Altered Functional and Structural Connectivity Networks in Psychogenic Non-Epileptic Seizures
Open accessAbstract
Psychogenic non-epileptic seizures (PNES) are paroxysmal behaviors that resemble epileptic seizures but lack abnormal electrical activity. Recent studies suggest aberrant functional connectivity involving specific brain regions in PNES. Little is known, however, about alterations of topological organization of whole-brain functional and structural connectivity networks in PNES. We constructed functional connectivity networks from resting-state functional MRI signal correlations and structural connectivity networks from diffusion tensor imaging tractography in 17 PNES patients and 20 healthy controls. Graph theoretical analysis was employed to compute network properties. Moreover, we investigated the relationship between functional and structural connectivity networks. We found that PNES patients exhibited altered small-worldness in both functional and structural networks and shifted towards a more regular (lattice-like) organization, which could serve as a potential imaging biomarker for PNES. In addition, many regional characteristics were altered in structural connectivity network, involving attention, sensorimotor, subcortical and default-mode networks. These regions with altered nodal characteristics likely reflect disease-specific pathophysiology in PNES. Importantly, the coupling strength of functional-structural connectivity was decreased and exhibited high sensitivity and specificity to differentiate PNES patients from healthy controls, suggesting that the decoupling strength of functional-structural connectivity might be an important characteristic reflecting the mechanisms of PNES. This is the first study to explore the altered topological organization in PNES combining functional and structural connectivity networks, providing a new way to understand the pathophysiological mechanisms of PNES.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Ding et al combined DTI and fMRI and discovered altered connectivity in attention, sensorimotor, subcortical, and default mode networks.
“Ding et al combined DTI and functional magnetic resonance imaging (fMRI) and discovered altered connectivity in attention, sensorimotor, subcortical, and default mode networks.14”
From White Matter Changes after Neurobehavioral Therapy for Functional Seizures (2023) · cites this paper as [14]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Tzourio-Mazoyer, N., Landeau, B., Papathanassiou, D., Crivello, F., Etard, O., Delcroix, N., Mazoyer, B., & Joliot, M. (2002) · NeuroImage · doi:10.1006/nimg.2001.0978 · Cited by 16,319 · see citing works
Complex brain networks: graph theoretical analysis of structural and functional systems
Bullmore, E., & Sporns, O. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2575 · Cited by 11,820 · see citing works
Self-citationComplex network measures of brain connectivity: Uses and interpretations
Rubinov, M., & Sporns, O. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2009.10.003 · Cited by 11,522 · see citing works
Self-citationHow do you feel? Interoception: The sense of the physiological condition of the body
Craig, A. D. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn894 · Cited by 6,006 · see citing works
Efficient behavior of small-world networks
Latora, V., & Marchiori, M. (2001) · Physical Review Letters · doi:10.1103/physrevlett.87.198701 · Cited by 5,119 · see citing works
Mapping the structural core of human cerebral cortex
Hagmann, P., Cammoun, L., Gigandet, X., Meuli, R., Honey, C. J., Wedeen, V. J., & Sporns, O. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060159 · Cited by 4,173 · see citing works
Self-citationPredicting human resting-state functional connectivity from structural connectivity
Honey, C. J., Sporns, O., Cammoun, L., Gigandet, X., Thiran, J. P., Meuli, R., & Hagmann, P. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811168106 · Cited by 3,307 · see citing works
Self-citationBassett, D. S., & Bullmore, E. (2006) · The Neuroscientist · doi:10.1177/1073858406293182 · Cited by 2,600 · see citing works
Achard, S., Salvador, R., Whitcher, B., Suckling, J., & Bullmore, E. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3874-05.2006 · Cited by 2,393 · see citing works
Resting-State Functional Connectivity Reflects Structural Connectivity in the Default Mode Network
Greicius, M. D., Supekar, K., Menon, V., & Dougherty, R. F. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhn059 · Cited by 2,175 · see citing works
Organization, development and function of complex brain networks
SPORNS, O., CHIALVO, D., KAISER, M., & HILGETAG, C. (2004) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2004.07.008 · Cited by 2,055 · see citing works
Self-citationFiber tracking: principles and strategies – a technical review
Mori, S., & van Zijl, P. C. M. (2002) · NMR in Biomedicine · doi:10.1002/nbm.781 · Cited by 2,019 · see citing works
Virtual in vivo interactive dissection of white matter fasciculi in the human brain
Catani, M., Howard, R. J., Pajevic, S., & Jones, D. K. (2002) · NeuroImage · doi:10.1006/nimg.2002.1136 · Cited by 1,637 · see citing works
Neurophysiological Architecture of Functional Magnetic Resonance Images of Human Brain
Salvador, R. M., John Suckling, A., Coleman, M. R., Pickard, J. D., Menon, D. K., & Bullmore, E. T. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi016 · Cited by 1,334 · see citing works
Whole-brain anatomical networks: does the choice of nodes matter?
