Overexpression of the Artemisia Orthologue of ABA Receptor, AaPYL9, Enhances ABA Sensitivity and Improves Artemisinin Content in Artemisia annua L
Open accessAbstract
The phytohormone abscisic acid (ABA) plays an important role in plant development and environmental stress response. In this study, we cloned an ABA receptor orthologue, AaPYL9, from Artemisia annua L. AaPYL9 is expressed highly in leaf and flower. AaPYL9 protein can be localized in both nucleus and cytoplasm. Yeast two-hybrid assay shows AaPYL9 can specifically interact with AtABI1 but not with AtABI2, AtHAB1 or AtHAB2. ABA can enhance the interaction between AaPYL9 and AtABI1 while AaPYL9-89 Pro→Ser and AaPYL9-116 His→Ala point mutations abolishes the interaction. BiFC assay shows that AaPYL9 interacts with AtABI1 in nucleus in planta. Transgenic Arabidopsis plants over-expressing AaPYL9 are more sensitive to ABA in the seed germination and primary root growth than wild type. Consistent with this, ABA report genes have higher expression in AaPYL9 overexpressing plants compared to wild type after ABA treatment. Moreover, overexpression of AaPYL9 in A. annua increases not only drought tolerance, but also artemisinin content after ABA treatment, with significant enhancement of the expression of key genes in artemisinin biosynthesis. This study provides a way to develop A. annua with high-yielding artemisinin and high drought resistance.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
ABA also modulates artemisinin biosynthesis through AabZIP1 and AaPLY9 transcription factors.
“ABA also modulates artemisinin biosynthesis through AabZIP1 and AaPLY9 TFs (Zhang et al. 2013, 2015).”
From Enhancing artemisinin content in and delivery from Artemisia annua: a review of alternative, classical, and transgenic approaches (2021) · cites this paper as Zhang et al. 2013
The Results section reports that ABA treatment increased artemisinin-biosynthesis gene expression and artemisinin content in plants overexpressing AaPYL9. But it identifies AaPYL9 as an ABA receptor, not a transcription factor; the paper does not establish the AabZIP1 portion of the jointly cited sentence. The claim also spells AaPYL9 as “AaPLY9.” (LLM, conf=0.90)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Pandey, S., Chen, J., Jones, A. M., & Assmann, S. M. (2006) · PLANT PHYSIOLOGY · doi:10.1104/pp.106.079038 · Cited by 231 · see citing works
RetractedS ALT AND D ROUGHT S TRESS S IGNAL T RANSDUCTION IN P LANTS
Zhu, J. (2002) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.53.091401.143329 · Cited by 5,808 · see citing works
Significance of Inducible Defense-related Proteins in Infected Plants
van Loon, L. C., Rep, M., & Pieterse, C. M. J. (2006) · Annual Review of Phytopathology · doi:10.1146/annurev.phyto.44.070505.143425 · Cited by 3,401 · see citing works
Abscisic Acid: Emergence of a Core Signaling Network
Cutler, S. R., Rodrı́guez, P. L., Finkelstein, R. R., & Abrams, S. R. (2010) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-042809-112122 · Cited by 3,169 · see citing works
Abscisic Acid Inhibits Type 2C Protein Phosphatases via the PYR/PYL Family of START Proteins
Park, S., Fung, P., Nishimura, N., Jensen, D. R., Fujii, H., Zhao, Y., Lumba, S., Santiago, J., Rodrigues, A., Chow, T.-F. F., et al. (2009) · Science · doi:10.1126/science.1173041 · Cited by 2,986 · see citing works
Regulators of PP2C Phosphatase Activity Function as Abscisic Acid Sensors
Ma, Y., Szostkiewicz, I., Korte, A., Moes, D., Yang, Y., Christmann, A., & Grill, E. (2009) · Science · doi:10.1126/science.1172408 · Cited by 2,467 · see citing works
Agrobacterium-mediated transformation of Arabidopsis thaliana using the floral dip method
Zhang, X., Henriques, R., Lin, S., Niu, Q., & Chua, N. (2006) · Nature Protocols · doi:10.1038/nprot.2006.97 · Cited by 2,344 · see citing works
Abscisic Acid Signaling in Seeds and Seedlings
