Ancient dispersal of the human fungal pathogen Cryptococcus gattii from the Amazon rainforest
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Over the past two decades, several fungal outbreaks have occurred, including the high-profile 'Vancouver Island' and 'Pacific Northwest' outbreaks, caused by Cryptococcus gattii, which has affected hundreds of otherwise healthy humans and animals. Over the same time period, C. gattii was the cause of several additional case clusters at localities outside of the tropical and subtropical climate zones where the species normally occurs. In every case, the causative agent belongs to a previously rare genotype of C. gattii called AFLP6/VGII, but the origin of the outbreak clades remains enigmatic. Here we used phylogenetic and recombination analyses, based on AFLP and multiple MLST datasets, and coalescence gene genealogy to demonstrate that these outbreaks have arisen from a highly-recombining C. gattii population in the native rainforest of Northern Brazil. Thus the modern virulent C. gattii AFLP6/VGII outbreak lineages derived from mating events in South America and then dispersed to temperate regions where they cause serious infections in humans and animals.
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All three VGIIa-like isolates are characterized by diminished virulence relative to the VGIIa clonal outbreak strains.
“All three isolates are characterized by diminished virulence relative to the VGIIa clonal outbreak strains (Fraser et al., 2005; Byrnes et al., 2010; Hagen et al., 2013).”
From Natural mismatch repair mutations mediate phenotypic diversity and drug resistance in Cryptococcus deuterogattii (2017) · cites this paper as Hagen et al., 2013
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Cites
Updated world map of the Köppen-Geiger climate classification
(2007) · doi:10.5194/hess-11-1633-2007 · Cited by 13,640 · see citing works
Global trends in emerging infectious diseases
Jones, K. E., Patel, N. G., Levy, M. A., Storeygard, A., Balk, D., Gittleman, J. L., & Daszak, P. (2008) · Nature · doi:10.1038/nature06536 · Cited by 8,338 · see citing works
Climate Warming and Disease Risks for Terrestrial and Marine Biota
Harvell, C. D., Mitchell, C. E., Ward, J. R., Altizer, S., Dobson, A. P., Ostfeld, R. S., & Samuel, M. D. (2002) · Science · doi:10.1126/science.1063699 · Cited by 2,729 · see citing works
The velocity of climate change
Loarie, S. R., Duffy, P. B., Hamilton, H., Asner, G. P., Field, C. B., & Ackerly, D. D. (2009) · Nature · doi:10.1038/nature08649 · Cited by 2,544 · see citing works
Aerial Dispersal of Pathogens on the Global and Continental Scales and Its Impact on Plant Disease
Brown, J. K. M., & Hovmøller, M. S. (2002) · Science · doi:10.1126/science.1072678 · Cited by 1,165 · see citing works
Bat White-Nose Syndrome: An Emerging Fungal Pathogen?
Blehert, D. S., Hicks, A. C., Behr, M. J., Meteyer, C. U., Berlowski-Zier, B. M., Buckles, E. L., Coleman, J. T. H., Darling, S. R., Gargas, A., Niver, R., et al. (2008) · Science · doi:10.1126/science.1163874 · Cited by 1,094 · see citing works
Atmospheric Movement of Microorganisms in Clouds of Desert Dust and Implications for Human Health
Griffin, D. W. (2007) · Clinical Microbiology Reviews · doi:10.1128/cmr.00039-06 · Cited by 803 · see citing works
Kidd, S. E., Hagen, F., Tscharke, R. L., Huynh, M., Bartlett, K. H., Fyfe, M. W., MacDougall, L., Boekhout, T., Kwon-Chung, K. J., & Meyer, W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402981101 · Cited by 758 · see citing works
Self-citationNatural habitat of Cryptococcus neoformans var. gattii
Ellis, D. H., & Pfeiffer, T. (1990) · Journal of Clinical Microbiology · doi:10.1128/jcm.28.7.1642-1644.1990 · Cited by 561 · see citing works
Anthropogenic Warming of Earth's Climate System
Levitus, S., Antonov, J. I., Wang, J., Delworth, T. L., Dixon, K. W., & Broccoli, A. J. (2001) · Science · doi:10.1126/science.1058154 · Cited by 543 · see citing works
Molecular Typing of IberoAmericanCryptococcus neoformansIsolates
