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Associations between Dopamine D4 Receptor Gene Variation with Both Infidelity and Sexual Promiscuity
Open accessAbstract
BACKGROUND: Human sexual behavior is highly variable both within and between populations. While sex-related characteristics and sexual behavior are central to evolutionary theory (sexual selection), little is known about the genetic bases of individual variation in sexual behavior. The variable number tandem repeats (VNTR) polymorphism in exon III of the human dopamine D4 receptor gene (DRD4) has been correlated with an array of behavioral phenotypes and may be predicatively responsible for variation in motivating some sexual behaviors, particularly promiscuity and infidelity. METHODOLOGY/PRINCIPAL FINDINGS: We administered an anonymous survey on personal history of sexual behavior and intimate relationships to 181 young adults. We also collected buccal wash samples and genotyped the DRD4 VNTR. Here we show that individuals with at least one 7-repeat allele (7R+) report a greater categorical rate of promiscuous sexual behavior (i.e., having ever had a "one-night stand") and report a more than 50% increase in instances of sexual infidelity. CONCLUSIONS/SIGNIFICANCE: DRD4 VNTR genotype varies considerably within and among populations and has been subject to relatively recent, local selective pressures. Individual differences in sexual behavior are likely partially mediated by individual genetic variation in genes coding for motivation and reward in the brain. Conceptualizing these findings in terms of r/K selection theory suggests a mechanism for selective pressure for and against the 7R+ genotype that may explain the considerable global allelic variation for this polymorphism.
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“Variations in a dopamine receptor gene have been found to correlate in humans with infidelity and sexual promiscuity (Garcia et al. 2010).”
From Natural Selection, Childrearing, and the Ethics of Marriage (and Divorce): Building a Case for the Neuroenhancement of Human Relationships (2012) · cites this paper as Garcia et al. 2010
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Citations
Cites
The Theory of Island Biogeography
MacArthur, R. H., & Wilson, E. O. (2001) · Princeton University Press eBooks · doi:10.1515/9781400881376 · Cited by 13,298
The Theory of Island Biogeography
Kirkby, M. J., MacArthur, R. H., & Wilson, E. O. (1968) · Geographical Journal · doi:10.2307/1796430 · Cited by 11,589
The Fagerstrom Test for Nicotine Dependence: a revision of the Fagerstrom Tolerance Questionnaire
HEATHERTON, T. F., KOZLOWSKI, L. T., FRECKER, R. C., & FAGERSTROM, K. (1991) · British Journal of Addiction · doi:10.1111/j.1360-0443.1991.tb01879.x · Cited by 10,738
Sexual strategies theory: an evolutionary perspective on human mating
Buss, D. M., & Schmitt, D. P. (1993) · Psychological Review · doi:10.1037/0033-295x.100.2.204 · Cited by 4,253
Heroin addicts have higher discount rates for delayed rewards than non-drug-using controls.
Kirby, K. N., Petry, N. M., & Bickel, W. K. (1999) · Journal of Experimental Psychology: General · doi:10.1037/0096-3445.128.1.78 · Cited by 2,171
Extra pair paternity in birds: a review of interspecific variation and adaptive function
Griffith, S. C., Owens, I. P. F., & Thuman, K. A. (2002) · Molecular Ecology · doi:10.1046/j.1365-294x.2002.01613.x · Cited by 1,426
Neuroendocrine perspectives on social attachment and love
Sue Carter, C. (1998) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(98)00055-9 · Cited by 1,425
The neurobiology of attachment
Insel, T. R., & Young, L. J. (2001) · Nature Reviews Neuroscience · doi:10.1038/35053579 · Cited by 1,173
depue, R. A., & morrone-strupinsky, J. V. (2005) · Behavioral and Brain Sciences · doi:10.1017/s0140525x05000063 · Cited by 958
Extra-Pair Paternity in Birds: Causes, Correlates, and Conflict
Westneat, D. F., & Stewart, I. R. K. (2003) · Annual Review of Ecology Evolution and Systematics · doi:10.1146/annurev.ecolsys.34.011802.132439 · Cited by 690
A Cross-Cultural Perspective on Romantic Love
Jankowiak, W. R., & Fischer, E. F. (1992) · Ethnology · doi:10.2307/3773618 · Cited by 646
Buss, D. M. (1995) · Springer eBooks · doi:10.1007/978-3-319-16999-6_1863-1 · Cited by 637
Li, D., Sham, P. C., Owen, M. J., & He, L. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl152 · Cited by 602
Evidence of positive selection acting at the human dopamine receptor D4 gene locus
Ding, Y. C., Chi, H. C., Grady, D., Morishima, A., Kidd, J., Kidd, K., Flodman, P., Spence, M., Schuck, S., Swanson, J., et al. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.012464099 · Cited by 506
Aragona, B. J., Liu, Y., Yu, Y. J., Curtis, J. T., Detwiler, J. M., Insel, T. R., & Wang, Z. (2006) · Nature Neuroscience · doi:10.1038/nn1613 · Cited by 473 · cited 2×
“Dopaminergic function is enhanced by oxytocin and arginine vasopressin acting on the hypothalamus to regulate attachment [15,17–20].”
