 137 · see citing works
Filippo, C. D., Marfella, R., Cuzzocrea, S., Piegari, E., Petronella, P., Giugliano, D., Rossi, F., & D’Amico, M. (2005) · Diabetes · doi:10.2337/diabetes.54.3.803 · Cited by 132 · see citing works
The heme-heme oxygenase system: a molecular switch in wound healing
Wagener, F. A. D. T. G., Beurden, H. E. V., den Hoff, J. W. V., Adema, G. J., & Figdor, C. G. (2003) · Blood · doi:10.1182/blood-2002-07-2248 · Cited by 132 · see citing works
Rossiter, H., Barresi, C., Pammer, J., Rendl, M., Haigh, J. J., Wagner, E. F., & Tschachler, E. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2581 · Cited by 130 · see citing works
Haem oxygenase-1: a novel player in cutaneous wound repair and psoriasis?
Hanselmann, C., Mauch, C., & Werner, S. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3530459 · Cited by 126 · see citing works
Heme oxygenase in diabetes-induced oxidative stress in the heart
Farhangkhoee, H. (2003) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2003.09.007 · Cited by 112 · see citing works
Abraham, N. G., Rezzani, R., Rodella, L. F., Kruger, A. L., Taller, D., Volti, G. L., Goodman, A. I., & Kappas, A. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01187.2003 · Cited by 109 · see citing works
MCP-1 is up-regulated in unstressed and stressed HO-1 knockout mice: Pathophysiologic correlates1
Pittock, S. T., Norby, S. M., Grande, J. P., Croatt, A. J., Bren, G. D., Badley, A. D., Caplice, N. M., Griffin, M. D., & Nath, K. A. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00439.x · Cited by 104 · see citing works
Anaemia in Diabetes: An Emerging Complication of Microvascular Disease
Thomas, M. C., Tsalamandris, C., MacIsaac, R. J., & Jerums, G. (2005) · Current Diabetes Reviews · doi:10.2174/1573399052952587 · Cited by 99 · see citing works
Pitfalls using metalloporphyrins in carbon monoxide research
Grundemar, L., & Ny, L. (1997) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(97)90622-2 · Cited by 98 · see citing works
Jaźwa, A., Łoboda, A., Gołda, S., Cisowski, J., Szeląg, M., Zagórska, A., Sroczyńska, P., Drukała, J., Józkowicz, A., & Dulak, J. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.11.016 · Cited by 91 · see citing works
Self-citationSuzuki, M., Iso-O, N., Takeshita, S., Tsukamoto, K., Mori, I., Sato, T., Ohno, M., Nagai, R., & Ishizaka, N. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00114-1 · Cited by 88 · see citing works
Haem oxygenase-1: a novel player in cutaneous wound repair and psoriasis?
Hanselmann, C., Mauch, C., & Werner, S. (2001) · Biochemical Journal · doi:10.1042/bj3530459 · Cited by 87 · see citing works
Effect of Prostaglandin-J 2 on VEGF Synthesis Depends on the Induction of Heme Oxygenase-1
Józkowicz, A., Huk, I., Nigisch, A., Weigel, G., Weidinger, F. F., & Dulak, J. (2002) · Antioxidants and Redox Signaling · doi:10.1089/15230860260220076 · Cited by 84 · see citing works
Self-citationTheilla, M., Singer, P., Cohen, J. D., & DeKeyser, F. G. (2007) · Clinical Nutrition · doi:10.1016/j.clnu.2007.06.015 · Cited by 79 · see citing works
Role of heme oxygenase-1 in hydrogen peroxide-induced VEGF synthesis: effect of HO-1 knockout
Cisowski, J., Łoboda, A., Józkowicz, A., Chen, S., Agarwal, A., & Dulak, J. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.11.083 · Cited by 79 · see citing works
Self-citationSambuceti, G., Morbelli, S. D., Vanella, L., Kusmic, C., Marini, C., Massollo, M., Augeri, C., Corselli, M., Ghersi, C., Chiavarina, B., et al. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0800 · Cited by 79 · see citing works
Heme oxygenase-1 prevents superoxide anion-associated endothelial cell sloughing in diabetic rats
Quan, S., Kaminski, P. M., Yang, L. M., Morita, T., Inaba, M., Ikehara, S., Goodman, A. I., Wolin, M. S., & Abraham, N. G. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.01.086 · Cited by 78 · see citing works
Patil, K., Bellner, L., Cullaro, G., Gotlinger, K. H., Dunn, M. W., & Schwartzman, M. L. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-1515 · Cited by 73 · see citing works
Assessment of wound-site redox environment and the significance of Rac2 in cutaneous healing
Ojha, N., Roy, S., He, G., Biswas, S., Velayutham, M., Khanna, S., Kuppusamy, P., Zweier, J. L., & Sen, C. K. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.10.056 · Cited by 71 · see citing works
Effects of interleukin‐8 on granulation tissue maturation
Moyer, K. E., Saggers, G. C., Allison, G. M., Mackay, D. R., & Ehrlich, H. P. (2002) · Journal of Cellular Physiology · doi:10.1002/jcp.10160 · Cited by 69 · see citing works
Avogaro, A., Pagnin, E., & Calò, L. A. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021025 · Cited by 68 · see citing works
Enhancement of glomerular heme oxygenase-1 expression in diabetic rats
Hayashi, K., Haneda, M., Koya, D., Maeda, S., Isshiki, K., & Kikkawa, R. (2001) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(01)00218-2 · Cited by 66 · see citing works
Galeano, M., Deodato, B., Altavilla, D., Squadrito, G., Seminara, P., Marini, H. R., d’Alcontres, F. S., Colonna, M. R., Calò, M., Cascio, P. L., et al. (2003) · Critical Care Medicine · doi:10.1097/01.ccm.0000059435.88283.c2 · Cited by 62 · see citing works
Recombinant human GM-CSF in the treatment of poorly healing wounds.