Finkelstein, R. R., Gampala, S. S. L., & Rock, C. D. (2002) · The Plant Cell · doi:10.1105/tpc.010441 · Cited by 2,300 · see citing works
Yamaguchi‐Shinozaki, K., & Shinozaki, K. (1994) · The Plant Cell · doi:10.1105/tpc.6.2.251 · Cited by 1,996 · see citing works
Molecular Aspects of Seed Dormancy
Finkelstein, R. R., Reeves, W., Ariizumi, T., & Steber, C. M. (2008) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.59.032607.092740 · Cited by 1,389 · see citing works
In vitro reconstitution of an abscisic acid signalling pathway
Fujii, H., Chinnusamy, V., Rodrigues, A., Rubio, S., Antoni, R., Park, S., Cutler, S. R., Sheen, J., Rodrı́guez, P. L., & Zhu, J. (2009) · Nature · doi:10.1038/nature08599 · Cited by 1,347 · see citing works
Raghavendra, A. S., Gonugunta, V. K., Christmann, A., & Grill, E. (2010) · Trends in Plant Science · doi:10.1016/j.tplants.2010.04.006 · Cited by 1,311 · see citing works
Nemhauser, J. L., Hong, F., & Chory, J. (2006) · Cell · doi:10.1016/j.cell.2006.05.050 · Cited by 947 · see citing works
Molecular Basis of the Core Regulatory Network in ABA Responses: Sensing, Signaling and Transport
Umezawa, T., Nakashima, K., Miyakawa, T., Kuromori, T., Tanokura, M., Shinozaki, K., & Yamaguchi‐Shinozaki, K. (2010) · Plant and Cell Physiology · doi:10.1093/pcp/pcq156 · Cited by 923 · see citing works
Furihata, T., Maruyama, K., Fujita, Y., Umezawa, T., Yoshida, R., Shinozaki, K., & Yamaguchi‐Shinozaki, K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505667103 · Cited by 849 · see citing works
Fujita, Y., Nakashima, K., Yoshida, T., Katagiri, T., Kidokoro, S., Kanamori, N., Umezawa, T., Fujita, M., Maruyama, K., Ishiyama, K., et al. (2009) · Plant and Cell Physiology · doi:10.1093/pcp/pcp147 · Cited by 733 · see citing works
A gate–latch–lock mechanism for hormone signalling by abscisic acid receptors
Melcher, K., Ng, L.-M., Zhou, X. E., Soon, F.-F., Xu, Y., Suino-Powell, K. M., Park, S.-Y., Weiner, J. J., Fujii, H., Chinnusamy, V., et al. (2009) · Nature · doi:10.1038/nature08613 · Cited by 731 · see citing works
Abscisic Acid Plays an Important Role in the Regulation of Strawberry Fruit Ripening
Jia, H., Chai, Y., Li, C., Lu, D., Luo, J., Qin, L., & Shen, Y. (2011) · PLANT PHYSIOLOGY · doi:10.1104/pp.111.177311 · Cited by 725 · see citing works
Santiago, J., Rodrigues, A., Saéz, Á., Rubio, S., Antoni, R., Dupeux, F., Park, S., Márquez, J. A., Cutler, S. R., & Rodrı́guez, P. L. (2009) · The Plant Journal · doi:10.1111/j.1365-313x.2009.03981.x · Cited by 597 · see citing works
González‐Guzmán, M., Pizzio, G. A., Antoni, R., Vera‐Sirera, F., Merilo, E., Bassel, G. W., Fernández, M. A., Holdsworth, M. J., Perez-Amador, M. A., Kollist, H., et al. (2012) · The Plant Cell · doi:10.1105/tpc.112.098574 · Cited by 582 · see citing works
Structural basis of abscisic acid signalling
Miyazono, K., Miyakawa, T., Sawano, Y., Kubota, K., Kang, H., Asano, A., Miyauchi, Y., Takahashi, M., Zhi, Y., Fujita, Y., et al. (2009) · Nature · doi:10.1038/nature08583 · Cited by 578 · see citing works
Jeong, S.-T., Goto‐Yamamoto, N., Kobayashi, S., & Esaka, M. (2004) · Plant Science · doi:10.1016/j.plantsci.2004.03.021 · Cited by 563 · see citing works
Leonhardt, N., Kwak, J. M., Robert, N., Waner, D., Leonhardt, G., & Schroeder, J. I. (2004) · The Plant Cell · doi:10.1105/tpc.019000 · Cited by 553 · see citing works
The abscisic acid receptor PYR1 in complex with abscisic acid
Santiago, J., Dupeux, F., Round, A. R., Antoni, R., Park, S., Jamin, M., Cutler, S. R., Rodrı́guez, P. L., & Márquez, J. A. (2009) · Nature · doi:10.1038/nature08591 · Cited by 536 · see citing works
Nishimura, N., Sarkeshik, A., Nito, K., Park, S., Wang, A., Carvalho, P. C., Lee, S., Caddell, D. F., Cutler, S. R., Chory, J., et al. (2009) · The Plant Journal · doi:10.1111/j.1365-313x.2009.04054.x · Cited by 505 · see citing works
Structural Mechanism of Abscisic Acid Binding and Signaling by Dimeric PYR1