Zalesky, A., Fornito, A., Harding, I. H., Cocchi, L., Yücel, M., Pantelis, C., & Bullmore, E. T. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2009.12.027 · Cited by 1,169 · see citing works
White matter maturation reshapes structural connectivity in the late developing human brain
Hagmann, P., Sporns, O., Madan, N., Cammoun, L., Pienaar, R., Wedeen, V. J., Meuli, R., Thiran, J.-P., & Grant, P. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009073107 · Cited by 700 · see citing works
Self-citationvan den Heuvel, M. P., Mandl, R. C. W., Stam, C. J., Kahn, R. S., & Pol, H. E. H. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2874-10.2010 · Cited by 662 · see citing works
Can structure predict function in the human brain?
Honey, C. J., Thivierge, J.-P., & Sporns, O. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.01.071 · Cited by 629 · see citing works
Self-citationAge- and Gender-Related Differences in the Cortical Anatomical Network
Gong, G., Rosa‐Neto, P., Carbonell, F., Chen, Z. J., Yong He, A., & Evans, A. C. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2308-09.2009 · Cited by 625 · see citing works
Zhang, Z., Liao, W., Chen, H., Mantini, D., Ding, J.-R., Xu, Q., Wang, Z., Yuan, C., Chen, G., Jiao, Q., et al. (2011) · Brain · doi:10.1093/brain/awr223 · Cited by 580 · see citing works
Self-citationEpilepsy as a Disorder of Cortical Network Organization
Kramer, M., & Cash, S. S. (2012) · The Neuroscientist · doi:10.1177/1073858411422754 · Cited by 573 · see citing works
An estimate of the prevalence of psychogenic non-epileptic seizures
Benbadis, S. R., & Hauser, W. A. (2000) · Seizure · doi:10.1053/seiz.2000.0409 · Cited by 535 · see citing works
Altered Functional Connectivity and Small-World in Mesial Temporal Lobe Epilepsy
Liao, W., Zhang, Z., Pan, Z., Mantini, D., Ding, J., Duan, X., Luo, C., Lu, G., & Chen, H. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008525 · Cited by 517 · see citing works
Self-citationAn investigation of functional and anatomical connectivity using magnetic resonance imaging
Koch, M. A., Norris, D. G., & Hund-Georgiadis, M. (2002) · NeuroImage · doi:10.1006/nimg.2001.1052 · Cited by 509 · see citing works
Skudlarski, P., Jagannathan, K., Anderson, K., Stevens, M. C. G., Calhoun, V. D., Skudlarska, B. A., & Pearlson, G. D. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.03.035 · Cited by 467 · see citing works
At the heart of the ventral attention system: The right anterior insula
Eckert, M. A., Menon, V., Walczak, A., Ahlstrom, J., Denslow, S., Horwitz, A., & Dubno, J. R. (2009) · Human Brain Mapping · doi:10.1002/hbm.20688 · Cited by 406 · see citing works
van den Heuvel, M., Mandl, R., Luigjes, J., & Hulshoff Pol, H. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2964-08.2008 · Cited by 349 · see citing works
Guye, M., Bettus, G., Bartoloméi, F., & Cozzone, P. J. (2010) · Magnetic Resonance Materials in Physics Biology and Medicine · doi:10.1007/s10334-010-0205-z · Cited by 298 · see citing works
Resting state networks change in clinically isolated syndrome
Roosendaal, S. D., Schoonheim, M. M., Hulst, H. E., Sanz‐Arigita, E., Smith, S. M., Geurts, J. J. G., & Barkhof, F. (2010) · Brain · doi:10.1093/brain/awq058 · Cited by 244 · see citing works
Decision-making cognition in neurodegenerative diseases
Gleichgerrcht, E. L., Ibáñez, A. M., Roca, M., Torralva, T., & Manes, F. F. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.148 · Cited by 231 · see citing works
Functional connectivity of dissociation in patients with psychogenic non-epileptic seizures
van der Kruijs, S. J. M., Bodde, N. M. G., Vaessen, M. J., Lazeron, R. H. C., Vonck, K. E. J., Boon, P., Hofman, P. A. M., Backes, W. H., Aldenkamp, A. P., & Jansen, J. F. A. (2011) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2011-300776 · Cited by 227 · see citing works
Psychogenic non-epileptic seizures: a model of their pathogenic mechanism
Baslet, G. (2011) · Seizure · doi:10.1016/j.seizure.2010.10.032 · Cited by 214 · see citing works
Differentiating between nonepileptic and epileptic seizures
Devinsky, O., Gazzola, D. M., & LaFrance, W. C., Jr. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2011.24 · Cited by 194 · see citing works