Groves, R. W., & Schmidt-Lucke, J. A. (2000) · PubMed · Cited by 61 · see citing works
Adaikalakoteswari, A., Balasubramanyam, M., Rema, M., & Mohan, V. (2006) · Diabetic Medicine · doi:10.1111/j.1464-5491.2006.01879.x · Cited by 59 · see citing works
Song, F., Qi, X., Chen, W., Jia, W., Yao, P., Nussler, A. K., Sun, X., & Liu, L. (2007) · European Journal of Nutrition · doi:10.1007/s00394-006-0632-9 · Cited by 57 · see citing works
Calzi, S. L., Purich, D. L., Chang, K. H., Afzal, A., Nakagawa, T., Busik, J. V., Agarwal, A., Segal, M. S., & Grant, M. B. (2008) · Diabetes · doi:10.2337/db08-0381 · Cited by 57 · see citing works
Michaels, J., V, Dobryansky, M., Galiano, R. D., Bhatt, K. A., Ashinoff, R. L., Ceradini, D. J., & Gurtner, G. C. (2005) · Wound Repair and Regeneration · doi:10.1111/j.1067-1927.2005.00071.x · Cited by 55 · see citing works
Wu, C.-C., Lu, K., Chen, J.-S., Hsieh, H.-Y., Lin, S., Chu, P., Wang, J., Sytwu, H., & Lin, Y. (2008) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfn247 · Cited by 55 · see citing works
Józkowicz, A., & Dulak, J. (2003) · Acta Biochimica Polonica · doi:10.18388/abp.2003_3715 · Cited by 53 · see citing works
Self-citationZhang, F., Hackett, N. R., Lam, G. F. M., Cheng, J., Pergolizzi, R. G., Luo, L., Shmelkov, S. V., Edelberg, J. M., Crystal, R. G., & Rafii, S. (2003) · Blood · doi:10.1182/blood-2003-01-0049 · Cited by 52 · see citing works
Zhao, W., Han, Q., Lin, H., Gao, Y., Sun, W., Zhao, Y., Wang, B., Chen, B., Xiao, Z., & Dai, J. (2008) · Journal of Molecular Medicine · doi:10.1007/s00109-008-0372-9 · Cited by 46 · see citing works
Almolki, A., Arnoux, A., Gołda, S., Boyer, L., Benallaoua, M., Amara, N., Bachoual, R., Martin, C., Rannou, F., Lanone, S., et al. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070863 · Cited by 41 · see citing works
Self-citationAltavilla, D., Galeano, M., Bitto, A., Minutoli, L., Squadrito, G., Seminara, P., Venuti, F. S., Torre, V., Calò, M., Colonna, M. R., et al. (2005) · Shock · doi:10.1097/01.shk.0000168523.37796.89 · Cited by 38 · see citing works
Heme oxygenase in the retina in diabetes
Cukiernik, M., Mukherjee, S., Downey, D. B., & Chakabarti, S. (2003) · Current Eye Research · doi:10.1076/ceyr.27.5.301.17227 · Cited by 38 · see citing works
Oksala, N., Lappalainen, J., Laaksonen, D. E., Khanna, S., Kaarniranta, K., Sen, C. K., & Atalay, M. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.1450 · Cited by 37 · see citing works
Moreira, T. J., Cebere, A., Cebers, G., Östenson, C., Efendić, S., & Liljequist, S. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600479 · Cited by 35 · see citing works
Macrophage-Derived Heme-Oxygenase-1: Expression, Regulation, and Possible Functions in Skin Repair
Kämpfer, H., Kolb, N., Manderscheid, M., Wetzler, C., Pfeilschifter, J. M., & Frank, S. (2001) · Molecular Medicine · doi:10.1007/bf03401854 · Cited by 33 · see citing works
Song, J., Sumiyoshi, S., Nakashima, Y., Doi, Y., Iida, M., Kiyohara, Y., & Sueishi, K. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.05.057 · Cited by 30 · see citing works
Induction of heme oxygenase 1 in liver of spontaneously diabetic rats
Cosso, L., Maineri, E. P., Traverso, N., Rosatto, N., Pronzato, M. A., Cottalasso, D., Marinari, U. M., & Odetti, P. R. (2001) · Free Radical Research · doi:10.1080/10715760100300171 · Cited by 29 · see citing works
da Silva, J.-L., Stoltz, R. A., Dunn, M. W., Abraham, N. G., & Shibahara, S. (1997) · Current Eye Research · doi:10.1076/ceyr.16.4.380.10695 · Cited by 25 · see citing works
Drukała, J., Bandura‐Morgan, L., Cieślik, K., & Korohoda, W. (2001) · Cell Transplantation · doi:10.3727/000000001783986251 · Cited by 21 · see citing works
Angiogenesis meets immunology: Cytokine gene therapy of cancer
Minuzzo, S. A., Moserle, L., Indraccolo, S., & Amadori, A. (2007) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2006.12.008 · Cited by 21 · see citing works
Dickens, S., Vermeulen, P., Hendrickx, B., den Berge, S. V., & Vranckx, J. J. (2008) · Tissue Engineering Part A · doi:10.1089/ten.a.2007.0060 · Cited by 20 · see citing works
Rossi, S., D’Amico, M., Capuano, A., Romano, M., Petronella, P., & Filippo, C. D. (2006) · Mediators of Inflammation · doi:10.1155/mi/2006/60285 · Cited by 19 · see citing works
Approach to skin ulcers in older patients.
