Genetic variation in the vasopressin receptor 1a gene ( AVPR1A ) associates with pair-bonding behavior in humans
Open accessAbstract
Pair-bonding has been suggested to be a critical factor in the evolutionary development of the social brain. The brain neuropeptide arginine vasopressin (AVP) exerts an important influence on pair-bonding behavior in voles. There is a strong association between a polymorphic repeat sequence in the 5' flanking region of the gene (avpr1a) encoding one of the AVP receptor subtypes (V1aR), and proneness for monogamous behavior in males of this species. It is not yet known whether similar mechanisms are important also for human pair-bonding. Here, we report an association between one of the human AVPR1A repeat polymorphisms (RS3) and traits reflecting pair-bonding behavior in men, including partner bonding, perceived marital problems, and marital status, and show that the RS3 genotype of the males also affects marital quality as perceived by their spouses. These results suggest an association between a single gene and pair-bonding behavior in humans, and indicate that the well characterized influence of AVP on pair-bonding in voles may be of relevance also for humans.
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Oxytocin, dopamine, and vasopressin regulate neural circuits responsible for generating bonds in animals and humans.
“Here, we provide an overview of the roles of oxytocin, dopamine, and vasopressin in regulating neural circuits responsible for generating bonds in animals and humans alike.”
From The Neurobiology of Love and Pair Bonding from Human and Animal Perspectives (2023) · cites this paper as [19]
The paper's introductory passage says vasopressin regulates pair-bonding in male voles, and its Discussion reports an association between an AVPR1A variant and pair-bonding traits in men. It does not establish that vasopressin regulates bond-generating neural circuits in humans, or discuss dopamine's role; oxytocin appears only in a cited study's title. Page numbers are not available in our copy. (LLM, conf=0.87)
Experimental — accuracy not yet measuredGenetic polymorphisms in the human OXTR and AVP1RA genes have been linked to bonding and relationship outcomes.
“Genetic polymorphisms in the human OXTR and AVP1RA genes have been linked to bonding and relationship outcomes.”
From The Neurobiology of Love and Pair Bonding from Human and Animal Perspectives (2023) · cites this paper as [19]
The Discussion reports an association between an AVPR1A polymorphism and partner bonding, marital problems, and marital status in men. The paper does not establish the claim's OXTR component; it also uses the gene name AVPR1A, rather than AVP1RA. (LLM, conf=0.90)
Experimental — accuracy not yet measuredThe 334 alleles are associated with an increased likelihood of having at least one instance of a marital crisis, decreased marital quality as assessed by one's spouse, and decreased likelihood of being married.
“The 334 alleles are also associated with an increased likelihood of having at least one instance of a marital crisis, decreased marital quality as assessed by one’s spouse, and decreased likelihood of being married.”
From The Neurobiology of Love and Pair Bonding from Human and Animal Perspectives (2023) · cites this paper as [19]
The RS3 repetitive polymorphism of the AVPR1A gene is associated with bonding in men, with those carrying one or two copies of the 334 alleles scoring lower on the Partner Bonding Scale than men who do not carry the 334 alleles.
“The RS3 repetitive polymorphism of the AVPR1A gene is associated with bonding in men, with those carrying one or two copies of the 334 alleles scoring lower on the Partner Bonding Scale than men who do not carry the 334 alleles [19].”
From The Neurobiology of Love and Pair Bonding from Human and Animal Perspectives (2023) · cites this paper as [19]
In humans, AVP has sex-specific effects on social communication and V1aR polymorphisms correlate with pair-bonding behavior in men, but not women.
“In humans, AVP has sex-specific effects on social communication (Thompson et al., 2006) and V1aR polymorphisms correlate with pair-bonding behavior in men, but not in women (Walum et al., 2008).”
From Sex-specific modulation of juvenile social play by vasopressin (2013) · cites this paper as Walum et al., 2008
In humans, AVP1A gene variants have sex-specific effects on pair-bonding.
“while AVP1A gene variants had sex-specific effects on pair-bondng and prepulse inhibition”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Walum et al., 2008
A polymorphic marker in AVPR1A is associated with pair bonding behavior in humans.
“Perhaps most remarkably, one of these polymorphic markers in the AVPR1A, which has been associated with altered brain activation patterns during a face processing task, has been associated with pair bonding behavior in humans, including measure of partner bonding, perceived marital problems, marital status, as well as spousal perception of marital quality [50].”
From The prairie vole: An emerging model organism for understanding the social brain (2010) · cites this paper as [50]
A polymorphic marker in AVPR1A is associated with altered brain activation patterns during a face processing task.
