Hypothesis: The Psychedelic Ayahuasca Heals Traumatic Memories via a Sigma 1 Receptor-Mediated Epigenetic-Mnemonic Process

Inserra, Antonio

doi:10.3389/fphar.2018.00330

Cited by 91Psychedelics and Drug StudiesPharmacological Receptor Mechanisms and EffectsPosttraumatic Stress Disorder Research

Hypothesis: The Psychedelic Ayahuasca Heals Traumatic Memories via a Sigma 1 Receptor-Mediated Epigenetic-Mnemonic Process

Open access

Inserra, Antonio·2018·Frontiers in Pharmacology

DOI 10.3389/fphar.2018.00330PMC PMC5895707

Open this paper in CoChat — free account Open PDF

Abstract

-Dimethyltryptamine (DMT, one of the alkaloids in Ayahuasca) activates sigma 1 receptor (SIGMAR1) and others. SIGMAR1 is a multi-faceted stress-responsive receptor which promotes cell survival, neuroprotection, neuroplasticity, and neuroimmunomodulation. Simultaneously, monoamine oxidase inhibitors (MAOIs) also present in Ayahuasca prevent the degradation of DMT. One peculiarity of SIGMAR1 activation and MAOI activity is the reversal of mnemonic deficits in pre-clinical models. Since traumatic memories in post-traumatic stress disorder (PTSD) are often characterised by "repression" and PTSD patients ingesting Ayahuasca report the retrieval of such memories, it cannot be excluded that DMT-mediated SIGMAR1 activation and the concomitant MAOIs effects during Ayahuasca ingestion might mediate such "anti-amnesic" process. Here I hypothesise that Ayahuasca, via hyperactivation of trauma and emotional memory-related centres, and via its concomitant SIGMAR1- and MAOIs- induced anti-amnesic effects, facilitates the retrieval of traumatic memories, in turn making them labile (destabilised). As Ayahuasca alkaloids enhance synaptic plasticity, increase neurogenesis and boost dopaminergic neurotransmission, and those processes are involved in memory reconsolidation and fear extinction, the fear response triggered by the memory can be reprogramed and/or extinguished. Subsequently, the memory is stored with this updated significance. To date, it is unclear if new memories replace, co-exist with or bypass old ones. Although the mechanisms involved in memory are still debated, they seem to require the involvement of cellular and molecular events, such as reorganisation of homo and heteroreceptor complexes at the synapse, synaptic plasticity, and epigenetic re-modulation of gene expression. Since SIGMAR1 mobilises synaptic receptor, boosts synaptic plasticity and modulates epigenetic processes, such effects might be involved in the reported healing of traumatic memories in PTSD patients. If this theory proves to be true, Ayahuasca could come to represent the only standing pharmacological treatment which targets traumatic memories in PTSD. Lastly, since SIGMAR1 activation triggers both epigenetic and immunomodulatory programmes, the mechanism here presented could help understanding and treating other conditions in which the cellular memory is dysregulated, such as cancer, diabetes, autoimmune and neurodegenerative pathologies and substance addiction.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3389/fphar.2018.00330