Psychogenic seizures: Ictal characteristics and diagnostic pitfalls
Leis, A. A., Ross, M. A., & Summers, A. K. (1992) · Neurology · doi:10.1212/wnl.42.1.95 · Cited by 187 · see citing works
Loss of network efficiency associated with cognitive decline in chronic epilepsy
Vlooswijk, M. C. G., Vaessen, M. J., Jansen, J. F. A., de Krom, M. C. T. F. M., Majoie, M., Hofman, P. A. M., Aldenkamp, A. P., & Backes, W. H. (2011) · Neurology · doi:10.1212/wnl.0b013e31822cfc2f · Cited by 173 · see citing works
Neuroanatomic correlates of psychogenic nonepileptic seizures: A cortical thickness and VBM study
Labate, A., Cerasa, A., Mula, M., Mumoli, L., Gioia, M. C., Aguglia, U., Quattrone, A., & Gambardella, A. (2012) · Epilepsia · doi:10.1111/j.1528-1167.2011.03347.x · Cited by 171 · see citing works
Failure to recognize psychogenic nonepileptic seizures may cause death
Reuber, M., Baker, G. A., Gill, R., Smith, D. F., & Chadwick, D. W. (2004) · Neurology · doi:10.1212/01.wnl.0000113755.11398.90 · Cited by 168 · see citing works
Psychogenic Nonepileptic Seizures
Tatum, W. O. (2013) · Springer eBooks · doi:10.1007/978-3-319-01366-4_29 · Cited by 114 · see citing works
Psychogenic nonepileptic seizures
Brown, R. J., Syed, T. U., Benbadis, S. R., LaFrance, W. C., Jr., & Reuber, M. (2011) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2011.02.016 · Cited by 99 · see citing works
Short-term outpatient EEG video with induction in the diagnosis of psychogenic seizures
Benbadis, S. R., Siegrist, K., Tatum, W. O., Heriaud, L., & Anthony, K. (2004) · Neurology · doi:10.1212/01.wnl.0000143273.18099.50 · Cited by 92 · see citing works
Psychogenic seizures and frontal disconnection: EEG synchronisation study
Knyazeva, M. G., Jalili, M., Frackowiak, R. S. J., & Rossetti, A. O. (2011) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2010.224873 · Cited by 68 · see citing works
Topological Fractionation of Resting-State Networks
Ding, J.-R., Liao, W., Zhang, Z., Mantini, D., Xu, Q., Wu, G., Lu, G., & Chen, H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026596 · Cited by 47 · see citing works
Self-citationPsychogenic nonepileptic seizures.
Gillig, P. M. (2013) · Europe PMC (PubMed Central) · Cited by 21 · see citing works
The neuropsychiatry of subcortical ischemic brain disease
Feil, D. G., & Kumar, A. (1999) · Current Psychiatry Reports · doi:10.1007/s11920-999-0012-2 · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
LaFrance, W. C., Baker, G. A., Duncan, R., Goldstein, L. H., & Reuber, M. (2013) · Epilepsia · doi:10.1111/epi.12356 · Cited by 856 · see citing works
Pick, S., Goldstein, L. H., Perez, D. L., & Nicholson, T. R. (2019) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2018-319201 · Cited by 296 · see citing works
Epidemiology of psychogenic nonepileptic seizures
Asadi‐Pooya, A. A., & Sperling, M. R. (2015) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2015.03.015 · Cited by 281 · see citing works
Understanding Structural-Functional Relationships in the Human Brain
Wang, Z., Dai, Z., Gong, G., Zhou, C., & Yong He, A. (2014) · The Neuroscientist · doi:10.1177/1073858414537560 · Cited by 222 · see citing works
Neuroimaging in functional neurological disorder: State of the field and research agenda
Perez, D. L., Nicholson, T. R., Asadi-Pooya, A. A., Bègue, I., Butler, M., Carson, A. J., David, A. S., Deeley, Q., Diez, I., Edwards, M. J., et al. (2021) · NeuroImage: Clinical · doi:10.1016/j.nicl.2021.102623 · Cited by 216 · see citing works
Nonepileptic seizures: an updated review
Perez, D. L., & LaFrance, W. C., Jr. (2016) · CNS Spectrums · doi:10.1017/s109285291600002x · Cited by 179 · see citing works
Psychiatric comorbidity in psychogenic nonepileptic seizures compared with epilepsy
Diprose, W. K., Sundram, F., & Menkes, D. B. (2016) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2015.12.037 · Cited by 164 · see citing works
Voon, V., Cavanna, A. E., Coburn, K. L., Sampson, S. M., Reeve, A., & LaFrance, W. C., Jr. (2016) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.14090217 · Cited by 162 · see citing works
Jiang, X., Shen, Y., Yao, J., Zhang, L., Xu, L., Feng, R., Cai, L., Liu, J., Chen, W., & Wang, J. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0467-9 · Cited by 120 · see citing works
