Modulating Pharmacokinetics, Tumor Uptake and Biodistribution by Engineered Nanoparticles

Nanocarriers as an emerging platform for cancer therapy

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Cancer nanotechnology: opportunities and challenges

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Nanoparticle therapeutics: an emerging treatment modality for cancer

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The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect

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Delivering nanomedicine to solid tumors

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Designing materials for biology and medicine

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Biological safety and tissue distribution of (16-mercaptohexadecyl)trimethylammonium bromide-modified cationic gold nanorods

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Hydroxyapatite-binding micelles for the detection of vascular calcification in atherosclerosis

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Gd-metallofullerenol drug delivery system mediated macrophage polarization enhances the efficiency of chemotherapy

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Liver-specific drug delivery platforms: Applications for the treatment of alcohol-associated liver disease

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Synthesis of star-branched PLA-b-PMPC copolymer micelles as long blood circulation vectors to enhance tumor-targeted delivery of hydrophobic drugs in vivo

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Using the power of organic synthesis for engineering the interactions of nanoparticles with biological systems

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Nanomedicine as a potent strategy in melanoma tumor microenvironment

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Optimal Route of Gold Nanoclusters Administration in Mice Targeting Parkinson’S Disease

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Biodistribution and fate of core-labeled 125 I polymeric nanocarriers prepared by Flash NanoPrecipitation (FNP)

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pHe-Induced Charge-Reversible NIR Fluorescence Nanoprobe for Tumor-Specific Imaging

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Hydrophobic Effect from Conjugated Chemicals or Drugs on In Vivo Biodistribution of RNA Nanoparticles

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ATP/Hyals dually responsive core-shell hyaluronan/chitosan-based drug nanocarrier for potential application in breast cancer therapy

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Acylsulfonamide‐Functionalized Zwitterionic Gold Nanoparticles for Enhanced Cellular Uptake at Tumor pH

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A core/shell stabilized polysaccharide-based nanoparticle with intracellular environment-sensitive drug delivery for breast cancer therapy

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Recent advancements and future submissions of silica core-shell nanoparticles

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PEGylated liposomal Gemcitabine: insights into a potential breast cancer therapeutic

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Pluronic based β-cyclodextrin polyrotaxanes for treatment of Niemann-Pick Type C disease

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Interaction of Lysozyme with a Dendritic Polyelectrolyte: Quantitative Analysis of the Free Energy of Binding and Comparison to Molecular Dynamics Simulations

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Nanomedicine innovations in colon and rectal cancer: advances in targeted drug and gene delivery systems

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RAFT Emulsion Polymerization as a Platform to Generate Well‐Defined Biocompatible Latex Nanoparticles

Gurnani, P., Sánchez-Cano, C., Abraham, K., Xandri‐Monje, H., Cook, A. B., Hartlieb, M., Lévi, F., Dallmann, R., & Perrier, S. (2018) · Macromolecular Bioscience · doi:10.1002/mabi.201800213 · Cited by 26

Trade-off effect of polymeric nano-medicine in anti-cancer drug delivery

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Challenges for the Development of Extracellular Vesicle-Based Nucleic Acid Medicines

Kuriyama, N., Yoshioka, Y., Kikuchi, S., Okamura, A., Azuma, N., & Ochiya, T. (2021) · Cancers · doi:10.3390/cancers13236137 · Cited by 27

Targeted delivery of nutraceuticals derived from food for the treatment of obesity and its related complications

Dai, Z., Zhang, Y., Meng, Y., Li, S., Suonan, Z., Sun, Y., Ji, J., Shen, Q., Zheng, H., & Xue, Y. (2023) · Food Chemistry · doi:10.1016/j.foodchem.2023.135980 · Cited by 27

Designing nanoparticles with improved tumor penetration: surface properties from the molecular architecture viewpoint

Zhang, L., Hao, P., Yang, D., Feng, S., Peng, B., Appelhans, D., Zhang, T., & Zan, X. (2019) · Journal of Materials Chemistry B · doi:10.1039/c8tb03034k · Cited by 26

Folate Receptor-Mediated Delivery of 1-MDT-Loaded Mesoporous Silica Magnetic Nanoparticles to Target Breast Cancer Cells

Hashemzadeh, N., Dolatkhah, M., Aghanejad, A., Barzegar-Jalali, M., Omidi, Y., Adibkia, K., & Barar, J. (2021) · Nanomedicine · doi:10.2217/nnm-2021-0176 · Cited by 25

Leveraging Electrostatic Interactions for Drug Delivery to the Joint

Kumar, S., & Sharma, B. (2020) · Bioelectricity · doi:10.1089/bioe.2020.0014 · Cited by 25

Nano-Medicines a Hope for Chagas Disease!