Meyer, W., Castañeda, A., Jackson, S. R., Huynh, M., Castañeda, E., & the IberoAmerican Cryptococcal Study Group (2003) · Emerging infectious diseases · doi:10.3201/eid0902.020246 · Cited by 521 · see citing works
Self-citationSame-sex mating and the origin of the Vancouver Island Cryptococcus gattii outbreak
Fraser, J. A., Giles, S. S., Wenink, E. C., Geunes-Boyer, S. G., Wright, J. R., Diezmann, S., Allen, A., Stajich, J. E., Dietrich, F. S., Perfect, J. R., et al. (2005) · Nature · doi:10.1038/nature04220 · Cited by 499 · see citing works
Byrnes, E. J., Li, W., Lewit, Y., Ma, H., Voelz, K., Ren, P., Carter, D. A., Chaturvedi, V., Bildfell, R. J., May, R. C., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000850 · Cited by 330 · see citing works
Self-citationSpread of Cryptococcus gattii into Pacific Northwest Region of the United States
Datta, K., Bartlett, K. H., Baer, R. J., Byrnes, E. J., Galanis, E., Heitman, J., Hoang, L., Leslie, M. J., MacDougall, L., Magill, S. S., et al. (2009) · Emerging infectious diseases · doi:10.3201/eid1508.081384 · Cited by 271 · see citing works
Self-citationKidd, S. E., Chow, Y., Mak, S., Bach, P., Chen, H., Hingston, A. O., Kronstad, J. W., & Bartlett, K. H. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.01330-06 · Cited by 235 · see citing works
Self-citationJames, T. Y., Litvintseva, A. P., Vilgalys, R. J., Morgan, J. A. T., Taylor, J. W., Fisher, M. C., Berger, L., Weldon, C., Preez, L. D., & Longcore, J. E. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000458 · Cited by 218 · see citing works
Projecting Global Occurrence ofCryptococcus gattii
Springer, D. J., & Chaturvedi, V. P. (2009) · Emerging infectious diseases · doi:10.3201/eid1601.090369 · Cited by 198 · see citing works
Byrnes, E. J., Bildfell, R. J., Frank, S., Mitchell, T. G., Marr, K. A., & Heitman, J. (2009) · The Journal of Infectious Diseases · doi:10.1086/597306 · Cited by 192 · see citing works
Ma, H., Hagen, F., Stekel, D. J., Johnston, S. A., Sionov, E., Falk, R., Polacheck, I., Boekhout, T., & May, R. C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902963106 · Cited by 185 · see citing works
Self-citationBovers, M., Hagen, F., Kuramae, E. E., & Boekhout, T. (2007) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2007.12.004 · Cited by 183 · see citing works
Self-citationRegional pattern of the molecular types of Cryptococcus neoformans and Cryptococcus gattii in Brazil
Trilles, L., Lazéra, M. D. S., Wanke, B., de Oliveira, R. D. V. C., Barbosa, G. G., Nishikawa, M. M., Morales, B. P., & Meyer, W. (2008) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/s0074-02762008000500008 · Cited by 160 · see citing works
Self-citationNgamskulrungroj, P., Gilgado, F., Faganello, J., Litvintseva, A. P., Leal, A. L., Tsui, C. K. M., Mitchell, T. G., Vainstein, M. H., & Meyer, W. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005862 · Cited by 159 · see citing works
Self-citationCryptococcus gattiiDispersal Mechanisms, British Columbia, Canada
Kidd, S. E., Bach, P., Hingston, A. O., Mak, S., Chow, Y., MacDougall, L., Kronstad, J. W., & Bartlett, K. H. (2007) · Emerging infectious diseases · doi:10.3201/eid1301.060823 · Cited by 147 · see citing works
Self-citationCryptococcosis in domestic animals in Western Australia: a retrospective study from 1995–2006
McGill, S., Malík, R., Saul, N., Beetson, S., Secombe, C. J., Robertson, I., & Irwin, P. (2009) · Medical Mycology · doi:10.1080/13693780802512519 · Cited by 143 · see citing works
Autochthonous and DormantCryptococcus gattiiInfections in Europe
Hagen, F., Colom, M. F., Swinne, D., Tintelnot, K., Iatta, R., Montagna, M. T., Torres-Rodrı́guez, J. M., Cogliati, M., Velegraki, A., Burggraaf, A., et al. (2012) · Emerging infectious diseases · doi:10.3201/eid1810.120068 · Cited by 142 · see citing works
Self-citationHagen, F., Zaragozí, M. T. I., Bartlett, K. H., Swinne, D., Geertsen, E., Klaassen, C. H. W., Boekhout, T., & Meis, J. F. G. M. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00746-10 · Cited by 122 · see citing works