Resting-state networks and dissociation in psychogenic non-epileptic seizures
van der Kruijs, S. J. M., Jagannathan, S. R., Bodde, N. M. G., Besseling, R. M. H., Lazeron, R. H. C., Vonck, K. E. J., Boon, P., Cluitmans, P. J. M., Hofman, P. A. M., Backes, W. H., et al. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.03.010 · Cited by 125 · see citing works
Bègue, I., Adams, C., Stone, J., & Perez, D. L. (2019) · NeuroImage: Clinical · doi:10.1016/j.nicl.2019.101798 · Cited by 124 · see citing works
Perez, D. L., Dworetzky, B. A., Dickerson, B. C., Leung, L., Cohn, R., Baslet, G. C., & Silbersweig, D. (2014) · Clinical EEG and Neuroscience · doi:10.1177/1550059414555905 · Cited by 125 · see citing works
Reuber, M., & Brown, R. J. (2016) · Seizure · doi:10.1016/j.seizure.2016.10.029 · Cited by 123 · see citing works
Xu, P., Xiong, X., Xue, Q., Li, P., Zhang, R., Wang, Z., Valdes-Sosa, P. A., Wang, Y., & Yao, D. (2014) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2014.2305159 · Cited by 113 · see citing works
The Dynamic Brain Networks of Motor Imagery: Time-Varying Causality Analysis of Scalp EEG
Li, F., Peng, W., Jiang, Y., Song, L., Liao, Y., Yi, C., Zhang, L., Si, Y., Zhang, T., Wang, F., et al. (2018) · International Journal of Neural Systems · doi:10.1142/s0129065718500168 · Cited by 111 · see citing works
Straathof, M., Sinke, M. R. T., Dijkhuizen, R. M., & Otte, W. M. (2018) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x18809547 · Cited by 109 · see citing works
Abnormal functional connectivity density in psychogenic non-epileptic seizures
Ding, J., An, D., Liao, W., Wu, G., Xu, Q., Zhou, D., & Chen, H. (2014) · Epilepsy Research · doi:10.1016/j.eplepsyres.2014.05.006 · Cited by 101 · see citing works
Self-citationFunctional neurological disorders: mechanisms and treatment
Lehn, A., Gelauff, J., Hoeritzauer, I., Ludwig, L., McWhirter, L., Williams, S., Gardiner, P., Carson, A. J., & Stone, J. (2015) · Journal of Neurology · doi:10.1007/s00415-015-7893-2 · Cited by 96 · see citing works
Neuroimaging studies in patients with psychogenic non-epileptic seizures: A systematic meta-review
McSweeney, M., Reuber, M., & Levita, L. (2017) · NeuroImage Clinical · doi:10.1016/j.nicl.2017.07.025 · Cited by 96 · see citing works
Psychogenic Non-epileptic Seizures: An Updated Primer
Baslet, G. C., Seshadri, A., Bermeo-Ovalle, A. C., Willment, K., & Myers, L. (2015) · Psychosomatics · doi:10.1016/j.psym.2015.10.004 · Cited by 91 · see citing works
Li, R., Li, Y., An, D., Gong, Q., Zhou, D., & Chen, H. (2015) · Scientific Reports · doi:10.1038/srep11635 · Cited by 84 · see citing works
Self-citationResting cortical PET metabolic changes in psychogenic non-epileptic seizures (PNES)
Arthuis, M., Micoulaud‐Franchi, J., Bartoloméi, F., McGonigal, A., & Guedj, É. (2014) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2014-309390 · Cited by 83 · see citing works
Psychogenic nonepileptic seizures: a concise review
Asadi‐Pooya, A. A. (2017) · Neurological Sciences · doi:10.1007/s10072-017-2887-8 · Cited by 83 · see citing works
Biomarkers in the diagnosis and study of psychogenic nonepileptic seizures: A systematic review
Sundararajan, T., Tesar, G. E., & Jimenez, X. F. (2015) · Seizure · doi:10.1016/j.seizure.2015.12.011 · Cited by 79 · see citing works
Hernando, K. A., Szaflarski, J. P., Ver Hoef, L. W., Lee, S., & Allendorfer, J. B. (2015) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2015.02.022 · Cited by 74 · see citing works
Li, R., Liu, K., Ma, X., Li, Z., Duan, X., An, D., Gong, Q., Zhou, D., & Chen, H. (2014) · Brain Topography · doi:10.1007/s10548-014-0413-3 · Cited by 74 · see citing works
Self-citationSzaflarski, J. P., & LaFrance, W. C., Jr. (2018) · Epiliepsy currents/Epilepsy currents · doi:10.5698/1535-7597.18.4.211 · Cited by 73 · see citing works
White matter diffusion abnormalities in patients with psychogenic non-epileptic seizures
Lee, S., Allendorfer, J. B., Gaston, T. E., Griffis, J. C., Hernando, K. A., Knowlton, R. C., Szaflarski, J. P., & Ver Hoef, L. W. (2015) · Brain Research · doi:10.1016/j.brainres.2015.04.050 · Cited by 72 · see citing works
Psychogenic Non-epileptic Seizures and Pseudo-Refractory Epilepsy, a Management Challenge