Cites

131 of 131 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Activation of S1R by DMT has been suggested to stimulate synaptic plasticity in addition to 5-HT2AR-induced modulation and is likely responsible for ayahuasca's antidepressant effects.
“Activation of S1R by DMT has been suggested to stimulate synaptic plasticity in addition to 5-HT2AR-induced modulation and is likely responsible for ayahuasca's antidepressant effects (64, 102).”
From Psychedelics and Neuroplasticity: A Systematic Review Unraveling the Biological Underpinnings of Psychedelics. (2021) · cites this paper as [102]
The Abstract (page unavailable) says DMT activates SIGMAR1 and that SIGMAR1 boosts synaptic plasticity; the Introduction also says DMT binds 5-HT2A receptors. But the paper does not identify DMT-driven SIGMAR1 plasticity as the likely cause of ayahuasca’s antidepressant effects. In ‘Ayahuasca Ingestion Modulates Neurotransmission’ (page unavailable), it says only that neurotransmission changes could be involved in those effects. (LLM, conf=0.88)
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The cholinergic hypothesis of geriatric memory dysfunction
Bartus, R. T., Dean, R. L., Beer, B., & Lippa, A. S. (1982) · Science · doi:10.1126/science.7046051 · Cited by 5,545 · see citing works
Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+
Bootman, M. D., Missiaen, L., Parys, J. B., SMEDT, H. D., & Casteels, R. (1995) · Biochemical Journal · doi:10.1042/bj3060445 · Cited by 5,120 · see citing works
Memory - A century of consolidation
McGaugh, J. L. (2000) · Science · doi:10.1126/science.287.5451.248 · Cited by 4,250 · see citing works
The molecular biology of memory storage: a dialogue between genes and synapses
Kandel, E. R. (2001) · Science · doi:10.1126/science.1067020 · Cited by 3,917 · see citing works
Emotional processing in anterior cingulate and medial prefrontal cortex
Etkin, A., Egner, T., & Kalisch, R. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.11.004 · Cited by 3,059 · cited 3× · see citing works
“…that Ayahuasca creates a pattern of brain activity which is conducive to the recall and/or re-experiencing of traumatic memories, or memories that have a negative connotation (Phillips et al., 1998; Ullsperger et al., 2010; Etkin et al., 2011; Zhu et al., 2012; Tabei, 2015; Urgesi et al., 2016).”
Background
Synaptic Plasticity and Memory: An Evaluation of the Hypothesis
Martin, S. J., Grimwood, P. D., & Morris, R. G. M. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.649 · Cited by 2,794 · see citing works
Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval
Nader, K., Schafe, G. E., & Le Doux, J. E. (2000) · Nature · doi:10.1038/35021052 · Cited by 2,706 · see citing works
Epigenetics: A landscape takes shape
Goldberg, A. D., Allis, C. D., & Bernstein, E. (2007) · Cell · doi:10.1016/j.cell.2007.02.006 · Cited by 2,466 · see citing works
Reciprocal Limbic-Cortical Function and Negative Mood: Converging PET Findings in Depression and Normal Sadness
Mayberg, H. S., Liotti, M., Brannan, S. K., McGinnis, S., Mahurin, R. K., Jerabek, P. A., Silva, J. A., Tekell, J. L., Martin, C. C., Lancaster, J. L., et al. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.5.675 · Cited by 2,416 · see citing works
Sigma-1 Receptor Chaperones at the ER- Mitochondrion Interface Regulate Ca2+ Signaling and Cell Survival
Hayashi, T., & Su, T.-P. (2007) · Cell · doi:10.1016/j.cell.2007.08.036 · Cited by 1,826 · see citing works
Mechanisms of fear extinction
Myers, K. M., & Davis, M. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001939 · Cited by 1,277 · see citing works
Preventing the return of fear in humans using reconsolidation update mechanisms
Schiller, D., Monfils, M.-H., Raio, C. M., Johnson, D. C., LeDoux, J. E., & Phelps, E. A. (2010) · Nature · doi:10.1038/nature08637 · Cited by 1,248 · see citing works
Amygdala, medial prefrontal cortex, and hippocampal function in PTSD
SHIN, L. M., RAUCH, S. L., & PITMAN, R. K. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1364.007 · Cited by 1,203 · see citing works
Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin
Carhart-Harris, R. L., Erritzoe, D., Williams, T., Stone, J. M., Reed, L. J., Colasanti, A., Tyacke, R. J., Leech, R., Malizia, A. L., Murphy, K., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119598109 · Cited by 1,172 · see citing works
Cellular Memory and the Histone Code
Turner, B. M. (2002) · Cell · doi:10.1016/s0092-8674(02)01080-2 · Cited by 1,142 · see citing works
Purification, molecular cloning, and expression of the mammalian sigma1-binding site.
Hanner, M., Moebius, F. F., Flandorfer, A., Knaus, H. G., Striessnig, J., Kempner, E. S., & Glossmann, H. H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.15.8072 · Cited by 906 · see citing works
Neural responses to facial and vocal expressions of fear and disgust
Phillips, M. L., Young, A. W., Scott, S. K., Calder, A., Andrew, C., Giampietro, V., Williams, S., Bullmore, E. T., Brammer, M. J., & Gray, J. A. (1998) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1998.0506 · Cited by 817 · see citing works
Traumatic stress: effects on the brain
Bremner, J. D. (2006) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2006.8.4/jbremner · Cited by 738 · see citing works
The synaptic plasticity and memory hypothesis: encoding, storage and persistence
Takeuchi, T., Duszkiewicz, A. J., & Morris, R. (2013) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0288 · Cited by 664 · see citing works
Amphetamine, 3,4-Methylenedioxymethamphetamine, Lysergic Acid Diethylamide, and Metabolites of the Catecholamine Neurotransmitters Are Agonists of a Rat Trace Amine Receptor
Bunzow, J. R., Sonders, M. S., Arttamangkul, S., Harrison, L. M., Zhang, G., Quigley, D. I., Darland, T., Suchland, K. L., Pasumamula, S., Kennedy, J. L., et al. (2001) · Molecular Pharmacology · doi:10.1124/mol.60.6.1181 · Cited by 651 · see citing works
An Update on Memory Reconsolidation Updating
Lee, J. L. C., Nader, K., & Schiller, D. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2017.04.006 · Cited by 557 · see citing works
The Hallucinogen <i>N,N</i> -Dimethyltryptamine (DMT) Is an Endogenous Sigma-1 Receptor Regulator
Fontanilla, D., Johannessen, M., Hajipour, A. R., Cozzi, N. V., Jackson, M. B., & Ruoho, A. E. (2009) · Science · doi:10.1126/science.1166127 · Cited by 535 · see citing works
Neural correlates of traumatic memories in posttraumatic stress disorder: a functional MRI investigation
Lanius, R. A., Williamson, P. C., Densmore, M., Boksman, K., Gupta, M. A., Neufeld, R. W., Gati, J. S., & Menon, R. S. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.11.1920 · Cited by 521 · see citing works
Synapses and Memory Storage
Mayford, M., Siegelbaum, S. A., & Kandel, E. R. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005751 · Cited by 500 · see citing works
Antidepressant Effects of a Single Dose of Ayahuasca in Patients With Recurrent Depression: A SPECT Study
Sanches, R. F., de Lima Osório, F., dos Santos, R. G., Macedo, L. R. H., Maia-de-Oliveira, J. P., Wichert-Ana, L., de Araujo, D. B., Riba, J., Crippa, J. A. S., & Hallak, J. E. C. (2016) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000436 · Cited by 466 · see citing works
Conscious perception of errors and its relation to the anterior insula
Ullsperger, M., Harsay, H. A., Wessel, J. R., & Ridderinkhof, K. R. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0261-1 · Cited by 463 · see citing works
The Psychedelic State Induced by Ayahuasca Modulates the Activity and Connectivity of the Default Mode Network
Palhano-Fontes, F., Andrade, K. C., Tofoli, L. F., Santos, A. C., Crippa, J. A. S., Hallak, J. E. C., Ribeiro, S., & de Araujo, D. B. (2015) · PLOS ONE · doi:10.1371/journal.pone.0118143 · Cited by 454 · see citing works
Human pharmacology of ayahuasca: Subjective and cardiovascular effects, monoamine metabolite excretion, and pharmacokinetics
Riba, J., Valle, M., Urbano, G., Yritia, M., Morte, A., & Barbanoj, M. J. (2003) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.049882 · Cited by 390 · see citing works
Serotonin, via 5-HT2A receptors, increases EPSCs in layer V pyramidal cells of prefrontal cortex by an asynchronous mode of glutamate release
Aghajanian, G. K., & Marek, G. J. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01224-x · Cited by 376 · see citing works
Understanding the Role of GPCR Heteroreceptor Complexes in Modulating the Brain Networks in Health and Disease
Borroto‐Escuela, D. O., Carlsson, J., Ambrogini, P., Narváez, M., Wydra, K., Tarakanov, A. O., Li, X., Millón, C., Ferraro, L., Cuppini, R., et al. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00037 · Cited by 375 · see citing works
The history of the cholinergic hypothesis
Contestabile, A. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.12.044 · Cited by 373 · see citing works
Differential modulation of a common memory retrieval network revealed by positron emission tomography