Self-citationHigh Prevalence of Cryptococcus neoformans var. gattii in Tropical and Subtropical Regions
Kwon-Chung, K. J., & Bennett, J. E. (1984) · Zentralblatt für Bakteriologie Mikrobiologie und Hygiene 1 Abt Originale A Medizinische Mikrobiologie Infektionskrankheiten und Parasitologie · doi:10.1016/s0174-3031(84)80074-8 · Cited by 108 · see citing works
Baró, T., Torres-Rodrı́guez, J. M., de Mendoza, M. H., Morera, Y., & Alía, C. (1998) · Journal of Clinical Microbiology · doi:10.1128/jcm.36.2.458-461.1998 · Cited by 97 · see citing works
Environmental prevalence ofCryptococcus neoformansandCryptococcus gattiiin India: An update
Chowdhary, A., Randhawa, H. S., Prakash, A., & Meis, J. F. G. M. (2011) · Critical Reviews in Microbiology · doi:10.3109/1040841x.2011.606426 · Cited by 92 · see citing works
Self-citationFortes, S. T., Lazéra, M. S., Nishikawa, M. M., de Macêdo, R. C. L., & Wanke, B. (2001) · Mycoses · doi:10.1046/j.1439-0507.2001.00651.x · Cited by 89 · see citing works
Carriconde, F., Gilgado, F., Arthur, I. H., Ellis, D., Malík, R., van de Wiele, N., Robert, V., Currie, B. J., & Meyer, W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016936 · Cited by 82 · see citing works
Self-citationPrimary endemic Cryptococcosis gattii by molecular type VGII in the state of Pará, Brazil
dos Santos, W. R. A., Meyer, W., Wanke, B., Costa, S. D. P. S. E., Trilles, L., do Nascimento, J. L. M., Medeiros, R., Morales, B. P., Bezerra, C. D. C. F., de Macêdo, R. C. L., et al. (2008) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/s0074-02762008000800012 · Cited by 80 · see citing works
Self-citationCryptococcosis outbreak in psittacine birds in Brazil
Raso, T. D. F., Werther, K., Miranda, E. T., & Mendes‐Giannini, M. J. S. (2004) · Medical Mycology · doi:10.1080/13693780410001712061 · Cited by 73 · see citing works
Cryptococcus gattii in Wildlife of Vancouver Island, British Columbia, Canada
Duncan, C., Schwantje, H. M., Stephen, C., Campbell, J., & Bartlett, K. H. (2006) · Journal of Wildlife Diseases · doi:10.7589/0090-3558-42.1.175 · Cited by 72 · see citing works
Self-citationXu, M., Huaracha, E., & Korban, S. S. (2001) · Genome · doi:10.1139/gen-44-1-63 · Cited by 72 · see citing works
Colom, M. F., Hagen, F., Gonzalez, A., Mellado, A., Morera, N., Linares, C. E. B., García, D., Sáez‐Peñataro, J., Boekhout, T., & Sánchez, M. (2011) · Medical Mycology · doi:10.3109/13693786.2011.574239 · Cited by 69 · see citing works
Self-citationTemperate Climate Niche for Cryptococcus gattii in Northern Europe
Chowdhary, A., Randhawa, H. S., Boekhout, T., Hagen, F., Klaassen, C. H. W., & Meis, J. F. G. M. (2012) · Emerging infectious diseases · doi:10.3201/eid1801.111190 · Cited by 67 · see citing works
Self-citationTrilles, L., Lazéra, M. D. S., Wanke, B., Theelen, B., & Boekhout, T. (2003) · Medical Mycology · doi:10.1080/1369378031000137206 · Cited by 64 · see citing works
Self-citationNgamskulrungroj, P., Serena, C., Gilgado, F., Malík, R., & Meyer, W. (2010) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2010.03222.x · Cited by 63 · see citing works
Self-citationCosta, S. D. P. S. E., Lazéra, M. D. S., dos Santos, W. R. A., Morales, B. P., Bezerra, C. C. F., Nishikawa, M. M., Barbosa, G. G., Trilles, L., do Nascimento, J. L. M., & Wanke, B. (2009) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/s0074-02762009000400023 · Cited by 30 · see citing works
Xue, C. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002869 · Cited by 29 · see citing works
The Search for the Natural Habitat of Cryptococcus gattii
Hagen, F., & Boekhout, T. (2010) · Mycopathologia · doi:10.1007/s11046-010-9313-6 · Cited by 26 · see citing works
Self-citation
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Research works printed but not linked: 1
- [36]Griffiths A (2006) M.Sc. thesis ‘Assessing exposure to Cryptococcus gattii’, University of British Columbia, Vancouver, BC, Canada. Available: https://circle.ubc.ca/handle/2429/17839. Accessed 4 July 2013.