Anzellotti, F., Dono, F., Evangelista, G., Pietro, M. D., Carrarini, C., Russo, M., Ferrante, C., Sensi, S. L., & ONOFRJ, M. C. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00461 · Cited by 72 · see citing works
Allendorfer, J. B., Nenert, R. E., Hernando, K. A., DeWolfe, J. L., Pati, S. B. B., Thomas, A. E., Billeaud, N., Martin, R. C., & Szaflarski, J. P. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.101967 · Cited by 66 · see citing works
Rommelfanger, K. S., Factor, S. A., LaRoche, S. M., Rosen, P., Young, R., & Rapaport, M. H. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00106 · Cited by 65 · see citing works
Popkirov, S., Carson, A. J., & Stone, J. (2018) · Seizure · doi:10.1016/j.seizure.2018.04.009 · Cited by 62 · see citing works
Facial emotion processing in patients with seizure disorders
Szaflarski, J. P., Allendorfer, J. B., Nenert, R. E., LaFrance, W. C., Jr., Barkan, H., DeWolfe, J. L., Pati, S. B. B., Thomas, A. E., & Hoef, L. V. (2018) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2017.12.004 · Cited by 55 · see citing works
The road ahead in clinical network neuroscience
Douw, L., van Dellen, E., Gouw, A. A., Griffa, A., de Haan, W., van den Heuvel, M. P., Hillebrand, A., Mieghem, P. V., Nissen, I. A., Otte, W. M., et al. (2019) · Network Neuroscience · doi:10.1162/netn_a_00103 · Cited by 46 · see citing works
Xu, P., Xiong, X., Xue, Q., Tian, Y., Peng, Y., Zhang, R., Li, P. Y., Wang, Y., & Yao, D. (2014) · Physiological Measurement · doi:10.1088/0967-3334/35/7/1279 · Cited by 49 · see citing works
Structural and functional connectivity in the default mode network in 22q11.2 deletion syndrome
Padula, M. C., Schaer, M., Scariati, E., Schneider, M., Ville, D. V. D., Debbané, M., & D, S. E. M. (2015) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-015-9120-y · Cited by 45 · see citing works
Neurobiological origin of psychogenic nonepileptic seizures: A review of imaging studies
Asadi‐Pooya, A. A. (2015) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2015.09.020 · Cited by 47 · see citing works
Varone, G., Boulila, W., Giudice, M. L., Benjdira, B., Mammone, N., Ieracitano, C., Dashtipour, K. K., Neri, S., Gasparini, S., Morabito, F. C., et al. (2021) · Sensors · doi:10.3390/s22010129 · Cited by 45 · see citing works
Sojka, P., Diez, I., Bareš, M., & Perez, D. L. (2021) · Human Brain Mapping · doi:10.1002/hbm.25304 · Cited by 43 · see citing works
The implication of salience network abnormalities in young male adult smokers
Li, Y., Yuan, K., Guan, Y., Cheng, J., Bi, Y., Shi, S., Xue, T., Lu, X., Qin, W., Yu, D., et al. (2016) · Brain Imaging and Behavior · doi:10.1007/s11682-016-9568-8 · Cited by 42 · see citing works
Psychogenic nonepileptic seizures are predominantly seen in women: potential neurobiological reasons
Asadi‐Pooya, A. A. (2016) · Neurological Sciences · doi:10.1007/s10072-016-2481-5 · Cited by 41 · see citing works
White matter and neurite morphology differ in psychogenic nonepileptic seizures
Goodman, A. M., Allendorfer, J. B., Blum, A. S., Bolding, M. S., Correia, S., Ver Hoef, L. W., Gaston, T. E., Grayson, L. E., Kraguljac, N. V., Lahti, A. C., et al. (2020) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51198 · Cited by 40 · see citing works
Social anxiety disorder exhibit impaired networks involved in self and theory of mind processing
Cui, Q., Vanman, E. J., Long, Z., Pang, Y., Chen, Y., Wang, Y., Duan, X., Chen, H., Gong, Q., Zhang, W., et al. (2017) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsx050 · Cited by 40 · see citing works
Self-citationWardrope, A., Dworetzky, B., Barkley, G., Baslet, G., Buchhalter, J., Doss, J., Goldstein, L., Hallett, M., Kozlowska, K., LaFrance, W., et al. (2021) · Seizure · doi:10.1016/j.seizure.2021.10.016 · Cited by 37 · see citing works
Balachandran, N., Goodman, A. M., Allendorfer, J. B., Martin, A. N., Tocco, K., Vogel, V., LaFrance, W. C., Jr., & Szaflarski, J. P. (2020) · Epilepsia · doi:10.1111/epi.16758 · Cited by 38 · see citing works
Vasta, R., Cerasa, A., Sarica, A., Bartolini, E., Martino, I., Mari, F., Metitieri, T. T., Quattrone, A., Gambardella, A., Guerrini, R., et al. (2018) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2018.09.008 · Cited by 38 · see citing works
Weber, S., Heim, S., Richiardi, J., Ville, D. V. D., Serranová, T., Jech, R., Marapin, R. S., Tijssen, M. A. J., & Aybek, S. (2022) · NeuroImage Clinical · doi:10.1016/j.nicl.2022.103090 · Cited by 37 · see citing works
New insights into psychogenic nonepileptic seizures 2011–2014
Wiseman, H., & Reuber, M. (2015) · Seizure · doi:10.1016/j.seizure.2015.03.008 · Cited by 37 · see citing works
Dissoziation: ein transdiagnostisches Phänomen
Wallis, H., Vogel, M., Junne, F., & Binneböse, M. (2023) · Die Psychotherapie · doi:10.1007/s00278-022-00641-7 · Cited by 36 · see citing works
Reduced limbic microstructural integrity in functional neurological disorder
Diez, I. P., Williams, B., Kubicki, M. R., Makris, N., & Perez, D. L. (2019) · Psychological Medicine · doi:10.1017/s0033291719003386 · Cited by 37 · see citing works
Ma, J., Liu, F., Yang, B., Xue, K., Wang, P., Zhou, J., Wang, Y., Niu, Y., & Zhang, J. (2020) · Neuroscience Bulletin · doi:10.1007/s12264-020-00580-w · Cited by 34 · see citing works
Wang, S., Gan, S., Yang, X., Li, T., Xiong, F., Jia, X., Sun, Y., Liu, J., Zhang, M., & Bai, L. (2021) · Brain Connectivity · doi:10.1089/brain.2020.0852 · Cited by 34 · see citing works
Allendorfer, J. B., & Szaflarski, J. P. (2014) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2014.03.023 · Cited by 33 · see citing works
Structural neuroimaging of somatoform disorders: A systematic review
Rossetti, M. G., Delvecchio, G., Calati, R., Perlini, C., Bellani, M., & Brambilla, P. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.12.017 · Cited by 29 · see citing works
Amiri, S., Mirbagheri, M. M., Asadi-Pooya, A. A., Badragheh, F., Ajam Zibadi, H., & Arbabi, M. (2021) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2020.107565 · Cited by 26 · see citing works
Foroughi, A. A., Nazeri, M., & Asadi‐Pooya, A. A. (2020) · Seizure · doi:10.1016/j.seizure.2020.08.024 · Cited by 25 · see citing works
Sone, D., Sato, N., Ota, M., Kimura, Y., & Matsuda, H. (2019) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s235159 · Cited by 25 · see citing works
Goodman, A. M., Allendorfer, J. B., LaFrance, W. C., Jr., & Szaflarski, J. P. (2022) · Epilepsia · doi:10.1111/epi.17179 · Cited by 23 · see citing works
Lin, Y., Du, P., Sun, H., Liang, Y., Wang, Z., Cui, Y., Chen, K., Xia, Y., Yao, D., Yu, L., et al. (2021) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2021.3071785 · Cited by 22 · see citing works
Ospina, J. P., Jalilianhasanpour, R., & Perez, D. L. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64196-0.00014-5 · Cited by 22 · see citing works
Westlin, C., Guthrie, A. J., Bleier, C., Finkelstein, S. A., Maggio, J., Ranford, J., MacLean, J., Godena, E. J., Millstein, D. J., Paredes-Echeverri, S., et al. (2025) · Brain Communications · doi:10.1093/braincomms/fcaf195 · Cited by 24 · see citing works
Transient cortico‐cortical disconnection during psychogenic nonepileptic seizures (PNES)
Madec, T., Lagarde, S., McGonigal, A., Arthuis, M., Bénar, C., & Bartoloméi, F. (2020) · Epilepsia · doi:10.1111/epi.16623 · Cited by 21 · see citing works
White Matter Changes after Neurobehavioral Therapy for Functional Seizures
Mueller, C., Goodman, A. M., Allendorfer, J. B., Nenert, R., Gaston, T. E., Grayson, L. E., Correia, S., Philip, N. S., LaFrance, W. C., & Szaflarski, J. P. (2023) · Annals of Neurology · doi:10.1002/ana.26665 · Cited by 19 · see citing works
“Ding et al combined DTI and functional magnetic resonance imaging (fMRI) and discovered altered connectivity in attention, sensorimotor, subcortical, and default mode networks.(14) One study using NODDI reported significant correlations between symptom severity and abnormalities in the uncinate, fornix/ stria terminal…”
BackgroundAmiri, S., Arbabi, M., Rahimi, M., Badragheh, F., Zibadi, H. A., Asadi‐Pooya, A. A., & Mirbagheri, M. M. (2021) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2021.108085 · Cited by 17 · see citing works
Biological underpinnings of psychogenic nonepileptic seizures: directions for future research
Asadi‐Pooya, A. A. (2016) · Neurological Sciences · doi:10.1007/s10072-016-2540-y · Cited by 18 · see citing works