Maguire, E. A., & Mummery, C. J. (1999) · Hippocampus · doi:10.1002/(sici)1098-1063(1999)9:1 · Cited by 362 · see citing works
Epigenetic Priming of Memory Updating during Reconsolidation to Attenuate Remote Fear Memories
Gräff, J., Joseph, N. F., Horn, M. E., Samiei, A., Meng, J., Seo, J., Rei, D., Bero, A. W., Phan, T. X., Wagner, F., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.020 · Cited by 357 · see citing works
The emerging field of epigenetics in neurodegeneration and neuroprotection
Hwang, J.-Y., Aromolaran, K. A., & Zukin, R. S. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.46 · Cited by 343 · see citing works
Different mechanisms of fear extinction dependent on length of time since fear acquisition
Myers, K. M., Ressler, K. J., & Davis, M. (2006) · Learning & Memory · doi:10.1101/lm.119806 · Cited by 334 · see citing works
What are memories made of? How Polycomb and Trithorax proteins mediate epigenetic memory
Steffen, P. A., & Ringrose, L. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3789 · Cited by 318 · see citing works
Phylogenetic Distribution of Fungal Sterols
Weete, J. D., Abril, M., & Blackwell, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010899 · Cited by 316 · see citing works
Influences of diet and the gut microbiome on epigenetic modulation in cancer and other diseases
Paul, B., Barnes, S., Demark-Wahnefried, W., Morrow, C., Salvador, C., Skibola, C., & Tollefsbol, T. O. (2015) · Clinical Epigenetics · doi:10.1186/s13148-015-0144-7 · Cited by 306 · see citing works
5-HT Modulation of Dopamine Release in Basal Ganglia in Psilocybin-Induced Psychosis in Man—A PET Study with [11C]raclopride
Vollenweider, F. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00108-0 · Cited by 305 · cited 2× · see citing works
“The authors suggested that, since psilocybin increases dopaminergic neurotransmission, and since drugs that increase dopamine availability are beneficial to fear extinction, psilocybin might be beneficial to fear extinction via enhancing dopaminergic neurotransmission (Aghajanian and Marek, 1999; Vollenweider et al.,…”
Background
Psychedelics and the Human Receptorome
Ray, T. S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009019 · Cited by 300 · see citing works
Positron Emission Tomography Measurement of Cerebral Metabolic Correlates of Yohimbine Administration in Combat-Related Posttraumatic Stress Disorder
Bremner, J. D. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830150070011 · Cited by 299 · see citing works
Memory formation, consolidation and transformation
Nadel, L., Hupbach, A., Gómez, R. L., & Newman-Smith, K. C. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.03.001 · Cited by 295 · see citing works
Sigma1 (σ1) receptor agonists and neurosteroids attenuate β25–35-amyloid peptide-induced amnesia in mice through a common mechanism
Maurice, T., Su, T., & Privat, A. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00405-3 · Cited by 291 · see citing works
Memory reconsolidation
Alberini, C. M., & LeDoux, J. E. (2013) · Current Biology · doi:10.1016/j.cub.2013.06.046 · Cited by 286 · see citing works
The Molecular Biology of Memory Storage: A Dialog Between Genes and Synapses
Kandel, E. R. (2004) · Bioscience Reports · doi:10.1007/s10540-005-2742-7 · Cited by 280 · see citing works
Co-activation of the amygdala, hippocampus and inferior frontal gyrus during autobiographical memory retrieval
Greenberg, D. L., Rice, H. J., Cooper, J. J., Cabeza, R., Rubin, D. C., & LaBar, K. S. (2005) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2004.09.002 · Cited by 273 · see citing works
Memory formation under stress: Quantity and quality
Schwabe, L., Wolf, O. T., & Oitzl, M. S. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.11.015 · Cited by 268 · see citing works
Effects of psilocybin on hippocampal neurogenesis and extinction of trace fear conditioning
Catlow, B. J., Song, S., Paredes, D. A., Kirstein, C. L., & Sanchez-Ramos, J. (2013) · Experimental Brain Research · doi:10.1007/s00221-013-3579-0 · Cited by 266 · see citing works
Cued and Contextual Fear Conditioning for Rodents
Rustay, N. R., Browman, K. E., & Curzon, P. (2008) · Frontiers in neuroscience · doi:10.1201/noe1420052343.ch2 · Cited by 254 · see citing works
The therapeutic potentials of Ayahuasca: possible effects against various diseases of civilization
Frecska, E., Bokor, P., & Winkelman, M. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00035 · Cited by 242 · see citing works
Increased frontal and paralimbic activation following ayahuasca, the pan-amazonian inebriant
Riba, J., Romero, S., Grasa, E., Mena, E., Carrió, I., & Barbanoj, M. J. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0358-7 · Cited by 241 · see citing works
The IκB Kinase Regulates Chromatin Structure during Reconsolidation of Conditioned Fear Memories
Lubin, F. D., & Sweatt, J. D. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.039 · Cited by 234 · see citing works
Ayahuasca: pharmacology, neuroscience and therapeutic potential
Domínguez-Clavé, E., Soler, J., Elices, M., Pascual, J. C., Álvarez, E., de la Fuente Revenga, M., Friedlander, P., Feilding, A., & Riba, J. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.03.002 · Cited by 226 · see citing works
Epigenetics of posttraumatic stress disorder: current evidence, challenges, and future directions
Zannas, A. S., Provençal, N., & Binder, E. B. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.04.003 · Cited by 218 · see citing works
Epigenetics, cellular memory and gene regulation
Henikoff, S., & Greally, J. M. (2016) · Current Biology · doi:10.1016/j.cub.2016.06.011 · Cited by 215 · see citing works
Dopamine and extinction: A convergence of theory with fear and reward circuitry
Abraham, A. D., Neve, K., & Lattal, K. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.11.007 · Cited by 211 · see citing works
Serotonin 5-Hydroxytryptamine2A Receptor Activation Suppresses Tumor Necrosis Factor-α-Induced Inflammation with Extraordinary Potency
Yu, B., Becnel, J., Zerfaoui, M., Rohatgi, R., Boulares, A. H., & Nichols, C. D. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.143461 · Cited by 211 · see citing works
Polycomb repression: from cellular memory to cellular proliferation and cancer
Jacobs, J. J. L., & van Lohuizen, M. (2002) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(02)00052-5 · Cited by 209 · see citing works
Dynamic Interaction between Sigma-1 Receptor and Kv1.2 Shapes Neuronal and Behavioral Responses to Cocaine
Kourrich, S., Hayashi, T., Chuang, J., Tsai, S., Su, T., & Bonci, A. (2013) · Cell · doi:10.1016/j.cell.2012.12.004 · Cited by 195 · see citing works
Psychedelic N,N-Dimethyltryptamine and 5-Methoxy-N,N-Dimethyltryptamine Modulate Innate and Adaptive Inflammatory Responses through the Sigma-1 Receptor of Human Monocyte-Derived Dendritic Cells
Szabo, A., Kovacs, A., Frecska, E., & Rajnavolgyi, E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106533 · Cited by 191 · see citing works
The alkaloids of Banisteriopsis caapi, the plant source of the Amazonian hallucinogen Ayahuasca, stimulate adult neurogenesis in vitro
Morales-García, J. A., de la Fuente Revenga, M., Alonso-Gil, S., Rodríguez-Franco, M. I., Feilding, A., Perez-Castillo, A., & Riba, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-05407-9 · Cited by 175 · see citing works
The role of hippocampus in memory: A hypothesis
Teyler, T. J., & DiScenna, P. G. (1985) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(85)90016-8 · Cited by 169 · see citing works
Reconsolidation of memory: A decade of debate
Besnard, A., Caboche, J., & Laroche, S. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.07.002 · Cited by 168 · see citing works
The role of the amygdala in the extinction of conditioned fear.
Barad, M., Gean, P., & Lutz, B. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.029 · Cited by 168 · see citing works
The Nuclear Envelope Protein Emerin Binds Directly to Histone Deacetylase 3 (HDAC3) and Activates HDAC3 Activity
Demmerle, J., Koch, A. J., & Holaska, J. M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.325308 · Cited by 168 · see citing works
Biology, Genetics, and Management of Ergot (Claviceps spp.) in Rye, Sorghum, and Pearl Millet
Miedaner, T., & Geiger, H. H. (2015) · Toxins · doi:10.3390/toxins7030659 · Cited by 164 · see citing works
A single dose of lysergic acid diethylamide influences gene expression patterns within the mammalian brain
Nichols, C. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00405-5 · Cited by 163 · see citing works
Localization of the CB1 type cannabinoid receptor in the rat basolateral amygdala: high concentrations in a subpopulation of cholecystokinin-containing interneurons
McDonald, A. J., & Mascagni, F. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00380-3 · Cited by 157 · cited 4× · see citing works
“Since CB1 receptors are enriched in the amygdala (one of the brain areas hyperactivated by Ayahuasca), and given that CB1 or NMDA agonists prevent fear expression during traumatic memory retrieval, this supports a role for Ayahuasca in the updating and reconsolidation of traumatic memories by modulating the fear respo…”