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Hagen, F., Khayhan, K., Theelen, B., Kolecka, A., Polacheck, I., Sionov, E., Falk, R., Parnmen, S., Lumbsch, H. T., & Boekhout, T. (2015) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2015.02.009 · Cited by 688 · see citing works
Self-citationCryptococcus: from environmental saprophyte to global pathogen
May, R. C., Stone, N. R. H., Wiesner, D. L., Bicanic, T., & Nielsen, K. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2015.6 · Cited by 541 · see citing works
Self-citationProbiotic Gastrointestinal Transit and Colonization After Oral Administration: A Long Journey
Han, S., Lu, Y., Xie, J., Fei, Y., Zheng, G., Wang, Z., Liu, J., Lv, L., Ling, Z., Berglund, B., et al. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.609722 · Cited by 498 · see citing works
Calvo, B., Melo, A. S. D. A., Mena, A. J. P., Hernandez, M., Francisco, E. C., Hagen, F., Meis, J. F. G. M., & Colombo, A. L. (2016) · Journal of Infection · doi:10.1016/j.jinf.2016.07.008 · Cited by 448 · see citing works
Self-citation(2014) · doi:10.1128/cmr.00126-13 · Cited by 437 · see citing works
Self-citationEllwanger, J. H., Kulmann‐Leal, B., Kaminski, V. D. L., Valverde-Villegas, J. M., da Veiga, A. B. G., Spilki, F. R., Fearnside, P. M., Caesar, L., Giatti, L. L., Wallau, G. L., et al. (2020) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765202020191375 · Cited by 428 · see citing works
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Köhler, J. R., Hube, B., Puccia, R., Casadevall, A., & Perfect, J. R. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.funk-0014-2016 · Cited by 301 · see citing works
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Peters, D. G., Connor, J. R., & Meadowcroft, M. D. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.08.007 · Cited by 145 · see citing works
Hagen, F., Lumbsch, H. T., Arsić-Arsenijević, V. S., Badali, H., Bertout, S., Billmyre, R. B., Bragulat, M. R., Cabañes, F. J., Carbia, M., Chakrabarti, A., et al. (2017) · mSphere · doi:10.1128/msphere.00238-17 · Cited by 144 · see citing works
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Cogliati, M., D’Amicis, R., Zani, A., Montagna, M. T., Caggiano, G., Giglio, O. D., Balbino, S., Donno, A. D., Serio, F., Susever, S., et al. (2016) · FEMS Yeast Research · doi:10.1093/femsyr/fow045 · Cited by 138 · see citing works
Self-citationEngelthaler, D. M., Hicks, N. D., Gillece, J. D., Roe, C. C., Schupp, J. M., Driebe, E. M., Gilgado, F., Carriconde, F., Trilles, L., Firacative, C., et al. (2014) · mBio · doi:10.1128/mbio.01464-14 · Cited by 133 · see citing works
Self-citationPaim, K. F., Andrade-Silva, L. E., Fonseca, F. M., Ferreira, T. B., Mora, D. J., Andrade-Silva, J., Khan, A., Dao, A., Reis, E. C., de Almeida, M. T. G., et al. (2017) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0005223 · Cited by 125 · see citing works
Self-citationGao, Y., Wang, Y., Zhai, X., He, Y., Chen, R., Zhou, J., Li, M., & Wang, Q. (2017) · PLoS ONE · doi:10.1371/journal.pone.0184869 · Cited by 123 · see citing works
Taylor, J. W., Hann-Soden, C., Branco, S., Sylvain, I. A., & Ellison, C. E. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1503159112 · Cited by 120 · see citing works
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Self-citationKhayhan, K., Hagen, F., Pan, W., Simwami, S. P., Fisher, M. C., Wahyuningsih, R., Chakrabarti, A., Chowdhary, A., Ikeda, R., Taj‐Aldeen, S. J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072222 · Cited by 100 · see citing works
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Farrer, R. A., Desjardins, C. A., Sakthikumar, S., Gujja, S., Saif, S., Zeng, Q., Chen, Y., Voelz, K., Heitman, J., May, R. C., et al. (2015) · mBio · doi:10.1128/mbio.00868-15 · Cited by 95 · see citing works
Self-citationRhodes, J. L., Desjardins, C. A., Sykes, S. M., Beale, M. A., Vanhove, M., Sakthikumar, S., Chen, Y., Gujja, S., Saif, S., Chowdhary, A., et al. (2017) · Genetics · doi:10.1534/genetics.117.203836 · Cited by 95 · see citing works