Datta, S. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.655435 · Cited by 25

Key Points in Remote-Controlled Drug Delivery: From the Carrier Design to Clinical Trials

Voronin, D. V., Abalymov, A. A., Svenskaya, Y. I., & Lomova, M. V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179149 · Cited by 26

Self-Assembled Benznidazole-Loaded Cationic Nanoparticles Containing Cholesterol/Sialic Acid: Physicochemical Properties, In Vitro Drug Release and In Vitro Anticancer Efficacy

Silva, A. M. D. S., de Caland, L. B., do Nascimento, E. G., Oliveira, A. L. C. D. S. L., de Araujo-Junior, R. F., Cornélio, A. M., Fernandes‐Pedrosa, M. D. F., & da Silva-Júnior, A. A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092350 · Cited by 23

In Vivo Pharmacokinetics, Biodistribution and Toxicity of Antibody-Conjugated Gold Nanoparticles in Healthy Mice

Daems, N., Verlinden, B., Hoecke, K. V., Cardinaels, T., Baatout, S., Michiels, C., Lucas, S., & Aerts, A. (2020) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2020.2928 · Cited by 23

Dual pH-Responsive and Tumor-Targeted Nanoparticle-Mediated Anti-Angiogenesis siRNA Delivery for Tumor Treatment

Zhang, X., Qin, B., Wang, M., Feng, J., Zhang, C., Zhu, C., He, S., Liu, H., Wang, Y., Averick, S. E., et al. (2022) · International Journal of Nanomedicine · doi:10.2147/ijn.s340926 · Cited by 23

Nanotechnology for the theranostic opportunity of breast cancer lung metastasis: recent advancements and future challenges

Lin, M., Kang, Y., & Zhang, X. F. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1410017 · Cited by 26

Nanoparticle–protein interactions: Water is the key

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Synthesis and targeting of gold-coated 177Lu-containing lanthanide phosphate nanoparticles—A potential theranostic agent for pulmonary metastatic disease

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Dual stimuli-guided lipid-based delivery system of cancer combination therapy

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In vivo MRI visualization of U87 glioblastoma development dynamics in the model of orthotopic xenotransplantation to the SCID mouse

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Clinical Failure of Nanoparticles in Cancer: Mimicking Nature'S Solutions

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Targeting the Inside of Cells with Biologicals: Chemicals as a Delivery Strategy

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Mannosylated polydopamine nanoparticles alleviate radiation- induced pulmonary fibrosis by targeting M2 macrophages and inhibiting the TGF-β1/Smad3 signaling pathway

Shen, L., Fu, S., Chen, Y., Li, W., Liu, S., Li, Z., Li, J., Li, Y., Ran, Y., Zhang, J., et al. (2023) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2023.113353 · Cited by 21

Cell Membrane-Coated Nanoparticles for Dental, Oral, and Craniofacial Diseases

Wang, K.-N., Li, Z., Zhou, K., Liu, B., Rao, L., & Bu, L. (2024) · Research · doi:10.34133/research.0478 · Cited by 21

Opsonisation of nanoparticles prepared from poly(β-hydroxybutyrate) and poly(trimethylene carbonate)-b-poly(malic acid) amphiphilic diblock copolymers: Impact on the in vitro cell uptake by primary human macrophages and HepaRG hepatoma cells

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A multifunctional CeO2@SiO2-PEG nanoparticle carrier for delivery of food derived proanthocyanidin and curcumin as effective antioxidant, neuroprotective and anticancer agent

Chen, Z., Xu, L., Gao, X., Wang, C., Li, R., Xu, J., Zhang, M., Panichayupakaranant, P., & Chen, H. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109674 · Cited by 21

Pharmacokinetic Analysis of Peptide-Modified Nanoparticles with Engineered Physicochemical Properties in a Mouse Model of Traumatic Brain Injury

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Metal-phenolic network-based polymeric nanocarriers facilitating antibody cytoplasmic delivery and anti-tumor effects to orthotopic breast tumors

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Radiolabeled multi-layered coated gold nanoparticles as potential biocompatible PET/SPECT tracers

Urîtu, C. M., Matarneh, C. M. A., Bostiog, D.-I., Coroabǎ, A., Ghizdovăţ, V., Filipiuc, S. I., Simionescu, N., Ştefănescu, C., Jalloul, W., Năstasă, V., et al. (2024) · Journal of Materials Chemistry B · doi:10.1039/d3tb02654j · Cited by 20

Selective Cytotoxicity of Manganese Nanoparticles against Human Glioblastoma Cells

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Sorafenib encapsulated in nanocarrier functionalized with glypican-3 specific peptide for targeted therapy of hepatocellular carcinoma

Feng, S., Zhou, J., Li, Z., Appelman, H. D., Zhao, L., Zhu, J., & Wang, T. D. (2019) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2019.110498 · Cited by 20

