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Cited by 404Nanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsNanoparticles: synthesis and applications

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Modulating Pharmacokinetics, Tumor Uptake and Biodistribution by Engineered Nanoparticles

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Arvizo, Rochelle R., Miranda, Oscar R., Moyano, Daniel F., Walden, Chad A., Giri, Karuna, Bhattacharya, Resham, Robertson, J. David, Rotello, Vincent M., Reid, Joel M., Mukherjee, Priyabrata·2011·PLoS ONE
DOI 10.1371/journal.pone.0024374PMC PMC3172229
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Abstract

BACKGROUND: Inorganic nanoparticles provide promising tools for biomedical applications including detection, diagnosis and therapy. While surface properties such as charge are expected to play an important role in their in vivo behavior, very little is known how the surface chemistry of nanoparticles influences their pharmacokinetics, tumor uptake, and biodistribution. METHOD/PRINCIPAL FINDINGS: Using a family of structurally homologous nanoparticles we have investigated how pharmacological properties including tumor uptake and biodistribution are influenced by surface charge using neutral (TEGOH), zwitterionic (Tzwit), negative (TCOOH) and positive (TTMA) nanoparticles. Nanoparticles were injected into mice (normal and athymic) either in the tail vein or into the peritoneum. CONCLUSION: Neutral and zwitterionic nanoparticles demonstrated longer circulation time via both i.p. and i.v. administration, whereas negatively and positively charged nanoparticles possessed relatively short half-lives. These pharmacological characteristics were reflected on the tumor uptake and biodistribution of the respective nanoparticles, with enhanced tumor uptake by neutral and zwitterionic nanoparticles via passive targeting.

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Crossref · 10.1371/journal.pone.0024374

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Figure 1 Structural representation of gold nanoparticles (2 nm core diameter) used. Gold nanoparticles (AuNPs) of different surface charges were generated by chemical modification of the terminal portion of the ligand bonded to the nanoparticle core. Four types of AuNPs were used neutral (TEGOH), positive (TTMA), negative (TCOOH) and zwitterionic (TZwit). The surface charge was measured by zeta potential.
Figure 1 Structural representation of gold nanoparticles (2 nm core diameter) used. Gold nanoparticles (AuNPs) of different surface charges were generated by chemical modification of the terminal portion of the ligand bonded to the nanoparticle core. Four types of AuNPs were used neutral (TEGOH), positive (TTMA), negative (TCOOH) and zwitterionic (TZwit). The surface charge was measured by zeta potential.CC BY · PubMed Central
Figure 2 Plasma profiles for gold nanoparticles. Normal mice were injected either (A) intravenously or (B) intraperitoneally. Data points are the mean +/− SEM from n = 3 animals.
Figure 2 Plasma profiles for gold nanoparticles. Normal mice were injected either (A) intravenously or (B) intraperitoneally. Data points are the mean +/− SEM from n = 3 animals.CC BY · PubMed Central
Figure 3 Quantification of in vivo accumulation of gold nanoparticles into tumors. Coinciding with the blood concentration, nanoparticles that showed a long retention time in circulation were able to extravasate and accumulate into the tumor. Data points are the mean +/− SEM from n = 5 animals.
Figure 3 Quantification of in vivo accumulation of gold nanoparticles into tumors. Coinciding with the blood concentration, nanoparticles that showed a long retention time in circulation were able to extravasate and accumulate into the tumor. Data points are the mean +/− SEM from n = 5 animals.CC BY · PubMed Central
Figure 4 Tissue distribution of gold nanoparticles in mice. In vivo mean gold concentration (µg) per gram of organ 24 hours post (A) IP injection and (B) IV injection. The mode of administration and the ligand end group of AuNPs affects the level of gold uptake in different tissues with the RES being the dominant mode of clearance. Data points are the mean +/− SEM from n = 5 animals. Results are reported as gold concentration (µg) per gram of organ.
Figure 4 Tissue distribution of gold nanoparticles in mice. In vivo mean gold concentration (µg) per gram of organ 24 hours post (A) IP injection and (B) IV injection. The mode of administration and the ligand end group of AuNPs affects the level of gold uptake in different tissues with the RES being the dominant mode of clearance. Data points are the mean +/− SEM from n = 5 animals. Results are reported as gold concentration (µg) per gram of organ.CC BY · PubMed Central

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Authors
Arvizo, R. R., Miranda, O. R., Moyano, D. F., Walden, C. A., Giri, K., Bhattacharya, R., Robertson, J. D., Rotello, V. M., Reid, J. M., & Mukherjee, P.
Affiliations
  • Mayo Clinic (US)
  • University of Massachusetts Amherst (US)
  • University of Missouri (US)
Corresponding author
Mukherjee, Priyabrata
ORCID
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2011-09-13
Volume
6
Issue
9
Pages
e24374
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0024374
PMC
PMC3172229
OpenAlex
W2053311966
Cited by
403
References
43
Citations by year
2026: 11 · 2025: 25 · 2024: 25 · 2023: 27 · 2022: 27 · 2021: 36 · 2020: 37 · 2019: 41 · 2018: 23 · 2017: 34 · 2016: 30 · 2015: 24 · 2014: 21 · 2013: 27 · 2012: 11
FWCI
8.13
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Figshare (submittedVersion, cc-by)
Funders
  • National Institutes of Health (GM077173)
  • National Cancer Institute (R01CA136494, CA135001, CA136494)
  • National Institute of General Medical Sciences (GM-077173, R01GM077173)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
Keywords
engineered nanoparticles, surface charge, surface chemistry, pharmacokinetics, tumor uptake, tissue distribution, circulation time, zwitterionic nanoparticles, passive targeting, nanoparticle clearance, nude mice, intraperitoneal injection, intravenous injection
MeSH terms
Animals, Gold, Ligands, Male, Neoplasms, Surface Properties, Time Factors, Tissue Distribution, Nanotechnology, Cell Line, Tumor, Mice, Metal Nanoparticles

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