Nishimura, N., Hitomi, K., Arvai, A. S., Rambo, R. P., Hitomi, C., Cutler, S. R., Schroeder, J. I., & Getzoff, E. D. (2009) · Science · doi:10.1126/science.1181829 · Cited by 493 · see citing works
Loreti, E., Povero, G., Novi, G., Solfanelli, C., Alpi, A., & Pierdomenico Perata, A. (2008) · New Phytologist · doi:10.1111/j.1469-8137.2008.02511.x · Cited by 476 · see citing works
Seki, M., Ishida, J., Narusaka, M., Fujita, M., Nanjo, T., Umezawa, T., Kamiya, A., Nakajima, M., Enju, A., Sakurai, T., et al. (2002) · Functional & Integrative Genomics · doi:10.1007/s10142-002-0070-6 · Cited by 471 · see citing works
Structural insights into the mechanism of abscisic acid signaling by PYL proteins
Yin, P., Fan, H., Hao, Q., Yuan, X., Wu, D., Pang, Y., Yan, C., Li, W., Wang, J., & Yan, N. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1730 · Cited by 462 · see citing works
The AIP2 E3 ligase acts as a novel negative regulator of ABA signaling by promoting ABI3 degradationPreprint
Zhang, X., Garretón, V., & Chua, N. (2005) · Genes & Development · doi:10.1101/gad.1318705 · Cited by 438 · see citing works
Reymond, M., Muller, B., Leonardi, A., Charcosset, A., & Tardieu, F. (2003) · Plant Physiology · doi:10.1104/pp.013839 · Cited by 428 · see citing works
Breeding for water-saving and drought-resistance rice (WDR) in China
Luo, L. (2010) · Journal of Experimental Botany · doi:10.1093/jxb/erq185 · Cited by 425 · see citing works
Kim, H.-M., Hwang, H., Hong, J.-W., Lee, Y.-N., Ahn, I. P., Yoon, I. S., Yoo, S.-D., Lee, S., Lee, S. C., & Kim, B. (2011) · Journal of Experimental Botany · doi:10.1093/jxb/err338 · Cited by 357 · see citing works
Graham, I. A., Besser, K., Blumer, S., Branigan, C. A., Czechowski, T., Elias, L., Guterman, I., Harvey, D., Isaac, P. G., Khan, A. M., et al. (2010) · Science · doi:10.1126/science.1182612 · Cited by 348 · see citing works
AFP is a novel negative regulator of ABA signaling that promotes ABI5 protein degradationPreprint
Lopez‐Molina, L., Mongrand, S., Kinoshita, N., & Chua, N. (2003) · Genes & Development · doi:10.1101/gad.1055803 · Cited by 345 · see citing works
Hoth, S., Morgante, M., Sanchez, J.-P., Hanafey, M. K., Tingey, S. V., & Chua, N. (2002) · Journal of Cell Science · doi:10.1242/jcs.00175 · Cited by 326 · see citing works
ABA receptors: the START of a new paradigm in phytohormone signalling
Klingler, J., Batelli, G., & Zhu, J. (2010) · Journal of Experimental Botany · doi:10.1093/jxb/erq151 · Cited by 305 · see citing works
Nishimura, N., Yoshida, T., Kitahata, N., Asami, T., Shinozaki, K., & Hirayama, T. (2007) · The Plant Journal · doi:10.1111/j.1365-313x.2007.03107.x · Cited by 286 · see citing works
A novel role for abscisic acid emerges from underground
Smet, I. D., Zhang, H., Inzé, D., & Beeckman, T. (2006) · Trends in Plant Science · doi:10.1016/j.tplants.2006.07.003 · Cited by 284 · see citing works
Structural and functional insights into core ABA signaling
Weiner, J. J., Peterson, F. C., Volkman, B. F., & Cutler, S. R. (2010) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2010.09.007 · Cited by 271 · see citing works
Kuhn, J. M., Boisson‐Dernier, A., Dizon, M. B., Maktabi, M. H., & Schroeder, J. I. (2005) · PLANT PHYSIOLOGY · doi:10.1104/pp.105.070318 · Cited by 266 · see citing works
Lackman, P., González‐Guzmán, M., Tilleman, S., Carqueijeiro, I., Pérez, A. C., Moses, T., Seo, M., Kanno, Y., Häkkinen, S. T., Montagu, M. C. E. V., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103010108 · Cited by 265 · see citing works
Molecular Pharmacology and Pharmacogenomics of Artemisinin and its Derivatives in Cancer Cells
Efferth, T. (2006) · Current Drug Targets · doi:10.2174/138945006776359412 · Cited by 263 · see citing works
FaPYR1 is involved in strawberry fruit ripening
Chai, Y., Jia, H., Li, C., Dong, Q., & Shen, Y. (2011) · Journal of Experimental Botany · doi:10.1093/jxb/err207 · Cited by 252 · see citing works
Artemisinins for schistosomiasis and beyond.