Kerr, W. T., Tatekawa, H., Lee, J. K., Karimi, A. H., Sreenivasan, S. S., O’Neill, J., Smith, J. M., Hickman, L. B., Savic, I., Nasrullah, N., et al. (2022) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2022.108858 · Cited by 18 · see citing works
Boschi, A., Brofiga, M., & Massobrio, P. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.705103 · Cited by 16 · see citing works
Kola, S., & LaFaver, K. (2021) · Epilepsy & Behavior Reports · doi:10.1016/j.ebr.2021.100510 · Cited by 17 · see citing works
Zhang, T., Li, M., Zhang, L., Biswal, B. B., Yao, D., & Xu, P. (2018) · IEEE Access · doi:10.1109/access.2018.2875492 · Cited by 15 · see citing works
Kannan, S., Patel, K., Basilio, D. D., Kirkby, A., Sivan, M., Jones, A. K. P., Mohanraj, R., & Das, A. (2025) · BMJ Neurology Open · doi:10.1136/bmjno-2025-001032 · Cited by 14 · see citing works
Characterizing the Time-Varying Brain Networks of Audiovisual Integration across Frequency Bands
Yang, X., Li, Q., Zhang, M., Liu, L., & Wu, J. (2020) · Cognitive Computation · doi:10.1007/s12559-020-09783-9 · Cited by 14 · see citing works
Myths and truths about pediatric psychogenic nonepileptic seizures
Yeom, J. S., Bernard, H., & Koh, S. (2020) · Korean Journal of Pediatrics · doi:10.3345/cep.2020.00892 · Cited by 14 · see citing works
Alterations of functional and structural connectivity in patients with brain metastases
Hua, B., Ding, X., Xiong, M., Zhang, F., Luo, Y., Ding, J., & Ding, Z. (2020) · PLoS ONE · doi:10.1371/journal.pone.0233833 · Cited by 13 · see citing works
Self-citationTime-varying EEG networks of major depressive disorder during facial emotion tasks
Yang, J., Li, B., Dong, W., Gao, X., & Lin, Y. (2024) · Cognitive Neurodynamics · doi:10.1007/s11571-024-10111-2 · Cited by 12 · see citing works
A minority of patients with functional seizures have abnormalities on neuroimaging
Kerr, W. T., Lee, J. K., Karimi, A. H., Tatekawa, H., Hickman, L. B., Connerney, M. A., Sreenivasan, S. S., Dubey, I., Allas, C. H., Smith, J. M., et al. (2021) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2021.117548 · Cited by 12 · see citing works
Designing Treatment Plans Based on Etiology of Psychogenic Nonepileptic Seizures
LaFrance, W. C., Jr., & Bjønæs, H. (2018) · Cambridge University Press eBooks · doi:10.1017/9781316275450.029 · Cited by 12 · see citing works
Mueller, C., & Szaflarski, J. P. (2023) · NeuroImage Clinical · doi:10.1016/j.nicl.2023.103462 · Cited by 12 · see citing works
Mueller, C., Sharma, A. A., & Szaflarski, J. P. (2023) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s437063 · Cited by 11 · see citing works
Tian, Y., Xu, W. L., & Li, Y. (2018) · Scientific Reports · doi:10.1038/s41598-018-24535-4 · Cited by 11 · see citing works
Memory and motor control in patients with psychogenic nonepileptic seizures
Dienstag, A., Ben‐Naim, S., Gilad, M., Ekstein, D., Arzy, S., & Eitan, R. (2019) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2019.07.026 · Cited by 11 · see citing works
Zhang, X., Zhang, S., Lu, B., Wang, Y., Li, N., Peng, Y., Hou, J., Qiu, J., Li, F., Yao, D., et al. (2022) · Journal of Neural Engineering · doi:10.1088/1741-2552/ac6d7c · Cited by 11 · see citing works
Asadi‐Pooya, A. A., Malekpour, M., Zamiri, B., Kashkooli, M., & Firouzabadi, N. (2023) · Epilepsia Open · doi:10.1002/epi4.12749 · Cited by 11 · see citing works
LaFrance, W. C., Jr. (2014) · Monographs in clinical neuroscience/Frontiers of neurology and neuroscience/Monographs in neural sciences · doi:10.1159/000360064 · Cited by 11 · see citing works
Arzy, S., Halje, P., Schechter, D. S., Spinelli, L., Seeck, M., & Blanke, O. (2013) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2013.10.017 · Cited by 11 · see citing works
Yuan, W., Meller, A., Shimony, J. S., Nash, T. A., Jones, B. V., Holland, S. K., Altaye, M., Barnard, H. D., Phillips, J. M., Powell, S., et al. (2016) · NeuroImage Clinical · doi:10.1016/j.nicl.2016.09.003 · Cited by 11 · see citing works
Clinical Approaches to Psychogenic Nonepileptic Seizures
Bajestan, S. N., & LaFrance, W. C., Jr. (2016) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.20160020 · Cited by 10 · see citing works
Butler, M., Bird, C., Maggio, C., Durden, A., Modlin, N. L., Campbell‐Coker, K., Edwards, M. J., Pick, S., Millman, L. S. M., Lowery, E., et al. (2024) · Wellcome Open Research · doi:10.12688/wellcomeopenres.22543.1 · Cited by 8 · see citing works