BackgroundInfluential
Plants of the Gods: Origins of Hallucinogenic Use
Brenan, J. P. M., Schultes, R. E., & Hofmann, A. (1980) · Kew Bulletin · doi:10.2307/4110029 · Cited by 154 · see citing works
Acute harmine administration induces antidepressive-like effects and increases BDNF levels in the rat hippocampus
Fortunato, J. J., Réus, G. Z., Kirsch, T. R., Stringari, R. B., Stertz, L., Kapczinski, F., Pinto, J. P., Hallak, J. E., Zuardi, A. W., Crippa, J. A., et al. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.07.021 · Cited by 150 · see citing works
Dissociative amnesia
Staniloiu, A., & Markowitsch, H. J. (2014) · The Lancet Psychiatry · doi:10.1016/s2215-0366(14)70279-2 · Cited by 148 · see citing works
Post-traumatic stress disorder and declarative memory functioning: a review
Samuelson, K. W. (2011) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2011.13.2/ksamuelson · Cited by 148 · see citing works
Agonist Properties of N,N-Dimethyltryptamine at Serotonin 5-HT2A and 5-HT2C Receptors
Smith, R. (1998) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(98)00110-5 · Cited by 147 · see citing works
3,4-Methylenedioxymethamphetamine facilitates fear extinction learning
Young, M. B., Andero, R., Ressler, K. J., & Howell, L. L. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.138 · Cited by 141 · see citing works
Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT
Dakic, V., Minardi Nascimento, J., Costa Sartore, R., Maciel, R. D. M., de Araujo, D. B., Ribeiro, S., Martins-de-Souza, D., & Rehen, S. K. (2017) · Scientific Reports · doi:10.1038/s41598-017-12779-5 · Cited by 134 · cited 2× · see citing works
“Significantly, the DMT analogue 5-methoxy-N,N-dimethyltryptamine as well as the synthetic psychedelic 2,5-Dimethoxy-4-iodoamphetamine downregulate this pathway, suggesting that DMT and Ayahuasca might present at least same degree of NFKB pathway modulation (Yu et al., 2008; Dakic et al., 2017).”
Background
High Occupancy of Sigma-1 Receptors in the Human Brain after Single Oral Administration of Fluvoxamine: A Positron Emission Tomography Study Using [11C]SA4503
Ishikawa, M., Ishiwata, K., Ishii, K., Kimura, Y., Sakata, M., Naganawa, M., Oda, K., Miyatake, R., Fujisaki, M., Shimizu, E., et al. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.04.001 · Cited by 132 · see citing works
Sigma-1 Receptor Chaperones and Diseases
Tsai, S., Hayashi, T., Mori, T., & Su, T. (2009) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/1871524910909030184 · Cited by 130 · see citing works
Epigenetic alterations in the lateral amygdala are required for reconsolidation of a Pavlovian fear memoryPreprint
Maddox, S. A., & Schafe, G. E. (2011) · Learning & Memory · doi:10.1101/lm.2243411 · Cited by 130 · see citing works
Sigma-1 receptor chaperones regulate the secretion of brain-derived neurotrophic factor
Fujimoto, M., Hayashi, T., Urfer, R., Mita, S., & Su, T.-P. (2012) · Synapse · doi:10.1002/syn.21549 · Cited by 124 · see citing works
The role of transmitter diffusion and flow versus extracellular vesicles in volume transmission in the brain neural–glial networks
Borroto‐Escuela, D. O., Agnati, L. F., Bechter, K., Jansson, A., Tarakanov, A. O., & Fuxé, K. (2015) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2014.0183 · Cited by 121 · see citing works
Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors
Albizu, L., Holloway, T., González-Maeso, J., & Sealfon, S. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.05.023 · Cited by 121 · see citing works
Functional brain imaging in 14 patients with dissociative amnesia reveals right inferolateral prefrontal hypometabolism
Brand, M., Eggers, C., Reinhold, N., Fujiwara, E., Kessler, J., Heiss, W., & Markowitsch, H. J. (2009) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2009.03.008 · Cited by 120 · see citing works
Decreased mental time travel to the past correlates with default-mode network disintegration under lysergic acid diethylamide
Speth, J., Speth, C., Kaelen, M., Schloerscheidt, A. M., Feilding, A., Nutt, D., & Carhart-Harris, R. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116628430 · Cited by 118 · see citing works
Hetero-dimerization of serotonin 5-HT2A and dopamine D2 receptors
Łukasiewicz, S., Polit, A., Kędracka–Krok, S., Wędzony, K., Maćkowiak, M., & Dziedzicka‐Wasylewska, M. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.08.010 · Cited by 118 · see citing works
Dissociation and memory fragmentation in post-traumatic stress disorder: An evaluation of the dissociative encoding hypothesis
Bedard-Gilligan, M., & Zoellner, L. A. (2012) · Memory · doi:10.1080/09658211.2012.655747 · Cited by 116 · cited 1× · see citing works
“It has been suggested that this mechanisms might be relevant to PTSD via the phenomenon of “dissociative encoding”, the insufficient encoding of the trauma memory following peritraumatic dissociation which prevents future re-elaboration of the traumatic memory (Bedard-Gilligan and Zoellner, 2012).”
Background
Sigma-1 receptor mediates cocaine-induced transcriptional regulation by recruiting chromatin-remodeling factors at the nuclear envelope
Tsai, S., Chuang, J., Tsai, M.-S., Wang, X.-F., Xi, Z., Hung, J., Chang, W., Bonci, A., & Su, T. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1518894112 · Cited by 115 · see citing works
Epigenetic mechanisms of memory formation and reconsolidation
Jarome, T. J., & Lubin, F. D. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.08.002 · Cited by 112 · see citing works
A possibly sigma-1 receptor mediated role of dimethyltryptamine in tissue protection, regeneration, and immunity.
Frecska, E., Szabo, A., Winkelman, M. J., Luna, L. E., & McKenna, D. J. (2013) · Journal of Neural Transmission · doi:10.1007/s00702-013-1024-y · Cited by 109 · cited 1× · see citing works
“SIGMAR1 is a transmembrane protein with neuroprotective, neurotrophic, and immunomodulatory properties found in high concentrations in limbic areas of the human brain and in immune cells (Ishikawa et al., 2007; Fujimoto et al., 2012; Frecska et al., 2013; Szabo et al., 2014).”
Background
PTSD-Like Memory Generated Through Enhanced Noradrenergic Activity is Mitigated by a Dual Step Pharmacological Intervention Targeting its Reconsolidation
Gazarini, L., Stern, C. A. J., Piornedo, R. R., Takahashi, R. N., & Bertoglio, L. J. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu026 · Cited by 102 · see citing works
Pyramidal Neurons in Rat Prefrontal Cortex Projecting to Ventral Tegmental Area and Dorsal Raphe Nucleus Express 5-HT2A Receptors
Vázquez, P. M., Cortés, R., & Artigas, F. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn204 · Cited by 102 · see citing works
Dopamine D2 and 5-hydroxytryptamine 5-HT2A receptors assemble into functionally interacting heteromers
Borroto‐Escuela, D. O., Romero‐Fernandez, W., Tarakanov, A. O., Marcellino, D. J., Ciruela, F., Agnati, L. F., & Fuxé, K. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.09.110 · Cited by 98 · see citing works
Voltage-gated sodium channel modulation by σ-receptors in cardiac myocytes and heterologous systems
Johannessen, M., Ramachandran, S., Riemer, L., Ramos-Serrano, A., Ruoho, A. E., & Jackson, M. B. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00431.2008 · Cited by 97 · see citing works
TRPV1 channels and the progesterone receptor Sig-1R interact to regulate pain
Ortíz-Rentería, M., Juárez-Contreras, R., González‐Ramírez, R., Islas, L. D., Sierra-Ramírez, F., Llorente, I., Simon, S. A., Hiriart, M., Rosenbaum, T., & Morales‐Lázaro, S. L. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1715972115 · Cited by 96 · see citing works
Hallucinogenic 5-HT2AR agonists LSD and DOI enhance dopamine D2R protomer recognition and signaling of D2-5-HT2A heteroreceptor complexes
Borroto‐Escuela, D. O., Romero‐Fernandez, W., Narváez, M., Oflijan, J., Agnati, L. F., & Fuxé, K. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.11.104 · Cited by 88 · see citing works
Epigenetic mechanisms in fear conditioning: Implications for treating post-traumatic stress disorder
Kwapis, J. L., & Wood, M. A. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.08.005 · Cited by 87 · see citing works
Memory Repression: Brain Mechanisms underlying Dissociative Amnesia
Kikuchi, H., Fujii, T., Abe, N., Suzuki, M., Takagi, M., Mugikura, S., Takahashi, S., & Mori, E. (2009) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2009.21212 · Cited by 85 · see citing works
Dynamic changes in prefrontal cortex gene expression following lysergic acid diethylamide administration
Nichols, C. D., Garcia, E. E., & Sanders-Bush, E. (2003) · Molecular Brain Research · doi:10.1016/s0169-328x(03)00029-9 · Cited by 82 · see citing works
Platelet serotonin uptake sites increased in drinkers ofayahuasca