Utzinger, J., Xiao, S.-H., Tanner, M., & Keiser, J. (2007) · PubMed · Cited by 232 · see citing works
Zhang, L., Jing, F., Li, F., Li, M., Wang, Y., Wang, G., Sun, X., & Tang, K. (2009) · Biotechnology and Applied Biochemistry · doi:10.1042/ba20080068 · Cited by 206 · see citing works
Self-citationCommon and unique elements of the ABA-regulated transcriptome of Arabidopsis guard cells
Wang, R., Pandey, S., Song, L., Gookin, T. E., Zhao, Z., Albert, R., & Assmann, S. M. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-216 · Cited by 196 · see citing works
Welcker, C., Boussuge, B., Bencivenni, C., Ribaut, J.-M., & Tardieu, F. (2006) · Journal of Experimental Botany · doi:10.1093/jxb/erl227 · Cited by 174 · see citing works
Identification and mechanism of ABA receptor antagonism
Melcher, K., Xu, Y., Ng, L.-M., Zhou, X. E., Soon, F.-F., Chinnusamy, V., Suino-Powell, K. M., Kovach, A., Tham, F. S., Cutler, S. R., et al. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1887 · Cited by 165 · see citing works
Functional genomics and the biosynthesis of artemisinin
Covello, P. S., Teoh, K. H., Polichuk, D. R., Reed, D. W., & Nowak, G. (2007) · Phytochemistry · doi:10.1016/j.phytochem.2007.02.016 · Cited by 152 · see citing works
Saavedra, X., Modrego, A., Rodriݩguez, D., González‐García, M. P., Sanz, L., Nicolaݩs, G., & Lorenzo, Ó. (2009) · PLANT PHYSIOLOGY · doi:10.1104/pp.109.146381 · Cited by 131 · see citing works
Jing, F., Zhang, L., Li, M., Tang, Y., Wang, Y., Wang, Y., Wang, Q., Pan, Q., Wang, G., & Tang, K. (2009) · Biologia · doi:10.2478/s11756-009-0040-8 · Cited by 123 · see citing works
Self-citationRomero, M. R., Serrano, M. A., Vallejo, M., Efferth, T., Alvarez, M., & Marı́n, J. J. G. (2006) · Planta Medica · doi:10.1055/s-2006-947198 · Cited by 122 · see citing works
Functional Genomics and the Biosynthesis of Artemisinin
Covello, P. S., Teoh, K. H., Polichuk, D. R., Reed, D. W., & Nowak, G. (2007) · ChemInform · doi:10.1002/chin.200742266 · Cited by 121 · see citing works
Structural basis for selective activation of ABA receptors
Peterson, F. C., Burgie, E. S., Park, S., Jensen, D. R., Weiner, J. J., Bingman, C. A., Chang, C. A., Cutler, S. R., Phillips, G. N., & Volkman, B. F. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1898 · Cited by 116 · see citing works
Mori, K., Sato, H., Goto‐Yamamoto, N., Kitayama, M., Kobayashi, S., Sugaya, S., Gemma, H., & Hashizume, K. (2015) · Vitis · doi:10.5073/vitis.2005.44.161-165 · Cited by 108 · see citing works
Moes, D., Himmelbach, A., Korte, A., Haberer, G., & Grill, E. (2008) · The Plant Journal · doi:10.1111/j.1365-313x.2008.03454.x · Cited by 104 · see citing works
Jeannette, E., Rona, J. P., Bardat, F., Cornel, D., Sotta, B., & Miginiac, É. (1999) · The Plant Journal · doi:10.1046/j.1365-313x.1999.00423.x · Cited by 94 · see citing works
Robert, N., Merlot, S., N’Guyen, V., Boisson‐Dernier, A., & Schroeder, J. I. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.07.047 · Cited by 92 · see citing works
Dude, Where's My Phenotype? Dealing with Redundancy in Signaling Networks
Cutler, S. R., & McCourt, P. (2005) · PLANT PHYSIOLOGY · doi:10.1104/pp.104.900152 · Cited by 83 · see citing works
Kim, J., Lee, B.-H., Kim, S., Oh, K.-H., & Cho, K. Y. (2006) · Journal of Plant Biology · doi:10.1007/bf03030784 · Cited by 62 · see citing works
El-Sayed, M., & Verpoorte, R. (2004) · Plant Growth Regulation · doi:10.1007/s10725-004-2604-5 · Cited by 57 · see citing works
Immunoquantitative analysis of artemisinin from Artemisia annua using polyclonal antibodies
Ferreira, J., & Janick, J. (1996) · Phytochemistry · doi:10.1016/0031-9422(95)00542-0 · Cited by 54 · see citing works
Identification of the abscisic acid receptor VvPYL1 in Vitis vinifera
Li, G., Xin, H., Zheng, X., Li, S., & Hu, Z. (2011) · Plant Biology · doi:10.1111/j.1438-8677.2011.00504.x · Cited by 37 · see citing works
Simultaneous Determination of Artemisinin and Its Bioprecursors in Artemisia annua