Gninenko, N., Müller, E., & Aybek, S. (2025) · NeuroImage Clinical · doi:10.1016/j.nicl.2025.103791 · Cited by 8 · see citing works
Ye, C., Huang, J., Li, L., Yan, Z., Qi, Z., Kang, X., Liu, Z., Dong, H., Lv, H., Ma, T., et al. (2022) · Journal of Neuroscience Research · doi:10.1002/jnr.25028 · Cited by 8 · see citing works
Pillai, J. A., Haut, S. R., & Masur, D. M. (2015) · Medical Hypotheses · doi:10.1016/j.mehy.2015.01.034 · Cited by 8 · see citing works
Structural brain network architecture and personalized medicine in epilepsy
Gleichgerrcht, E. L., & Bonilha, L. (2017) · Expert Review of Precision Medicine and Drug Development · doi:10.1080/23808993.2017.1364133 · Cited by 7 · see citing works
Differentiation of epilepsy and psychogenic nonepileptic events based on body fluid characteristics
Xia, Y., Lai, W., Li, S., Wen, Z., & Chen, L. (2023) · Epilepsia Open · doi:10.1002/epi4.12775 · Cited by 7 · see citing works
Decreased uncinate fasciculus integrity in functional seizures following traumatic brain injury
Byington, C. G., Goodman, A. M., Allendorfer, J. B., Correia, S., LaFrance, W. C., Jr., & Szaflarski, J. P. (2024) · Epilepsia · doi:10.1111/epi.17896 · Cited by 6 · see citing works
Why should we change the term psychogenic nonepileptic seizures?
Labate, A., & Gambardella, A. (2015) · Epilepsia · doi:10.1111/epi.13014 · Cited by 6 · see citing works
Gargiulo, Á. J. M., Colombini, A. P., Trovato, A., Gargiulo, A. P. Í., & D’Alessio, L. (2022) · Psychiatry Research Communications · doi:10.1016/j.psycom.2022.100071 · Cited by 5 · see citing works
Goodman, A. M., Allendorfer, J. B., Taylor, G. C., Philip, N. S., Correia, S., Blum, A. S., LaFrance, W. C., Jr., & Szaflarski, J. P. (2024) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2024.109877 · Cited by 5 · see citing works
Krámská, L., Myers, L., Hrešková, L., Krámský, D., Chvál, M., & Vojtěch, Z. (2022) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2022.108584 · Cited by 5 · see citing works
Zeng, Z., Xu, Y., Chen, C., Zhou, L., Wang, Y., Liu, M., Meng, L., Zhou, Y., & Chen, W. (2023) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2023.3294909 · Cited by 5 · see citing works
Are Functional (Psychogenic Nonepileptic) Seizures the Sole Expression of Psychological Processes?
Sojka, P., Paredes-Echeverri, S., & Perez, D. L. (2021) · Current topics in behavioral neurosciences · doi:10.1007/7854_2021_225 · Cited by 5 · see citing works
Westlin, C., Guthrie, A. J., Bleier, C., Finkelstein, S. A., Maggio, J., Ranford, J., MacLean, J., Godena, E. J., Millstein, D. J., Freeburn, J. L., et al. (2025) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2025.10.010 · Cited by 5 · see citing works
- Authors
- Ding, J.-R., An, D., Liao, W., Li, J., Wu, G.-R., Xu, Q., Long, Z., Gong, Q., Zhou, D., Sporns, O., & Chen, H.
- Affiliations
- University of Electronic Science and Technology of China (CN)
- West China Hospital of Sichuan University (CN)
- Hangzhou Normal University (CN)
- Indiana University Bloomington (US)
- Corresponding author
- Zhou, Dong
- Chen, Huafu
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-05-22
- Volume
- 8
- Issue
- 5
- Pages
- e63850
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3661726
- OpenAlex
- W1981081286
- Cited by
- 132
- References
- 44
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 11 · 2023: 10 · 2022: 8 · 2021: 13 · 2020: 13 · 2019: 9 · 2018: 12 · 2017: 6 · 2016: 11 · 2015: 15 · 2014: 12 · 2013: 3
- FWCI
- 7.50
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- National Natural Science Foundation of China (61035006, 61125304)
- Specialized Research Fund for the Doctoral Program of Higher Education of China (20120185110028)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- psychogenic non-epileptic seizures, functional connectivity, structural connectivity, small-worldness, network biomarkers, default mode network, sensorimotor network, attentional networks, subcortical network
- MeSH terms
- Adult, Brain, Brain Mapping, Epilepsy, Female, Humans, Magnetic Resonance Imaging, Male, Nerve Net, Neural Pathways, Biomarkers, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