Frank, C. (2004) · PubMed · Cited by 15 · see citing works
Singh, H., Abdullah, A., & Herndon, D. N. (1992) · Journal of Burn Care & Rehabilitation · doi:10.1097/00004630-199211000-00002 · Cited by 12 · see citing works
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Krzyszczyk, P., Schloss, R. S., Palmer, A. F., & Francois Berthiaume, B. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00419 · Cited by 1,562 · see citing works
Guan, Y., Niu, H. M., Liu, Z., Dang, Y., Shen, J., Zayed, M. A., Ma, L., & Guan, J. (2021) · Science Advances · doi:10.1126/sciadv.abj0153 · Cited by 649 · see citing works
MAIT cells are imprinted by the microbiota in early life and promote tissue repair
Constantinides, M. G., Link, V. M., Tamoutounour, S., Wong, A. C., Perez-Chaparro, P. J., Han, S.-J., Chen, Y. E., Li, K., Farhat, S., Weckel, A., et al. (2019) · Science · doi:10.1126/science.aax6624 · Cited by 567 · see citing works
Free radical biology and medicine
(2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00484-2 · Cited by 549 · see citing works
Targeting heme oxygenase-1 and carbon monoxide for therapeutic modulation of inflammation
Ryter, S. W., & Choi, A. M. K. (2015) · Translational research · doi:10.1016/j.trsl.2015.06.011 · Cited by 363 · see citing works
Heme Oxygenase-1/Carbon Monoxide
Ryter, S. W., & Choi, A. M. K. (2009) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2009-0170tr · Cited by 309 · see citing works
Heme Oxygenases in Cardiovascular Health and Disease
Ayer, A., Zarjou, A., Agarwal, A., & Stocker, R. (2016) · Physiological Reviews · doi:10.1152/physrev.00003.2016 · Cited by 243 · see citing works
HO-1 Induction in Cancer Progression: A Matter of Cell Adaptation
Nitti, M., Piras, S., Marinari, U. M., Moretta, L., Pronzato, M. A., & Furfaro, A. L. (2017) · Antioxidants · doi:10.3390/antiox6020029 · Cited by 222 · see citing works
Kim, Y., Pae, H., Park, J. E., Lee, Y. C., Woo, J. M., Kim, N., Choi, Y. K., Lee, B.-S., Kim, S. R., & Chung, H. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3153 · Cited by 222 · see citing works
Heme Oxygenase-1 and Carbon Monoxide in the Heart
Otterbein, L. E., Foresti, R., & Motterlini, R. (2016) · Circulation Research · doi:10.1161/circresaha.116.306588 · Cited by 215 · see citing works
Curcumin-induced angiogenesis hastens wound healing in diabetic rats
Kant, V., Gopal, A., Kumar, D., Pathak, N. N., Ram, M., Jangir, B. L., Tandan, S. K., & Kumar, D. (2014) · Journal of Surgical Research · doi:10.1016/j.jss.2014.10.019 · Cited by 217 · see citing works
Cellular and molecular mechanisms of inflammation‐induced angiogenesis
Szade, A., Grochot‐Przeczek, A., Florczyk, U., Józkowicz, A., & Dulak, J. (2015) · IUBMB Life · doi:10.1002/iub.1358 · Cited by 199 · see citing works
Self-citationNew Insights into Intracellular Locations and Functions of Heme Oxygenase-1
Dunn, L., Midwinter, R. G., Ni, J., Hamid, H. A., Parish, C. R., & Stocker, R. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5675 · Cited by 175 · see citing works
Vitamin C promotes wound healing through novel pleiotropic mechanisms
Mohammed, B. M., Fisher, B. J., Kraskauskas, D., Ward, S. I., Wayne, J. S., Brophy, D. F., Fowler, A. A., Yager, D. R., & Natarajan, R. (2015) · International Wound Journal · doi:10.1111/iwj.12484 · Cited by 170 · see citing works
Wound Administration of M2-Polarized Macrophages Does Not Improve Murine Cutaneous Healing Responses
Jetten, N., Roumans, N., Gijbels, M. J., Romano, A., Post, M. J., de Winther, M. P. J., van der Hulst, R. R. W. J., & Xanthoulea, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102994 · Cited by 162 · see citing works
Skrzypek, K., Tertil, M., Gołda, S., Cieśla, M., Węglarczyk, K., Collet, G., Guichard, A., Kozakowska, M., Boczkowski, J., Waś, H., et al. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5184 · Cited by 145 · see citing works
Self-citationHaem oxygenase-1: non-canonical roles in physiology and pathology
Grochot‐Przeczek, A., Dulak, J., & Józkowicz, A. (2011) · Clinical Science · doi:10.1042/cs20110147 · Cited by 145 · see citing works