Vandenberghe, D., Vergauwe, A., Montagu, M. V., & den Eeckhout, E. G. V. (1995) · Journal of Natural Products · doi:10.1021/np50119a027 · Cited by 36 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Zhang, F., Fu, X., Lv, Z., Lu, X., Shen, Q., Zhang, L., Zhu, M., Wang, G., Sun, X., Liao, Z., et al. (2015) · Molecular Plant · doi:10.1016/j.molp.2014.12.004 · Cited by 248 · see citing works
Self-citationTranscriptional regulatory network of high-value active ingredients in medicinal plants
Zheng, H., Fu, X., Shao, J., Tang, Y., Yu, M., Li, L., Huang, L., & Tang, K. (2023) · Trends in Plant Science · doi:10.1016/j.tplants.2022.12.007 · Cited by 196 · see citing works
Self-citationHormonal regulation of anthocyanin biosynthesis for improved stress tolerance in plants
Li, Z., & Ahammed, G. J. (2023) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2023.107835 · Cited by 156 · see citing works
Plant Metabolic Engineering Strategies for the Production of Pharmaceutical Terpenoids
Lu, X., Tang, K., & Li, P. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.01647 · Cited by 141 · see citing works
Self-citationGenome-wide identification and characterization of ABA receptor PYL gene family in rice
Yadav, S. K., Kumar, V. V. S., Verma, R. K., Yadav, P. D., Saroha, A., Wankhede, D. P., Chaudhary, B., & Chinnusamy, V. (2020) · BMC Genomics · doi:10.1186/s12864-020-07083-y · Cited by 139 · see citing works
Lv, Z., Wang, S., Zhang, F., Chen, L., Hao, X., Pan, Q., Fu, X., Li, L., Sun, X., & Tang, K. (2016) · Plant and Cell Physiology · doi:10.1093/pcp/pcw118 · Cited by 133 · see citing works
Self-citationOverexpression of ABA Receptor PYL10 Gene Confers Drought and Cold Tolerance to Indica Rice
Verma, R. K., Kumar, V. V. S., Yadav, S. K., Pushkar, S., Rao, M. V., & Chinnusamy, V. (2019) · Frontiers in Plant Science · doi:10.3389/fpls.2019.01488 · Cited by 132 · see citing works
A Review of Biotechnological Artemisinin Production in Plants
Ikram, N. K. K., & Simonsen, H. T. (2017) · Frontiers in Plant Science · doi:10.3389/fpls.2017.01966 · Cited by 130 · see citing works
Transgenic approach to increase artemisinin content in Artemisia annua L.
Tang, K., Shen, Q., Yan, T., & Fu, X. (2014) · Plant Cell Reports · doi:10.1007/s00299-014-1566-y · Cited by 96 · see citing works
Self-citationArtemisia annua glandular secretory trichomes: the biofactory of antimalarial agent artemisinin
Ling Zhi, X. I. A. O., Tan, H., & Zhang, L. (2016) · 中国科学通报:英文版 · doi:10.1007/s11434-015-0980-z · Cited by 94 · see citing works
Self-citationKumar, A., Mosa, K. A., Ji, L., Kage, U., Dhokane, D., Karre, S., Madalageri, D. M., & Pathania, N. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1285752 · Cited by 90 · see citing works
Wani, K. I., Choudhary, S., Zehra, A., Naeem, M., Weathers, P., & Aftab, T. (2021) · Planta · doi:10.1007/s00425-021-03676-3 · Cited by 74 · see citing works
Gao, Z., Li, Q., Li, J., Chen, Y., Luo, M., Li, H., Wang, J., Wu, Y., Duan, S., Wang, L., et al. (2018) · Frontiers in Plant Science · doi:10.3389/fpls.2018.00592 · Cited by 73 · see citing works
Molecular regulation of the key specialized metabolism pathways in medicinal plants
Shi, M., Siwei, Z., Zheng, Z., Maoz, I., Zhang, L., & Kai, G. (2024) · Journal of Integrative Plant Biology · doi:10.1111/jipb.13634 · Cited by 59 · see citing works
Self-citationMuangphrom, P., Seki, H., Fukushima, E. O., & Muranaka, T. (2016) · Journal of Natural Medicines · doi:10.1007/s11418-016-1008-y · Cited by 59 · see citing works
Zhang, F., Xiang, L., Yu, Q., Zhang, H., Zhang, T., Zeng, J., Chen, G., Li, L., Fu, X., Shen, Q., et al. (2017) · Journal of Experimental Botany · doi:10.1093/jxb/erx444 · Cited by 59 · see citing works
Self-citationXiang, L., Zhu, S., Zhao, T., Zhang, M., Liu, W., Chen, M., Lan, X., & Liao, Z. (2015) · Plant Growth Regulation · doi:10.1007/s10725-014-0004-z · Cited by 52 · see citing works
A Putative PP2C-Encoding Gene Negatively Regulates ABA Signaling in Populus euphratica
Chen, J., Zhang, D., Zhang, C., Xia, X., Yin, W., & Tian, Q. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139466 · Cited by 48 · see citing works