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Self-citationBillmyre, R. B., Croll, D., Li, W., Mieczkowski, P., Carter, D. A., Cuomo, C. A., Kronstad, J. W., & Heitman, J. (2014) · mBio · doi:10.1128/mbio.01494-14 · Cited by 90 · see citing works
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Springer, D. J., Billmyre, R. B., Filler, E. E., Voelz, K., Pursall, R., Mieczkowski, P. A., Larsen, R. A., Dietrich, F. S., May, R. C., Filler, S. G., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004285 · Cited by 90 · see citing works
Self-citationAnwar, A., Abruzzo, P. M., Pasha, S., Rajpoot, K., Bolotta, A., Ghezzo, A., Marini, M., Posar, A., Visconti, P., Thornalley, P. J., et al. (2018) · Molecular Autism · doi:10.1186/s13229-017-0183-3 · Cited by 86 · see citing works
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Billmyre, R. B., Clancey, S. A., & Heitman, J. (2017) · eLife · doi:10.7554/elife.28802 · Cited by 79 · see citing works
Sanz, B., Calatayud, M. P., Biasi, E. D., Lima, E., Mansilla, M. V., Zysler, R. D., Ibarra, M. R., & Goya, G. F. (2016) · Scientific Reports · doi:10.1038/srep38733 · Cited by 76 · see citing works
Yu, B., Li, X., Zheng, W., Feng, Y., Wong, Y.-S., & Chen, T. (2014) · Journal of Materials Chemistry B · doi:10.1039/c4tb00399c · Cited by 75 · see citing works
Nguyen, H. T., Tran, T. H., Kim, J. O., Yong, C. S., & Nguyen, C. N. (2014) · Archives of Pharmacal Research · doi:10.1007/s12272-014-0424-3 · Cited by 74 · see citing works
Liang, F., Feng, Y., Wan, H., Shi, G., & Niu, W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100866 · Cited by 73 · see citing works
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Rosli, N., Leduc, D., Rowden, A. A., & Probert, P. K. (2017) · Marine Biodiversity · doi:10.1007/s12526-017-0801-5 · Cited by 67 · see citing works
Sexual Reproduction of Human Fungal PathogensPreprint
Heitman, J., Carter, D. A., Dyer, P. S., & Soll, D. R. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a019281 · Cited by 66 · see citing works
Bonilla‐Bedoya, S., Mora, A., Yánez, A. V., Estrella, A., & Herrera, M. Á. (2019) · Computers Environment and Urban Systems · doi:10.1016/j.compenvurbsys.2019.101420 · Cited by 65 · see citing works
Luo, Z., Liang, L., Sheng, J., Pang, Y., Li, J., Huang, L., & Li, X. (2014) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2013.12.066 · Cited by 63 · see citing works
Dou, H., Xu, Y., Wang, H.-Z., & Li, T. (2014) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-014-2289-2 · Cited by 63 · see citing works
Che, H., Zhang, L., Ding, L., Xie, W., Jiang, X., Xue, C., Zhang, T., & Wang, Y. (2020) · Food & Function · doi:10.1039/c9fo02323b · Cited by 61 · see citing works
Diel periodicity of Drosophila suzukii (Diptera: Drosophilidae) under field conditions
Evans, R. K., Toews, M. D., & Sial, A. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171718 · Cited by 59 · see citing works
Noda, T., & Takahashi, H. (2015) · European Journal of Neuroscience · doi:10.1111/ejn.13007 · Cited by 58 · see citing works
Sources of Fungal Genetic Variation and Associating It with Phenotypic Diversity
Taylor, J. W., Branco, S., Gao, C. D., Hann-Soden, C., Montoya, L., Sylvain, I. A., & Gladieux, P. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.funk-0057-2016 · Cited by 58 · see citing works
Vogel, A., Fester, T., Eisenhauer, N., Scherer‐Lorenzen, M., Schmid, B., Weisser, W. W., & Weigelt, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070997 · Cited by 55 · see citing works
Lizarazo, J., Escandón, P., Agudelo, C. I., Firacative, C., Meyer, W., & Castañeda, E. (2014) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0003272 · Cited by 54 · see citing works
Self-citationSouto, A. C., Bonfietti, L. X., Paim, K. F., Trilles, L., Martins, M. D. A., Alves, M. R., Pham, C. D., Martins, L. M. S., dos Santos, W., Chang, M. R., et al. (2016) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0004885 · Cited by 54 · see citing works
Self-citationRobinson, G., Waddington, K. E., Pineda‐Torra, I., & Jury, E. C. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01636 · Cited by 52 · see citing works
Cryptococcus neoformans: Sex, morphogenesis, and virulence
Zhao, Y., & Lin, X. (2021) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2021.104731 · Cited by 51 · see citing works