Self-citationMaamoun, H., Tarek, B., Pintus, G., Munusamy, S., & Agouni, A. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00070 · Cited by 141 · see citing works
Lima, C. F., Pereira‐Wilson, C., & Rattan, S. I. S. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000221 · Cited by 136 · see citing works
Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis
Muliaditan, T., Caron, J., Okesola, M., Opzoomer, J. W., Kosti, P., Georgouli, M., Gordon, P., Lall, S. K., Kuzeva, D. M., Pedro, L., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05346-7 · Cited by 133 · see citing works
Lowe, D. T. (2017) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2017.09.008 · Cited by 122 · see citing works
Heme Oxygenase-1 Inhibits Myoblast Differentiation by Targeting Myomirs
Kozakowska, M., Cieśla, M., Stefanska, A., Skrzypek, K., Waś, H., Jaźwa, A., Grochot‐Przeczek, A., Kotlinowski, J., Szymula, A., Bartelik, A., et al. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.3964 · Cited by 119 · see citing works
Self-citationBeneficial Effects of Green Tea EGCG on Skin Wound Healing: A Comprehensive Review
Xu, F.-W., Lv, Y.-L., Zhong, Y., Xue, Y., Wang, Y., Zhang, L., Hu, X. M., & Tan, W. (2021) · Molecules · doi:10.3390/molecules26206123 · Cited by 123 · see citing works
Role of Heme Oxygenase-1 in Human Endothelial Cells
Taha, H., Skrzypek, K., Guevara, I., Nigisch, A., Mustafa, S., Grochot‐Przeczek, A., Ferdek, P. E., Waś, H., Kotlinowski, J., Kozakowska, M., et al. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.207316 · Cited by 107 · see citing works
Self-citationRedox Functions of Heme Oxygenase-1 and Biliverdin Reductase in Diabetes
Rochette, L., Zeller, M., Cottin, Y., & Vergely, C. (2017) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2017.11.005 · Cited by 103 · see citing works
Therapeutic angiogenesis for revascularization in peripheral artery disease
Grochot‐Przeczek, A., Dulak, J., & Józkowicz, A. (2013) · Gene · doi:10.1016/j.gene.2013.03.097 · Cited by 90 · see citing works
Self-citationHeme Oxygenase, Inflammation, and Fibrosis: The Good, the Bad, and the Ugly?
Lundvig, D. M. S., Immenschuh, S., & Wagener, F. A. D. T. G. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00081 · Cited by 86 · see citing works
Topical application of substance P promotes wound healing in streptozotocin-induced diabetic rats
Kant, V., Kumar, D., Kumar, D., Prasad, R., Gopal, A., Pathak, N. N., Kumar, P., & Tandan, S. K. (2015) · Cytokine · doi:10.1016/j.cyto.2014.12.015 · Cited by 79 · see citing works
Cao, X., Chen, Y., Zhang, J., You, M., Wang, K., & Hu, F. (2017) · Phytomedicine · doi:10.1016/j.phymed.2017.06.001 · Cited by 76 · see citing works
The Multifunctional Role and Therapeutic Potential of HO-1 in the Vascular Endothelium
Calay, D., & Mason, J. C. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5659 · Cited by 73 · see citing works
Proximal tubule-targeted heme oxygenase-1 in cisplatin-induced acute kidney injury
Bolisetty, S., Traylor, A., Joseph, R., Zarjou, A., & Agarwal, A. (2015) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00335.2015 · Cited by 70 · see citing works
Hormesis: Wound healing and keratinocytes
Calabrese, E. J., Dhawan, G., Kapoor, R., Agathokleous, E., & Calabrese, V. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106393 · Cited by 66 · see citing works
Hasegawa‐Moriyama, M., Kurimoto, T., Nakama, M., Godai, K., Kojima, M., Kuwaki, T., & Kanmura, Y. (2013) · Pain · doi:10.1016/j.pain.2013.04.039 · Cited by 63 · see citing works
Exendin-4, a glucagon-like peptide-1 analogue, accelerates diabetic wound healing
Roan, J., Cheng, H.-N., Young, C.-C., Lee, C.-J., Yeh, M., Luo, C.-Y., Tsai, Y.-S., & Lam, C.-F. (2016) · Journal of Surgical Research · doi:10.1016/j.jss.2016.09.024 · Cited by 60 · see citing works
Targeting angiogenesis in Duchenne muscular dystrophy
Podkalicka, P., Mucha, O., Dulak, J., & Łoboda, A. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03006-7 · Cited by 57 · see citing works
Self-citationHaem oxygenase-1 and cardiovascular disease: mechanisms and therapeutic potential