Guo, Z., Hao, K., Lv, Z., Yu, L., Bu, Q., Ren, J., Zhang, H., Chen, R., & Zhang, L. (2022) · Plant Biotechnology Journal · doi:10.1111/pbi.13974 · Cited by 45 · see citing works
Self-citationDalal, M., & Inupakutika, M. A. (2014) · Molecular Breeding · doi:10.1007/s11032-014-0114-3 · Cited by 40 · see citing works
Overexpression of AaPIF3 promotes artemisinin production in Artemisia annua
Zhang, Q., Wu, N., Jian, D., Jiang, R., Yang, C., Lan, X., Chen, M., Zhang, F., & Liao, Z. (2019) · Industrial Crops and Products · doi:10.1016/j.indcrop.2019.111476 · Cited by 37 · see citing works
Self-citationLiu, L., Liu, C.-Y., Wang, H., Yu, S., Guan, T., Huang, Y., & Li, R.-C. (2020) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-020-01872-9 · Cited by 36 · see citing works
Zhong, Y., Li, L., Hao, X., Fu, X., Ma, Y., Xie, L., Shen, Q., Kayani, S., Pan, Q., Sun, X., et al. (2018) · Frontiers in Plant Science · doi:10.3389/fpls.2018.01777 · Cited by 30 · see citing works
Self-citationChen, Z., Kong, L., Zhou, Y., Chen, Z., Tian, D., Lin, Y., Wang, F., & Chen, S. (2017) · Functional Plant Biology · doi:10.1071/fp16314 · Cited by 29 · see citing works
Kageyama, A., Ishizaki, K., Kohchi, T., Matsuura, H., & Takahashi, K. (2015) · Phytochemistry · doi:10.1016/j.phytochem.2015.05.009 · Cited by 29 · see citing works
Yang, L., Li, Y., Lan, Y., Zhao, Y., Han, M., & Yang, L. (2020) · Industrial Crops and Products · doi:10.1016/j.indcrop.2020.112686 · Cited by 28 · see citing works
Ma, T., Gao, H., Zhang, D., Shi, Y., Zhang, T., Shen, X., Wu, L., Li, X., & Chen, S. (2020) · Chinese Medicine · doi:10.1186/s13020-020-00344-8 · Cited by 28 · see citing works
Genetic engineering of artemisinin biosynthesis: prospects to improve its production
Abdin, M. Z., & Alam, P. (2015) · Acta Physiologiae Plantarum · doi:10.1007/s11738-015-1771-5 · Cited by 25 · see citing works
Trihelix Transcriptional Factor GhGT26 of Cotton Enhances Salinity Tolerance in Arabidopsis
Li, Y., Hu, Z., Dong, Y., & Xie, Z. (2022) · Plants · doi:10.3390/plants11202694 · Cited by 22 · see citing works
Wang, Y., Zhang, G., Zhou, H., Yin, S., Li, Y., Ma, C., Chen, P., Sun, L., & Hao, F. (2023) · BMC Plant Biology · doi:10.1186/s12870-023-04330-8 · Cited by 22 · see citing works
Type 2C Phosphatase 1 of Artemisia annua L. Is a Negative Regulator of ABA Signaling
Zhang, F., Fu, X., Lv, Z., Shen, Q., Yan, T., Jiang, W., Wang, G., Sun, X., & Tang, K. (2014) · BioMed Research International · doi:10.1155/2014/521794 · Cited by 21 · see citing works
Self-citationAaABCG40 Enhances Artemisinin Content and Modulates Drought Tolerance in Artemisia annua
Fu, X., Liu, H., Hassani, D., Peng, B., Yan, X., Wang, Y., Wang, C., Li, L., Pin, L., Pan, Q., et al. (2020) · Frontiers in Plant Science · doi:10.3389/fpls.2020.00950 · Cited by 21 · see citing works
Self-citationLi, Y., Wang, D., Sun, C., Hu, X., Mu, X., Jing-jiang, H., Yang, Y., Zhang, Y., Xie, C., & Zhou, X. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.04.116 · Cited by 20 · see citing works
Cui, L., Huang, F., Zhang, D., Lin, Y., Liao, P., Zong, J., & Kai, G. (2015) · Molecular Genetics and Genomics · doi:10.1007/s00438-015-1005-y · Cited by 20 · see citing works
Liu, H., He, W., Yao, X., Yan, X., Wang, X., Peng, B., Zhang, Y., Shao, J., Hu, X., Miao, Q., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612929 · Cited by 18 · see citing works
Self-citationCui, Y., Xu, Z., Chen, X., Li-Ping, N. I. E., Wu, L., Wang, Y., Song, J., & Yao, H. (2020) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(20)30072-8 · Cited by 18 · see citing works
Specialized metabolites in seeds
Corso, M., Perreau, F., Rajjou, L., Malek, R. B., Lepiniec, L., & Mouille, G. (2020) · Advances in botanical research · doi:10.1016/bs.abr.2020.11.001 · Cited by 17 · see citing works
Li, Q., Tian, Q., Zhang, Y., Niu, M., Yu, X., Lian, C., Liu, C., Wang, H., Yin, W., & Xia, X. (2022) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-021-02178-0 · Cited by 15 · see citing works