Callaway, J. C., Airaksinen, M. M., McKenna, D. J., Brito, G. S., & Grob, C. S. (1994) · Psychopharmacology · doi:10.1007/bf02245347 · Cited by 81 · see citing works
The anterior left inferior frontal gyrus contributes to semantic unification
Zhu, Z., Peter Hagoort, A., Zhang, J. X., Feng, G., Chen, H.-C., BASTIAANSEN, M. C. M., & Wang, S. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.02.036 · Cited by 77 · see citing works
Impaired right inferior frontal gyrus response to contextual cues in male veterans with PTSD during response inhibition
van Rooij, S. J. H., Rademaker, A. R., Kennis, M., Vink, M., Kahn, R. S., & Geuze, E. (2014) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.130223 · Cited by 75 · see citing works
Differential interactions of dimethyltryptamine (DMT) with 5-HT1A and 5-HT2 receptors
Deliganis, A. V., Pierce, P. A., & Peroutka, S. J. (1991) · Biochemical Pharmacology · doi:10.1016/0006-2952(91)90178-8 · Cited by 73 · see citing works
Evidence for an anti-amnesic effect of JO 1784 in the rat: a potent and selective ligand for the sigma receptor
Earley, B., Burke, M. G., Leonard, B. E., Gouret, C.-J., & Junien, J. (1991) · Brain Research · doi:10.1016/0006-8993(91)91492-j · Cited by 68 · see citing works
Effects of long-term alcohol drinking on the dopamine D2 receptor: Gene expression and heteroreceptor complexes in the striatum in rats
Feltmann, K., Borroto‐Escuela, D. O., Rüegg, J., Pinton, L., de Oliveira Sergio, T., Narváez, M., Jimenez‐Beristain, A., Ekström, T. J., Fuxe, K., & Steensland, P. (2018) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13568 · Cited by 67 · see citing works
Sigma receptors are associated with cortical limbic areas in the primate brain
Mash, D. C., & Zabetian, C. P. (1992) · Synapse · doi:10.1002/syn.890120304 · Cited by 66 · see citing works
Small but sturdy: small RNAs in cellular memory and epigeneticsPreprint
Stuwe, E., Tóth, K. F., & Aravin, A. A. (2014) · Genes & Development · doi:10.1101/gad.236414.113 · Cited by 66 · see citing works
Modulation of voltage‐gated channel currents by harmaline and harmane
Splettstoesser, F., Bonnet, U., Wiemann, M., Bingmann, D., & Büsselberg, D. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706024 · Cited by 65 · see citing works
Requirement for BDNF in the Reconsolidation of Fear Extinction
Radiske, A., Rossato, J. I., Köhler, C. A., González, M. C., Medina, J. H., & Cammarota, M. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4093-14.2015 · Cited by 61 · see citing works
The calcium-sensitive Sigma-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases
Sánchez‐Blázquez, P., Rodríguez-Muñoz, M., Herrero-Labrador, R., Burgueño, J., Zamanillo, D., & Garzón, J. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145714000029 · Cited by 57 · see citing works
A mnemonic role for vasopressin: The evidence for and against
Strupp, B. J., & Levitsky, D. A. (1985) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(85)90018-1 · Cited by 56 · see citing works
Heteroreceptor Complexes and their Allosteric Receptor–Receptor Interactions as a Novel Biological Principle for Integration of Communication in the CNS: Targets for Drug Development
Fuxé, K., & Borroto‐Escuela, D. O. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.244 · Cited by 55 · see citing works
A Direct Interaction between the Sigma-1 Receptor and the hERG Voltage-gated K+ Channel Revealed by Atomic Force Microscopy and Homogeneous Time-resolved Fluorescence (HTRF®)
Balasuriya, D., D’Sa, L., Talker, R., Dupuis, E., Maurin, F., Martin, P., Borgèse, F., Soriani, O., & Edwardson, J. M. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.603506 · Cited by 54 · see citing works
Volume transmission and receptor-receptor interactions in heteroreceptor complexes: understanding the role of new concepts for brain communication
Fuxé, K., & Borroto‐Escuela, D. O. (2016) · Neural Regeneration Research · doi:10.4103/1673-5374.189168 · Cited by 53 · see citing works
Recovery from amnesia induced by pre-test injections of monoamine oxidase inhibitors
Botwinick, C. Y., & Quartermain, D. (1974) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(74)90083-5 · Cited by 53 · see citing works
Inferior Frontal Gyrus Activation Underlies the Perception of Emotions, While Precuneus Activation Underlies the Feeling of Emotions during Music Listening
Tabei, K. (2015) · Behavioural Neurology · doi:10.1155/2015/529043 · Cited by 52 · see citing works
Changes in aminoacidergic and monoaminergic neurotransmission in the hippocampus and amygdala of rats after ayahuasca ingestion
de Castro-Neto, E. F., da Cunha, R. H., da Silveira, D. X., Yonamine, M., Gouveia, T. L. F., Cavalheiro, É. A., Amado, D., & Naffah‐Mazzacoratti, M. D. G. (2013) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v4.i4.141 · Cited by 52 · see citing works
L-Type Voltage-Gated Calcium Channels in the Basolateral Amygdala Are Necessary for Fear Extinction
Davis, S. E., & Bauer, E. P. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0809-12.2012 · Cited by 51 · see citing works
PET Tracers for Serotonin Receptors and Their Applications
Kumar, J. S. D., & Mann, J. (2015) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/1871524914666141030124316 · Cited by 48 · see citing works
Anti‐amnesic properties of (±)‐PPCC, a novel sigma receptor ligand, on cognitive dysfunction induced by selective cholinergic lesion in rats
Antonini, V., Prezzavento, O., Coradazzi, M., Marrazzo, A., Ronsisvalle, S., Arena, E., & Leanza, G. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06000.x · Cited by 48 · see citing works
Structure activity relationship of synaptic and junctional neurotransmission
Goyal, R. K., & Chaudhury, A. (2013) · Autonomic Neuroscience · doi:10.1016/j.autneu.2013.02.012 · Cited by 43 · see citing works
L-type voltage-gated calcium channels in conditioned fear: A genetic and pharmacological analysisPreprint
McKinney, B. C., Sze, W., White, J. A., & Murphy, G. G. (2008) · Learning & Memory · doi:10.1101/lm.893808 · Cited by 43 · see citing works
Updating stored memory requires adult hippocampal neurogenesis
Suárez‐Pereira, I., & Carrión, Á. M. (2015) · Scientific Reports · doi:10.1038/srep13993 · Cited by 42 · see citing works
Gamma-Aminobutyric Acid Type A Receptor Alpha 4 Subunit Knockout Mice Are Resistant to the Amnestic Effect of Isoflurane
Rau, V., Iyer, S. V., Oh, I., Chandra, D., Harrison, N. L., Eger, E. I., Fanselow, M. S., Homanics, G. E., & Sonner, J. M. (2009) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e3181bf6ae6 · Cited by 41 · see citing works
Ayahuasca as a Candidate Therapy for PTSD
Nielson, J. L., & Megler, J. D. (2013) · Springer eBooks · doi:10.1007/978-3-642-40426-9_3 · Cited by 40 · see citing works
The dorsal prefrontal and dorsal anterior cingulate cortices exert complementary network signatures during encoding and retrieval in associative memory
Woodcock, E. A., White, R. T., & Diwadkar, V. A. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.04.050 · Cited by 39 · see citing works
Imaging dopamine neurotransmission in live human brain
Badgaiyan, R. D. (2014) · Progress in brain research · doi:10.1016/b978-0-444-63425-2.00007-6 · Cited by 38 · see citing works
The role of sigma-1 receptor and brain-derived neurotrophic factor in the development of diabetes and comorbid depression in streptozotocin-induced diabetic rats
Lenart, L., Hodrea, J., Hosszú, Á., Kőszegi, S., Zelena, D., Balogh, D., Szkibinszkij, E., Veres-Székely, A., Wagner, L., Vannay, Á., et al. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4209-x · Cited by 28 · see citing works
Tell it to a child! A brain stimulation study of the role of left inferior frontal gyrus in emotion regulation during storytelling
Urgesi, C., Mattiassi, A. D. A., Buiatti, T., & Marini, A. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.05.039 · Cited by 25 · see citing works
Epigenetic control of epilepsy target genes contributes to a cellular memory of epileptogenesis in cultured rat hippocampal neurons
Kiese, K., Jablonski, J., Hackenbracht, J., Wrosch, J. K., Groemer, T. W., Kornhuber, J., Blümcke, I., & Kobow, K. (2017) · Acta Neuropathologica Communications · doi:10.1186/s40478-017-0485-x · Cited by 25 · see citing works
Cocaine modulates allosteric D2-σ1 receptor-receptor interactions on dopamine and glutamate nerve terminals from rat striatum
Beggiato, S., Borelli, A. C., Borroto‐Escuela, D. O., Corbucci, I., Tomasini, M. C., Marti, M., Antonelli, T., Tanganelli, S., Fuxé, K., & Ferraro, L. (2017) · Cellular Signalling · doi:10.1016/j.cellsig.2017.09.007 · Cited by 25 · see citing works
The L-type voltage-gated calcium channel CaV1.2 mediates fear extinction and modulates synaptic tone in the lateral amygdalaPreprint
Temme, S. J., & Murphy, G. G. (2017) · Learning & Memory · doi:10.1101/lm.045773.117 · Cited by 24 · see citing works
Sigma-1 Receptor Agonists Directly Inhibit NaV1.2/1.4 Channels
Gao, X.-F., Yao, J.-J., He, Y., Hu, C., & Mei, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049384 · Cited by 21 · see citing works