Chan, K. H., Ng, M., & Stocker, R. (2011) · Clinical Science · doi:10.1042/cs20100508 · Cited by 54 · see citing works
Grochot‐Przeczek, A., Kotlinowski, J., Kozakowska, M., Starowicz, K., Jagodzinska, J., Stachurska, A., Volger, O. L., Bukowska-Straková, K., Florczyk, U., Tertil, M., et al. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5426 · Cited by 53 · see citing works
Self-citationNegi, G., Nakkina, V., Kamble, P., & Sharma, S. S. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.09.014 · Cited by 50 · see citing works
Hemostatic and Wound Healing Properties ofChromolaena odorataLeaf Extract
Pandith, H., Zhang, X., Liggett, J. L., Min, K., Gritsanapan, W., & Baek, S. J. (2013) · ISRN Dermatology · doi:10.1155/2013/168269 · Cited by 50 · see citing works
Heme Oxygenase-1 Influences Satellite Cells and Progression of Duchenne Muscular Dystrophy in Mice
Pietraszek‐Gremplewicz, K., Kozakowska, M., Bronisz-Budzyńska, I., Cieśla, M., Mucha, O., Podkalicka, P., Madej, M., Głowniak-Kwitek, U., Szade, K., Stępniewski, J., et al. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7435 · Cited by 50 · see citing works
Self-citationJaźwa, A., Stępniewski, J., Zamykal, M., Jagodzinska, J., Meloni, M., Emanueli, C., Józkowicz, A., & Dulak, J. (2012) · Cardiovascular Research · doi:10.1093/cvr/cvs284 · Cited by 49 · see citing works
Self-citationKnockdown of heme oxygenase-2 impairs corneal epithelial cell wound healing
Halilovic, A., Patil, K., Bellner, L., Marrazzo, G., Castellano, K., Cullaro, G., Dunn, M. W., & Schwartzman, M. L. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22502 · Cited by 47 · see citing works
Waś, H., Sokołowska, M., Bartelik, A., Dominik, P., Skrzypek, K., Lackowska, B., Pratnicki, A., Grochot‐Przeczek, A., Taha, H., Kotlinowski, J., et al. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.07.025 · Cited by 47 · see citing works
Self-citationHormesis: wound healing and fibroblasts
Calabrese, E. J., Dhawan, G., Kapoor, R., Agathokleous, E., & Calabrese, V. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106449 · Cited by 46 · see citing works
Nazari, M., Taremi, S., Elahi, R., Mostanadi, P., & Esmaeilzadeh, A. (2024) · Stem Cell Reviews and Reports · doi:10.1007/s12015-024-10806-3 · Cited by 46 · see citing works
Wound healing activity of carbon monoxide liberated from CO-releasing molecule (CO-RM)
Ahanger, A. A., Prawez, S., Kumar, D., Prasad, R., Amarpal, Tandan, S. K., & Kumar, D. (2011) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-011-0653-7 · Cited by 46 · see citing works
Park, N.-Y., & Lim, Y. (2011) · Nutrition & Metabolism · doi:10.1186/1743-7075-8-80 · Cited by 46 · see citing works
Costantini, E., Sinjari, B., D’Angelo, C., Murmura, G., Reale, M., & Caputi, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092108 · Cited by 42 · see citing works
Tomczyk, M., Kraszewska, I., Szade, K., Bukowska-Straková, K., Meloni, M., Józkowicz, A., Dulak, J., & Jaźwa, A. (2017) · Basic Research in Cardiology · doi:10.1007/s00395-017-0629-y · Cited by 41 · see citing works
Self-citationZrelli, H., Kusunoki, M., & Miyazaki, H. (2015) · Phytotherapy Research · doi:10.1002/ptr.5339 · Cited by 41 · see citing works
Godai, K., Hasegawa‐Moriyama, M., Kurimoto, T., Saito, T., Yamada, T., Sato, T., Kojima, M., & Kanmura, Y. (2014) · Molecular Pain · doi:10.1186/1744-8069-10-36 · Cited by 40 · see citing works
Antioxidant Activities of Natural Compounds from Caribbean Plants to Enhance Diabetic Wound Healing
Accipe, L., Abadie, A., Nevière, R., & Bercion, S. (2023) · Antioxidants · doi:10.3390/antiox12051079 · Cited by 40 · see citing works
Horiba, M., Kamiya, T., Hara, H., & Adachi, T. (2017) · Scientific Reports · doi:10.1038/srep42208 · Cited by 38 · see citing works
Redox regulation of gasotransmission in the vascular system: A focus on angiogenesis
Mistry, R. K., & Brewer, A. C. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.04.025 · Cited by 37 · see citing works
Heme oxygenase-1 in neovascularisation: A diabetic perspective
Grochot‐Przeczek, A., Dulak, J., & Józkowicz, A. (2010) · Thrombosis and Haemostasis · doi:10.1160/th09-12-0825 · Cited by 37 · see citing works