Walum, H., Westberg, L., Henningsson, S., Neiderhiser, J. M., Reiss, D., Igl, W., Ganiban, J. M., Spotts, E. L., Pedersen, N. L., Eriksson, E., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803081105 · Cited by 460
Melis, M. R., & Argiolas, A. (1995) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(94)00020-2 · Cited by 428
The Genetic Architecture of Selection at the Human Dopamine Receptor D4 (DRD4) Gene Locus
Wang, E., Ding, Y.-C., Flodman, P. L., Kidd, J. R., Kídd, K. K., Grady, D. L., Ryder, O. A., Spence, M. A., Swanson, J. M., & Moyzis, R. K. (2004) · The American Journal of Human Genetics · doi:10.1086/420854 · Cited by 406
How Well Does Paternity Confidence Match Actual Paternity?
Anderson, K. G. (2006) · Current Anthropology · doi:10.1086/504167 · Cited by 360
Defining the Brain Systems of Lust, Romantic Attraction, and Attachment
Fisher, H. E., Aron, A., Mashek, D., Li, H., & Brown, L. L. (2002) · Archives of Sexual Behavior · doi:10.1023/a:1019888024255 · Cited by 317
Chen, C., Burton, M., Greenberger, E., & Dmitrieva, J. (1999) · Evolution and Human Behavior · doi:10.1016/s1090-5138(99)00015-x · Cited by 302
Anatomy of love: the natural history of monogamy, adultery, and divorce
(1993) · Choice Reviews Online · doi:10.5860/choice.30-5663 · Cited by 291
Human Sperm Competition: Copulation, Masturbation and Infidelity
Baker, R. R., & Bellis, M. A. (1999) · Cited by 266
An Evolutionary Psychological Perspective on Male Sexual Proprietariness and Violence Against Wives
WILSON, M. I., & Daly, M. (1993) · Violence and Victims · doi:10.1891/0886-6708.8.3.271 · Cited by 257
Schmitt, D. P., & International Sexuality Description Project (2004) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.86.4.560 · Cited by 250
Hook-up behavior: A biopsychosocial perspective.
Garcia, J. R., & Reiber, C. (2008) · Journal of Social, Evolutionary, and Cultural Psychology · doi:10.1037/h0099345 · Cited by 249
Self-citationHuman sperm competition: Copulation, masturbation and infidelity
Birkhead, T. R. (1995) · Animal Behaviour · doi:10.1016/0003-3472(95)80117-0 · Cited by 232
Congdon, E., Lesch, K. P., & Canli, T. (2008) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30557 · Cited by 218
Dreber, A., Apicella, C. L., Eisenberg, D. T. A., Garcia, J. R., Zamore, R. S., Lum, J. K., & Campbell, B. (2009) · Evolution and Human Behavior · doi:10.1016/j.evolhumbehav.2008.11.001 · Cited by 217
Self-citationThe human dopamine D4 receptor repeat sequences modulate expression
Schoots, O., & Van Tol, H. H. M. (2003) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500208 · Cited by 213
Extra‐pair Copulations in a Monogamous Gibbon (Hylobates lar)
Reichard, U. H. (1995) · Ethology · doi:10.1111/j.1439-0310.1995.tb00319.x · Cited by 178
Hamer, D. H., & Sirota, L. A. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000662 · Cited by 158
The DRD4 exon 3 VNTR polymorphism and addiction-related phenotypes: A review
McGeary, J. E. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.03.010 · Cited by 123
Hamarman, S., Fossella, J., Ülger, C., Brimacombe, M. B., & Dermody, J. J. (2004) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2004.14.564 · Cited by 118
Ben-Zion, I., Tessler, R. J., Cohen, L., Lerer, E., Raz, Y., Bachner‐Melman, R., Gritsenko, I., Nemanov, L., Zohar, A. H., Belmaker, R. H., et al. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001832 · Cited by 117
Determinants of DNA yield and quality from buccal cell samples collected with mouthwash.