Rasouli, F., Kiani‐Pouya, A., Movahedi, A., Wang, Y., Li, L., Yu, M., Pourkheirandish, M., Zhou, M., Chen, Z., Zhang, H., et al. (2022) · Plant and Cell Physiology · doi:10.1093/pcp/pcac158 · Cited by 14 · see citing works
Li, Y., Yang, Y., Li, P., Sheng, M., Li, L., Ma, X., Du, Z., Tang, K., Hao, X., & Kai, G. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.127345 · Cited by 14 · see citing works
Self-citationWang, L., Zhang, Y., Fu, X., Zhang, T., Ma, J., Zhang, L., Qian, H., Tang, K., Li, S., & Zhao, J. (2017) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1600223 · Cited by 13 · see citing works
Self-citationMADS-box gene AaSEP4 promotes artemisinin biosynthesis in Artemisia annua
Chen, T.-T., Yao, X., Liu, H., Li, Y., Qin, W. D., Yan, X., Wang, X., Peng, B., Zhang, Y., Shao, J., et al. (2022) · Frontiers in Plant Science · doi:10.3389/fpls.2022.982317 · Cited by 13 · see citing works
Self-citationKhan, S. H., & Rahman, L. U. (2017) · Reference series in phytochemistry · doi:10.1007/978-3-319-28669-3_15 · Cited by 13 · see citing works
Perassolo, M., Cardillo, A. B., Busto, V. D., Giulietti, A. M., & Talou, J. R. (2018) · Springer eBooks · doi:10.1007/978-3-319-78274-4_4 · Cited by 12 · see citing works
Zhang, T., Gou, Y., Bai, F., Bai, G., Chen, M., Zhang, F., & Liao, Z. (2019) · FEBS Letters · doi:10.1002/1873-3468.13350 · Cited by 10 · see citing works
Self-citationGuo, C., Xu, S., & Guo, X. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47070545 · Cited by 7 · see citing works
ABA Receptors: Prospects for Enhancing Biotic and Abiotic Stress Tolerance of Crops
Dalal, M., & Chinnusamy, V. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2211-6_10 · Cited by 6 · see citing works
Current state, strategies, and perspectives in enhancing artemisinin production
Zakariya, A. M., Saiman, M. Z., Simonsen, H. T., & Ikram, N. K. K. (2023) · Phytochemistry Reviews · doi:10.1007/s11101-023-09897-6 · Cited by 5 · see citing works
Liu, R., Wang, J., Xiao, M., Gao, X., Chen, J., & Dai, Y. (2020) · Genes · doi:10.3390/genes11020221 · Cited by 5 · see citing works
Fu, X., Shi, P., Shen, Q., Jiang, W., Tang, Y., Lv, Z., Yan, T., Li, L., Wang, G., Sun, X., et al. (2015) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.1440 · Cited by 5 · see citing works
Self-citationZhao, Y., Xiao, N., Long, Y., Luo, J., Liu, X., & Zhang, X. (2023) · Canadian Journal of Plant Science · doi:10.1139/cjps-2023-0119 · Cited by 4 · see citing works
Characterization of terpene synthase gene family in 'Artemisia annua' L.
Jia, W., Wang, Y., Yu, X., Zhang, L., Liu, S., & Huang, Z. (2014) · Plant Omics · Cited by 3 · see citing works
Self-citationYuan, Y., Zhou, M., Yang, M., Wang, M., Zhan, J., Wang, T., Chen, H., & Zheng, T. (2026) · Plant Stress · doi:10.1016/j.stress.2026.101367 · Cited by 2 · see citing works
Khan, S. H., & Rahman, L. U. (2016) · Springer eBooks · doi:10.1007/978-3-319-27490-4_15-1 · Cited by 2 · see citing works
Sustainable Metabolic Engineering and Epigenetic Modulation
Saurabh, S., Kiran, S., Pranay, K., Kumari, R., & Kumar, N. (2024) · Wiley eBooks · doi:10.1002/9781394186631.ch18 · Cited by 2 · see citing works
He, J., Gao, Q., Liao, T., & Zeng, Q.-P. (2015) · doi:10.7287/peerj.preprints.827v1 · Cited by 2 · see citing works
He, J., Gao, Q., Liao, T., & Zeng, Q.-P. (2015) · doi:10.7287/peerj.preprints.827 · Cited by 1 · see citing works
Antimalarial Compound Synthesis from Transgenic Cultures
Kundu, S., Mukherjee, S., & Ghosh, B. (2017) · Reference series in phytochemistry · doi:10.1007/978-3-319-28669-3_22
Antimalarial Compound Synthesis from Transgenic Cultures
Kundu, S., Mukherjee, S., & Ghosh, B. (2016) · Springer eBooks · doi:10.1007/978-3-319-27490-4_22-1
Ma, T., Gao, H., Zhang, D., Shi, Y., Zhang, T., Shen, X., Wu, L., Xiang, L., & Chen, S. (2020) · Figshare · doi:10.6084/m9.figshare.12599340
Ma, T., Gao, H., Zhang, D., Shi, Y., Zhang, T., Shen, X., Wu, L., Xiang, L., & Chen, S. (2020) · Figshare · doi:10.6084/m9.figshare.12599346