Self-citationAlmeida, A., Soares, N., Vieira, M., Gramsbergen, J., & Vieira, H. (2016) · PLoS ONE · doi:10.1371/journal.pone.0154781 · Cited by 33 · see citing works
Ali, Z. E., Ollivier, A., Manin, S., Rivard, M., Motterlini, R., & Foresti, R. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101521 · Cited by 36 · see citing works
Critical Role of 5-Lipoxygenase and Heme Oxygenase-1 in Wound Healing
Brogliato, A. R., Moor, A. N., Kesl, S., Guilherme, R. F., Georgii, J. L., Peters-Golden, M. L., Canetti, C. D. A., Gould, L. J., & Benjamim, C. F. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.493 · Cited by 35 · see citing works
Heme Oxygenase-1 as Therapeutic Target for Diabetic Foot Ulcers
Leal, E. C., & Carvalho, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231912043 · Cited by 34 · see citing works
Liu, F.-C., Yu, H., Hwang, T., & Tsai, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0053203 · Cited by 33 · see citing works
Argon Mitigates Impaired Wound Healing Process and Enhances Wound Healing In Vitro and In Vivo
Ning, J., Zhao, H., Chen, B., Mi, E., Yang, Z. L., Qing, W., Lam, K. W. J., Yi, B., Chen, Q., Gu, J., et al. (2019) · Theranostics · doi:10.7150/thno.29361 · Cited by 33 · see citing works
Heme oxygenase-1 in protozoan infections: A tale of resistance and disease tolerance
Silva, R. C. M. C., Travassos, L. H., Paiva, C. N., & Bozza, M. T. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008599 · Cited by 32 · see citing works
Hemin attenuated oxidative stress and inflammation to improve wound healing in diabetic rats
Kumar, D., Jena, G. R., Ram, M., Lingaraju, M. C., Singh, V., Prasad, R., Kumawat, S., Kant, V., Gupta, P., Kumar, D., et al. (2019) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-019-01682-7 · Cited by 31 · see citing works
The Heme-Heme Oxygenase System in Wound Healing; Implications for Scar Formation
Wagener, F. A. D. T. G., Scharstuhl, A., Tyrrell, R. M., den Hoff, J. W. V., Józkowicz, A., Dulak, J., Rüssel, F. G. M., & Kuijpers‐Jagtman, A. M. (2010) · Current Drug Targets · doi:10.2174/1389450111009011571 · Cited by 31 · see citing works
Self-citationPro-healing potential of hemin: An inducer of heme oxygenase-1
Ahanger, A. A., Prawez, S., Leo, M. D., Kathirvel, K., Kumar, D., Tandan, S. K., & Malik, J. K. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.06.048 · Cited by 30 · see citing works
Novel Insights into the Vasoprotective Role of Heme Oxygenase‐1
Marcantoni, E., Francesco, L. D., Dovizio, M., Bruno, A., & Patrignani, P. (2012) · International Journal of Hypertension · doi:10.1155/2012/127910 · Cited by 30 · see citing works
Bauer, A., Mylroie, H., Thornton, C. C., Calay, D., Birdsey, G. M., Kiprianos, A. P., Wilson, G. K., Soares, M. P., Yin, X., Mayr, M., et al. (2016) · Scientific Reports · doi:10.1038/srep29417 · Cited by 29 · see citing works
Krzyszczyk, P., Kang, H. J., Kumar, S., Meng, Y., O'Reggio, M. D., Patel, K. P., Pires, I. S., Yarmush, M. L., Schloss, R. S., Palmer, A. F., et al. (2020) · Wound Repair and Regeneration · doi:10.1111/wrr.12814 · Cited by 28 · see citing works
The metabolic landscape in chronic rotator cuff tear reveals tissue‐region‐specific signatures
Olie, C. S., van Zeijl, R. J. M., el Abdellaoui, S., Kolk, A., Overbeek, C. L., Nelissen, R. G. H. H., Heijs, B., & Raz, V. (2021) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12873 · Cited by 27 · see citing works
Choi, D. S., Kim, S., Lim, Y., Gwon, H., Park, J. S., Nho, Y., & Kwon, J. (2012) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-012-0036-2 · Cited by 27 · see citing works
Cremers, N. A. J., SUTTORP, M. J., Gerritsen, M. M., Wong, R. J., Breda, C. V. R., van Dam, G. M., Brouwer, K. M., Kuijpers‐Jagtman, A. M., Carels, C. E. L., Lundvig, D. M. S., et al. (2015) · Frontiers in Medicine · doi:10.3389/fmed.2015.00086 · Cited by 27 · see citing works
Nowak, W. N., Borys, S., Kusińska, K., Bukowska-Straková, K., Witek, P., Koblik, T., Józkowicz, A., Malecki, M. T., & Dulak, J. (2013) · Journal of Diabetes Investigation · doi:10.1111/jdi.12131 · Cited by 24 · see citing works