Current trends in the prevalence of Cryptococcus gattii in the United States and Canada
Espinel‐Ingroff, A., & Kidd, S. E. (2015) · Infection and Drug Resistance · doi:10.2147/idr.s57686 · Cited by 51 · see citing works
Brito‐Santos, F., Barbosa, G. G., Trilles, L., Nishikawa, M. M., Wanke, B., Meyer, W., Carvalho‐Costa, F. A., & Lazéra, M. D. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0115866 · Cited by 50 · see citing works
Self-citationBalmonte, J. P., Arnosti, C., Underwood, S., McKee, B. A., & Teske, A. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01441 · Cited by 50 · see citing works
Unisexual versus bisexual mating in Cryptococcus neoformans: Consequences and biological impacts
Fu, C., Sun, S., Billmyre, R. B., Roach, K. C., & Heitman, J. (2014) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2014.08.008 · Cited by 48 · see citing works
McTaggart, L. R., Brown, E. M., & Richardson, S. E. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159396 · Cited by 47 · see citing works
Patel, R. P., Wutke, S., Lenz, D., Mukherjee, S., Ramakrishnan, U., Veron, G., Fickel, J., Wilting, A., & Förster, D. W. (2017) · Journal of Heredity · doi:10.1093/jhered/esx017 · Cited by 47 · see citing works
Metabolic responses of endophytic Nicotiana benthamiana plants experiencing water stress
Dastogeer, K. M. G., Li, H., Sivasithamparam, K., Jones, M. G. K., Du, X., Ren, Y., & Wylie, S. J. (2017) · Environmental and Experimental Botany · doi:10.1016/j.envexpbot.2017.08.008 · Cited by 47 · see citing works
Dating the Cryptococcus gattii Dispersal to the North American Pacific Northwest
Roe, C. C., Bowers, J. R., Oltean, H. N., DeBess, E. E., Dufresne, P. J., McBurney, S., Overy, D. P., Wanke, B., Lysén, C., Chiller, T. M., et al. (2018) · mSphere · doi:10.1128/msphere.00499-17 · Cited by 45 · see citing works
Self-citationShamsah, A. H., Cartmell, S. H., Richardson, S. M., & Bosworth, L. A. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00437 · Cited by 44 · see citing works
Cogliati, M., Desnos‐Ollivier, M., Smith, I. M., Rickerts, V., Paim, K. F., Meyer, W., Boekhout, T., Hagen, F., Theelen, B., Inácio, J., et al. (2019) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2019.04.001 · Cited by 43 · see citing works
Self-citationCasadevall, A., Freij, J. B., Hann-Soden, C., & Taylor, J. W. (2017) · mSphere · doi:10.1128/msphere.00103-17 · Cited by 42 · see citing works
Global prevalence of chlamydial infections in birds: A systematic review and meta-analysis
Sukon, P., Nam, N. H., Kittipreeya, P., Sara-in, A., Phatthanaprat, W., Inchuai, R., & Weerakhun, S. (2021) · Preventive Veterinary Medicine · doi:10.1016/j.prevetmed.2021.105370 · Cited by 41 · see citing works
Polyol production during heterofermentative growth of the plant isolate Lactobacillus florum 2F
Tyler, C., Kopit, L. M., Doyle, C., Yu, A. O., Hugenholtz, J., & Marco, M. L. (2016) · Journal of Applied Microbiology · doi:10.1111/jam.13108 · Cited by 41 · see citing works
Engelthaler, D. M., & Casadevall, A. (2019) · mBio · doi:10.1128/mbio.02193-19 · Cited by 39 · see citing works
The potential of feeding patterns to assess generic welfare in growing-finishing pigs
Bus, J. D., Boumans, I. J. M. M., Webb, L. E., & Bokkers, E. A. M. (2021) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2021.105383 · Cited by 39 · see citing works
Adaptive adhesion systems mediate glioma cell invasion in complex environments
Gritsenko, P. G., & Friedl, P. (2018) · Journal of Cell Science · doi:10.1242/jcs.216382 · Cited by 38 · see citing works
Steenwyk, J. L., Soghigian, J., Perfect, J. R., & Gibbons, J. G. (2016) · BMC Genomics · doi:10.1186/s12864-016-3044-0 · Cited by 37 · see citing works
Socioecological system and potential deforestation in Western Amazon forest landscapes
Bonilla‐Bedoya, S., Estrella, A., Molina, J. R., & Herrera, M. Á. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.07.028 · Cited by 37 · see citing works
Antifungal Resistance in Cryptococcal Infections