Anticancer Vaccination with Immunogenic Micelles That Capture and Release Pristine CD8+ T-Cell Epitopes and Adjuvants

Ren, H., Li, J., Liu, G., Sun, Y., Yang, X., Jiang, Z., Zhang, J., Lovell, J. F., & Zhang, Y. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c18117 · Cited by 19

Enhancing Cisplatin Efficacy with Low Toxicity in Solid Breast Cancer Cells Using pH-Charge-Reversal Sericin-Based Nanocarriers: Development, Characterization, and In Vitro Biological Assessment

Bahremand, K., Aghaz, F., & Bahrami, K. (2024) · ACS Omega · doi:10.1021/acsomega.3c09361 · Cited by 19

Recent Advances in Nanomedicine for the Diagnosis and Treatment of Prostate Cancer Bone Metastasis

Hagaman, D., Damasco, J. A., Perez, J. V. D., Rojo, R. D., & Melancon, M. P. (2021) · Molecules · doi:10.3390/molecules26020384 · Cited by 20

PEGylation of Metal Oxide Nanoparticles Modulates Neutrophil Extracellular Trap Formation

Snoderly, H. T., Freshwater, K. A., de la Torre, C. M., Panchal, D. M., Vito, J. N., & Bennewitz, M. F. (2022) · Biosensors · doi:10.3390/bios12020123 · Cited by 20

Advances in biodistribution of gold nanoparticles: the influence of size, surface charge, and route of administration

Sodipo, B. K., & Mohammed, Z. K. (2024) · Biomedical Materials · doi:10.1088/1748-605x/ad5484 · Cited by 18

Oral delivery of polyester nanoparticles for brain-targeting: Challenges and opportunities

Wang, P., Wang, Y., Li, P., Chen, C., Ma, S., Zhao, L., He, H., Yin, T., Zhang, Y. X., Tang, X., et al. (2022) · Chinese Chemical Letters · doi:10.1016/j.cclet.2022.07.034 · Cited by 18

Local drug delivery in the urinary tract: current challenges and opportunities

Mittal, R., Pan, D. R., Parrish, J. M., Huang, E. H. ‐., Yang, Y., Patel, A. P., Malhotra, A. K., Mittal, J., Chhibber, S., & Harjai, K. (2017) · Journal of drug targeting · doi:10.1080/1061186x.2017.1419356 · Cited by 18

Programmed ‘triple-mode’ anti-tumor therapy: Improving peritoneal retention, tumor penetration and activatable drug release properties for effective inhibition of peritoneal carcinomatosis

Cherukula, K., Bae, W. K., Lee, J. H., & Park, I. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.03.051 · Cited by 18

Optimal size and PEG coating of gold nanoparticles for prolonged blood circulation: a statistical analysis of published data

Nevozhay, D., Rauch, R. A., Wang, Z., & Sokolov, K. (2025) · Nanoscale Advances · doi:10.1039/d4na00782d · Cited by 17

PPL catalyzed four-component PASE synthesis of 5-monosubstituted barbiturates: Structure and pharmacological properties

Bihani, M., Bora, P. P., Verma, A. K., Baruah, R., Boruah, H. P. D., & Bez, G. (2015) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2015.10.088 · Cited by 17

Zwitterionic Modification of Ultrasmall Iron Oxide Nanoparticles for Reduced Protein Corona Formation

García, K. P., Rühl, C. L., Lam, R., Barreto, J. A., Ang, C., Scammells, P. J., Comba, P., Spiccia, L., Graham, B., Joshi, T., et al. (2017) · ChemPlusChem · doi:10.1002/cplu.201700052 · Cited by 17

The Role of Polymeric Coatings for a Safe-by-Design Development of Biomedical Gold Nanoparticles Assessed in Zebrafish Embryo

Floris, P., Garbujo, S., Rolla, G. A., Giustra, M., Salvioni, L., Catelani, T., Colombo, M., Mantecca, P., & Fiandra, L. (2021) · Nanomaterials · doi:10.3390/nano11041004 · Cited by 17

Coating an adenovirus with functionalized gold nanoparticles favors uptake, intracellular trafficking and anti-cancer therapeutic efficacy

González‐Pastor, R., Hernández, Y., Gimeno, M., Martino, A. D., Man, Y. K. S., Halldén, G., Quintanilla, M., de la Fuente, J. M., & Martín‐Duque, P. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.07.047 · Cited by 17

Advancements in nanomedicines for the detection and treatment of diabetic kidney disease

Tillman, L., Tabish, T. A., Kamaly, N., Moss, P., El-briri, A., Thiemermann, C., Pranjol, M. Z. I., & Yaqoob, M. M. (2022) · Biomaterials and Biosystems · doi:10.1016/j.bbiosy.2022.100047 · Cited by 16

