Cited by 83Muscle Physiology and DisordersHops Chemistry and ApplicationsPhytochemicals and Antioxidant Activities

Prevention of Disuse Muscle Atrophy by Dietary Ingestion of 8-Prenylnaringenin in Denervated Mice

Open access
Mukai, Rie, Horikawa, Hitomi, Fujikura, Yutaka, Kawamura, Tomoyuki, Nemoto, Hisao, Nikawa, Takeshi, Terao, Junji·2012·PLoS ONE

Abstract

Flavonoids have attracted considerable attention in relation to their effects upon health. 8-Prenylnaringenin (8-PN) is found in the common hop (Humulus lupulus) and assumed to be responsible for the health impact of beer consumption. We wanted to clarify the effects of prenylation on the physiological functions of dietary flavonoids by comparing the effects of 8-PN with that of intact naringenin in the prevention of disuse muscle atrophy using a model of denervation in mice. Consumption of 8-PN (but not naringenin) prevented loss of weight in the gastrocnemius muscle further supported by the lack of induction of the protein content of a key ubiquitin ligase involved in muscle atrophy, atrogin-1, and by the activation of Akt phosphorylation. 8-PN content in the gastrocnemius muscle was tenfold higher than that of naringenin. These results suggested that, compared with naringenin, 8-PN was effectively concentrated into skeletal muscle to exert its preventive effects upon disuse muscle atrophy. It is likely that prenylation generates novel functions for 8-PN by enhancing its accumulation into muscle tissue through dietary intake.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1371/journal.pone.0045048

Cites

50 of 50 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Dietary ingestion of 8-prenylnaringenin prevents denervation-induced muscle atrophy in C57BL/6 mice by stimulating the phosphorylation of protein kinase B and downregulating MAFbx.

    “Dietary ingestion of 8-prenylnaringenin prevents denervation-induced muscle atrophy in C57BL/6 mice by stimulating the phosphorylation of protein kinase B and downregulating MAFbx [119].”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. [30]McClung JM, Davis JM, Wilson MA, Goldsmith EC, Carson JA (2006) Estrogen status and skeletal muscle recovery from disuse atrophy. Journal of Applied Physiology 100: 2012– 2023. 16497837

Cited by

Sorted by citations

Authors
Mukai, R., Horikawa, H., Fujikura, Y., Kawamura, T., Nemoto, H., Nikawa, T., & Terao, J.
Affiliations
Tokushima University (JP)
Corresponding author
Terao, Junji
Venue
PLoS ONE
Published
2012-09-19
Volume
7
Issue
9
Pages
e45048
ISSN
1932-6203 (ISSN-L)
OpenAlex
W2020517997
Cited by
83
References
50
Citations by year
2026: 2 · 2025: 4 · 2024: 3 · 2023: 6 · 2022: 8 · 2021: 12 · 2020: 7 · 2019: 8 · 2018: 3 · 2017: 4 · 2016: 6 · 2015: 7 · 2014: 7 · 2013: 6
FWCI
2.57
Type
journal article
Language
en
Open access
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Institutional Repositories DataBase (IRDB) (publishedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Ministry of Education, Culture, Sports, Science and Technology
  • Japan Society for the Promotion of Science (23780136, 22380077)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Hops Chemistry and Applications
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords
8-prenylnaringenin, naringenin, flavonoids, prenylation, disuse atrophy, denervation, gastrocnemius, atrogin-1, ubiquitin ligase, Akt phosphorylation, skeletal muscle, dietary flavonoids
MeSH terms
Animals, Cell Line, Chromatography, High Pressure Liquid, Diet, Male, Mice, Inbred C57BL, Muscle Denervation, Muscular Atrophy, Phosphorylation, Powders, Water, Muscle, Skeletal, Muscle Fibers, Skeletal, Muscular Disorders, Atrophic, Humulus, Flavanones, Proto-Oncogene Proteins c-akt, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review