Cited by 218Fungal Infections and StudiesGenetic diversity and population structurePlant Pathogens and Fungal Diseases

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Ancient Dispersal of the Human Fungal Pathogen Cryptococcus gattii from the Amazon Rainforest

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Hagen, Ferry, Ceresini, Paulo C., Polacheck, Itzhack, Ma, Hansong, Nieuwerburgh, Filip van, Gabaldón, Toni, Kagan, Sarah, Pursall, E. Rhiannon, Hoogveld, Hans L., van Iersel, Leo J. J., Klau, Gunnar W., Kelk, Steven M., Stougie, Leen, Bartlett, Karen H., Voelz, Kerstin, Pryszcz, Leszek P., Castañeda, Elizabeth, Lazera, Marcia, Meyer, Wieland, Deforce, Dieter, Meis, Jacques F., May, Robin C., Klaassen, Corné H. W., Boekhout, Teun·2013·PLoS ONE

DOI 10.1371/journal.pone.0071148PMC PMC3737135

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Abstract

Over the past two decades, several fungal outbreaks have occurred, including the high-profile 'Vancouver Island' and 'Pacific Northwest' outbreaks, caused by Cryptococcus gattii, which has affected hundreds of otherwise healthy humans and animals. Over the same time period, C. gattii was the cause of several additional case clusters at localities outside of the tropical and subtropical climate zones where the species normally occurs. In every case, the causative agent belongs to a previously rare genotype of C. gattii called AFLP6/VGII, but the origin of the outbreak clades remains enigmatic. Here we used phylogenetic and recombination analyses, based on AFLP and multiple MLST datasets, and coalescence gene genealogy to demonstrate that these outbreaks have arisen from a highly-recombining C. gattii population in the native rainforest of Northern Brazil. Thus the modern virulent C. gattii AFLP6/VGII outbreak lineages derived from mating events in South America and then dispersed to temperate regions where they cause serious infections in humans and animals.

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Griffiths A (2006) M.Sc. thesis ‘Assessing exposure to Cryptococcus gattii’, University of British Columbia, Vancouver, BC, Canada. Available: https://circle.ubc.ca/handle/2429/17839. Accessed 4 July 2013.

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Authors: Hagen, F., Ceresini, P. C., Polacheck, I., Ma, H., Nieuwerburgh, F. V., Gabaldón, T., Kagan, S., Pursall, E. R., Hoogveld, H. L., van Iersel, L. J. J., Klau, G. W., Kelk, S. M., Stougie, L., Bartlett, K. H., Voelz, K., Pryszcz, L. P., Castañeda, E., Lazera, M., Meyer, W., Deforce, D., Meis, J. F., May, R. C., Klaassen, C. H. W., & Boekhout, T.
Affiliations: Westerdijk Fungal Biodiversity Institute (NL)
Universidade Estadual Paulista (Unesp) (BR)
Hadassah Medical Center (IL)
University of Birmingham (GB)
Ghent University (BE)
Centre for Genomic Regulation (ES)
Netherlands Institute of Ecology (NL)
Centrum Wiskunde & Informatica (NL)
University of British Columbia (CA)
Instituto Nacional de Salud (CO)
The University of Sydney (AU)
Radboud University Medical Center (NL)
Canisius-Wilhelmina Ziekenhuis (NL)
Second Military Medical University (CN)
Corresponding author: Boekhout, Teun
ORCID: Hagen, Ferry
Ceresini, Paulo C.
Polacheck, Itzhack
Ma, Hansong
Nieuwerburgh, Filip van
Gabaldón, Toni
Klau, Gunnar W.
Kelk, Steven M.
Stougie, Leen
Bartlett, Karen H.
Voelz, Kerstin
Pryszcz, Leszek P.
Castañeda, Elizabeth
Meyer, Wieland
Deforce, Dieter
Meis, Jacques F.
May, Robin C.
Klaassen, Corné H. W.
Boekhout, Teun
Venue: PLoS ONE
Publisher: Public Library of Science (PLoS)
Published: 2013-08-07
Volume: 8
Issue: 8
Pages: e71148
ISSN: 1932-6203 (ISSN-L)
DOI: 10.1371/journal.pone.0071148
PMC: PMC3737135
OpenAlex: W2152772772
Cited by: 218
References: 42
Citations by year: 2026: 1 · 2025: 5 · 2024: 4 · 2023: 6 · 2022: 4 · 2021: 28 · 2020: 18 · 2019: 14 · 2018: 19 · 2017: 33 · 2016: 21 · 2015: 27 · 2014: 30 · 2013: 4
FWCI: 19.92
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
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Funders: Qatar Foundation
Fonds National de la Recherche Luxembourg
Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Qatar National Research Fund
Topics: Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Pathogens and Fungal Diseases
Keywords: Cryptococcus gattii, fungal outbreak, human fungal infections, Amazon rainforest, population dispersal, recombination, phylogenetics, multilocus sequence typing, Northern Brazil, fungal genotypes
MeSH terms: Animals, Brazil, British Columbia, Cells, Cultured, Cryptococcosis, Disease Outbreaks, Genes, Fungal, Humans, Macrophages, Mice, Inbred BALB C, Molecular Sequence Data, Phylogeny, Polymorphism, Restriction Fragment Length, Trees, Tropical Climate, Virulence, Northwestern United States, Likelihood Functions, Mycological Typing Techniques, Mice, Cryptococcus gattii, Multilocus Sequence Typing

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Ancient Dispersal of the Human Fungal Pathogen Cryptococcus gattii from the Amazon Rainforest

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