Flagged first, then by citations

Sorted by citations

Psychedelics and Neuroplasticity: A Systematic Review Unraveling the Biological Underpinnings of Psychedelics.
de Vos, C. M. H., Mason, N. L., & Kuypers, K. P. C. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.724606 · Cited by 269 · see citing works
Reviewing the Potential of Psychedelics for the Treatment of PTSD
Krediet, E., Bostoen, T., Breeksema, J., van Schagen, A., Passie, T., & Vermetten, E. (2020) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyaa018 · Cited by 260 · see citing works
Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms
Inserra, A., De Gregorio, D., & Gobbi, G. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000056 · Cited by 232 · see citing works
Self-citation
Treatment of Posttraumatic Stress Disorder: A State-of-the-art Review
Burback, L., Brémault‐Phillips, S., Nijdam, M. J., McFARLANE, A. C., & Vermetten, E. H. G. J. M. (2023) · Current Neuropharmacology · doi:10.2174/1570159x21666230428091433 · Cited by 232 · see citing works
Modulation of serum brain-derived neurotrophic factor by a single dose of ayahuasca: observation from a randomized controlled trial
Almeida, R. N. D., Galvão, A. C. D. M., da Silva, F. S., Silva, E. A. D. S., Palhano-Fontes, F., Maia-de-Oliveira, J. P., de Araújo, L.-S. B., Lobão-Soares, B., & Galvão-Coelho, N. L. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.01234 · Cited by 177 · see citing works
The acute effects of classic psychedelics on memory in humans
Healy, C. J. (2021) · Psychopharmacology · doi:10.1007/s00213-020-05756-w · Cited by 95 · see citing works
Efficacy of 3,4 Methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for posttraumatic stress disorder: a systematic review and meta-analysis
Bahji, A., Forsyth, A., Groll, D., & Hawken, E. R. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109735 · Cited by 88 · see citing works
The Psychedelic Future of Post-Traumatic Stress Disorder Treatment
Zaretsky, T. G., Jagodnik, K. M., Barsic, R., Antonio, J. H., Bonanno, P. A., MacLeod, C., Pierce, C., Carney, H., Morrison, M. T., Saylor, C. F., et al. (2024) · Current Neuropharmacology · doi:10.2174/1570159x22666231027111147 · Cited by 85 · see citing works
Ceremonial Ayahuasca in Amazonian Retreats—Mental Health and Epigenetic Outcomes From a Six-Month Naturalistic Study
Ruffell, S., Netzband, N., Tsang, W., Davies, M., Inserra, A., Butler, M., Rucker, J., Tófoli, L. F., Dempster, E. L., Young, A. H., et al. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.687615 · Cited by 74 · see citing works
Self-citation
Critical Period Plasticity as a Framework for Psychedelic-Assisted Psychotherapy
Lepow, L., Morishita, H., & Yehuda, R. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.710004 · Cited by 73 · see citing works
Psychedelics as a novel approach to treating autoimmune conditions
Thompson, C., & Szabó, A. (2020) · Immunology Letters · doi:10.1016/j.imlet.2020.10.001 · Cited by 71 · see citing works
Diverse therapeutic developments for post-traumatic stress disorder (PTSD) indicate common mechanisms of memory modulation
Raut, S. B., Marathe, P. A., van Eijk, L., Eri, R. D., Ravindran, M., Benedek, D. M., Ursano, R. J., Canales, J. J., & Johnson, L. R. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108195 · Cited by 71 · see citing works
The Roles of Intracellular Chaperone Proteins, Sigma Receptors, in Parkinson’s Disease (PD) and Major Depressive Disorder (MDD)
Yang, K., Wang, C., & Sun, T. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00528 · Cited by 55 · see citing works
Psychedelics: Alternative and Potential Therapeutic Options for Treating Mood and Anxiety Disorders
Lowe, H. I. C., Toyang, N., Steele, B., Grant, J. F., Ali, A., Gordon, L., & Ngwa, W. (2022) · Molecules · doi:10.3390/molecules27082520 · Cited by 50 · see citing works
The Pharmacology of Visual Hallucinations in Synucleinopathies
Russo, M., Carrarini, C., Dono, F., Rispoli, M. G., Pietro, M. D., Stefano, V. D., Ferri, L., Bonanni, L., Sensi, S. L., & ONOFRJ, M. C. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01379 · Cited by 56 · see citing works
A Review of Epigenetics of PTSD in Comorbid Psychiatric Conditions
Blacker, C. J., Frye, M. A., Morava, É., Kozicz, T., & Veldić, M. (2019) · Genes · doi:10.3390/genes10020140 · Cited by 56 · see citing works
Exploring DMT: Endogenous role and therapeutic potential
Schimmelpfennig, J., & Jankowiak-Siuda, K. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110314 · Cited by 54 · see citing works
An introduction to psychedelic neuroscience
Calvey, T., & Howells, F. M. (2018) · Progress in brain research · doi:10.1016/bs.pbr.2018.09.013 · Cited by 49 · see citing works
The Bright Side of Psychedelics: Latest Advances and Challenges in Neuropharmacology
Mastinu, A., Anyanwu, M., Carone, M., Abate, G., Bonini, S. A., Peron, G., Tirelli, E., Pucci, M., Ribaudo, G., Oselladore, E., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021329 · Cited by 49 · see citing works
The pharmacological interaction of compounds in ayahuasca: a systematic review
Ruffell, S., Netzband, N., Bird, C., Young, A. H., & Juruena, M. F. (2020) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2020-0884 · Cited by 45 · see citing works
Pharmahuasca and DMT rescue ROS production and differentially expressed genes observed after predator and psychosocial stress: Relevance to human PTSD
Kelley, D. P., Venable, K., Destouni, A., Billac, G., Ebenezer, P., Stadler, K., Nichols, C., Barker, S., & Francis, J. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.1c00660 · Cited by 42 · see citing works
Self-Improvising Memory: A Perspective on Memories as Agential, Dynamically Reinterpreting Cognitive Glue
Levin, M. G. (2024) · Entropy · doi:10.3390/e26060481 · Cited by 44 · see citing works
Modulation of DNA methylation and protein expression in the prefrontal cortex by repeated administration of D-lysergic acid diethylamide (LSD): Impact on neurotropic, neurotrophic, and neuroplasticity signaling
Inserra, A., Campanale, A., Cheishvili, D., Dymov, S., Wong, A. H. Y., Marçal, N., Syme, R. A., Taylor, L., Gregorio, D. D., Kennedy, T. E., et al. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110594 · Cited by 41 · see citing works
Self-citation
N,N‐dimethyltryptamine and Amazonian ayahuasca plant medicine
James, E., Keppler, J., Robertshaw, T. L., & Sessa, B. (2022) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2835 · Cited by 43 · see citing works
Using Psychedelics With Therapeutic Intent Is Associated With Lower Shame and Complex Trauma Symptoms in Adults With Histories of Child Maltreatment
Healy, C. J., Lee, K. A., & D'Andrea, W. M. (2021) · Chronic Stress · doi:10.1177/24705470211029881 · Cited by 38 · see citing works
A case report SPECT study and theoretical rationale for the sequential administration of ibogaine and 5-MeO-DMT in the treatment of alcohol use disorder
Barsuglia, J. P., Polanco, M., Palmer, R., Malcolm, B. J., Kelmendi, B., & Calvey, T. (2018) · Progress in Brain Research · doi:10.1016/bs.pbr.2018.08.002 · Cited by 38 · see citing works
Psychedelics for acquired brain injury: a review of molecular mechanisms and therapeutic potential
Allen, J., Dames, S., Foldi, C. J., & Shultz, S. R. (2024) · Molecular Psychiatry · doi:10.1038/s41380-023-02360-0 · Cited by 38 · see citing works
The multiscale wisdom of the body: collective intelligence as a tractable interface for next-generation biomedicine
Levin, M. (2025) · BioEssays · doi:10.1002/bies.202400196 · Cited by 34 · see citing works
Impact of Two Neuronal Sigma-1 Receptor Modulators, PRE084 and DMT, on Neurogenesis and Neuroinflammation in an Aβ1–42-Injected, Wild-Type Mouse Model of AD
Borbély, E., Varga, V. É., Szögi, T., Schuster, I., Bozsó, Z., Penke, B., & Fülöp, L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052514 · Cited by 34 · see citing works
Molecular Pathways of the Therapeutic Effects of Ayahuasca, a Botanical Psychedelic and Potential Rapid-Acting Antidepressant
Rossi, G. N., Guerra, L. T. L., Baker, G. B., Dursun, S. M., Bouso, J. C., Hallak, J. E. C., & SANTOS, R. G. D. (2022) · Biomolecules · doi:10.3390/biom12111618 · Cited by 33 · see citing works
A Comprehensive Review of the Current Status of the Cellular Neurobiology of Psychedelics
Banushi, B., & Polito, V. (2023) · Biology · doi:10.3390/biology12111380 · Cited by 25 · see citing works
Components of Banisteriopsis caapi, a Plant Used in the Preparation of the Psychoactive Ayahuasca, Induce Anti-Inflammatory Effects in Microglial Cells
Santos, B. W. L., Moreira, D. C., Borges, T. K. D. S., & Caldas, E. D. (2022) · Molecules · doi:10.3390/molecules27082500 · Cited by 30 · see citing works
The potential of psychedelics for the treatment of Alzheimer's disease and related dementias
Winkelman, M., Szabó, A., & Frecska, E. (2023) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2023.07.003 · Cited by 27 · see citing works
Epigenetic Mechanisms of Rapid-Acting Antidepressants
Inserra, A., Campanale, A., Rezai, T., Romualdi, P., & Rubino, T. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-03055-y · Cited by 27 · see citing works
Self-citation
Psychedelic 5-HT2A receptor agonism alters neurovascular coupling and differentially affects neuronal and hemodynamic measures of brain function
Padawer-Curry, J. A., Krentzman, O. J., Kuo, C., Wang, X., Bice, A. R., Nicol, G. E., Snyder, A. Z., Siegel, J. S., McCall, J. G., & Bauer, A. Q. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-02069-z · Cited by 28 · see citing works
Epigenetic Echoes: Bridging Nature, Nurture, and Healing Across Generations
Banushi, B., Collova, J. R., & Milroy, H. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073075 · Cited by 27 · see citing works
Finding the divine within: exploring the role of the sacred in psychedelic integration therapy for sexual trauma and dysfunction
Goldpaugh, D. D. (2021) · Sexual & Relationship Therapy · doi:10.1080/14681994.2021.1994138 · Cited by 22 · see citing works
Anti-inflammatory activity of ayahuasca: therapeutical implications in neurological and psychiatric diseases
da Silva, M. G., Daros, G. C., & de Bitencourt, R. M. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.113003 · Cited by 22 · see citing works
“Meeting the Medicine Halfway”: Ayahuasca Ceremony Leaders’ Perspectives on Preparation and Integration Practices for Participants
Callon, C., Williams, M., & Lafrance, A. (2021) · Journal of Humanistic Psychology · doi:10.1177/00221678211043300 · Cited by 21 · see citing works
Psychedelics: A review of their effects on recalled aversive memories and fear/anxiety expression in rodents
Werle, I., & Bertoglio, L. J. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105899 · Cited by 23 · see citing works
Ayahuasca, a potentially rapid acting antidepressant: focus on safety and tolerability
Rossi, G. N., Dias, I. C. D. S., Baker, G. B., Bouso, J. C., Dursun, S. M., Hallak, J. E. C., & SANTOS, R. G. D. (2022) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2022.2054988 · Cited by 21 · see citing works