Feigelson, H. S., Rodríguez, C., Robertson, A. S., Jacobs, E., Calle, E. E., Reid, Y. A., & Thun, M. J. (2001) · PubMed · Cited by 105
Harpending, H. C., & Cochran, G. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012612799 · Cited by 100
MacKillop, J. M., Menges, D., McGeary, J. E., & Lisman, S. A. (2007) · Behavioral and Brain Functions · doi:10.1186/1744-9081-3-11 · Cited by 90
Self-citationRay, L. A., Bryan, A. D., MacKillop, J. M., McGeary, J. E., Hesterberg, K. G., & Hutchison, K. E. (2008) · Addiction Biology · doi:10.1111/j.1369-1600.2008.00120.x · Cited by 79
Self-citationCherkas, L. F., Oelsner, E. C., Mak, Y. T., Valdes, A. M., & Spector, T. D. (2004) · Twin Research · doi:10.1375/1369052042663922 · Cited by 77
Multiple breeding strategies in the swift fox, Vulpes velox
Kitchen, A. M., Gese, E. M., Waits, L. P., Karki, S. M., & Schauster, E. R. (2006) · Animal Behaviour · doi:10.1016/j.anbehav.2005.06.015 · Cited by 71
The neuroscience of investing: fMRI of the reward system
Peterson, R. L. (2005) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2005.06.015 · Cited by 65
Genetic and Environmental Influences on Risky Sexual Behaviour and its Relationship With Personality
Zietsch, B. P., Verweij, K. J. H., Bailey, J. M., Wright, M. J., & Martin, N. G. (2009) · Behavior Genetics · doi:10.1007/s10519-009-9300-1 · Cited by 63
Dopamine transporter, gender, and number of sexual partners among young adults
Guo, G., Tong, Y., Xie, C.-W., & Lange, L. A. (2007) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201763 · Cited by 44
Polymorphisms in the Dopamine D4 and D2 Receptor Genes and Reproductive and Sexual Behaviors
Eisenberg, D. T. A., Campbell, B., MacKillop, J. M., Modi, M. E., Dang, D. T., Lum, J. K., & Wilson, D. S. (2007) · Evolutionary Psychology · doi:10.1177/147470490700500402 · Cited by 29
Self-citationGene-Environment Contributions to Young Adult Sexual Partnering
Halpern, C. T., Kaestle, C. E., Guo, G., & Hallfors, D. D. (2006) · Archives of Sexual Behavior · doi:10.1007/s10508-006-9084-9 · Cited by 26
Eisenberg, D. T. A., Apicella, C. L., Campbell, B., Dreber, A., Garcia, J. R., & Lum, J. K. (2008) · Nature Precedings · doi:10.1093/scan/nsp026 · Cited by 14
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- [22]Neuman MG 2008 The Truth about Cheating: Why Men Stray and What You Can Do to Prevent It. New Jersey John Wiley & Sons, Inc
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Garcia, J. R., Reiber, C., Massey, S. G., & Merriwether, A. M. (2012) · Review of General Psychology · doi:10.1037/a0027911 · Cited by 572
Self-citationFemale extrapair mating behavior can evolve via indirect selection on males
Forstmeier, W., Martin, K., Bolund, E., Schielzeth, H., & Kempenaers, B. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103195108 · Cited by 223
Stark, R. M., Klucken, T., Potenza, M. N., Brand, M., & Strahler, J. (2018) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-018-0162-9 · Cited by 193
Perceived threat of infectious disease and its implications for sexual attitudes
Murray, D. R., Jones, D. N., & Schaller, M. (2012) · Personality and Individual Differences · doi:10.1016/j.paid.2012.08.021 · Cited by 124
MacKillop, J. (2012) · Journal of the Experimental Analysis of Behavior · doi:10.1002/jeab.4 · Cited by 120
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Metadata
- Authors
- Garcia, J. R., MacKillop, J., Aller, E. L., Merriwether, A. M., Wilson, D. S., & Lum, J. K.
- Affiliations
- Binghamton University (US)
- University of Georgia (US)
- Corresponding author
- Garcia, Justin R.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2010-11-30
- Volume
- 5
- Issue
- 11
- Pages
- e14162
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC2994774
- OpenAlex
- W1997660607
- Cited by
- 134
- References
- 48
- Citations by year
- 2026: 8 · 2025: 5 · 2023: 3 · 2022: 4 · 2021: 24 · 2020: 6 · 2019: 3 · 2018: 8 · 2017: 8 · 2016: 13 · 2015: 16 · 2014: 10 · 2013: 8 · 2012: 10
- FWCI
- 3.36
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- The Open Repository - Binghamton (Binghamton University) (submittedVersion, cc-by)
- Funders
- National Institutes of Health (DA027827)
- Binghamton University
- National Institute on Alcohol Abuse and Alcoholism (K23AA016936)
- National Institute on Drug Abuse (P30DA027827)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Evolutionary Psychology and Human Behavior
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Keywords
- dopamine D4 receptor, 7-repeat allele, sexual infidelity, promiscuity, one-night stands, sexual selection, young adults
- MeSH terms
- Female, Genotype, Humans, Male, Motivation, Polymorphism, Genetic, Surveys and Questionnaires, Reward, Sexual Behavior, Sex Factors, Smoking, Linear Models, Minisatellite Repeats, Statistics, Nonparametric, Receptors, Dopamine D4, Young Adult
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