“Perhaps most remarkably, one of these polymorphic markers in the AVPR1A, which has been associated with altered brain activation patterns during a face processing task, has been associated with pair bonding behavior in humans, including measure of partner bonding, perceived marital problems, marital status, as well as spousal perception of marital quality [50].”
From The prairie vole: An emerging model organism for understanding the social brain (2010) · cites this paper as [50]
Romantic relationship status, relationship quality, and sexual behaviors have been linked to OXTR variation in women and AVPR1a variation in men.
“Romantic relationship status, relationship quality, and sexual behaviors have been linked to OXTR variation in women and AVPR1a variation in men, although this sexual division is not always straighforward (12, 35 -37).”
From Variation in the β-endorphin, oxytocin, and dopamine receptor genes is associated with different dimensions of human sociality (2017) · cites this paper as [37]
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“Specifically, men with a particular polymorphism of the avpr1a gene reported significantly more marital problems and were more likely to be in a nonmarried relationship compared to men who had different avpr1a polymorphisms (Walum et al., 2008).”
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“The RS3 repetitive polymorphism of the AVPR1A gene is associated with bonding in men, with those carrying one or two copies of the 334 alleles scoring lower on the Partner Bonding Scale than men who do not carry the 334 alleles [19].”
BackgroundDonaldson, Z. R., & Young, L. J. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003729 · Cited by 52 · see citing works
Beyond “oxytocin = good”: neural complexities and the flipside of social bonds
van Anders, S. M., Goodson, J. L., & Kingsbury, M. A. (2013) · Archives of Sexual Behavior · doi:10.1007/s10508-013-0134-9 · Cited by 52 · see citing works
Yang, S. Y., Cho, S.-C., Yoo, H. J., Cho, I. H., Park, M., Kim, B.-N., Kim, J.-W., Shin, M.-S., Park, T.-W., Son, J.-W., et al. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.05.050 · Cited by 45 · see citing works
Associations between oxytocin-related genes and autistic-like traits
Hovey, D., Zettergren, A., Jonsson, L., Melke, J., Anckarsäter, H., Lichtenstein, P., & Westberg, L. (2014) · Social Neuroscience · doi:10.1080/17470919.2014.897995 · Cited by 37 · see citing works
Oxytocin and the social brain: beware the complexity
Bartels, A. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.71 · Cited by 31 · see citing works
Evolutionary diversity as a catalyst for biological discovery
JOHNSON, Z. V., & YOUNG, L. J. (2018) · Integrative Zoology · doi:10.1111/1749-4877.12339 · Cited by 25 · see citing works
Vollebregt, O., Koyama, E., Zai, C. C., Shaikh, S. A., Lisoway, A. J., Kennedy, J. L., & Beitchman, J. H. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.05.062 · Cited by 13 · see citing works
On the origins of diversity in social behavior
YOUNG, L. J., & ZHANG, Q. (2021) · Japanese Journal of Animal Psychology · doi:10.2502/janip.71.1.4 · Cited by 13 · see citing works
Real-life helping behaviours in North America: A genome-wide association approach.
Primes, G., & Fieder, M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0190950 · Cited by 4 · see citing works
- Authors
- Walum, H., Westberg, L., Henningsson, S., Neiderhiser, J. M., Reiss, D., Igl, W., Ganiban, J. M., Spotts, E. L., Pedersen, N. L., Eriksson, E., & Lichtenstein, P.
- Affiliations
- Karolinska Institutet (SE)
- University of Gothenburg (SE)
- Pennsylvania State University (US)
- Yale University (US)
- George Washington University (US)
- National Institutes of Health (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2008-09-16
- Volume
- 105
- Issue
- 37
- Pages
- 14153-14156
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2533683
- OpenAlex
- W2167789289
- Cited by
- 460
- References
- 30
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 8 · 2023: 14 · 2022: 8 · 2021: 16 · 2020: 13 · 2019: 18 · 2018: 25 · 2017: 33 · 2016: 31 · 2015: 36 · 2014: 38 · 2013: 41 · 2012: 42
- FWCI
- 51.80
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Riksbankens Jubileumsfond
- National Institute of Mental Health (R01MH054610)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Evolutionary Psychology and Human Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- vasopressin 1a receptor, AVPR1A, vasopressin, single nucleotide polymorphisms, 5'-flanking region, monogamy, marital quality, marital status, human genetics
- MeSH terms
- Alleles, Family Characteristics, Female, Humans, Male, Polymorphism, Genetic, Sexual Behavior, Twins, Receptors, Vasopressin, Spouses, Microsatellite Repeats, 5' Flanking Region
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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