One-Step Synthesis of Nanoliposomal Copper Diethyldithiocarbamate and Its Assessment for Cancer Therapy

Paun, R. A., Dumut, D. C., Centorame, A., Thuraisingam, T., Hajdúch, M., Mistrík, M., Džubák, P., Sanctis, J. B. D., Radzioch, D., & Tabrizian, M. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14030640 · Cited by 16

Stimuli-responsive chitosan based nanoparticles in cancer therapy and diagnosis: A review

Fang, G., Peng, H., Qiao, R., Liu, B., Shi, X., Wang, Z., & Sun, P. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.137709 · Cited by 16

Magnetic Nanoparticle Hyperthermia

Bellizzi, G. G., & Bucci, O. M. (2018) · Springer eBooks · doi:10.1007/978-3-319-75007-1_6 · Cited by 16

Near-Infrared-Fluorescent Erythrocyte-Mimicking Particles: Physical and Optical Characteristics

Tang, J. C., Partono, A., & Anvari, B. (2018) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2018.2866368 · Cited by 16

Brain-targeted nanoparticles to overcome the blood-brain barrier

Seko, I., ŞAHİN, A., Tonbul, H., & Çapan, Y. (2020) · Journal of Pharmaceutical Technolgy · doi:10.37662/jpt.2020.4 · Cited by 16

PSMA-Targeting Reduction-Cleavable Hyperbranched Polyamide-Amine Gene Delivery System to Treat the Bone Metastases of Prostate Cancer

Ye, Y., Zhang, L., Dai, Y., Wang, Z., Li, C., Peng, Y., Ma, D., & He, P. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s268398 · Cited by 16

Surface-functionalized nanoparticles for targeted drug delivery across the blood-brain barrier: advances and challenges in neurodegenerative disease therapy

Pramoda, G., Verma, R. K., Kesharwani, P., & Shukla, R. (2025) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2025.127938 · Cited by 15

Polyglycerol‐Based Lipids: A Next‐Generation Alternative to PEG in Lipid Nanoparticles for Advanced Drug Delivery Systems

Ensminger, Y., Rashmi, R., Karimov, M., Nölte, G., Hafke, M., Schmitt, A., Díaz‐Oviedo, C. D., Köbberling, J., & Haag, R. (2025) · Macromolecular Rapid Communications · doi:10.1002/marc.202500428 · Cited by 15

Design of nanoparticle-based systems for the systemic delivery of chemotherapeutics: Alternative potential routes via sublingual and buccal administration for systemic drug delivery

Bahrami, K., Lee, E., Morse, B. A., Lanier, O. L., & Peppas, N. A. (2023) · Drug Delivery and Translational Research · doi:10.1007/s13346-023-01493-7 · Cited by 15

Influence of nanoparticles surface coating on physicochemical properties for CRISPR gene delivery

Alallam, B., Doolaanea, A. A., Oo, M. K., Nasir, M. H. M., & Taher, M. (2021) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.102910 · Cited by 15

Enhanced electrostatic discrimination of proteins on nanoparticle-coated surfaces

Xu, Y., Engel, Y., Yan, Y., Chen, K., Moyano, D. F., Dubin, P. L., & Rotello, V. M. (2013) · Journal of Materials Chemistry B · doi:10.1039/c3tb20377h · Cited by 15

Large-Scale 3D Optical Mapping and Quantitative Analysis of Nanoparticle Distribution in Tumor Vascular Microenvironment

Koo, D.-J., Choi, J., Ahn, M., Ahn, B. H., Min, D., & Kim, S. (2020) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.0c00263 · Cited by 16

Gelatin nanocarriers in oncology: A biocompatible strategy for targeted drug delivery

Khandal, J., Dohare, S., Dongsar, T. S., Gupta, G., Alsayari, A., Wahab, S., & Kesharwani, P. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.143244 · Cited by 14

In vivo toxicity evaluation of gold-dendrimer composite nanodevices with different surface charges

Kasturirangan, V., Nair, B. M., Kariapper, M. T. S., Lesniak, W. G., Tan, W., Bizimungu, R., Kanter, P. M., Tóth, K., Buitrago, S. M., Rustum, Y. M., et al. (2012) · Nanotoxicology · doi:10.3109/17435390.2012.668570 · Cited by 14

Internalisation and Biological Activity of Nucleic Acids Delivering Cell-Penetrating Peptide Nanoparticles Is Controlled by the Biomolecular Corona

Lorents, A., Maloverjan, M., Padari, K., & Pooga, M. (2021) · Pharmaceuticals · doi:10.3390/ph14070667 · Cited by 14

Novel Development of Nanoparticles—A Promising Direction for Precise Tumor Management

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Targeted Nanocarrier Delivery of RNA Therapeutics to Control HIV Infection

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