Melhem, M. D. S. C., Júnior, D. P. L., Takahashi, J. P. F., Macioni, M. B., de Oliveira, L., Araujo, L. S., Fava, W. S., Bonfietti, L. X., Paniago, A. M. M., Venturini, J., et al. (2024) · Pathogens · doi:10.3390/pathogens13020128 · Cited by 36 · see citing works
Style, S., Beard, J., Fry, H. A. H., Sengupta, A., Jha, S., Shrestha, B. P., Rai, A., Paudel, V., Thondoo, M., Pulkki‐Brännström, A., et al. (2017) · Global Health Action · doi:10.1080/16549716.2017.1330858 · Cited by 36 · see citing works
Romdhani, M., Hammouda, O., Smari, K., Chaabouni, Y., Mahdouani, K., Driss, T., & Souissi, N. (2018) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000002614 · Cited by 36 · see citing works
Drivers for emerging issues in animal and plant health
Richardson, J., Lockhart, C., Pongolini, S., Karesh, W. B., Baylis, M., Goldberg, T. L., Slingenbergh, J., Gale, P., Venturini, T., Catchpole, M., et al. (2016) · EFSA Journal · doi:10.2903/j.efsa.2016.s0512 · Cited by 36 · see citing works
Reis, F. C. G., Costa, J. H., Honorato, L., Nimrichter, L., Fill, T. P., & Rodrigues, M. L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.654574 · Cited by 35 · see citing works
Hernandez-Gomez, M. C., Runavot, J.-L., Guo, X., Bourot, S., Benians, T. A. S., Willats, W. G. T., Meulewaeter, F., & Knox, J. P. (2015) · Plant and Cell Physiology · doi:10.1093/pcp/pcv101 · Cited by 34 · see citing works
Genotypic diversity and clinical outcome of cryptococcosis in renal transplant recipients in Brazil
Ponzio, V., Chen, Y., Rodrigues, A. M., Tenor, J. L., Toffaletti, D. L., Medina-Pestana, J. O., Colombo, A. L., & Perfect, J. R. (2019) · Emerging Microbes & Infections · doi:10.1080/22221751.2018.1562849 · Cited by 34 · see citing works
Advances in Cryptococcus genomics: insights into the evolution of pathogenesis
Cuomo, C. A., Rhodes, J. L., & Desjardins, C. A. (2018) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/0074-02760170473 · Cited by 34 · see citing works
Filho, J. E., dos Santos, I. B., Reis, C. M. S., Patané, J. S. L., Paredes, V., Bernardes, J. P. R. A., Poggiani, S. D. S. C., Castro, T. D. C. B., Gómez, O. M., Pereira, S. A., et al. (2020) · Emerging Microbes & Infections · doi:10.1080/22221751.2020.1847001 · Cited by 32 · see citing works
Herkert, P. F., Hagen, F., Salvador, G. L. D. O., Gomes, R. R., Ferreira, M. S., Vicente, V. A., Muro, M. D., Pinheiro, R. L., Meis, J. F. G. M., & Queiroz‐Telles, F. (2016) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-016-2731-8 · Cited by 30 · see citing works
Self-citationPrevalence of sarcopenia in patients with geriatric depression diagnosis
Yazar, H. O., & Yazar, T. (2019) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-018-01957-7 · Cited by 30 · see citing works
Mimicking the Annulus Fibrosus Using Electrospun Polyester Blended Scaffolds
Shamsah, A. H., Cartmell, S. H., Richardson, S. M., & Bosworth, L. A. (2019) · Nanomaterials · doi:10.3390/nano9040537 · Cited by 30 · see citing works
Alves, G. S. B., Freire, A. K. L., Bentes, A. D. S., Pinheiro, J. F. D. S., de Souza, J. V. B., Wanke, B., Matsuura, T., & Matsuura, A. B. J. (2016) · Mycoses · doi:10.1111/myc.12499 · Cited by 30 · see citing works
Hong, N., Chen, M., & Xu, J. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.683670 · Cited by 29 · see citing works
Rising to the challenge of multiple Cryptococcus species and the diseases they cause
Idnurm, A., & Lin, X. (2015) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2015.05.002 · Cited by 29 · see citing works
Fungal Infections Complicating Lung Transplantation
Clark, N. M., WEIGT, S. S., Fishbein, M. C., Kubak, B., Belperio, J. A., & Lynch, J. P. (2018) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0037-1617443 · Cited by 28 · see citing works
A simple dot-blot–Sirius red-based assay for collagen quantification
Rodríguez‐Rodríguez, P., Arribas, S. M., de Pablo, Á. L. L., González, M. C., Abderrahim, F., & Condezo‐Hoyos, L. (2013) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-013-7101-0 · Cited by 28 · see citing works
Valencia, L. M., Martins, A. B., Ortiz, E. M., & Fiore, A. D. (2018) · PLoS ONE · doi:10.1371/journal.pone.0201254 · Cited by 27 · see citing works
How Much Information is Needed to Infer Reticulate Evolutionary Histories?