Ayahuasca and Dimethyltryptamine Adverse Events and Toxicity Analysis: A Systematic Thematic Review
White, E., Kennedy, T., Ruffell, S., Perkins, D., & Sarris, J. J. (2024) · International Journal of Toxicology · doi:10.1177/10915818241230916 · Cited by 21 · see citing works
Serotonergic psychedelic 5-MeO-DMT alters plasticity-related gene expression and generates anxiolytic effects in stressed mice
Nogueira, M., Golbert, D. C. F., de Menezes, R. S. T., de Almeida, R. N., Coelho, N. L. G., Siroky, A. N., Lima, T. Z., Maia, H., Leão, K. E., & Leão, R. N. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02655-w · Cited by 20 · see citing works
Therapeutic modulation of the kynurenine pathway in severe mental illness and comorbidities: A potential role for serotonergic psychedelics
Campanale, A., Inserra, A., & Comai, S. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.111058 · Cited by 18 · see citing works
Self-citation
Lysergic Acid Diethylamide (LSD) for the Treatment of Anxiety Disorders: Preclinical and Clinical Evidence
Inserra, A., Piot, A., Gregorio, D. D., & Gobbi, G. (2023) · CNS Drugs · doi:10.1007/s40263-023-01008-5 · Cited by 17 · see citing works
Self-citation
Evidence on the impairing effects of Ayahuasca on fear memory reconsolidation
Daneluz, D. M., Sohn, J. M. B., Silveira, G. D. O., Yonamine, M., & Stern, C. A. J. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06217-2 · Cited by 16 · see citing works
Vegetative value: promissory horizons of therapeutic innovation in the global circulation of ayahuasca
Sanabria, E. (2021) · BioSocieties · doi:10.1057/s41292-020-00222-4 · Cited by 16 · see citing works
PTSD as an Endothelial Disease: Insights From COVID-19
Sfera, A., Osorio, C. P., Rahman, L., del Campo, C. M. Z.-M., Maldonado, J. C., Jafri, N., Cummings, M. A., Maurer, S., & Kozlakidis, Z. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.770387 · Cited by 16 · see citing works
Natural psychedelics in the treatment of depression; a review focusing on neurotransmitters
Jahanabadi, S., Amiri, S., Karkeh-abadi, M., & Razmi, A. (2023) · Fitoterapia · doi:10.1016/j.fitote.2023.105620 · Cited by 14 · see citing works
Psychedelics and autobiographical memory – six open questions
Kangaslampi, S., & Lietz, M. (2025) · Psychopharmacology · doi:10.1007/s00213-025-06771-5 · Cited by 10 · see citing works
Unveiling GABA and Serotonin Interactions During Neurodevelopment to Re-Open Adult Critical Periods for Neuropsychiatric Disorders
Beretta, E., Cuboni, G., & Deidda, G. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26125508 · Cited by 12 · see citing works
Psychoactive substances for the treatment of neuropsychiatric disorders
Zhen, Z., Sun, X., Yuan, S., & Zhang, J. (2024) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2024.104193 · Cited by 9 · see citing works
Epigenetic drugs and psychedelics as emerging therapies for alcohol use disorder: insights from preclinical studies
Hilal, F. F., Jeanblanc, J., Deschamps, C., Naassïla, M., Pierrefiche, O., & Hamida, S. B. (2024) · Journal of Neural Transmission · doi:10.1007/s00702-024-02757-3 · Cited by 8 · see citing works
Examining the epigenetic transmission of risk for chronic pain associated with paternal post-traumatic stress disorder: a focus on veteran populations
Freeman, J., Salberg, S., Noel, M. E., & Mychasiuk, R. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03267-w · Cited by 6 · see citing works
Critical Period Plasticity as a Framework for Psychedelic-Assisted Psychotherapy
Lepow, L., Morishita, H., & Yehuda, R. (2023) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.23021012 · Cited by 8 · see citing works
The Effects of Ayahuasca on Psychological Disorders: A Systematic Literature Review
Sheth, R., Parikh, E., Olayeye, K., Pfeifer, K., & Khanna, D. (2024) · Cureus · doi:10.7759/cureus.55574 · Cited by 8 · see citing works
The multiscale wisdom of the body: collective intelligence as a tractable interface for next-generation biomedicinePreprint
Levin, M. G. (2024) · doi:10.31219/osf.io/yq9xe · Cited by 5 · see citing works
Clinical pharmacology of ayahuasca: potential applications and future considerations
Guerra, L. T. L., Dias, I. C. D. S., Hallak, J. E. C., & SANTOS, R. G. D. (2025) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2025.2577726 · Cited by 3 · see citing works
Epigenetics of neural networks in neurocognitive conditions: A review
Stolberg, V. B. (2025) · Brain Network Disorders · doi:10.1016/j.bnd.2025.08.001 · Cited by 3 · see citing works
A Qualitative Assessment of Risks and Benefits of Ayahuasca for Trauma Survivors
Nielson, J. L., Megler, J. D., & Cavnar, C. (2021) · Springer eBooks · doi:10.1007/978-3-030-55688-4_5 · Cited by 3 · see citing works
Effects of ayahuasca on fear and anxiety: cross-talk between 5HT1A and 5HT2A receptors
Guerra, L. T. L., dos Santos, R. D., & Hallak, J. E. C. (2024) · Psychedelics · doi:10.61373/pp024i.0037 · Cited by 2 · see citing works
Unique biological and physiological properties of endogenous N, N-dimethyltryptamine from the perspective of functioning of the nervous system
Schimmelpfennig, J., & Jankowiak-Siuda, K. (2023) · Neuropsychiatria i Neuropsychologia · doi:10.5114/nan.2023.129068 · Cited by 2 · see citing works
Pharmaco-Analysis of Psychedelics—Philo-Fictions about New Materialism, Quantum Mechanics, Information Science, and the Philosophy of Immanence
Paulus, S. (2023) · Philosophies · doi:10.3390/philosophies9010007 · Cited by 2 · see citing works
All-natural 5-MeO-DMT sigma receptor 1 agonist and its therapeutic impact in mental and neurodegener-ative diseases through mitochondrial activation
Batalla, M. (2023) · Science Reviews Biology · doi:10.57098/scirevs.biology.2.2.1 · Cited by 2 · see citing works
Preliminary effects of ayahuasca on mental and physical health: A systematic review of prospective studies
Haupt, M. J., Carra, S., Boehnke, K. F., & Aday, J. S. (2026) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2026.111634 · Cited by 2 · see citing works
Trials, trips, and tribulations: pathways for implementing psychedelic therapy in Ireland
Kelly, J. R., Sheridan, C., Iusan, P., Coakley, L., Burke, L., Brennan, C., MacDonald, A. A., Ivers, J., Trépel, D., Tormey, G., et al. (2026) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyag028 · Cited by 1 · see citing works
Medical Use of Cannabinoids and Psychedelic Compounds
Inserra, A., Gregorio, D. D., & Gobbi, G. (2023) · Springer eBooks · doi:10.1007/978-3-030-42825-9_141-1 · Cited by 1 · see citing works
Self-citation
Tryptamine based drugs
Greene, S. L. (2025) · Comprehensive analytical chemistry · doi:10.1016/bs.coac.2024.12.002 · Cited by 1 · see citing works
Novel harmala-ocudelic tuning (HOT) for ocular disorders
Lansky, E. S. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.109834 · Cited by 1 · see citing works
Evaluation of Hippocampal Allostatic Load-Associated Factors in Animal Models of Post-Traumatic Stress Disorder: Relevance to Human PTSD
Kelley, D. P. (2022) · doi:10.31390/gradschool_dissertations.5761 · Cited by 1 · see citing works
Avaliação da variação morfológica, anatômica e fitoquímica de Banisteriopsis caapi (Spruce ex Griseb.) C.v. Morton e Psychotria viridis Ruiz & Pav em diferentes ambientes, teor de alcaloides e citotoxicidade do chá Ayahuasca
de Miranda, O. F. (2020) · doi:10.11606/t.11.2020.tde-12022021-101623
Avaliação das possíveis interações entre o canabidiol e a ayahuasca em voluntários saudáveis: um estudo randomizado, duplo-cego e controlado com placebo
Rossi, G. N. (2020) · doi:10.11606/d.17.2020.tde-08022021-150020
Understanding the Regulation of Transcription in Mental Illness
O’Sullivan, S. J. (2021) · OBM Genetics · doi:10.21926/obm.genet.2104143
Proceedings 榊原カンファレンス今回の症例 : 心房細動 : 薬物療法の経過からカテーテルアブレーション実施に至るまで
梅村, 純. (2012)
O receptor aril de hidrocarbonetos (AhR) em melanomas: associação com mutações BRAF, com a progressão da doença e identificação de ligantes
de Sales, M. C. O. P. (2020) · doi:10.11606/t.9.2020.tde-01072021-144540
O Uso da ibogaína no manejo da dependência de drogas no Brasil
Gomes, B. R. (2021) · doi:10.47749/t/unicamp.2021.1245563
Therapeutic potential of N,N-dimethyltryptamine in the treatment of psychiatric and neurodegenerative disorders
Schimmelpfennig, J., & Jankowiak-Siuda, K. (2023) · Pharmacotherapy in Psychiatry and Neurology · doi:10.5114/fpn.2023.131979
Medical Use of Cannabinoids and Psychedelic Compounds
Inserra, A., Gregorio, D. D., & Gobbi, G. (2023) · Springer eBooks · doi:10.1007/978-3-030-42825-9_141-2
Self-citation
Medical Use of Cannabinoids and Psychedelic Compounds
Inserra, A., Gregorio, D. D., & Gobbi, G. (2024) · Springer eBooks · doi:10.1007/978-3-030-51366-5_141
Self-citation
Towards therapeutic paths with mindfulness meditation–based and psychedelics assisted psychotherapies in PTSD: Randomized controlled trials systematic review and meta-analysis
Maeder, S., Fahim, C., & Martin-Söelch, C. (2025) · Cortica · doi:10.26034/cortica.2025.8925
The Effects of Psychedelics on Repressed Memory: A Scoping Review
Kooman, L., Griesfeller, A.-F., Henry, & Kloft, L. (2024) · Open Science Framework · doi:10.17605/osf.io/tdcxk
Ayahuasca, DMT, and Mental Health: A Current Review of Scientific Studies
Araújo, D. B., Maia, L. O., Sanchez, T. A., Coelho, N. L. G., & Palhano-Fontes, F. (2026) · Current Addiction Reports · doi:10.1007/s40429-026-00721-7
Serotonergic psychedelics as epigenetic modulators: A paradigm shift in Alzheimer's disease therapeutics
Gojani, E. G., Farzin, H., Sutherland, R. J., & Mohajerani, M. H. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106619
INTERVENTIONS AND TREATMENT FOR THE EFFECTS OF ACEs
Riley, D., & Pates, R. M. (2026) · doi:10.1002/9781394282432.ch13
Anything that helps: cancer patient and carer perspectives on psychedelic-assisted therapy
Wech, A., Akroyd, A., Clayden, C., & Reynolds, L. M. (2026) · Supportive Care in Cancer · doi:10.1007/s00520-026-10693-z
Pivotal physical states: The somatic equivalent to pivotal mental states
Uthaug, M. V., Allocca, J. G., Havenith, M. N., Szabó, A., Rosas, F. E., Mason, N. L., Hargraves, H., & Ramaekers, J. G. (2026) · Journal of Psychedelic Studies · doi:10.1556/2054.2026.00482
Cellular mechanisms of serotonergic psychedelics - apical hypercontextualisation
Kaup, K., Jiménez, J. H., & Aru, J. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106876
A neuroprotective target in the shadows: a scoping review of pharmacological gaps in σ1R agonists for glutamate-induced neurotoxicity
Xiang, A. Q., Thalmann, M., Khanna, I., Harish, S., Khanna, M., Kulkarni, A., & Chen, L. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1829506
Psilocybin and ayahuasca in treatment-resistant depression: clinical evidence, methodological constraints and ethical challenges: a narrative review
Civardi, S. C., Besana, F., Durbano, F., Toscano, M. O. M., Raffone, F., Dell’Osso, B. M., & Olivola, M. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1858319

