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Cited by 193Dementia and Cognitive Impairment ResearchCancer-related cognitive impairment studiesCognitive Abilities and Testing

The DOI matches its Crossref record; 62 of the 63 references it cites were found in a registry or an index.

Factors Predicting Reversion from Mild Cognitive Impairment to Normal Cognitive Functioning: A Population-Based Study

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Sachdev, Perminder S., Lipnicki, Darren M., Crawford, John, Reppermund, Simone, Kochan, Nicole A., Trollor, Julian N., Wen, Wei, Draper, Brian, Slavin, Melissa J., Kang, Kristan, Lux, Ora, Mather, Karen A., Brodaty, Henry, the Sydney Memory, Team, Ageing Study·2013·PLoS ONE
DOI 10.1371/journal.pone.0059649PMC PMC3609866
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Abstract

INTRODUCTION: Mild cognitive impairment (MCI) is associated with an increased risk of developing dementia. However, many individuals diagnosed with MCI are found to have reverted to normal cognition on follow-up. This study investigated factors predicting or associated with reversion from MCI to normal cognition. METHODS: Our analyses considered 223 participants (48.9% male) aged 71-89 years, drawn from the prospective, population-based Sydney Memory and Ageing Study. All were diagnosed with MCI at baseline and subsequently classified with either normal cognition or repeat diagnosis of MCI after two years (a further 11 participants who progressed from MCI to dementia were excluded). Associations with reversion were investigated for (1) baseline factors that included diagnostic features, personality, neuroimaging, sociodemographics, lifestyle, and physical and mental health; (2) longitudinal change in potentially modifiable factors. RESULTS: There were 66 reverters to normal cognition and 157 non-reverters (stable MCI). Regression analyses identified diagnostic features as most predictive of prognosis, with reversion less likely in participants with multiple-domain MCI (p = 0.011), a moderately or severely impaired cognitive domain (p = 0.002 and p = 0.006), or an informant-based memory complaint (p = 0.031). Reversion was also less likely for participants with arthritis (p = 0.037), but more likely for participants with higher complex mental activity (p = 0.003), greater openness to experience (p = 0.041), better vision (p = 0.014), better smelling ability (p = 0.040), or larger combined volume of the left hippocampus and left amygdala (p<0.040). Reversion was also associated with a larger drop in diastolic blood pressure between baseline and follow-up (p = 0.026). DISCUSSION: Numerous factors are associated with reversion from MCI to normal cognition. Assessing these factors could facilitate more accurate prognosis of individuals with MCI. Participation in cognitively enriching activities and efforts to lower blood pressure might promote reversion.

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Figure 1 Flow diagram of sample selection.
Figure 1 Flow diagram of sample selection.CC BY · PubMed Central
Figure 2 Baseline factors associated with reversion from mild cognitive impairment to normal cognitive functioning. Univariate analyses identified measures that discriminated between reverters and non-reverters. Each of these measures was assigned to one of six sets of related variables: cognitive reserve, sensory, health and genetic, neuroimaging, personality, and diagnostic. For each of these sets we performed a separate multivariable regression containing the discriminating measures assigned to that set, controlling for age and sex (and intracranial volume for the neuroimaging set). A separate Nagelkerke R2 value is shown for each of the six sets. The factors on the right hand side are those from among the variables in the relevant set that were independently associated with reversion (p<0.05).
Figure 2 Baseline factors associated with reversion from mild cognitive impairment to normal cognitive functioning. Univariate analyses identified measures that discriminated between reverters and non-reverters. Each of these measures was assigned to one of six sets of related variables: cognitive reserve, sensory, health and genetic, neuroimaging, personality, and diagnostic. For each of these sets we performed a separate multivariable regression containing the discriminating measures assigned to that set, controlling for age and sex (and intracranial volume for the neuroimaging set). A separate Nagelkerke R2 value is shown for each of the six sets. The factors on the right hand side are those from among the variables in the relevant set that were independently associated with reversion (p<0.05).CC BY · PubMed Central

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Metadata

Authors
Sachdev, P. S., Lipnicki, D. M., Crawford, J., Reppermund, S., Kochan, N. A., Trollor, J. N., Wen, W., Draper, B., Slavin, M. J., Kang, K., Lux, O., Mather, K. A., Brodaty, H., Memory, T. S., & Team, A. S.
Affiliations
UNSW Sydney (AU)
Corresponding author
Sachdev, Perminder S.
ORCID
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2013-03-27
Volume
8
Issue
3
Pages
e59649
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0059649
PMC
PMC3609866
OpenAlex
W1984399440
Cited by
193
References
63
Citations by year
2026: 4 · 2025: 13 · 2024: 16 · 2023: 12 · 2022: 26 · 2021: 22 · 2020: 28 · 2019: 13 · 2018: 9 · 2017: 7 · 2016: 14 · 2015: 15 · 2014: 10 · 2013: 4
FWCI
10.19
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • UNSWorks (University of New South Wales, Sydney, Australia) (submittedVersion, cc-by-nc-nd)
  • UNSWorks (UNSW Sydney) (submittedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Figshare (submittedVersion, cc-by)
Funders
  • Eli Lilly and Company
  • Pfizer
  • Sanofi
  • Neuroscience Research Australia
  • Medical Research Council (350833)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
Keywords
mild cognitive impairment, normal cognition, dementia risk, prognosis, arthritis, personality, openness to experience, vision, olfaction, hippocampus, amygdala, diastolic blood pressure, cognitive enrichment, Sydney Memory and Ageing Study
MeSH terms
Aged, Aged, 80 and over, Antihypertensive Agents, Cognition, Demography, Female, Follow-Up Studies, Health, Humans, Life Style, Male, Cognitive Dysfunction

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