Prenatal exposure to urban air nanoparticles in mice causes altered neuronal differentiation and depression-like responses
Open accessAbstract
Emerging evidence suggests that excessive exposure to traffic-derived air pollution during pregnancy may increase the vulnerability to neurodevelopmental alterations that underlie a broad array of neuropsychiatric disorders. We present a mouse model for prenatal exposure to urban freeway nanoparticulate matter (nPM). In prior studies, we developed a model for adult rodent exposure to re-aerosolized urban nPM which caused inflammatory brain responses with altered neuronal glutamatergic functions. nPMs are collected continuously for one month from a local freeway and stored as an aqueous suspension, prior to re-aerosolization for exposure of mice under controlled dose and duration. This paradigm was used for a pilot study of prenatal nPM impact on neonatal neurons and adult behaviors. Adult C57BL/6J female mice were exposed to re-aerosolized nPM (350 µg/m(3)) or control filtered ambient air for 10 weeks (3×5 hour exposures per week), encompassing gestation and oocyte maturation prior to mating. Prenatal nPM did not alter litter size, pup weight, or postnatal growth. Neonatal cerebral cortex neurons at 24 hours in vitro showed impaired differentiation, with 50% reduction of stage 3 neurons with long neurites and correspondingly more undifferentiated neurons at Stages 0 and 1. Neuron number after 24 hours of culture was not altered by prenatal nPM exposure. Addition of exogenous nPM (2 µg/ml) to the cultures impaired pyramidal neuron Stage 3 differentiation by 60%. Adult males showed increased depression-like responses in the tail-suspension test, but not anxiety-related behaviors. These pilot data suggest that prenatal exposure to nPM can alter neuronal differentiation with gender-specific behavioral sequelae that may be relevant to human prenatal exposure to urban vehicular aerosols.
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Male offspring exposed to PM0.1 prior to mating and throughout gestation displayed increased depression-like responses.
“Davis et al. [79] exposed mice to PM0.1 collected from an urban freeway (as detailed above) prior to mating and throughout gestation. Male offspring displayed increased depression-like responses.”
From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [79]
Studies in animal models (rodents) and humans described developmental effects of air pollution following prenatal and early life exposure, such as altered neuronal differentiation, impaired cognitive functions, and white matter abnormalities.
“Studies in animal models (rodents) and humans described developmental effects of air pollution following prenatal and early life exposure, such as altered neuronal differentiation, impaired cognitive functions, and white matter abnormalities (89–91).”
From Gene × Environment Interactions in Autism Spectrum Disorders: Role of Epigenetic Mechanisms (2014) · cites this paper as [91]
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- Authors
- Davis, D. A., Bortolato, M., Godar, S. C., Sander, T. K., Iwata, N., Pakbin, P., Shih, J. C., Berhane, K., McConnell, R., Sioutas, C., Finch, C. E., & Morgan, T. E.
- Affiliations
- University of Southern California (US)
- University of Kansas (US)
- Corresponding author
- Finch, Caleb E.
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-05-29
- Volume
- 8
- Issue
- 5
- Pages
- e64128
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3667185
- OpenAlex
- W2102920891
- Cited by
- 123
- References
- 59
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 11 · 2023: 8 · 2022: 14 · 2021: 6 · 2020: 16 · 2019: 9 · 2018: 11 · 2017: 12 · 2016: 11 · 2015: 9 · 2014: 10 · 2013: 1
- FWCI
- 7.58
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- KU ScholarWorks (The University of Kansas) (submittedVersion, cc-by)
- Funders
- National Institutes of Health
- National Institute on Aging (R21AG040683, R21AG040753, T32AG000037)
- National Institute of Environmental Health Sciences (P30ES007048)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R21HD070611)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- prenatal air pollution exposure, traffic-related air pollution, neuronal differentiation, cortical neurons, depression-like behavior, anxiety-like behavior, brain development, sex differences, mouse model
- MeSH terms
- Air Pollutants, Animals, Animals, Newborn, Cell Differentiation, Cells, Cultured, Cities, Depressive Disorder, Female, Hippocampus, Humans, Male, Mice, Inbred C57BL, Neurons, Pilot Projects, Pregnancy, Prenatal Exposure Delayed Effects, Blotting, Western, Neurites, Maze Learning, JNK Mitogen-Activated Protein Kinases, Mice, Particulate Matter, Nanoparticles
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