Effects of ayahuasca on emotional memory in rats
da Silva, D. A. K. (2012) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Evidence on the impairing effects of Ayahuasca on fear memory reconsolidation
Daneluz, D. M., Sohn, J. M. B., Silveira, G. D. O., Yonamine, M., & Stern, C. A. J. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06217-2 · Cited by 16 · see citing works
N,N‐dimethyltryptamine and Amazonian ayahuasca plant medicine
James, E., Keppler, J., Robertshaw, T. L., & Sessa, B. (2022) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2835 · Cited by 43 · see citing works
RESEARCH ARTICLE Effects of Long-Term Ayahuasca Administration on Memory and Anxiety in Rats
Favaro, V. M., Yonamine, M., Carlota, J., Soares, K., & Oliveira, G. M. (2016)
Ayahuasca Impairs Fear Memory Reconsolidation and Promotes Rapid Structural Plasticity in the Hippocampus and Prelimbic Cortex
Daneluz, D. M., dos Santos, A. S., de Melo, S. R., de Oliveira, R. M. W., & Stern, C. A. J. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-06264-2

Authors: Inserra, A.
Affiliations: Flinders University (AU)
Corresponding author: Inserra, Antonio
ORCID: Inserra, Antonio
Venue: Frontiers in Pharmacology
Publisher: Frontiers Media SA
Published: 2018-04-05
Volume: 9
Pages: 330-330
ISSN: 1663-9812 (ISSN-L)
DOI: 10.3389/fphar.2018.00330
PMC: PMC5895707
OpenAlex: W2794934757
Cited by: 91
References: 131
Citations by year: 2026: 10 · 2025: 10 · 2024: 16 · 2023: 14 · 2022: 11 · 2021: 13 · 2020: 9 · 2019: 5 · 2018: 2 · 2012: 1
FWCI: 8.52
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Pharmacology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Flinders Academic Commons (Flinders University) (submittedVersion)
Topics: Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pharmacological Receptor Mechanisms and Effects
Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Keywords: ayahuasca, dimethyltryptamine, sigma-1 receptor, monoamine oxidase inhibitors, post-traumatic stress disorder, traumatic memory, memory reconsolidation, fear extinction, synaptic plasticity, epigenetic modulation, anti-amnesic effect, memory retrieval, neuroimmunomodulation, psychedelic therapy, neurogenesis, dopamine signaling

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Hypothesis: The Psychedelic Ayahuasca Heals Traumatic Memories via a Sigma 1 Receptor-Mediated Epigenetic-Mnemonic Process

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks