Characterisation of Innate Fungal Recognition in the Lung
Open accessAbstract
The innate recognition of fungi by leukocytes is mediated by pattern recognition receptors (PRR), such as Dectin-1, and is thought to occur at the cell surface triggering intracellular signalling cascades which lead to the induction of protective host responses. In the lung, this recognition is aided by surfactant which also serves to maintain the balance between inflammation and pulmonary function, although the underlying mechanisms are unknown. Here we have explored pulmonary innate recognition of a variety of fungal particles, including zymosan, Candida albicans and Aspergillus fumigatus, and demonstrate that opsonisation with surfactant components can limit inflammation by reducing host-cell fungal interactions. However, we found that this opsonisation does not contribute directly to innate fungal recognition and that this process is mediated through non-opsonic PRRs, including Dectin-1. Moreover, we found that pulmonary inflammatory responses to resting Aspergillus conidia were initiated by these PRRs in acidified phagolysosomes, following the uptake of fungal particles by leukocytes. Our data therefore provides crucial new insights into the mechanisms by which surfactant can maintain pulmonary function in the face of microbial challenge, and defines the phagolysosome as a novel intracellular compartment involved in the innate sensing of extracellular pathogens in the lung.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Certain macrophage receptors have been shown to facilitate engulfment of resting and germinating conidia: DC-SIGN, Dectin-1, an unidentified macrophage glycoprotein-scavenger receptor recognizing FleA, and soluble PRR including PTX3 and surfactant D.
“Despite the lack of specificity of the phagocytosis process, certain macrophage receptors have been shown to facilitate engulfment of resting and germinating conidia: the C-type lectin II receptor DC-SIGN (CD209) (235), Dectin-1 (236), an unidentified macrophage glycoprotein-scavenger receptor recognizing the Aspergillus FleA fucose-binding lectin (214), and soluble pattern recognition receptors (”
From Aspergillus fumigatus and Aspergillosis in 2019 (2019) · cites this paper as [236]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Recognition of microorganisms and activation of the immune response
Medzhitov, R. (2007) · Nature · doi:10.1038/nature06246 · Cited by 2,862 · see citing works
Dectin-1 Mediates the Biological Effects of β-Glucans
Brown, G. D., Herre, J., Williams, D. L., Willment, J. A., Marshall, A. S. J., & Gordon, S. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021890 · Cited by 1,209 · see citing works
Self-citationDectin-1: a signalling non-TLR pattern-recognition receptor
Brown, G. D. (2006) · Nature Reviews Immunology · doi:10.1038/nri1745 · Cited by 1,158 · see citing works
Self-citationDectin-1 is required for β-glucan recognition and control of fungal infection
Taylor, P. R., Tsoni, S. V., Willment, J. A., Dennehy, K. M., Rosas, M., Findon, H., Haynes, K., Steele, C. H., Botto, M., Gordon, S., et al. (2006) · Nature Immunology · doi:10.1038/ni1408 · Cited by 1,155 · see citing works
Self-citationDectin-1 Is A Major β-Glucan Receptor On Macrophages
Brown, G. D., Taylor, P. R., Reid, D. M., Willment, J. A., Williams, D. L., Martínez‐Pomares, L., Wong, S. Y. C., & Gordon, S. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020470 · Cited by 1,015 · see citing works
Self-citationPathogenesis of <i>Aspergillus fumigatus</i> in Invasive Aspergillosis
Dagenais, T. R. T., & Keller, N. P. (2009) · Clinical Microbiology Reviews · doi:10.1128/cmr.00055-08 · Cited by 993 · see citing works
Regulation of Phagosome Maturation by Signals from Toll-Like Receptors
Blander, J. M., & Medzhitov, R. (2004) · Science · doi:10.1126/science.1096158 · Cited by 991 · see citing works
Immunoregulatory functions of surfactant proteins
Wright, J. R. (2005) · Nature reviews. Immunology · doi:10.1038/nri1528 · Cited by 966 · see citing works
Antimicrobial mechanisms of phagocytes and bacterial evasion strategies
Flannagan, R. S., Cosío, G., & Grinstein, S. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2128 · Cited by 947 · see citing works
Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity
Groß, O., Gewies, A., Finger, K., Schäfer, M., Sparwasser, T. D., Peschel, C., Förster, I., & Ruland, J. (2006) · Nature · doi:10.1038/nature04926 · Cited by 855 · see citing works
Surface hydrophobin prevents immune recognition of airborne fungal spores
Aimanianda, V., Bayry, J., Bozza, S., Kniemeyer, O., Perruccio, K., Elluru, S. R., Clavaud, C., Paris, S., Brakhage, A. A., Kaveri, S. V., et al. (2009) · Nature · doi:10.1038/nature08264 · Cited by 792 · see citing works
Gardai, S. J., Xiao, Y., Dickinson, M. G., Nick, J. A., Voelker, D. R., Greene, K. E., & Henson, P. M. (2003) · Cell · doi:10.1016/s0092-8674(03)00758-x · Cited by 651 · see citing works
Surfactant Proteins A and D and Pulmonary Host Defense
Crouch, E. C., & Wright, J. R. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.521 · Cited by 634 · see citing works
The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor
Ewald, S. E., Lee, B. L., Lau, L., Wickliffe, K. E., Shi, G., Chapman, H. A., & Barton, G. M. (2008) · Nature · doi:10.1038/nature07405 · Cited by 616 · see citing works
Luther, K., Torosantucci, A., Brakhage, A. A., Heesemann, J., & Ebel, F. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00796.x · Cited by 582 · see citing works
The Beta-Glucan Receptor Dectin-1 Recognizes Specific Morphologies of Aspergillus fumigatus
Steele, C., Rapaka, R. R., Metz, A., Pop, S. M., Williams, D. L., Gordon, S., Kolls, J. K., & Brown, G. D. (2005) · PLoS Pathogens · doi:10.1371/journal.ppat.0010042 · Cited by 509 · see citing works
Self-citationGringhuis, S. I., den Dunnen, J., Litjens, M., van der Vlist, M., Wevers, B. A., Bruijns, S. C. M., & Geijtenbeek, T. B. H. (2009) · Nature Immunology · doi:10.1038/ni.1692 · Cited by 490 · see citing works
Robinson, M. J., Osorio, F., Rosas, M., Freitas, R. P., Schweighoffer, E., Groß, O., Verbeek, J. S., Ruland, J., Tybulewicz, V. L. J., Brown, G. D., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20082818 · Cited by 464 · see citing works
Self-citationAspergillus fumigatus Triggers Inflammatory Responses by Stage-Specific β-Glucan Display
Hohl, T. M., Van Epps, H. L., Rivera, A., Morgan, L. A., Chen, P. L., Feldmesser, M., & Pamer, E. G. (2005) · PLoS Pathogens · doi:10.1371/journal.ppat.0010030 · Cited by 428 · see citing works
C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia
Yamasaki, S., Matsumoto, M., Takeuchi, O., Matsuzawa, T., Ishikawa, E., Sakuma, M., Tateno, H., Uno, J., Hirabayashi, J., Mikami, Y., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805177106 · Cited by 424 · see citing works
Innate Antifungal Immunity: The Key Role of Phagocytes
Brown, G. D. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101229 · Cited by 424 · see citing works
Self-citationPhilippe, B., Ibrahim-Granet, O., Prévost, M. C., Gougerot-Pocidalo, M. A., Sanchez Perez, M., Van der Meeren, A., & Latgé, J. P. (2003) · Infection and Immunity · doi:10.1128/iai.71.6.3034-3042.2003 · Cited by 415 · see citing works
Requisite Role for the Dectin-1 β-Glucan Receptor in Pulmonary Defense against Aspergillus fumigatus
Werner, J. L., Metz, A. E., Horn, D., Schoeb, T. R., Hewitt, M. M., Schwiebert, L. M., Faro‐Trindade, I., Brown, G. D., & Steele, C. H. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0804250 · Cited by 412 · see citing works
Self-citationDennehy, K. M., Ferwerda, G., Faro-Trindade, I., Pyż, E., Willment, J. A., Taylor, P. R., Kerrigan, A. M., Tsoni, S. V., Gordon, S., Meyer-Wentrup, F., et al. (2008) · European Journal of Immunology · doi:10.1002/eji.200737741 · Cited by 391 · see citing works
Self-citationThe role of Dectin-1 in the host defence against fungal infections
Drummond, R. A., & Brown, G. D. (2011) · Current Opinion in Microbiology · doi:10.1016/j.mib.2011.07.001 · Cited by 294 · see citing works
Self-citationMadan, T., Eggleton, P., Kishore, U., Strong, P., Aggrawal, S. S., Sarma, P. U., & Reid, K. B. M. (1997) · Infection and Immunity · doi:10.1128/iai.65.8.3171-3179.1997 · Cited by 293 · see citing works
Immunomodulatory Roles of Surfactant Proteins A and D: Implications in Lung Disease
Pastva, A. M., Wright, J. R., & Williams, K. L. (2007) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200701-018aw · Cited by 277 · see citing works
Phagocytosis and Intracellular Fate of<i>Aspergillus fumigatus</i>Conidia in Alveolar Macrophages
Ibrahim-Granet, O., Philippe, B., Boleti, H., Boisvieux-Ulrich, E., Grenet, D., Stern, M., & Latgé, J. P. (2003) · Infection and Immunity · doi:10.1128/iai.71.2.891-903.2003 · Cited by 277 · see citing works
Shimada, T., Park, B. G., Wolf, A. J., Brikos, C., Goodridge, H. S., Becker, C. A., Reyes, C. N., Miao, E. A., Aderem, A., Götz, F., et al. (2010) · Cell Host & Microbe · doi:10.1016/j.chom.2009.12.008 · Cited by 274 · see citing works
Pulmonary Surfactant: An Immunological Perspective
Chroneos, Z. C., Sever-Chroneos, Z., & Shepherd, V. L. (2009) · Cellular Physiology and Biochemistry · doi:10.1159/000272047 · Cited by 203 · see citing works
Differential Use of CARD9 by Dectin-1 in Macrophages and Dendritic Cells
Goodridge, H. S., Shimada, T., Wolf, A. J., Hsu, Y.-M. S., Becker, C. A., Lin, X., & Underhill, D. M. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.2.1146 · Cited by 202 · see citing works
Thywißen, A., Heinekamp, T., Dahse, H., Schmaler-Ripcke, J., Nietzsche, S., Zipfel, P. F., & Brakhage, A. A. (2011) · Frontiers in Microbiology · doi:10.3389/fmicb.2011.00096 · Cited by 161 · see citing works
Macrophage recognition of zymosan particles
Underhill, D. M. (2003) · Journal of Endotoxin Research · doi:10.1177/09680519030090030601 · Cited by 161 · see citing works
Ramirez‐Ortiz, Z. G., Specht, C. A., Wang, J. P., Lee, C. K., Bartholomeu, D. C., Gazzinelli, R. T., & Levitz, S. M. (2008) · Infection and Immunity · doi:10.1128/iai.00047-08 · Cited by 151 · see citing works
Ip, W. K. E., Sokolovska, A., Charriere, G. M., Boyer, L., Dejardin, S., Cappillino, M. P., Yantosca, L. M., Takahashi, K., Moore, K. J., Lacy-Hulbert, A., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000110 · Cited by 148 · see citing works
Surfactant Collectins and Innate Immunity
Haagsman, H. P., Hogenkamp, A., van Eijk, M., & Veldhuizen, E. J. A. (2008) · Neonatology · doi:10.1159/000121454 · Cited by 129 · see citing works
Macrophage recognition of zymosan particles
Underhill, D. M. (2003) · Journal of Endotoxin Research · doi:10.1179/096805103125001586 · Cited by 126 · see citing works
Stage-Specific Sampling by Pattern Recognition Receptors during Candida albicans Phagocytosis
Heinsbroek, S. E. M., Taylor, P. R., Martínez, F. O., Martínez‐Pomares, L., Brown, G. D., & Gordon, S. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000218 · Cited by 124 · see citing works
Self-citationFernandez‐Mora, E., Polidori, M. C., Lührmann, A., Schaible, U. E., & Haas, A. (2005) · Traffic · doi:10.1111/j.1600-0854.2005.00304.x · Cited by 114 · see citing works
Taylor, P. R., Brown, G. D., Geldhof, A. B., Martínez‐Pomares, L., & Gordon, S. (2003) · European Journal of Immunology · doi:10.1002/eji.200324003 · Cited by 114 · see citing works
Self-citationSoluble Dectin-1 as a tool to detect β-glucans
Graham, L. M., Tsoni, S. V., Willment, J. A., Williams, D. L., Taylor, P. R., Gordon, S., Dennehy, K. M., & Brown, G. D. (2006) · Journal of Immunological Methods · doi:10.1016/j.jim.2006.05.013 · Cited by 114 · see citing works
Self-citationComplement C3 Plays an Essential Role in the Control of Opportunistic Fungal Infections
Tsoni, S. V., Kerrigan, A. M., Marakalala, M. J., Srinivasan, N., Duffield, M., Taylor, P. R., Botto, M., Steele, C. H., & Brown, G. D. (2009) · Infection and Immunity · doi:10.1128/iai.00233-09 · Cited by 96 · see citing works
Self-citationInternalization of Dectin‐1 terminates induction of inflammatory responses
Hernanz‐Falcón, P., Joffre, O. P., Williams, D. L., & Sousa, C. R. E. (2009) · European Journal of Immunology · doi:10.1002/eji.200838687 · Cited by 93 · see citing works
Role of Pulmonary Surfactant Protein D in Innate Defense againstCandida albicans
van Rozendaal, B. A. W. M., van Spriel, A. B., van de Winkel, J. G. J., & Haagsman, H. P. (2000) · The Journal of Infectious Diseases · doi:10.1086/315799 · Cited by 89 · see citing works
Interactions of Surfactant Proteins A and D withSaccharomyces cerevisiaeandAspergillus fumigatus
Allen, M. J., Voelker, D. R., & Mason, R. J. (2001) · Infection and Immunity · doi:10.1128/iai.69.4.2037-2044.2001 · Cited by 88 · see citing works
Binding of Rat and Human Surfactant Proteins A and D toAspergillus fumigatusConidia
Allen, M. J., Harbeck, R. J., Smith, B., Voelker, D. R., & Mason, R. J. (1999) · Infection and Immunity · doi:10.1128/iai.67.9.4563-4569.1999 · Cited by 83 · see citing works
Kasperkovitz, P. V., Cardenas, M. L., & Vyas, J. M. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002760 · Cited by 75 · see citing works
Madan, T., Reid, K. B. M., Clark, H. W., Singh, M., Nayak, A., Sarma, P. U., Hawgood, S. B., & Kishore, U. (2010) · Molecular Immunology · doi:10.1016/j.molimm.2010.02.027 · Cited by 63 · see citing works
Stokes, R. W., Thorson, L., & Speert, D. P. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.11.5514 · Cited by 61 · see citing works
Distinct Roles for Lung Collectins in Pulmonary Host Defense
Shepherd, V. L. (2002) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.26.3.f227 · Cited by 40 · see citing works
A method to enable the investigation of murine bronchial immune cells, their cytokines and mediators
Maxeiner, J., Karwot, R., Hausding, M., Sauer, K., Scholtes, P., & Finotto, S. (2007) · Nature Protocols · doi:10.1038/nprot.2007.8 · Cited by 37 · see citing works
Lekkala, M., LeVine, A. M., Linke, M. J., Crouch, E. C., Linders, B., Brummer, E., & Stevens, D. A. (2006) · Infection and Immunity · doi:10.1128/iai.00243-06 · Cited by 33 · see citing works
Pulmonary function response to EDTA, an additive in nebulized bronchodilators
Asmus, M. J., Barros, M. D., Liang, J., Chesrown, S. E., & Hendeles, L. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.111591 · Cited by 30 · see citing works
Singh, M., Madan, T., Waters, P. J., Sonar, S. S., Singh, S. K., Kamran, M. F., Bernal, A. L., Sarma, P. U., Singh, V. K., Crouch, E. C., et al. (2009) · Molecular Immunology · doi:10.1016/j.molimm.2009.03.019 · Cited by 29 · see citing works
Coping with Candida Infections
Evans, S. E. (2010) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200907-075al · Cited by 27 · see citing works
Immunology of Fungal Infections
Bidula, S. M., & Brown, G. D. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-374279-7.13001-2 · Cited by 26 · see citing works
Self-citationKelly, M. M., McNagny, K. M., Williams, D. L., van Rooijen, N., Maxwell, L., Gwozd, C., Mody, C. H., & Kubes, P. (2007) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2007-0045oc · Cited by 26 · see citing works
Kishore, U., & Reid, K. B. M. (2007) · Springer eBooks · doi:10.1007/1-4020-5492-0_7 · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Aspergillus fumigatus and Aspergillosis in 2019
Latgé, J.-P., & Chamilos, G. (2019) · Clinical Microbiology Reviews · doi:10.1128/cmr.00140-18 · Cited by 1,400 · see citing works
The mycobiota: interactions between commensal fungi and the host immune system
Underhill, D. M., & Iliev, I. D. (2014) · Nature reviews. Immunology · doi:10.1038/nri3684 · Cited by 692 · see citing works
Fungal allergy in asthma-state of the art and research needs
Denning, D. W., Pashley, C., Hartl, D., Wardlaw, A., Godet, C., Del Giacco, S., Delhaes, L., & Sergejeva, S. (2014) · Clinical and Translational Allergy · doi:10.1186/2045-7022-4-14 · Cited by 357 · see citing works
Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus
Stappers, M. H. T., Clark, A. E., Aimanianda, V., Bidula, S., Reid, D. M., Asamaphan, P., Hardison, S. E., Dambuza, I. M., Valsecchi, I., Kerscher, B., et al. (2018) · Nature · doi:10.1038/nature25974 · Cited by 200 · see citing works
Self-citationThe Intracellular Life ofCryptococcus neoformans
Coelho, C., Bocca, A. L., & Casadevall, A. (2013) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-012513-104653 · Cited by 130 · see citing works
The innate immune response to Aspergillus fumigatus at the alveolar surface
Margalit, A., & Kavanagh, K. A. (2015) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuv018 · Cited by 129 · see citing works
Mitogen activated protein kinases SakA HOG1 and MpkC collaborate for Aspergillus fumigatus virulence
Nascimento, A. C. M. D. O. B., dos Reis, T. F., de Castro, P. A., Hori, J. I., Bom, V. L. P., de Assis, L. J., Ramalho, L. N. Z., Rocha, M. C., Malavazi, I., Brown, N. A., et al. (2016) · Molecular Microbiology · doi:10.1111/mmi.13354 · Cited by 95 · see citing works
The mycobiome of the human urinary tract: potential roles for fungi in urology
Ackerman, A. L., & Underhill, D. M. (2017) · Annals of Translational Medicine · doi:10.21037/atm.2016.12.69 · Cited by 91 · see citing works
First Line of Defense: Innate Cell-Mediated Control of Pulmonary Aspergillosis
Espinosa, V., & Rivera, A. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00272 · Cited by 77 · see citing works
PAMPs of the Fungal Cell Wall and Mammalian PRRs
Hatinguais, R., Willment, J. A., & Brown, G. D. (2020) · Current topics in microbiology and immunology · doi:10.1007/82_2020_201 · Cited by 71 · see citing works
Self-citationStriking a balance: fungal commensalism versus pathogenesis
Iliev, I. D., & Underhill, D. M. (2013) · Current Opinion in Microbiology · doi:10.1016/j.mib.2013.05.004 · Cited by 68 · see citing works
Cellular immune reactions in the lung
Hasenberg, M., Stegemann‐Koniszewski, S., & Gunzer, M. (2012) · Immunological Reviews · doi:10.1111/imr.12020 · Cited by 65 · see citing works
Effects of Aspergillus fumigatus colonization on lung function in cystic fibrosis
Speirs, J. J., van der Ent, C. K., & Beekman, J. M. (2012) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0b013e328358d50b · Cited by 62 · see citing works
Current concepts: host–pathogen interactions in cystic fibrosis airways disease
Tang, A., Turvey, S. E., Alves, M. P., Regamey, N., Tümmler, B., & Hartl, D. (2014) · European Respiratory Review · doi:10.1183/09059180.00006113 · Cited by 57 · see citing works
Desoubeaux, G., & Cray, C. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00841 · Cited by 55 · see citing works
Immune cells fold and damage fungal hyphae
Bain, J. M., Alonso, M. F., Childers, D. S., Walls, C. A., Mackenzie, K. S., Pradhan, A., Lewis, L. E., Louw, J., Avelar, G. M., Larcombe, D. E., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2020484118 · Cited by 52 · see citing works
Self-citationThe Response of Human Macrophages to β-Glucans Depends on the Inflammatory Milieu
Municio, C., Álvarez, Y., Montero, O., Hugo, E., Rodríguez, M. R., Domingo, E., Alonso, S., Fernández, N., & Crespo, M. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062016 · Cited by 48 · see citing works
Animal Models of Aspergillosis.
Désoubeaux, G., & Cray, C. (2018) · Europe PMC (PubMed Central) · Cited by 47 · see citing works
Pollmächer, J., & Figge, M. T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111630 · Cited by 46 · see citing works
Bom, V. L. P., de Castro, P. A., Winkelströter, L. K., Mariné, M., Hori, J. I., Ramalho, L. N. Z., dos Reis, T. F., Goldman, M. H. S., Brown, N. A., Rajendran, R., et al. (2015) · Eukaryotic Cell · doi:10.1128/ec.00008-15 · Cited by 45 · see citing works
Dubey, L. K., Moeller, J. B., Schlosser, A. G., Sørensen, G. L., & Holmskov, U. (2013) · Immunobiology · doi:10.1016/j.imbio.2013.10.003 · Cited by 43 · see citing works
Profiling phagosome proteins identifies PD-L1 as a fungal-binding receptor
Li, K., Chatterjee, A., Chen, Q., Lagree, K., Wang, Y., Becker, C. A., Freeman, M. R., Murali, R., Yang, W., & Underhill, D. M. (2024) · Nature · doi:10.1038/s41586-024-07499-6 · Cited by 38 · see citing works
Amarsaikhan, N., O’Dea, E. M., Tsoggerel, A., Owegi, H. O., Gillenwater, J. A., & Templeton, S. P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100430 · Cited by 31 · see citing works
Santiago, K. L., Bomfim, G. F., Criado, P. R., & de Almeida, S. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110879 · Cited by 30 · see citing works
Innate Lung Defense during Invasive Aspergillosis: New Mechanisms
Garth, J. M., & Steele, C. H. (2017) · Journal of Innate Immunity · doi:10.1159/000455125 · Cited by 28 · see citing works
Self-citationClinical potential of oligonucleotide-based therapeutics in the respiratory system
Moschos, S. A., Usher, L., & Lindsay, M. A. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.10.009 · Cited by 26 · see citing works
Fc‐conjugated C‐type lectin receptors: Tools for understanding host–pathogen interactions
Willment, J. A. (2021) · Molecular Microbiology · doi:10.1111/mmi.14837 · Cited by 24 · see citing works
Self-citationPhagocytes as central players in the defence against invasive fungal infection
Hünniger, K., & Kurzai, O. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.03.021 · Cited by 23 · see citing works
Chung, D., Thammahong, A., Shepardson, K. M., Blosser, S. J., & Cramer, R. A. (2014) · Molecular Microbiology · doi:10.1111/mmi.12626 · Cited by 20 · see citing works
The cell biology of the innate immune response to Aspergillus fumigatus
Mansour, M. K., Tam, J. M., & Vyas, J. M. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06837.x · Cited by 20 · see citing works
Rand, T. G., Robbins, C., Rajaraman, D., Sun, M., & Miller, J. D. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1042-4 · Cited by 19 · see citing works
Modeling Mucosal Candidiasis in Larval Zebrafish by Swimbladder Injection
Gratacap, R. L., Bergeron, A. C., & Wheeler, R. T. (2014) · Journal of Visualized Experiments · doi:10.3791/52182 · Cited by 18 · see citing works
Shevchenko, M. A., Bolkhovitina, E. L., Servuli, E. A., & Sapozhnikov, A. M. (2013) · Respiratory Research · doi:10.1186/1465-9921-14-78 · Cited by 18 · see citing works
Brunel, S. F., Willment, J. A., Brown, G. D., Devereux, G., & Warris, A. (2018) · ERJ Open Research · doi:10.1183/23120541.00068-2017 · Cited by 17 · see citing works
Self-citationLim, J.-Y., Kim, Y. J., Woo, S. A., Jeong, J. W., Lee, Y., Kim, C., & Park, H. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.756206 · Cited by 16 · see citing works
Inmunopatología de las micosis invasivas por hongos filamentosos
García‐Vidal, C., & Salavert, M. (2014) · Revista Iberoamericana de Micología · doi:10.1016/j.riam.2014.09.001 · Cited by 15 · see citing works
Phagocytosis: a process that shapes immune responses to engulfed meals
Li, K., & Underhill, D. M. (2025) · Nature reviews. Immunology · doi:10.1038/s41577-025-01231-9 · Cited by 12 · see citing works
Zhao, G., Qiu, X.-Y., Lin, J., Li, Q., Hu, L., Wang, Q., & Li, H. (2016) · International Journal of Ophthalmology · doi:10.18240/ijo.2016.02.01 · Cited by 11 · see citing works
Computational Modeling of Macrophage Iron Sequestration during Host Defense against Aspergillus
Adhikari, B., Scindia, Y. M., Vieira, L. S., Ribeiro, H. D. A. L., Masison, J., Yang, N., Fonseca, L. L., Wheeler, M., Knapp, A., Mei, Y., et al. (2022) · mSphere · doi:10.1128/msphere.00074-22 · Cited by 10 · see citing works
Usefulness of animal models of aspergillosis in studying immunity against Aspergillus infections
Mirkov, I. I., Aleksandrov, A. P., Lazovic, B., Glamočlija, J., & Kataranovski, M. V. (2019) · Journal de Mycologie Médicale · doi:10.1016/j.mycmed.2019.01.006 · Cited by 9 · see citing works
Rivera-Mariani, F. E., Vysyaraju, K., Negherbon, J. P., Levetin, E., Horner, W. E., Härtung, T., & Breysse, P. N. (2013) · International Archives of Allergy and Immunology · doi:10.1159/000357036 · Cited by 9 · see citing works
Velez-Haro, J. M., Pérez-Rodríguez, F., Velazquéz‐Marquez, S., Medina, H. R., & Velázquez-Márquez, N. (2024) · Springer eBooks · doi:10.1007/978-3-031-62558-9_16 · Cited by 4 · see citing works
Patel, D., Challagundla, N., Mandaliya, D. K., Yadav, S., Naik, O., Dalai, P., Shah, D., Vora, H., & Agrawal-Rajput, R. (2022) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2022.2043899 · Cited by 4 · see citing works