Self-citationLoPresti, S. T., Popovic, B., Kulkarni, M., Skillen, C. D., & Brown, B. N. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119376 · Cited by 24 · see citing works
Tendera, M., Cybulski, W., Zuba‐Surma, E. K., Szade, K., Florczyk, U., Kozakowska, M., Szymula, A., Krzych, Ł. J., Pasławska, U., Pasławski, R., et al. (2012) · Thrombosis and Haemostasis · doi:10.1160/th12-05-0303 · Cited by 23 · see citing works
Self-citationDeSouza-Vieira, T. S., Iniguez, E., Serafim, T. D., de Castro, W., Karmakar, S., Disotuar, M. M., Cecílio, P., Lacsina, J. R., Meneses, C., Nagata, B. M., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108317 · Cited by 22 · see citing works
Kozakowska, M., Kotlinowski, J., Grochot‐Przeczek, A., Cieśla, M., Pilecki, B., Derlacz, R., Dulak, J., & Józkowicz, A. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0063-8 · Cited by 22 · see citing works
Self-citationHolowiecki, A., O'Shields, B., & Jenny, M. J. (2016) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2016.09.022 · Cited by 22 · see citing works
Mangiferin alleviates hyperglycemia-induced endothelial impairment via Nrf2 signaling pathway
Jayasuriya, R., & Ramkumar, K. M. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175359 · Cited by 19 · see citing works
Peripheral Nerve Block Facilitates Acute Inflammatory Responses Induced by Surgical Incision in Mice
Yamada, T., Hasegawa‐Moriyama, M., Kurimoto, T., Saito, T., Kuwaki, T., & Kanmura, Y. (2016) · Regional Anesthesia & Pain Medicine · doi:10.1097/aap.0000000000000458 · Cited by 19 · see citing works
Cytoprotective responses in HaCaT keratinocytes exposed to high doses of curcumin
Lundvig, D. M. S., Pennings, S. W. C., Brouwer, K. M., Mtaya, M., Mugonzibwa, E. A., Kuijpers‐Jagtman, A. M., Wagener, F. A. D. T. G., & den Hoff, J. W. V. (2015) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.06.002 · Cited by 19 · see citing works
Heme catabolism and heme oxygenase-1-expressing myeloid cells in pathophysiology
Consonni, F. M., Incerti, M., Bertolotti, M., Ballerini, G., Garlatti, V., & Sica, A. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1433113 · Cited by 19 · see citing works
Carbon Monoxide in Plasma and Agriculture: Just a Foe or a Potential Friend?
Carbone, E., & Douat, C. (2018) · Plasma Medicine · doi:10.1615/plasmamed.2018024519 · Cited by 17 · see citing works
Honey Therapy in Diabetic Foot Ulcers: A Promising Strategy for Effective Wound Healing
Bezerra, A. B. G., Fonseca, H., Rodrigues, F., Delerue-Matos, C. M., Gouvinhas, I., & Garcia, J. (2023) · Applied Sciences · doi:10.3390/app132312820 · Cited by 17 · see citing works
Khorsandi, K., Fekrazad, R., & Hamblin, M. R. (2021) · Journal of Biophotonics · doi:10.1002/jbio.202100005 · Cited by 17 · see citing works
Kotlinowski, J., Grochot‐Przeczek, A., Taha, H., Kozakowska, M., Pilecki, B., Skrzypek, K., Bartelik, A., Derlacz, R., Horrevoets, A. J. G., Pap, A., et al. (2014) · Cardiovascular Diabetology · doi:10.1186/s12933-014-0150-7 · Cited by 16 · see citing works
Self-citationLiu, F.-C., Hwang, T., Lau, Y., & Yu, H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025907 · Cited by 15 · see citing works
The Role of Heme Oxygenase-1 in Remote Ischemic and Anesthetic Organ Conditioning
Bauer, I., & Raupach, A. (2019) · Antioxidants · doi:10.3390/antiox8090403 · Cited by 15 · see citing works
Zheng, R., Heck, D. E., Black, A. T., Gow, A., Laskin, D., & Laskin, J. (2013) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2013.10.011 · Cited by 15 · see citing works
Terenzi, D., Bakbak, E., Teoh, H., Krishnaraj, A., Puar, P., Rotstein, O., Cosentino, F., Goldenberg, R. M., Verma, S., & Hess, D. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvae016 · Cited by 10 · see citing works
Kaminski, T. W., Sivanantham, A., Mozhenkova, A., Smith, A., Ungarala, R., Dubey, R. K., Shrestha, B., Hanway, C., Katoch, O., Tejero, J., et al. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00386.2023 · Cited by 13 · see citing works
Delayed cutaneous wound closure in HO ‐2 deficient mice despite normal HO ‐1 expression