Ma, T., Gao, H., Zhang, D., Shi, Y., Zhang, T., Shen, X., Wu, L., Xiang, L., & Chen, S. (2020) · Figshare · doi:10.6084/m9.figshare.12599352
Ma, T., Gao, H., Zhang, D., Shi, Y., Zhang, T., Shen, X., Wu, L., Xiang, L., & Chen, S. (2020) · Figshare · doi:10.6084/m9.figshare.12599355
Research progress in the stress-improved medicinal plants
LÜ, B., Wang, H., & Jin, H. (2025) · Scientia Sinica Vitae · doi:10.1360/ssv-2024-0125
Yadav, S. K., Santosh Kumar, V. V., Verma, R. K., Yadav, P., Saroha, A., Wankhede, D. P., Chaudhary, B., & Chinnusamy, V. (2020) · Figshare · doi:10.6084/m9.figshare.13031233
Ma, T., Gao, H., Zhang, D., Shi, Y., Zhang, T., Shen, X., Wu, L., Xiang, L., & Chen, S. (2020) · Figshare · doi:10.6084/m9.figshare.12599349
Ma, T., Gao, H., Zhang, D., Shi, Y., Zhang, T., Shen, X., Wu, L., Xiang, L., & Chen, S. (2020) · Figshare · doi:10.6084/m9.figshare.12599361
Yadav, S. K., Santosh Kumar, V. V., Verma, R. K., Yadav, P., Saroha, A., Wankhede, D. P., Chaudhary, B., & Chinnusamy, V. (2020) · Figshare · doi:10.6084/m9.figshare.13031242
Wang, Y., Zhang, G., Zhou, H., Yin, S., Li, Y., Ma, C., Chen, P., Sun, L., & 郝福顺 (2024) · Figshare · doi:10.6084/m9.figshare.26596214
Ma, T., Gao, H., Zhang, D., Shi, Y., Zhang, T., Shen, X., Wu, L., Xiang, L., & Chen, S. (2020) · Figshare · doi:10.6084/m9.figshare.12599343
Yadav, S. K., Santosh Kumar, V. V., Verma, R. K., Yadav, P., Saroha, A., Wankhede, D. P., Chaudhary, B., & Chinnusamy, V. (2020) · Figshare · doi:10.6084/m9.figshare.13031245
Wang, Y., Zhang, G., Zhou, H., Yin, S., Li, Y., Ma, C., Chen, P., Sun, L., & 郝福顺 (2024) · Figshare · doi:10.6084/m9.figshare.26596217
Ma, T., Gao, H., Zhang, D., Shi, Y., Zhang, T., Shen, X., Wu, L., Xiang, L., & Chen, S. (2020) · Figshare · doi:10.6084/m9.figshare.12599358
Yadav, S. K., Santosh Kumar, V. V., Verma, R. K., Yadav, P., Saroha, A., Wankhede, D. P., Chaudhary, B., & Chinnusamy, V. (2020) · Figshare · doi:10.6084/m9.figshare.13031227
Yadav, S. K., Santosh Kumar, V. V., Verma, R. K., Yadav, P., Saroha, A., Wankhede, D. P., Chaudhary, B., & Chinnusamy, V. (2020) · Figshare · doi:10.6084/m9.figshare.13031236
Yadav, S. K., Santosh Kumar, V. V., Verma, R. K., Yadav, P., Saroha, A., Wankhede, D. P., Chaudhary, B., & Chinnusamy, V. (2020) · Figshare · doi:10.6084/m9.figshare.13031230
Yadav, S. K., Santosh Kumar, V. V., Verma, R. K., Yadav, P., Saroha, A., Wankhede, D. P., Chaudhary, B., & Chinnusamy, V. (2020) · Figshare · doi:10.6084/m9.figshare.13031239
- Authors
- Zhang, F., Lu, X., Lv, Z., Zhang, L., Zhu, M., Jiang, W., Wang, G., Sun, X., & Tang, K.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Tang, Kexuan
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-02-20
- Volume
- 8
- Issue
- 2
- Pages
- e56697
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3577733
- OpenAlex
- W1964082165
- Cited by
- 73
- References
- 65
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 7 · 2022: 4 · 2021: 2 · 2020: 19 · 2019: 3 · 2018: 3 · 2017: 8 · 2016: 6 · 2015: 9 · 2014: 5
- FWCI
- 8.05
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- Fudan University
- Arizona Biomedical Research Commission
- Shanghai Leading Academic Discipline Project (2011AA100605)
- National High-tech Research and Development Program
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Stress Responses and Tolerance
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Seed Germination and Physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Keywords
- abscisic acid receptor, Artemisia annua, artemisinin biosynthesis, ABA sensitivity, drought tolerance, transgenic Arabidopsis, seed germination, root growth, abscisic acid signaling
- MeSH terms
- Abscisic Acid, Carrier Proteins, Phosphoprotein Phosphatases, Plant Growth Regulators, Arabidopsis, Receptors, Cytoplasmic and Nuclear, Gene Expression Regulation, Plant, Plant Leaves, Plant Roots, Germination, Arabidopsis Proteins, Plants, Genetically Modified, Artemisia annua, Artemisinins, Intracellular Signaling Peptides and Proteins, Droughts, Plant Development
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review