Endosomal sensing of fungi: current understanding and emerging concepts
Bercusson, A., de Boer, L. L., & Armstrong-James, D. P. H. (2016) · Medical Mycology · doi:10.1093/mmy/myw072 · Cited by 3 · see citing works
Ma, T., Chen, R., Li, X., Lu, C., & Xi, L. (2015) · Microbial Pathogenesis · doi:10.1016/j.micpath.2015.07.001 · Cited by 2 · see citing works
Aspergilosis invasora en el paciente con enfermedad oncohematológica
Solano, C., & Vázquez, L. (2018) · Revista Iberoamericana de Micología · doi:10.1016/j.riam.2018.10.001 · Cited by 2 · see citing works
Recent advances in antifungal immunity
Drummond, R. A. (2025) · Advances in immunology · doi:10.1016/bs.ai.2025.04.003 · Cited by 1 · see citing works
4 Receptor–Ligand Interactions in Fungal Infections
Hardison, S. E., & Brown, G. D. (2013) · Springer eBooks · doi:10.1007/978-3-642-39432-4_4
Self-citationBercusson, A. (2019) · Spiral (Imperial College London) · doi:10.25560/82028
Yu, J., & Park, H.-S. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.732766538.793544105
Gaffen, S. L., & Richardson, J. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.732766538.793545163
Lung Immunity to Fungal Infections by Macrophages: Mechanisms and Implications
Sharma, J., Kulkarni, N. A., & Nanjappa, S. G. (2024) · IntechOpen eBooks · doi:10.5772/intechopen.1007542
Interferon crosstalk at the lung barrier in viral and fungal infection
Brochero, M. I. V., & Rivera, A. (2026) · Infection and Immunity · doi:10.1128/iai.00295-26
- Authors
- Faro-Trindade, I., Willment, J. A., Kerrigan, A. M., Redelinghuys, P., Hadebe, S., Reid, D. M., Srinivasan, N., Wainwright, H., Lang, D. M., Steele, C., & Brown, G. D.
- Affiliations
- University of Aberdeen (GB)
- University of Cape Town (ZA)
- University of Alabama at Birmingham (US)
- Corresponding author
- Brown, Gordon D.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-04-20
- Volume
- 7
- Issue
- 4
- Pages
- e35675
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3334970
- OpenAlex
- W2088903425
- Cited by
- 55
- References
- 58
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2022: 2 · 2021: 5 · 2020: 1 · 2019: 3 · 2018: 7 · 2017: 3 · 2016: 5 · 2015: 3 · 2014: 9 · 2013: 8 · 2012: 3
- FWCI
- 3.22
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Aberdeen University Research Archive (Aberdeen University) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Open University of Cape Town (University of Cape Town) (submittedVersion, cc-by)
- Funders
- American Lung Association
- Wellcome Trust (086558, 070018)
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL080317, HL080317)
- National Institute of Allergy and Infectious Diseases (R01AI068917, AI068917)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Keywords
- pulmonary innate immunity, pattern recognition receptors, Dectin-1, pulmonary surfactant, opsonization, zymosan, Candida albicans, Aspergillus fumigatus, phagolysosomes, fungal conidia, lung inflammation, host-pathogen interaction
- MeSH terms
- Dectin-1, Animals, Antigens, Fungal, Aspergillus fumigatus, Bronchoalveolar Lavage Fluid, Candida albicans, Candidiasis, Female, Immunity, Innate, Lung Diseases, Fungal, Lysosomes, Mice, Inbred BALB C, Phagocytosis, Phagosomes, Pneumonia, Protein Binding, Pulmonary Surfactants, Receptors, Immunologic, Spores, Fungal, Zymosan, Lectins, C-Type, Mice, Host-Pathogen Interactions, Pulmonary Aspergillosis, Mice, 129 Strain
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