Lundvig, D. M. S., Scharstuhl, A., Cremers, N. A. J., Pennings, S. W. C., Paske, J. T., van Rheden, R. E. M., Breda, C. V. R., Regan, R. F., Rüssel, F. G. M., Carels, C. E. L., et al. (2014) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12389 · Cited by 13 · see citing works
Emad, A. M., Mahrous, E. A., Rasheed, D. M., Gomaa, F. A. M., Hamdan, A. M., Selim, H. M. R. M., Yousef, E. M., Abo-Zalam, H. B., El-Gazar, A. A., & Ragab, G. M. (2024) · Pharmaceuticals · doi:10.3390/ph17060733 · Cited by 11 · see citing works
Jennewein, M., Bubel, M., Guthörl, S., Metzger, W., WEIGERT, M. G., Pohlemann, T., & Oberringer, M. (2016) · Cell and Tissue Research · doi:10.1007/s00441-016-2391-0 · Cited by 11 · see citing works
Li, Q., Liang, S., Lai, Q., Shen, L., Zhang, Y., & Guo, R. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.10646 · Cited by 10 · see citing works
Unknown biological effects of l-glucose, ALA, and PUFA
Yamada, K., Sato, D., Nakamura, T., Amano, H., & Morimoto, Y. (2017) · The Journal of Physiological Sciences · doi:10.1007/s12576-017-0544-x · Cited by 9 · see citing works
Bednarz, A., Lipiński, P., Starzyński, R. R., Tomczyk, M., Kraszewska, I., Herman, S., Kowalski, K., Gruca, E., Jończy, A., Mazgaj, R., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207754 · Cited by 7 · see citing works
Heme oxygenase-2 suppresses acute inflammation and improves the survival of skin allografts
Chen, R., Wang, Z., Chen, Q., Zhang, T.-Y., Zhu, Y., Xian, X., & Han, X. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.08.009 · Cited by 8 · see citing works
Effects of Remote Ischemic Preconditioning on Heme Oxygenase-1 Expression and Cutaneous Wound Repair
Cremers, N. A. J., Wever, K. E., Wong, R. J., van Rheden, R. E. M., Vermeij, E. A., Dam, G. M. V., Carels, C. E. L., Lundvig, D. M. S., & Wagener, F. A. D. T. G. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18020438 · Cited by 7 · see citing works
HIF‐2α/ARNT complex regulates hair development via induction of p21 Waf1/Cip1 and p27 Kip1
Imamura, Y., Tomita, S., Imanishi, M., Kihira, Y., Ikeda, Y., Ishizawa, K., Tsuchiya, K., & Tamaki, T. (2014) · The FASEB Journal · doi:10.1096/fj.13-244079 · Cited by 6 · see citing works
Paradoxical effects of heme arginate on survival of myocutaneous flaps
Edmunds, M.-C., Czopek, A., Wigmore, S. J., & Kluth, D. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00240.2013 · Cited by 6 · see citing works
- Authors
- Grochot-Przeczek, A., Lach, R., Mis, J., Skrzypek, K., Gozdecka, M., Sroczynska, P., Dubiel, M., Rutkowski, A., Kozakowska, M., Zagorska, A., Walczynski, J., Was, H., Kotlinowski, J., Drukala, J., Kurowski, K., Kieda, C., Herault, Y., Dulak, J., & Jozkowicz, A.
- Affiliations
- Jagiellonian University (PL)
- Adamed (Poland) (PL)
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2009-06-04
- Volume
- 4
- Issue
- 6
- Pages
- e5803
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC2686151
- OpenAlex
- W2135022152
- Cited by
- 131
- References
- 79
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 5 · 2023: 5 · 2022: 7 · 2021: 9 · 2020: 5 · 2019: 9 · 2018: 9 · 2017: 12 · 2016: 8 · 2015: 10 · 2014: 8 · 2013: 14 · 2012: 7
- FWCI
- 3.49
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Homo Politicus (Academy of Humanities and Economics in Lodz) (submittedVersion, cc-by)
- HAL (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Wellcome Trust
- European Commission
- Fundacja na rzecz Nauki Polskiej
- Institut National Du Cancer
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heme Oxygenase-1 and Carbon Monoxide
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- heme oxygenase-1, skin wound healing, neovascularization, angiogenesis, re-epithelialization, tin protoporphyrin IX, keratinocytes, diabetic wound healing, db/db mice, adenoviral gene transfer, transgenic mice
- MeSH terms
- Adenoviridae, Animals, Anti-Inflammatory Agents, Diabetes Mellitus, Experimental, Humans, Inflammation, Keratins, Mice, Inbred C57BL, Promoter Regions, Genetic, Wound Healing, Gene Transfer Techniques, Transgenes, Angiogenesis Inhibitors, Mice, Heme Oxygenase-1
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