Removal of GABAA Receptor γ2 Subunits from Parvalbumin Neurons Causes Wide-Ranging Behavioral Alterations
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We investigated the behavioral significance of fast synaptic inhibition by αβγ2-type GABA(A) receptors on parvalbumin (Pv) cells. The GABA(A) receptor γ2 subunit gene was selectively inactivated in Pv-positive neurons by Cre/loxP recombination. The resulting Pv-Δγ2 mice were relatively healthy in the first postnatal weeks; but then as Cre started to be expressed, the mice progressively developed wide-ranging phenotypic alterations including low body weight, motor deficits and tremor, decreased anxiety levels, decreased pain sensitivity and deficient prepulse inhibition of the acoustic startle reflex and impaired spatial learning. Nevertheless, the deletion was not lethal, and mice did not show increased mortality even after one year. Autoradiography with t-butylbicyclophosphoro[(35)S]thionate suggested an increased amount of GABA(A) receptors with only α and β subunits in central nervous system regions that contained high levels of parvalbumin neurons. Using BAC-transgenesis, we reduced some of the Pv-Δγ2 phenotype by selectively re-expressing the wild-type γ2 subunit back into some Pv cells (reticular thalamic neurons and cerebellar Pv-positive neurons). This produced less severe impairments of motor skills and spatial learning compared with Pv-Δγ2 mice, but all other deficits remained. Our results reveal the widespread significance of fast GABAergic inhibition onto Pv-positive neurons for diverse behavioral modalities, such as motor coordination, sensorimotor integration, emotional behavior and nociception.
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Findings from selective knockout of γ2GABAARs in PV+ interneurons were confounded by other phenotypic changes including low body weight and impaired motor performance.
“However, the findings were confounded by other phenotypic changes in the conditional knockout mice, including low body weight and impaired motor performance [88].”
From An emerging circuit pharmacology of GABAA receptors (2018) · cites this paper as [88]
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- Authors
- Leppä, E., Linden, A.-M., Vekovischeva, O. Y., Swinny, J. D., Rantanen, V., Toppila, E., Höger, H., Sieghart, W., Wulff, P., Wisden, W., & Korpi, E. R.
- Affiliations
- University of Helsinki (FI)
- University of Oxford (GB)
- Finnish Institute of Occupational Health (FI)
- Medical University of Vienna (AT)
- Heidelberg University (DE)
- Corresponding author
- Wisden, William
- Korpi, Esa R.
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-09-02
- Volume
- 6
- Issue
- 9
- Pages
- e24159
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3166293
- OpenAlex
- W2004314727
- Cited by
- 30
- References
- 89
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 1 · 2018: 5 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 5 · 2012: 2
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Aberdeen University Research Archive (Aberdeen University) (acceptedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Työväentutkimus Vuosikirja (submittedVersion, other-oa)
- Funders
- Deutsche Forschungsgemeinschaft
- Volkswagen Foundation
- Academy of Finland
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Keywords
- GABAA receptor, gamma2 subunit, parvalbumin neurons, GABAergic inhibition, behavioral phenotypes, prepulse inhibition, acoustic startle response, spatial learning, anxiety, pain sensitivity, motor impairment, tremor, gene deletion, Cre-loxP system, BAC transgenesis, nociception
- MeSH terms
- Zolpidem, Analgesics, Animals, Anxiety, Behavior, Animal, Binding Sites, Brain, Carbolines, Female, gamma-Aminobutyric Acid, Learning, Male, Motor Activity, Neurons, Parvalbumins, Phenotype, Pyridines, Receptors, GABA-A, Spatial Behavior, Species Specificity, Temperature, Gene Silencing, Mice, Nociception
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