Cited by 220Genetics and Neurodevelopmental DisordersAutism Spectrum Disorder ResearchNeuroendocrine regulation and behavior

The DOI matches its Crossref record; 126 of the 126 references it cites were found in a registry or an index.

Communication Impairments in Mice Lacking Shank1: Reduced Levels of Ultrasonic Vocalizations and Scent Marking Behavior

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Abstract

Autism is a neurodevelopmental disorder with a strong genetic component. Core symptoms are abnormal reciprocal social interactions, qualitative impairments in communication, and repetitive and stereotyped patterns of behavior with restricted interests. Candidate genes for autism include the SHANK gene family, as mutations in SHANK2 and SHANK3 have been detected in several autistic individuals. SHANK genes code for a family of scaffolding proteins located in the postsynaptic density of excitatory synapses. To test the hypothesis that a mutation in SHANK1 contributes to the symptoms of autism, we evaluated Shank1(-/-) null mutant mice for behavioral phenotypes with relevance to autism, focusing on social communication. Ultrasonic vocalizations and the deposition of scent marks appear to be two major modes of mouse communication. Our findings revealed evidence for low levels of ultrasonic vocalizations and scent marks in Shank1(-/-) mice as compared to wildtype Shank1(+/+) littermate controls. Shank1(-/-) pups emitted fewer vocalizations than Shank1(+/+) pups when isolated from mother and littermates. In adulthood, genotype affected scent marking behavior in the presence of female urinary pheromones. Adult Shank1(-/-) males deposited fewer scent marks in proximity to female urine than Shank1(+/+) males. Call emission in response to female urinary pheromones also differed between genotypes. Shank1(+/+) mice changed their calling pattern dependent on previous female interactions, while Shank1(-/-) mice were unaffected, indicating a failure of Shank1(-/-) males to learn from a social experience. The reduced levels of ultrasonic vocalizations and scent marking behavior in Shank1(-/-) mice are consistent with a phenotype relevant to social communication deficits in autism.

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Crossref · 10.1371/journal.pone.0020631

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  1. J Nyby, 1979, Elicitation of male mouse (Mus musculus) ultrasonic vocalizations: I. Urinary cues., J Comp Physiol Psychol, 93, 957, 10.1037/h0077623 · DOI

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Metadata

Authors
Wöhr, M., Roullet, F. I., Hung, A. Y., Sheng, M., & Crawley, J. N.
Affiliations
  • National Institutes of Health (US)
  • Massachusetts Institute of Technology (US)
Corresponding author
  • Wöhr, Markus
  • Crawley, Jacqueline N.
Venue
PLoS ONE
Published
2011-06-09
Volume
6
Issue
6
Pages
e20631
ISSN
1932-6203 (ISSN-L)
OpenAlex
W2115330604
Cited by
220
References
126
Citations by year
2026: 7 · 2025: 8 · 2024: 10 · 2023: 11 · 2022: 14 · 2021: 14 · 2020: 10 · 2019: 11 · 2018: 9 · 2017: 16 · 2016: 21 · 2015: 23 · 2014: 21 · 2013: 19 · 2012: 22
FWCI
13.17
Type
journal article
Language
en
Open access
Locations
  • PLoS ONE (publishedVersion, public-domain)
  • PubMed Central (publishedVersion, public-domain)
  • PubMed (publishedVersion)
  • Lirias (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
Funders
  • National Institutes of Health
  • National Institute of Mental Health
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords
Shank1, autism spectrum disorder, social communication, ultrasonic vocalizations, scent marking, urinary pheromones, postsynaptic scaffolding proteins, social learning, social behavior deficits
MeSH terms
Aging, Animals, Body Temperature, Body Weight, Female, Male, Membrane Proteins, Nerve Tissue Proteins, Odorants, Reflex, Ultrasonics, Vocalization, Animal, Mice

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