Cited by 143Neuroscience and Neural EngineeringNeural dynamics and brain functionUndergraduate Neuroscience Education and Research

A Wireless Multi-Channel Recording System for Freely Behaving Mice and Rats

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Fan, David, Rich, Dylan, Holtzman, Tahl, Ruther, Patrick, Dalley, Jeffrey W., Lopez, Alberto, Rossi, Mark A., Barter, Joseph W. +5 more·2011·PLoS ONE

Abstract

To understand the neural basis of behavior, it is necessary to record brain activity in freely moving animals. Advances in implantable multi-electrode array technology have enabled researchers to record the activity of neuronal ensembles from multiple brain regions. The full potential of this approach is currently limited by reliance on cable tethers, with bundles of wires connecting the implanted electrodes to the data acquisition system while impeding the natural behavior of the animal. To overcome these limitations, here we introduce a multi-channel wireless headstage system designed for small animals such as rats and mice. A variety of single unit and local field potential signals were recorded from the dorsal striatum and substantia nigra in mice and the ventral striatum and prefrontal cortex simultaneously in rats. This wireless system could be interfaced with commercially available data acquisition systems, and the signals obtained were comparable in quality to those acquired using cable tethers. On account of its small size, light weight, and rechargeable battery, this wireless headstage system is suitable for studying the neural basis of natural behavior, eliminating the need for wires, commutators, and other limitations associated with traditional tethered recording systems.

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Crossref · 10.1371/journal.pone.0022033

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  1. [36]Paxinos G Watson C 1998 The rat brain in sterotaxic coordinates San Diego Academic Press

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Authors
Fan, D., Rich, D., Holtzman, T., Ruther, P., Dalley, J. W., Lopez, A., Rossi, M. A., Barter, J. W., Salas-Meza, D., Herwik, S., Holzhammer, T., Morizio, J., & Yin, H. H.
Affiliations
  • Duke University (US)
  • Howard Hughes Medical Institute (US)
  • University of Cambridge (GB)
  • University of Freiburg (DE)
Corresponding author
  • Morizio, James
  • Yin, Henry H.
Venue
PLoS ONE
Published
2011-07-12
Volume
6
Issue
7
Pages
e22033
ISSN
1932-6203 (ISSN-L)
OpenAlex
W2127394904
Cited by
143
References
39
Citations by year
2026: 3 · 2025: 10 · 2024: 2 · 2023: 5 · 2022: 8 · 2021: 10 · 2020: 4 · 2019: 12 · 2018: 12 · 2017: 13 · 2016: 8 · 2015: 17 · 2014: 14 · 2013: 13 · 2012: 9
FWCI
5.03
Type
journal article
Language
en
Open access
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • DukeSpace (Duke University) (submittedVersion, cc-by-nc-nd)
Funders
  • Howard Hughes Medical Institute
  • Wellcome Trust (027017, 093875)
  • Medical Research Council
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Undergraduate Neuroscience Education and Research
Keywords
multichannel recording, freely moving animals, single-unit recording, local field potentials, dorsal striatum, substantia nigra, ventral striatum, prefrontal cortex, neural basis of behavior, mice, rats
MeSH terms
Animals, Behavior, Animal, Conditioning, Operant, Reaction Time, Telemetry, Video Recording, Neostriatum, Rotarod Performance Test, Mice, Rats, Wireless Technology

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