Huber, K. T., van Iersel, L. J. J., Moulton, V., & Wu, T. (2014) · Systematic Biology · doi:10.1093/sysbio/syu076 · Cited by 25 · see citing works
Spruijtenburg, B., Meis, J. F. G. M., Verweij, P. E., de Groot, T., & Meijer, E. F. J. (2024) · Mycopathologia · doi:10.1007/s11046-024-00877-8 · Cited by 24 · see citing works
Self-citationMorera, N., Hagen, F., Juan‐Sallés, C., Artigas, C., Patrício, R., Serra, J. I., & Colom, M. F. (2014) · Mycopathologia · doi:10.1007/s11046-014-9773-1 · Cited by 24 · see citing works
Self-citationWang, B., Jedlicka, S. S., & Cheng, X. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109815 · Cited by 24 · see citing works
Andersson, M. O., Tolf, C., Tamba, P., Stefanache, M., Radbea, G., Frangoulidis, D., Tomaso, H., Waldenström, J., Dobler, G., & Chitimia‐Dobler, L. (2018) · Parasites & Vectors · doi:10.1186/s13071-018-2756-1 · Cited by 24 · see citing works
Liang, J., Gao, X., Zeng, G., Hua, S., Zhong, M., Li, X., & Li, X. (2018) · Scientific Reports · doi:10.1038/s41598-017-18594-2 · Cited by 24 · see citing works
Epidemiology of Cryptococcus gattii, British Columbia, Canada, 1999–2007
Galanis, E. (2010) · Emerging infectious diseases · doi:10.3201/eid1601.090900 · Cited by 24 · see citing works
Cryptococcosis due to Cryptococcus gattii in Germany from 2004–2013
Smith, I. M., Stephan, C., Hogardt, M., Klawe, C., Tintelnot, K., & Rickerts, V. (2015) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2015.08.023 · Cited by 23 · see citing works
- Authors
- Hagen, F., Ceresini, P. C., Polacheck, I., Ma, H., Nieuwerburgh, F. V., Gabaldón, T., Kagan, S., Pursall, E. R., Hoogveld, H. L., van Iersel, L. J. J., Klau, G. W., Kelk, S. M., Stougie, L., Bartlett, K. H., Voelz, K., Pryszcz, L. P., Castañeda, E., Lazera, M., Meyer, W., Deforce, D., Meis, J. F., May, R. C., Klaassen, C. H. W., & Boekhout, T.
- Affiliations
- Westerdijk Fungal Biodiversity Institute (NL)
- Universidade Estadual Paulista (Unesp) (BR)
- Hadassah Medical Center (IL)
- University of Birmingham (GB)
- Ghent University (BE)
- Centre for Genomic Regulation (ES)
- Netherlands Institute of Ecology (NL)
- Centrum Wiskunde & Informatica (NL)
- University of British Columbia (CA)
- Instituto Nacional de Salud (CO)
- The University of Sydney (AU)
- Radboud University Medical Center (NL)
- Canisius-Wilhelmina Ziekenhuis (NL)
- Second Military Medical University (CN)
- Corresponding author
- Boekhout, Teun
- ORCID
- Hagen, Ferry
- Ceresini, Paulo C.
- Polacheck, Itzhack
- Ma, Hansong
- Nieuwerburgh, Filip van
- Gabaldón, Toni
- Klau, Gunnar W.
- Kelk, Steven M.
- Stougie, Leen
- Bartlett, Karen H.
- Voelz, Kerstin
- Pryszcz, Leszek P.
- Castañeda, Elizabeth
- Meyer, Wieland
- Deforce, Dieter
- Meis, Jacques F.
- May, Robin C.
- Klaassen, Corné H. W.
- Boekhout, Teun
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-08-07
- Volume
- 8
- Issue
- 8
- Pages
- e71148
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3737135
- OpenAlex
- W2152772772
- Cited by
- 218
- References
- 42
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 4 · 2023: 6 · 2022: 4 · 2021: 28 · 2020: 18 · 2019: 14 · 2018: 19 · 2017: 33 · 2016: 21 · 2015: 27 · 2014: 30 · 2013: 4
- FWCI
- 19.92
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Americanae (AECID Library) (publishedVersion, other-oa)
- KNAW research portal (Royal Academy of Art and Sciences (KNAW)) (publishedVersion, cc-by)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (publishedVersion, cc-by)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (publishedVersion, other-oa)
- VU Research Portal (publishedVersion, other-oa)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion, other-oa)
- Centrum Wiskunde & Informatica (CWI), the national research institute for mathematics and computer science in the Netherlands (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, cc-by)
- Acervo Digital da Universidade Estadual Paulista (Universidade Estadual Paulista) (submittedVersion, other-oa)
- Research Publications (Maastricht University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion, other-oa)
- Repositori digital de la UPF (Universitat Pompeu Fabra) (submittedVersion, cc-by)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Radboud Repository (Radboud University) (submittedVersion)
- Apollo (University of Cambridge) (submittedVersion, cc-by)
- Radboud Repository (Radboud University) (submittedVersion, other-oa)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Apollo (cc-by)
- Funders
- Qatar Foundation
- Fonds National de la Recherche Luxembourg
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Qatar National Research Fund
- Topics
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Plant Pathogens and Fungal Diseases
- Keywords
- Cryptococcus gattii, fungal outbreak, human fungal infections, Amazon rainforest, population dispersal, recombination, phylogenetics, multilocus sequence typing, Northern Brazil, fungal genotypes
- MeSH terms
- Animals, Brazil, British Columbia, Cells, Cultured, Cryptococcosis, Disease Outbreaks, Genes, Fungal, Humans, Macrophages, Mice, Inbred BALB C, Molecular Sequence Data, Phylogeny, Polymorphism, Restriction Fragment Length, Trees, Tropical Climate, Virulence, Northwestern United States, Likelihood Functions, Mycological Typing Techniques, Mice, Cryptococcus gattii, Multilocus Sequence Typing
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