Chronic Psychological Stress Induces the Accumulation of Myeloid-Derived Suppressor Cells in Mice
Open accessAbstract
Chronic psychological stress has been shown to adversely impact immune system functions and compromise host defenses against various infections. However, the underlying mechanisms remain elusive. Recent studies have demonstrated that myeloid-derived suppressor cells (MDSCs) play an important role in regulating immunity. It is of interest to explore whether or not chronic psychological stress plays immunosuppressive functions partially by inducing MDSCs accumulation. In this work, we report that chronic psychological stress led to the accumulation of CD11b+Gr1+ cells in the bone marrow of BALB/c mice. Repeated β-agonist infusion showed no such effect. However, β-adrenergic blockade, but not glucocorticoids blockade, partially reversed the accumulation of CD11b+Gr1+ cells under the condition of chronic psychological stress, suggesting catecholamines collaborate with other factors to induce the accumulation. Further exploration indicates that cyclooxygenase 2 (COX-2)-prostaglandin E2 (PGE2) loop might act downstream to induce the accumulation. A majority of the accumulated CD11b+Gr1+ cells were Ly6G+Ly6C(low) immature neutrophils, which inhibited cytokine release of macrophages as well as T cell responsiveness. Moreover, the accumulated CD11b+Gr1+ cells under the condition of chronic psychological stress expressed multiple inhibitory molecules. Taken together, our data demonstrate for the first time that chronic psychological stress induces MDSCs accumulation in mice, which can contribute to immunosuppression.
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Chronic restraint stress is associated with diminished NK cell function, cytokine secretion, and enhanced viral replication, and its opposing immune effects on myeloid cells compared with RSD can be accounted for by differences in circulating GCs.
“For example, several studies investigated the immune response to chronic restraint stress and reported diminished natural killer (NK) cell function, cytokine secretion, and enhanced viral replication (Hunzeker et al, 2004;Tseng et al, 2005;Jin et al, 2013).”
From Repeated Social Defeat, Neuroinflammation, and Behavior: Monocytes Carry the Signal (2017) · cites this paper as Jin et al, 2013
ATP binds to P2X 7 and initiates K + efflux from the cell.
“ATP binds to P2X 7 and initiates K + efflux from the cell.”
From Repeated Social Defeat, Neuroinflammation, and Behavior: Monocytes Carry the Signal (2017) · cites this paper as [65]
Stress-induced ATP can stimulate IL-1β release to influence behavior via the NLRP3 inflammasome.
“Clear evidence that stress-induced ATP can stimulate IL-1β release to influence behavior and does so via the NLRP3 inflammasome.”
From Repeated Social Defeat, Neuroinflammation, and Behavior: Monocytes Carry the Signal (2017) · cites this paper as [65]
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- Authors
- Jin, J., Wang, X., Wang, Q., Guo, X., Cao, J., Zhang, X., Zhu, T., Zhang, D., Wang, W., Wang, J., Shen, B., Gao, X., Shi, Y., & Zhang, J.
- Affiliations
- Harbin Medical University (CN)
- Inner Mongolia Medical College Hospital (CN)
- Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences (CN)
- Corresponding author
- Gao, Xu
- Shi, Yanchun
- Zhang, Jiyan
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-09-18
- Volume
- 8
- Issue
- 9
- Pages
- e74497
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3776856
- OpenAlex
- W2049400932
- Cited by
- 53
- References
- 42
- Citations by year
- 2025: 6 · 2024: 4 · 2023: 5 · 2022: 1 · 2021: 2 · 2020: 9 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 7 · 2015: 7 · 2014: 3
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Natural Science Foundation of China (31270960, 31100544)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- chronic psychological stress, myeloid-derived suppressor cells, immunosuppression, CD11b+Gr1+ cells, beta-adrenergic blockade, catecholamines, cyclooxygenase-2, prostaglandin E2, immature neutrophils, T cell responsiveness, inhibitory molecules, bone marrow
- MeSH terms
- Animals, Catecholamines, Cell Count, Chronic Disease, Female, Mice, Inbred BALB C, Organ Size, Restraint, Physical, Stress, Psychological, Dinoprostone, Myeloid Cells, CD11b Antigen, Mice, Cyclooxygenase 2
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